Clinical trials: Post-thrombotic Syndrome
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Deep Vein Thrombosis
Full-Leg vs Below-Knee Elastic Stockings for Prevention of the Post-Thrombotic Syndrome
Prospective controlled randomized clinical trial. Consecutive patients with acute proximal deep vein thrombosis of the lower extremities, with or without contemporary manifestations of pulmonary embolism, are randomized to…
- Trial name
- NCT00426075
- Testing
- Elastic stockings
- Where
- Italy
- Sponsor
- University of Padova
Post Thrombotic Syndrome, Deep Vein Thrombosis
Long-term Outcome After Heparin and Edoxaban Versus Heparin Plus Vit K Antagonists for Acute DVT and PE
Centers that participated in the HOKUSAI VTE trial will be invited to collect follow of previously enrolled patients at least 2 years after the index VTE.
- Conditions
- Post Thrombotic Syndrome, Deep Vein Thrombosis, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT03757481
- Testing
- no intervention
- Where
- 11 sites in France
- Volunteers
- 156 people
- Sponsor
- University Hospital, Montpellier
Deep Venous Thrombosis
The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome
The purpose of this study is to determine whether elastic compression stockings used for 2 years are effective in preventing the post-thrombotic syndrome in patients with symptomatic proximal deep venous thrombosis.
- Trial name
- NCT00143598
- Testing
- Knee-length, graduated elastic compression stocking
- Where
- 25 sites in United States, Canada
- Volunteers
- 806 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Post-Thrombotic Syndrome of Both Legs
Inflow Improve for Deep Vein ThrombOsis with Ultrasound AcceLerated ThrombOlysis and Venoplasty
Aim of the IDOLO study is to investigate clinical efficacy on ultrasound accelerated thrombolysis and venoplasty in patients with post-thrombotic syndrome secondary to chronical femoro-popliteal vein occlusion for previous deep…
- Trial name
- NCT06198816
- Testing
- ultrasound accelerated thrombolysis and venoplasty
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Venous Obstruction
RECANA OUS - Recana Thrombectomy Catheter System for Venous Obstruction and Occlusion Study (RECANA-OUS-UK)
The goal of this clinical investigation is to learn if the Recana Thrombectomy Catheter System can treat chronic venous obstruction and occlusion in participants with symptomatic post-thrombotic venous inflow/outflow obstruction.
- Trial name
- NCT07219758
- Testing
- Recana Thrombectomy Catheter System
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Intervene, Inc.
Deep Vein Thrombosis, Venous Thrombosis
Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
The purpose of this study is to determine if the use of adjunctive Pharmacomechanical Catheter Directed Thrombolysis, which includes the intrathrombus administration of rt-PA--Activase (Alteplase),can prevent the post-thrombotic…
- Conditions
- Deep Vein Thrombosis, Venous Thrombosis, Postphlebitic Syndrome, Venous Thromboembolism
- Trial name
- ATTRACT (NCT00790335)
- Testing
- Recombinant tissue plasminogen activator (rt-PA)
- Where
- 56 sites in United States
- Volunteers
- 692 people
- Sponsor
- Washington University School of Medicine
Hairy Cell Leukemia
US Post-Marketing Safety Study of Moxetumomab Pasudotox-tdfk (LUMOXITI)
This study is being conducted to satisfy a post-marketing requirement (PMR) to provide evidence characterizing 1) the safety of moxetumomab pasudotox-tdfk in patients who are 65 years of age and older and/or 2) the safety of…
- Trial name
- PROXY (NCT04125290)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- AstraZeneca
Venous Thrombosis Deep (Limbs), Post-thrombotic Syndrome
Design and Rationale of the COLT Study
Deep vein thrombosis (DVT) is a condition in which a blood clot forms in the deep veins of the leg and can lead to long-term problems such as leg pain, swelling, and reduced quality of life.
