Clinical trials: Posterior Circulation Ischemic Stroke
Ischemic Stroke
Total Posterior-circulation Infarct Volume in Basilar Artery Stroke
Preprocedural predictors of outcome in patients with acute basilar artery occlusion (ABAO) who underwent endovascular treatment (EVT) remain controversial.
- Trial name
- TPCIV-ABAO (NCT04650022)
- Testing
- Mechanical thrombectomy
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Acute Ischemic Stroke Related to Tandem Occlusion, Acute Ischemic Stroke Due to Isolated Cervical Artery Occlusion
Risk Factors and Outcomes of Ischemic Stroke Associated With Tandem or Isolated Cervical Artery Occlusion in Anterior and Posterior Circulation
CERES-TANDEM is a multicenter study designed to improve the understanding of "tandem" ischemic stroke -those caused by two blockages in series, one in a neck artery and one in a brain artery-.
- Trial name
- CERES-TANDEM (NCT06965036)
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 2,880 people
- Sponsor
- Azienda Unità Sanitaria Locale della Romagna
Acute Ischemic Stroke
Pro-urokinase for Extended-Window Posterior Circulation Stroke
This study aims to evaluate whether, in patients with imaging-confirmed acute ischemic stroke of the posterior circulation presenting within 4.5-24 hours after symptom onset and not scheduled for endovascular thrombectomy…
- Trial name
- PROMISE (NCT07617870)
- Testing
- rhPro-UK, Aspirin
- Where
- China
- Volunteers
- 586 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Endovascular Thrombectomy
Medical Imaging Screening for Posterior-circulation Ischemic Stroke
Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment.
- Trial name
- NCT06094569
- Testing
- Endovascular Therapy
- Where
- 4 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Huanhu Hospital
Ischemic Stroke
Acetyl-leucine in Post-stroke Ataxia
Along with the current clinical trial, the efficacy and safety of 4 gram of acetyl-leucine daily for three months in patients with post-stroke ataxia following posterior-circulation ischaemic stroke assessed through BBS, SARA…
- Trial name
- NCT07275749
- Testing
- Acetyl-Leucine, Clopidogrel 75 Mg Oral Tablet, aspirin 100mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Kafrelsheikh University
Stroke Ischemic
Tenecteplase in ReperfUsion Therapy for Posterior Circulation Stroke With Extended Time Window: the TRUST Trial
The primary hypothesis being tested in this trial is that ischemic stroke patients in posterior circulation at 4.5 - 24 hours post onset of stroke will have improved clinical outcomes when given intravenous TNK compared to…
- Trial name
- NCT07073469
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg), Standard medical treatment
- Volunteers
- 330 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Posterior Circulation Brain Infarction
Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke in Posterior Circulation
There is few randomized controlled clinical to investigated the impact of anesthetic type on outcome in patients with acute ischemic stroke in posterior cerebral circulation.
- Trial name
- CANVAS-II (NCT03317535)
- Testing
- General anesthesia, Local anesthesia/concious sedation, Spontaneous breath
- Where
- 2 sites in China
- Volunteers
- 93 people
- Sponsor
- Beijing Tiantan Hospital
Posterior Circulation Ischemic Stroke
Endovascular Treatment for Posterior Circulation Ischemic Stroke Post 1 Day （24 Hours）
To evaluate the efficacy and safety of endovascular therapy for posterior circulation ischemic stroke presenting more than 24 hours after symptom onset.
- Trial name
- ETP1-PC (NCT07699029)
- Testing
- Endovascular treatment combined with standard pharmacological treatment, Standard pharmacological treatment
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Ischemic Stroke
Efficacy and Safety of Tenecteplase Intravenous Thrombolysis in Acute Posterior Circulation Ischemic Stroke Within 4.5-24 Hours After Onset
This study aims to evaluate the efficacy and safety of tenecteplase (TNK) intravenous thrombolysis within the extended time window (4.5 to 24 hours) in patients with acute posterior circulation ischemic stroke.
- Trial name
- NCT07094763
- Testing
- TNK plus standard medical treatment, standard medical management
- Where
- China
- Volunteers
- 406 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Basilar Artery Occlusion, Posterior Circulation Large Infarct
Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct
The purpose of this study is to evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) leads to better functional outcomes than BMM alone in patients with acute basilar artery occlusion with…
- Trial name
- NCT06924996
- Testing
- Endovascular Thrombectomy (EVT)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Feng Gao
Infarction, Middle Cerebral Artery, Infarction, Anterior Cerebral Artery
Effect of Mesenchymal Stem Cells(MSCs) Transplantation for Acute Cerebral Infarction Patients
This is a placebo controlled, randomized, double blinded study including Phase 1 and Phase 2. Phase I study is a safety assessment and Phase 2 study is incline to assess effectiveness of MSCs.
- Conditions
- Infarction, Middle Cerebral Artery, Infarction, Anterior Cerebral Artery, Cerebral Infarction, Stroke, Ischemic
- Trial name
- NCT04093336
- Testing
- human umbilical cord mesenchymal stem cells, standardized treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai East Hospital
Stroke, Ischemic, Intracranial Atherosclerosis
Predictors of Intracranial Atherosclerotic Disease in Posterior Circulation: a Cohort Study
Early identification of intracranial atherosclerotic disease (ICAD) may impact the management of patients undergoing mechanical thrombectomy (MT).
- Conditions
- Stroke, Ischemic, Intracranial Atherosclerosis, Posterior Circulation Brain Infarction
- Trial name
- NCT06453252
- Testing
- we are aiming to develop a Scoring system based on certain variables derived from both groups
- Where
- 2 sites in United States, Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
TIA, Stroke
Evaluation of the HARM for the Detection of a Cerebral Ischemia in TIA/TNA Patients
The research project investigates the incidence of the hyperintense acute reperfusion marker (HARM) in patients with transient ischemic attack (TIA) or transient neurological attack (TNA).
- Conditions
- TIA, Stroke, Ischemia, Diagnoses Disease
- Trial name
- NCT03555643
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Universitätsmedizin Mannheim
Stroke, Acute Ischemic
EXtending the Time Window for Thrombolysis in Posterior Circulation Stroke Without Early CT Signs
The primary hypothesis being tested in this trial is that ischemic stroke patients in posterior circulation at 4.5 - 24 hours post onset of stroke will have improved clinical outcomes when given intravenous tissue plasminogen…
- Trial name
- NCT05429476
- Testing
- Tissue Plasminogen Activator (Alteplase)
- Where
- 27 sites in China
- Volunteers
- 234 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Ischemic Stroke, Arterial Thrombosis
Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)
The CHOICE study suggested that the use of adjunct intra-arterial alteplase after successful endovascular reperfusion in large vessel occlusion acute ischemic strokes may result in a greater likelihood of excellent neurological…
- Conditions
- Acute Ischemic Stroke, Arterial Thrombosis, Posterior Circulation Brain Infarction
- Trial name
- NCT05897554
- Testing
- intra-arterial alteplase
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Vertebral Artery Ischemia
Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral Artery Occlusions
Isolated vertebral artery occlusions (VAO) account for approximately one third of posterior circulation occlusions, but have been given the least attention among posterior circulation strokes.
- Conditions
- Ischemic Stroke, Vertebral Artery Ischemia, Arterial Occlusive Diseases, Vertebrobasilar Insufficiency
- Trial name
- BRAVO (NCT05503212)
- Testing
- Conservative treatment (CT), Intravenous thrombolysis (IVT), Endovascular thrombectomy (EVT) ± intravenous thrombolysis (IVT)
- Where
- Switzerland
- Volunteers
- 682 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Ischemic Stroke, Basilar Artery Occlusion
Endovascular Therapy for Acute Basilar Artery Occlusion With Large Ischemic Core
Acute basilar artery occlusion is associated with high mortality and severe disability. Previous randomized trials have demonstrated the benefit of endovascular therapy in selected patients with basilar artery occlusion; however…
- Conditions
- Acute Ischemic Stroke, Basilar Artery Occlusion, Large Ischemic Core
- Trial name
- NCT07672795
- Testing
- Endovascular Therapy, Best Medical Management
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Stroke Ischemic, Stroke Acute
Posterior Circulation ASTRAL Prognostic Score
The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke…
- Conditions
- Stroke Ischemic, Stroke Acute, Posterior Circulation Brain Infarction, Risk Score
- Trial name
- NCT05906420
- Testing
- ASTRAL prognostic score
- Where
- 2 sites in Greece, Switzerland
- Volunteers
- 2,000 people
- Sponsor
- University of Thessaly
Ischemic Stroke
Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Posterior Circulation Large Vessel Occlusion Stroke
This is an investigator-initiated phase III clinical trial employing a randomized, double-blind, placebo-controlled design. The primary objective of this study is to investigate the efficacy and safety of an interleukin-6…
- Trial name
- IRIS-3 (NCT07509645)
- Testing
- Tocilizumab
- Where
- 30 sites in China
- Volunteers
- 348 people
- Sponsor
- Capital Medical University
Posterior Ischemic Stroke, Cerebral Infarction
Derivation and External Validation of the "FORECAST-PC" Prediction Scores
This study aims to develop and externally validate machine learning prediction models (FORECAST-PC) to determine 90-day functional outcomes for patients suffering from acute ischemic stroke in the posterior circulation who are…
- Conditions
- Posterior Ischemic Stroke, Cerebral Infarction, Cerebrovascular Disorders
- Trial name
- FORECAST-PC (NCT07750015)
- Testing
- FORECAST-PC Prediction Models
- Where
- Switzerland
- Volunteers
- 732 people
- Sponsor
- Dr. med. Alexander Salerno, MD-PhD