Clinical trials: Post-traumatic
Depression, Postpartum, Depression
Interpersonal Treatment Program to Prevent Depression and Post-Traumatic Stress Disorder in Low-Income Pregnant Women With Partner Abuse
This study will evaluate the effectiveness of an interpersonally oriented treatment program called Reach Out for a Safe Environment in preventing depression and post-traumatic stress disorder in low-income pregnant women who have…
- Trial name
- NCT00602732
- Testing
- The Reach Out for a Safe Environment (ROSE) program, Enhanced care as usual (ECU)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Post Traumatic Stress Disorder, Smoking
Computerized Tailored Intervention for Behavioral Sequelae of PTSD in Veterans
This project assesses the usability and feasibility of a multi-behavioral computerized, tailored intervention (CTI) or expert system delivered via the Internet for veterans with Post-Traumatic Stress symptoms.
- Conditions
- Post Traumatic Stress Disorder, Smoking, Anxiety, Depression
- Trial name
- CTI-PTSD (NCT01510834)
- Testing
- Multibehavioral, Computerized Tailored Intervention STR2IVE
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System
Stress, Emotional, Stress-related Mental Disorders
Effects of Parent-Adolescent Joint Interventions for Adolescents With Adverse Childhood Experiences
The study aims to examine the effectiveness of joint parent-adolescent intervention in improving the mental health outcomes of participants, specifically by reducing symptoms of depression, anxiety, and PTSD, as measured by the…
- Conditions
- Stress, Emotional, Stress-related Mental Disorders, Adverse Childhood Experiences
- Trial name
- EASY-PEP (NCT06619821)
- Testing
- Emotiaonl skill enhancement, PCE promotion, Psychoeducation
- Where
- 2 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking University
Post-Traumatic Stress Symptoms, Poor Sleep Quality
Psychoeducation-Supported Breathing and Relaxation for Earthquake Survivors
This randomized controlled study evaluated whether a structured program combining psychoeducation, breathing exercises, and relaxation techniques could reduce post-traumatic stress symptoms and improve sleep quality among adult…
- Trial name
- NCT07781904
- Testing
- Psychoeducation-Supported Breathing and Relaxation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rana Ceviz
Post-traumatic Stress Disorder
Perception of Stressful Social Stimuli After Trauma Exposure.
Post-traumatic stress disorder is associated with altered processing of sensory stimuli. The clinical phenotype PTSD has predominantly been described for the visual and auditory sensory modalities.
- Trial name
- NCT03421587
- Testing
- Processing of social olfactory and tactile stimuli
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Post Traumatic Stress Disorder, Anxiety
PTSD Symptoms Among Health Workers and Public Service Providers After the COVID-19 Outbreak: A 3 Month Follow up
The aim of this study is to investigate the levels of trauma and mental symptoms (i.e., depression and anxiety) among health workers and public service providers 3 months after (T2) the strict social distancing government…
- Conditions
- Post Traumatic Stress Disorder, Anxiety, Depression
- Trial name
- NCT04442243
- Volunteers
- 889 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Traumatic Brain Injury
Exercise and Rehabilitation After Traumatic Brain Injury
The purpose of this study is to examine the effects of exercise on recovery after traumatic brain injury. Investigators will determine if exercise enhances rehabilitation by increasing substances (proteins) that can facilitate…
- Trial name
- NCT03407924
- Testing
- Aerobic Exercise (AER), Rehabilitation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre for Neuro Skills
Moral Injury
Assessing the Implementation and Feasibility of the SMART-MR
The objective of the proposed pilot study is to assess the feasibility and implementation of the SMART-MR program, an integration of stress management, general resilience, and moral resilience skills, with frontline staff who…
- Trial name
- NCT05122910
- Testing
- Stress Management and Resilience Training - Moral Resilience (SMART-MR) program
- Where
- Canada
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Post Traumatic Stress Disorder, Anxiety
Level and Predictors of Trauma-symptoms Among Health Workers and Public Service Providers During the COVID-19 Outbreak
The aim of this study is to investigate the levels of trauma and mental symptoms (i.e., depression and anxiety) among health workers and public service providers during the strict social distancing government-initiated…
- Conditions
- Post Traumatic Stress Disorder, Anxiety, Depression
- Trial name
- NCT04374097
- Where
- Norway
- Volunteers
- 1,778 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Posttraumatic Stress Disorder
The Effectiveness of CFT for Reducing Self-criticism in Patients With Complex PTSD: a Single-case Experimental Study
PTSD is a mental disorder including psychological symptoms related to severe traumatic event(s). PTSD can negatively affect people's functioning in several life domains.