- Conditions
- Venous Thrombosis Deep (Limbs), Post-thrombotic Syndrome, Venous Thromboembolism (VTE), Venous Insufficiency
- Trial name
- COLT (NCT07432529)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Volunteers
- 940 people
- Sponsor
- Azienda Sanitaria Locale ASL 6, Livorno
Deep Vein Thrombosis
Comparison Of Percutaneous Mechanical Thrombectomy With Different Access in Treatment of Acute Deep Venous Thrombosis
The study aims to compare the modified approach through ipsilateral deep calf venous access or contralateral femoral venous access with the traditional approach through ipsilateral popliteal venous access for iliofemoral deep…
- Trial name
- NCT06124768
- Testing
- Percutaneous mechanical thrombectomy (PMT) by the modified approach, Percutaneous mechanical thrombectomy (PMT) by the traditional approach, Traditional approach
- Where
- China
- Volunteers
- 210 people
- Sponsor
- RenJi Hospital
Deep Vein Thrombosis, Venous Stasis
Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)
The purpose of this study is to determine if the use of image-guided, endovascular therapy (EVT) is an effective strategy with which to reduce Post Thrombotic Syndrome (PTS) disease severity and improve quality of life in…
- Conditions
- Deep Vein Thrombosis, Venous Stasis, Venous Insufficiency, Venous Leg Ulcer
- Trial name
- C-TRACT (NCT03250247)
- Testing
- Stents
- Where
- 29 sites in United States
- Volunteers
- 225 people
- Sponsor
- Washington University School of Medicine
Deep Vein Thrombosis
Comparison Of Different Mechanical Thrombectomy Devices in Endovascular Treatment of Acute Iliofemoral Venous Thrombosis
A head-to-head comparison of two different types of percutaneous mechanical thrombectomy (PMT) - ClotTriever System versus aspiration thrombectomy (including rheolytic thrombectomy) - in patients with acute iliofemoral deep vein…
- Trial name
- NCT07622212
- Testing
- Percutaneous mechanical thrombectomy by ClotTriever System, Percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
Post Thrombotic Syndrome
Angioplasty-stenting vs Optimal Medical Treatment on Post-thrombotic Syndrome Reduction
The project will highlight the potential benefit of endovascular therapy on post thrombotic syndrome reduction after proximal iliac DVT. There is actually not real standard of care for the treatment of this pathology.
- Trial name
- EndoPTS (NCT04250025)
- Testing
- 60 patients benefit from immediate venous angioplasty stenting plus medical treatment, i.e. elastic compression and anticoagulation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Chronic Venous Insufficiency, Chronic Venous Thrombosis
Best Endovenous Treatment, Including STenting, Versus Non-endovenous Treatment in Chronic Proximal Deep Venous Disease
Chronic obstruction of the iliac veins or inferior vena cava can occur as a result of deep vein thrombosis (DVT), or due to extrinsic compression in non-thrombotic iliac vein lesions (NIVLs).
- Conditions
- Chronic Venous Insufficiency, Chronic Venous Thrombosis, Iliac Vein Stenosis, Iliac Vein Obstruction
- Trial name
- BEST (NCT05622500)
- Testing
- Deep venous stenting, Best medical therapy
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Deep Vein Thrombosis
Catheter-Directed Venous Thrombolysis in Acute Iliofemoral Vein Thrombosis
Deep vein thrombosis (DVT) is a severe disease, and conventional treatment with low molecular weight heparin (LMWH) and warfarin is associated with some degree of long-term sequelae, i.e. post-thrombotic syndrome (PTS).
- Trial name
- CaVenT (NCT00251771)
- Testing
- catheter-directed venous thrombolysis
- Where
- Norway
- Volunteers
- 209 people
- Sponsor
- Oslo University Hospital
Post Thrombotic Syndrome
The Use of Intermittent Pneumatic Compression Device for Symptomatic Relief in Patients With Post Thrombotic Syndrome
The use of ActiveCare+S.F.T 3rd generation (an Intermittent Pneumatic Compression Device) will improve quality of life in patients suffering from Post Thrombotic Syndrome compared to compression stockings which is the current…
- Trial name
- NCT01637428
- Testing
- ActiveCare+S.F.T 3rd generation
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Deep Vein Thrombosis, Post Thrombotic Syndrome
Tinzaparin Lead-In to Prevent the Post-Thrombotic Syndrome
The TILE pilot study will be a multicenter, open-label, assessor-blinded RCT (randomized control trial) comparing extended LMWH (Low Molecular Weight Heparin) vs.
- Trial name
- TILE (NCT04794569)
- Testing
- tinzaparin, Rivaroxaban
- Where
- 5 sites in Canada
- Volunteers
- 9 people
- Sponsor
- Sunnybrook Health Sciences Centre
Post Thrombotic Syndrome, Venous Thromboembolism
Long Term Assessment of Post Thrombotic Syndrome : OPTIMEV Study ( SPOT )
Post-thrombotic syndrome (PTS) is a frequent and burdensome complication of deep-vein thrombosis (DVT). In the absence of curative treatment of established PTS, its management is based on the prevention of its occurrence thanks…
- Conditions
- Post Thrombotic Syndrome, Venous Thromboembolism, Cardiovascular Diseases
- Trial name
- SPOT (NCT03054727)
- Testing
- Villalta phone score > or = to 5, Villalta phone score < 5
- Where
- France
- Volunteers
- 2,475 people
- Sponsor
- Association des Médecins Vasculaires Hospitaliers
Postthrombotic Syndrome
Flow Augmentation Study in Postthrombotic Patients
Rationale: Stent therapy has been proven to be an effective form of therapy in the treatment of chronic iliofemoral and iliocaval post-thrombotic obstruction.
- Trial name
- NCT03111758
- Testing
- Flow augmentation
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Acute Renal Failure, Chronic Kidney Failure
The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)
To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.
- Conditions
- Acute Renal Failure, Chronic Kidney Failure, Endothelial Dysfunction, Hemolytic-uremic Syndrome (HUS)
- Trial name
- NCT00358306
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham