Clinical trials: Postmenopausal Syndrome
HR+ HER2- Men, Pre/Postmenopausal Advanced Breast Cancer
Treatment of Canadian Men and Pre/Peri/Post-menopausal Women With ER+ Advanced Breast Cancer in the Real-World Setting With Hormone Therapy ± Targeted Therapy
Although randomized controlled trials (RCTs) provide evidence of efficacy, generalization of these results to patients in the real-world setting is challenging, given RCTs are conducted in highly selected patient populations.
- Trial name
- Treat ER+ight (NCT02753686)
- Testing
- Endocrine therapy may include one of the following therapies: letrozole, anastrozole, exemestane, tamoxifen or fulvestrant, Endocrine therapy in combination with targeted therapy may include: everolimus plus exemestane or CDK4/6 inhibitor plus endocrine therapy
- Where
- 25 sites in Canada
- Volunteers
- 440 people
- Sponsor
- Novartis Pharmaceuticals
Postmenopausal Osteoporosis
CLCF1 Gene Associated With Postmenopausal Osteoporosis of Kidney Yin Deficiency Syndrome
For nearly 112 million patients with osteoporosis in China, it is of great significance for preventing and treating by clearly understanding the molecular mechanism of kidney deficiency.
- Trial name
- PMOP (NCT02981732)
- Testing
- Liuwei Dihuang Pill
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- xuhuijuan
Postmenopausal Metabolic Health
Physical Activity and Basal Metabolic Rate in Postmenopausal Women
The primary purpose of this study is to expand research on the effects of physical activity on basal metabolic rate (BMR) in healthy postmenopausal women, and to further compare the effects of long-term habitual exercise to the…
- Trial name
- NCT01550536
- Testing
- Resistance and aerobic exercise
- Where
- 3 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Menopause, Metabolic Syndrome
Low Sexual Desire and Metabolic Syndrome
Objective: To evaluate the prevalence of hypoactive sexual desire disorder (HSDD) in postmenopausal women diagnosed with metabolic syndrome (MS) and to compare it to that of a control group without MS.
- Conditions
- Menopause, Metabolic Syndrome, Hypoactive Sexual Desire Disorder, Obesity
- Trial name
- NCT02430987
- Testing
- Female sexual function index questionnaire, Evaluation of presence of metabolic syndrome, Evaluation of the body mass index
- Where
- Brazil
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Metabolic Syndrome
Effect of Laser Acupuncture on Metabolic Syndrome in Obese Postmenopausal Women
Thirty postmenopausal women were collected from outpatient clinic of faculty of physical therapy in Benha University to participate in this study.
- Trial name
- NCT05651451
- Testing
- Laser acupuncture, energy-restricted diet
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Postmenopausal Symptoms
Efficacy/Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms (VMS)
The purpose of this study is to assess the safety \& efficacy of Brisdelle (paroxetine mesylate) Capsules 7.5 mg for treatment of vasomotor symptoms (VMS) associated with menopause.
- Trial name
- N30-003 (NCT01361308)
- Testing
- Brisdelle (paroxetine mesylate)
- Where
- 74 sites in United States
- Volunteers
- 614 people
- Sponsor
- Noven Therapeutics
Postmenopausal Symptoms
PNF and Frenkel's Exercises for Postmenopausal Women
Postural stability is impaired due to the decrease in estrogen in the postmenopausal period, which may lead to disruption of balance and risk of falling.
- Trial name
- NCT04266067
- Testing
- PNF exercise, Frenkel exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Hilal Yeşil
Menopausal Syndrome, Sexual Dysfunctions
Investigation of the Effects of Pilates Exercises on Menopause Symptoms and Sexual Dysfunction in Postmenopausal Women
Menopause represents a major transition in a woman's life as estrogen and progesterone levels decline, and this hormonal shift is associated with a range of symptoms that can significantly impact a woman's quality of life…
- Conditions
- Menopausal Syndrome, Sexual Dysfunctions, Quality of Life and Menopause
- Trial name
- NCT06837714
- Testing
- PİLATES GROUP, Behavioral: lifestyle changes
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Batman University
Postmenopausal Syndrome, Muscle Weakness
The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women
The bilateral deficit phenomenon (BLD) is defined as an inability of the neuromuscular system to generate maximal force when two homonymous limb operate simultaneously (bilateral contraction) with respect to the force developed…
- Trial name
- NCT02434185
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Genitourinary Syndrome of Menopause, Vaginal Health
Efficacy of Non-Ablative Radiofrequency on Vaginal and Sexual Health in Postmenopausal Women
This study will test if non-ablative monopolar radiofrequency can help improve vaginal tissue and reduce symptoms of Genitourinary Syndrome of Menopause (GSM) in postmenopausal women.
- Conditions
- Genitourinary Syndrome of Menopause, Vaginal Health, Sexual Dysfunction
- Trial name
- NCT06925139
- Testing
- Non-ablative monopolar radiofrequency treatment
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Castilla-La Mancha
Menopause
TRANSDERMAL HRT RELIEVING POSTMENOPAUSAL SYMPTOMS
There is a dilemma and a permanent debate about side effects on drugs administered orally. The first-pass metabolism is related with many side effects, since the metabolites of these compounds affect the course of human…
- Trial name
- THRT (NCT02033512)
- Testing
- Transdermal Hormone Replacement Therapy, Transdermal Nanoformulation, Transdermal formulation
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Potiguar
HIV Infections
A Phase 4 Cross-Sectional Study of Bone Mineral Density in HIV-1 Infected Subjects
A Phase 4 study is to characterize the profile of low bone mineral density (BMD) in ≥ 50 year old male subjects and post-menopausal female subjects on any tenofovir disoproxil fumarate (TDF)-based regimen
- Trial name
- NCT01850212
- Where
- 73 sites in Austria, Belgium and 11 more
- Volunteers
- 476 people
- Sponsor
- Gilead Sciences
Menopause, Postmenopausal Disorder
Metabotyping in the Postmenopausal Stage
Menopause is defined as the absence of menstrual periods for twelve consecutive months. Although the onset may vary, natural menopause occurs between the ages of 45 and 55 and is considered a stage in the aging process for women.
- Conditions
- Menopause, Postmenopausal Disorder, Postmenopausal Symptoms
- Trial name
- SHE-HEALTH (NCT05397015)
- Testing
- No intervention will be done
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Metabolic Syndrome, Dyslipidemias
12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal Women
The purpose of this study was to examine the impacts of a 12-week resistance band exercise program on insulin resistance, blood lipid profiles, body composition, and blood pressure in postmenopausal women with obesity.
- Conditions
- Metabolic Syndrome, Dyslipidemias, Insulin Resistance, Hypertension
- Trial name
- NCT04014686
- Testing
- No exercise intervention group, Resistance band exercise intervention group
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Pusan National University
Hot Flashes
Study of Gabapentin Extended Release (G-ER)in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women.
Depomed's Gabapentin Extended Release is an investigational, extended release formulation of gabapentin that is being studied for the treatment of hot flashes in postmenopausal women
- Trial name
- NCT00777023
- Testing
- Gabapentin Extended-Release (G-ER) 1200 mg, Gabapentin Extended-Release (G-ER) 1800 mg
- Where
- 45 sites in United States
- Volunteers
- 565 people
- Sponsor
- Depomed
Sleep Disturbance, Postmenopausal Symptoms
Effect of Sleep Restriction on Adipose Tissue and Skeletal Muscle Insulin Sensitivity
Inadequate sleep is an independent risk factor for metabolic abnormalities (such as obesity, insulin resistance, and hyperglycemia).
- Conditions
- Sleep Disturbance, Postmenopausal Symptoms, Insulin Sensitivity, Cardiovascular Risk Factor
- Trial name
- SLEEP-IN (NCT04286451)
- Testing
- Sleep Restriction, Habitual Sleep
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Urinary Incontinence, Postmenopausal Symptoms
Kegel and Abdominal Exercises on Urinary Incontinence Severity, Quality of Life, and Sleep Quality in Menopausal Women
The aim of this randomized, controlled experimental study is to investigate the effectiveness of Kegel exercises and abdominal exercises on urinary incontinence severity, quality of life, and sleep quality in menopausal women…
- Conditions
- Urinary Incontinence, Postmenopausal Symptoms, Sleep Quality
- Trial name
- NCT06096818
- Testing
- Experimental Group: Kegel exercises and abdominal exercises, Control Group: Kegel exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Drug-Drug Interaction Study of MK 8527 With a Combined Oral Contraceptive (LNG/EE)
This study is designed to assess the effect of a single dose of MK-8527 on the single-dose pharmacokinetics (PK) and the safety and tolerability of levonorgestrel/ethinyl estradiol (LNG/EE) in healthy adult postmenopausal or…
- Trial name
- NCT06783192
- Testing
- MK-8527, LNG/EE
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Genitourinary Syndrome of Menopause
Laser Therapy for Treatment of Genitourinary Syndrome of Menopause (GSM) in Postmenopausal Women
This is a prospective, multi-centre, double blinded, randomized controlled trial, which will be conducted under a common protocol.
- Trial name
- LASER_2022 (NCT05305209)
- Testing
- Intervention group, Control Group
- Where
- Spain
- Volunteers
- 189 people
- Sponsor
- University of Malaga
Sexual Pain Disorders, Postmenopausal Symptoms
Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatment
This study will evaluate the use of topical 5 or 10% sinecatechins, a botanical drug derived from green tea for the alleviation of sexual pain in the area around the vaginal opening (the vulvar vestibule), that is a main source…
- Conditions
- Sexual Pain Disorders, Postmenopausal Symptoms, Vulvovaginal Atrophy, Female Sexual Dysfunction
- Trial name
- NCT03682601
- Testing
- 5% sinecatechins ointment, 10% sinecatechins ointment
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GTO Pharmaceutical, LLC