Clinical trials: Postmenopausal Disorder
Osteoporosis, Hypercalcemia of Malignancy
One Week Comparison Study of PTH and PTHrP Infusions
This is a dose escalation study to determine the maximum tolerable dose of Parathyroid Hormone-related Protein, PTHrP, or Parathyroid Hormone, PTH, that can be given safely over one week in healthy African-American volunteers.
- Conditions
- Osteoporosis, Hypercalcemia of Malignancy, Hyperparathyroidism, Bone Diseases, Endocrine
- Trial name
- NCT01333267
- Testing
- Parathyroid Hormone-related Protein (1-36), parathyroid hormone (1-34), PTH (1-34) and PTHrP (1-36)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteoporosis
The Change of Bone Markers After Low Dose Alendronate in Postmenopausal Women With Bone Loss
High bone turnover with the bone resorption exceeding bone formation is a major mechanism of postmenopausal osteoporosis. Therefore, inhibition of bone resorption is a rational approach for the prevention.
- Trial name
- NCT00460057
- Testing
- Alendronate
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Eulji University Hospital
Osteoporosis, Postmenopausal
Circulating Myokine Levels and Bone Metabolism
Circulating levels of several myokines will be measured in serum samples obtained from women in various categories of bone density and according to the presence of fracture or not as well as before and after treatment with…
- Trial name
- NCT04206618
- Testing
- Teriparatide, Denosumab
- Where
- Greece
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- 424 General Military Hospital
Osteopenia
A First-in-human Study Evaluating Romosozumab (AMG 785) in Healthy Men and Postmenopausal Women
The primary objective of this study is to assess the safety and tolerability of romosozumab following single dose subcutaneous (SC) or intravenous (IV) administration in healthy men and postmenopausal women.
- Trial name
- NCT01059435
- Testing
- Romosozumab
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Amgen
Post-Menopausal Osteoporosis, Post-Menopausal Osteopenia
Vitamin K Supplementation in Post-Menopausal Osteopenia
The purpose of this study is to determine whether supplementation with 5 mg vitamin K daily over a 2-year period will prevent bone loss in post-menopausal women with osteopenia.
- Trial name
- NCT00150969
- Testing
- vitamin K1 (phylloquinone)
- Where
- 5 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Menopause, Obesity
Effects of SlimTrack® Platform on Diet Adherence, Anthropometry and Arterial Stiffness in Postmenopausal Women
Introduction:The weight gain expected in the postmenopausal period has deleterious effects on the physical and mental health of the female population.
- Conditions
- Menopause, Obesity, Overweight
- Trial name
- SlimTrack (NCT06497946)
- Testing
- SlimTrack Plataform, Diet prescription
- Where
- Brazil
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Relative Bioavailability
A Relative Bioavailability Study of FOR-6219 in Capsule and Tablet Formulations
This is a phase 1, randomised, open-label, three-way, three-period, crossover relative bioavailability study to assess the single-dose pharmacokinetics of FOR-6219 in capsule and tablet formulations in postmenopausal women.
- Trial name
- NCT04686669
- Testing
- FOR-6219 capsule formulation, FOR-6219 tablet formulation
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Forendo Pharma Ltd
Menopause, Hypertension
Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure
Calcitonin, calcitonin gene-related peptides (CGRPs), adrenomedullin, and amylin belong to a unique group of peptide hormones important for the regulation of calcium balance, neurotransmission, cardiovascular homeostasis, and…
- Trial name
- NCT00133783
- Testing
- intermedin
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Osteoporosis Postmenopausal
Effect of Mechanical Loading and Bone Loss on Motor Neuron Activity-H-Reflex Relationship
Weight-bearing exercises (e.g., running, jumping, whole-body vibration) are widely practiced due to their beneficial effects on bone development and their role in the prevention and treatment of osteoporosis.