- Trial name
- NCT05791760
- Testing
- Compassion-focused therapy (CFT) for complex PTSD
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Twente
PTSD, Anxiety, Post Traumatic
Xyrem for Treatment Refractory Insomnia Due to PTSD
Xyrem (sodium oxybate) is an agent with the propensity to improve slow wave sleep and sleep efficiency. It is FDA approved to treat cataplexy (drop attacks) associated with narcolepsy (sleep attacks).
- Trial name
- NCT00330291
- Testing
- Xyrem
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
The purpose of this clinical study is to assess pharmacokinetic interactions between ethanol (EtOH) and PT150 (900 mg qd) in non-treatment-seeking alcohol-experienced volunteers-(to include military service members, veterans…
- Trial name
- NCT04331288
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pop Test Oncology LLC
Post-traumatic Stress Disorder, Depression
Randomized Control Trial of Group Intervention With Former War-affected Boys in the Democratic Republic of Congo
The purpose of this study is to evaluate, in a randomised control trial (RCT), the effectiveness of group-based, trauma-focused Cognitive Behaviour Therapy (TF-CBT) in reducing psychological distress in former child soldiers and…
- Conditions
- Post-traumatic Stress Disorder, Depression, Conduct Disorder
- Trial name
- NCT01494831
- Testing
- TF-CBT
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Post-Traumatic Stress Disorder
Evaluation of a Yoga Intervention for Post-Traumatic Stress Disorder
The main objective of this preliminary randomized controlled clinical trial is to establish efficacy and feasibility of a yoga-based treatment for PTSD in military veterans as compared to a delayed yoga treatment (waitlist…
- Trial name
- EYIPTSD (NCT00962403)
- Testing
- Yoga treatment
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Posttraumatic Stress Disorder (PTSD)
Oxytocin and Affect Processing in Posttraumatic Stress Disorder
The investigators will use multiple methods (including Oxytocin intranasal inhalation, neuroimaging, behavioral measures, peripheral hormone measurements) to examine how individuals' behavior, cognition, and brain function is…
- Trial name
- NCT02546570
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
PTSD, Alzheimer Disease
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)
The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: What is the safety of single ascending doses of the…
- Conditions
- PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease
- Trial name
- NCT05921929
- Testing
- Fluoroethylnormemantine (FENM)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- ReST Therapeutics
Stress, Trauma
Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness
The purpose of this study is to investigate justice-involved Black/African American female adolescents' (JI BAFAs; N=35) self-reported outcomes: stress, posttraumatic stress disorder (PTSD), recidivism, etc., as well as their…
- Conditions
- Stress, Trauma, PTSD, HPA
- Trial name
- NCT06311188
- Testing
- ITR Healing intervention
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoarthritis, Traumatic Arthritis
The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy
A clinical trial to evaluate the long-term efficacy and safety of Chondron (Autologous cultured Chondrocyte) administered through arthroscopy from the drug's 48 weeks efficacy and safety evaluation with 96 weeks follow-up in…
- Trial name
- NCT02539069
- Testing
- Chondron Implantation
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Stress Disorders, Post-Traumatic
Computational Assessment of GABA Receptor Modulation in PTSD
A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications.
- Trial name
- NCT06852469
- Testing
- Lorazepam 1 mg tablet
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post-Traumatic Headache
Investigate the Mechanisms, Predictors, and Prevention of Persistent Post-Traumatic Headache
This is a United States Department of Defense funded Focused Program study that aims to identify mechanisms and predictors for persistent of post-traumatic headache attributed to mild traumatic brain injury, and identify methods…
- Trial name
- NCT04369729
- Where
- 5 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic