Clinical trials: Posterior Wall Isolation
Atrial Fibrillation (AF)
Redo-Pulmonary Vein Isolation With Versus Without Posterior Wall Ablation - The REDO-PIFPAF-PFA Study
The study will compare two ablation strategies in patients with paroxysmal or persistent atrial fibrillation undergoing repeat ablation using pulsed-field ablation: redo pulmonary vein isolation only versus redo pulmonary vein…
- Trial name
- NCT07745543
- Testing
- Pulmonary vein isolation with posterior wall ablation, Pulmonary vein isolation without posterior wall ablation
- Where
- 5 sites in Switzerland
- Volunteers
- 270 people
- Sponsor
- University Hospital, Basel, Switzerland
Persistent Atrial Fibrillation
PFLotus With the DePolar Mapping System in Patients With Persistent Atrial Fibrillation
This clinical trial aims to evaluate the safety and efficacy of pulmonary vein isolation (PVI), focal, and linear ablation in patients with persistent atrial fibrillation (PersAF) using a novel shape-adaptive pulsed field…
- Trial name
- NCT07321002
- Testing
- Ablation with the PFLotus catheter and Depolar system
- Volunteers
- 35 people
- Sponsor
- The Third People's Hospital of Chengdu
Persistent Atrial Fibrillation
Using a Novel Balloon-shaped Large-Focal Pulsed Field Ablation Catheter in Persistent Atrial Fibrillation
This clinical trial aims to evaluate the safety and effectiveness of pulmonary vein isolation (PVI) and linear ablation using a large-focal pulsed field ablation (PFA) catheter in patients with persistent atrial fibrillation…
- Trial name
- PFApple-Per AF (NCT07294742)
- Testing
- a novel Balloon-shaped Large-Focal Pulsed Field Ablation Catheter
- Where
- China
- Volunteers
- 34 people
- Sponsor
- The Third People's Hospital of Chengdu
Atrial Fibrillation
PeAF-BOX: Feasibility, Safety and Efficacy of PVI + Box Ablation in Persistent Atrial Fibrillation
Title: PeAF-Box. Feasibility, Safety and Efficacy of Isolating the Left Atrial Posterior Wall (PWI) added to Pulmonary Vein Isolation (PVI) as First-Line Strategy in Treatment of Persistent Atrial Fibrillation (PeAF) Design: A…
- Trial name
- PeAF-BOX (NCT05045131)
- Testing
- Left atrial combined pulmonary vein isolation and posterior wall isolation
- Volunteers
- 24 people
- Sponsor
- René Husted Worck
Atrial Fibrillation
Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF
The primary objective of this clinical investigation is to demonstrate the safety and 12-month effectiveness of pulmonary vein isolation (PVI) and posterior LA wall isolation in the treatment of subjects with symptomatic…
- Trial name
- POLARIS (NCT06099730)
- Testing
- Pulsed Field Ablation (PFA)
- Where
- 6 sites in United States
- Volunteers
- 442 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation
Reduction in Arrhythmia Burden With Left Atrial Posterior Wall Ablation for Persistent AF
RABLAP-AF will compare pulmonary vein isolation (PVI) in combination with posterior wall isolation (PWI) for patients with persistent atrial fibrillation (AF).
- Trial name
- RABLAP-AF (NCT05195268)
- Testing
- Intracardiac Catheter Ablation
- Where
- United Kingdom
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Recurred Atrial Fibrillation
Comparison of Circumferential Pulmonary Vein Isolation and Complex Pulmonary Vein Isolation Additional Linear Ablation for Recurred Atrial Fibrillation After Previous Catheter Ablation: Prospective Randomized Trial (RILI Trial)
The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for repeat ablation procedure among the patients with recurred atrial fibrillation after de novo catheter ablation.
- Trial name
- NCT02747498
- Testing
- Procedure with circumferential pulmonary vein isolation, Procedure with linear ablation in addiction to pulmonary vein isolation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Outcome of Atrial Fibrillation Ablation After Permanent Pulmonary Vein Antrum Isolation With or Without Proven Left Atrial Posterior Wall Isolation
Objective: This prospective study aims to examine the outcome of atrial fibrillation (AF) ablation after permanent pulmonary vein antrum isolation or pulmonary vein antrum isolation plus left atrial posterior wall isolation is…
- Trial name
- NCT01660100
- Testing
- Pulmonary vein antrum isolation (PVAI), PVAI plus left atrial posterior wall (LAPW) isolation
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Persistent Atrial Fibrillation
Pulsed Field Ablation Versus Radiofrequency Ablation: Effects of Pulmonary Vein Isolation Combined With Left Atrial Posterior Wall Isolation on Postoperative Gastric Motility in Patients With Persistent Atrial Fibrillation
This is a single-center, prospective, matched cohort study comparing the effect of Pulsed Field Ablation (PFA) versus Radiofrequency Ablation (RF) on postoperative gastric motility in patients with persistent atrial fibrillation…
- Trial name
- PFA-GM (NCT07612241)
- Testing
- Pulsed Field Ablation, Radiofrequency Ablation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Recurrent Paroxysmal Atrial Fibrillation Despite Prior Pulmonary Vein Isolation
Endocardial Vs Epicardial Ablation for Recurrent Paroxysmal AF
There is no current accepted and predictably effective ablative therapy for patients with recurrent paroxysmal atrial fibrillation after prior pulmonary vein isolation (PVI).