- Trial name
- NCT07253493
- Testing
- H-reflex, Bone myoregulation reflex
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Muscle Loss
A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 (ActRIIB-IgG1)in Healthy Postmenopausal Volunteers
Single center, randomized, single dose study to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic effects of ACE-031 in healthy postmenopausal volunteers
- Trial name
- NCT00755638
- Testing
- ACE-031
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
Mental Health
Effects of Crossover Point Exercise on Depression, Anxiety and Stress in Chinese Postmenopausal Women
To analyze the effects of the Crossover Point (COP) Exercise Program on Chinese postmenopausal women.
- Trial name
- NCT06449807
- Testing
- crossover point intensity exercise
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Osteoporosis
To Estimate Relative Bioavailability of 5 Formulations of Ronacaleret Given to Healthy Postmenopausal Females
This study will examine the effects of formulation on the relative bioavailability of SB-751689 (400 mg) administered to healthy postmenopausal women.
- Trial name
- NCT00651534
- Testing
- Ronacaleret
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Menopause
Symptom Management Program Based on Story Theory for Postmenopausal Women (SEMSTOP)
Purpose: To investigate the effect of the Symptom Management Program Based on Story Theory on vasomotor symptoms and sleep quality in postmenopausal women.
- Trial name
- SEMSTOP (NCT05697133)
- Testing
- SEMSTOP, control
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Arthralgia, Breast Cancer
Joint Pain and Medication Adherence in Postmenopausal Women Receiving Aromatase Inhibitors
RATIONALE: Gathering information over time about joint pain and stiffness from postmenopausal women with early-stage breast cancer who are receiving aromatase inhibitors may help doctors plan treatment and help patients live more…
- Trial name
- NCT00954564
- Testing
- aromatase inhibition therapy - OBSERVATIONAL ONLY, medical chart review, questionnaire administration
- Where
- 2 sites in United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity, Postmenopausal Women
Tocotrienols for Obesity of Postmenopausal Women
Postmenopausal women are at a risk of excessive weight gain, bone loss, hypertension, and metabolic syndrome. Obesity-induced chronic low-grade inflammation is initiated by excess nutrients in metabolic cells.
- Trial name
- VitE-obesity (NCT03705845)
- Testing
- DeltaGold® Tocotrienol 70%
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Overactive Bladder (OAB)
Vaginal CO2 Laser in Postmenopausal Women With Overactive Bladder Syndrome (OAB)
This study evaluates the clinical efficacy and symptom relief of vaginal fractional CO2 laser treatment in post-menopausal women with Overactive Bladder syndrome(OAB).
- Trial name
- NCT03846895
- Testing
- Microablative Fractional CO2 laser
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Osteoporosis, Postmenopausal
MRI Study of the Distal Radius Bone Marrow Fat Fraction in Osteoporotic and Healthy Women
The aim of the study is to test whether the distal radius bone marrow show significant difference in the fat fraction in young women compared to post menopausal women with and without osteoporosis.
- Trial name
- NCT03742362
- Testing
- MRI scans of distal radius
- Where
- Israel
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Uri Nevo
Postmenopausal Osteoporosis
Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption
The aim of the study is to assess the relative antiresorptive properties of 2 osteoporosis medications when combined with teriparatide.
- Trial name
- NCT01750086
- Testing
- Teriparatide 40-mcg subcutaneous injection, Denosumab Injection, Alendronate Oral Tablet
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Postmenopausal Osteoporosis
Delayed Release (DR) Risedronate Compared to Immediate Release (IR) in Postmenopausal Women
Randomized, multicenter, double-blind, double-dummy, active-controlled, parallel-design study in approximately 201 postmenopausal women.
- Trial name
- NCT00918749
- Testing
- 150 mg, 75 mg, 100 mg
- Where
- 6 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Warner Chilcott
Menopause, Aging
Role of Menopause in Thermoregulation
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events.
- Trial name
- NCT06798571
- Testing
- Elagolix Oral Tablet, Estradiol patch
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University