- Trial name
- REPEAL-AF (NCT04506814)
- Testing
- Endocardial PVI, Epicardial Posterior Wall Isolation + LAA Exclusion + Endocardial PVI
- Where
- United States
- Sponsor
- University of Rochester
Persistent Atrial Fibrillation, Atrial Fibrillation Ablation
Oesophageal Pacing to Check Left Atrial Posterior Wall Isolation
Patients undergoing hybrid AF ablation second stage catheter ablation have the posterior left atrium mapped to see it if is electrically isolated.
- Trial name
- NCT05086861
- Testing
- Oesophageal pacing after left atrial posterior wall isolation
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University Hospital Plymouth NHS Trust
Paroxysmal Atrial Fibrillation
Cryoballoon PVI With PWI Versus PVI Alone In Patients With PAF
Cryoballoon ablation has emerged as a safe and effective strategy for treatment of atrial fibrillation (AF) for which it has recently received a 'first-line' therapy indication by the FDA.
- Trial name
- NCT05296824
- Testing
- Cryoballoon ablation for the treatment of atrial fibrillation
- Where
- 4 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Sacramento EP Research
Atrial Fibrillation Paroxysmal
Posterior Wall Substrate Modification Using Irreversible Electroporation for Paroxysmal Atrial Fibrillation
The purpose of this study is to compare the efficacy and safety between pulmonary vein isolation (PVI) alone versus PVI with left atrial (LA) posterior wall isolation (PWI) using pulsed-field ablation (PFA) in the treatment of…
- Trial name
- (SMILE-AF) (NCT06364215)
- Testing
- Farapulse PFA, Pulmonary Vein Isolation alone, Farapulse PFA, Pulmonary Vein Isolation and Left atrial Posterior Wall Isolation
- Where
- 18 sites in United States
- Volunteers
- 198 people
- Sponsor
- Jorge Romero
Persistent Atrial Fibrillation
The PIFPAF-PFA Study
Pulmonary vein isolation (PVI) is very effective for rhythm control in patients with paroxysmal atrial fibrillation (AF), but less successful in patients with persistent AF.
- Trial name
- PIFPAF-PFA (NCT05986526)
- Testing
- Pulmonary vein isolation without posterior wall ablation, Pulmonary vein isolation with posterior wall ablation
- Where
- 6 sites in Switzerland
- Volunteers
- 206 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Persistent Atrial Fibrillation
Optimized Posterior Left Atrial Wall Ablation Strategy for PeAF
This is an open-label, multicenter, randomized parallel-controlled clinical trial. The study aims to investigate the optimal ablation method for the posterior left atrial wall in patients with persistent atrial fibrillation…
- Trial name
- NCT06633523
- Testing
- PVI + Posterior Wall Isolation (PWI) + Electrogram Ablation (EGM), PVI + Posterior Wall Isolation (PWI), Pulmonary Vein Isolation (PVI) alone
- Volunteers
- 384 people
- Sponsor
- Shanghai Chest Hospital
Postoperative Atrial Fibrillation
Prophylactic Radiofrequency Left Atrial Posterior Wall Isolation to Prevent Atrial Fibrillation After Cardiac Surgery
The goal of this clinical trial is to learn if an epicardial radiofrequency left atrial posterior wall isolation (box lesion ablation) prevents atrial fibrillation after cardiac surgery.
- Trial name
- PROBOX (NCT06823778)
- Testing
- Radiofrequency ablation
- Where
- Russia
- Volunteers
- 216 people
- Sponsor
- Vasily I. Kaleda
Atrial Fibrillation (AF)
Comparative Effectiveness of Different Techniques for Repeat Ablation of Atrial Fibrillation
Atrial fibrillation (AF) is the most common type of irregular heartbeat doctors see. People with AF sometimes have a procedure called an ablation to help get their heart back into a normal rhythm.
- Trial name
- REPEAT-AF (NCT06988202)
- Testing
- Pulmonary Vein Isolation (PVI) without Left Atrial Posterior Wall Isolation (PWI), Pulmonary Vein Isolation (PVI) with Left Atrial Posterior Wall Isolation (PWI)
- Where
- United States
- Volunteers
- 630 people
- Sponsor
- University of Rochester
Persistent Atrial Fibrillation
Study on the Ablation of Persistent Atrial Fibrillation Using Pulsed Electric Fields Under Different Surgical Procedures
Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice, and there are more than 20 million AF patients in my country.
- Trial name
- NCT06671197
- Testing
- Pulmonary vein isolation, Pulmonary vein isolation+posterior left atrial wall line+superior vena cava isolation
- Where
- China
- Volunteers
- 436 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atrial Fibrillation
Evaluation of PWI Assisted by Marshall Ethanolization in Ablation of Persistent Atrial Fibrillation
This is a prospective, randomized controlled, single-blind, multi-center clinical trial study aiming to investigate whether the strategy of posterior wall isolation (PWI) assisted by vein of Marshall ethanol infusion (VOMEI)…
- Trial name
- NCT06363604
- Testing
- VOMEI + PVI + linear ablation of mitral isthmus, Posterior wall isolation
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation (AF)
PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF
To date, no optimal treatment has been established to improve outcomes in patients with persistent atrial fibrillation. The safety and efficacy of pulsed-field ablation (PFA) have been demonstrated in several studies, and its…
- Trial name
- POBI-PFA (NCT06929897)
- Testing
- Pulmonary Vein Isolation, Additional Left Atrial Posterior Wall Ablation, Non-PV trigger test
- Where
- South Korea
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital