Clinical trials: Postoperative; Dysfunction Following Cardiac Surgery
Inflammasomes, Cognitive Dysfunction
Correlation of NLRP3 With Cognitive Dysfunction Early After Heart Valve Replacement Surgery
The investigators decided to assess the prognostic value of NLRP3 inflammasome level in early after heart valve replacement surgery and whether it was related to postoperative cognitive dysfunction.
- Conditions
- Inflammasomes, Cognitive Dysfunction, Pyrin Domain-Containing 3 Protein, Postoperative Complications
- Trial name
- NCT04191642
- Where
- China
- Volunteers
- 75 people
- Sponsor
- General Hospital of Ningxia Medical University
Acute Lung Injury, Metabolic Disturbances
Acute Lung Injury After Cardiac Surgery: Pathogenesis
The purpose of the present study is to visualize the inflammatory response and coagulation disorders during cardiac surgery in order to identify possible predictors for acute lung injury postoperatively.
- Conditions
- Acute Lung Injury, Metabolic Disturbances, Inflammation, Coagulation; Intravascular
- Trial name
- ALI (NCT02475694)
- Testing
- No intervention
- Volunteers
- 50 people
- Sponsor
- Aalborg University Hospital
Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Cognitive Dysfunction
n-3 Enriched Nutrition Therapy and Postoperative Cognitive Dysfunction After Cardiac Surgery
Background: Delirium and long-term cognitive dysfunction (CD) are important complications of major surgery and intensive care treatment.
- Trial name
- NCT00757913
- Testing
- n-3 enriched nutrition
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Basel, Switzerland
Hearing Loss, Cardiac Surgery
Prevalence of Auditory Dysfunction and ICU-acquired Delirium Following Cardiac Surgery With Cardiopulmonary Bypass: a Prospective Observational Study
AUDICS-ICU is a prospective observational aiming to evaluate the prevalence of auditive dysfunction following cardiac surgery. Participants will undergo audiometric testings before and 3 months after cardiac surgery with…
- Conditions
- Hearing Loss, Cardiac Surgery, Cardiopulmonary Bypass, Postoperative Cognitive Dysfunction
- Trial name
- AUDICS-ICU (NCT04151914)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- European Georges Pompidou Hospital
Other Functional Disturbances Following Cardiac Surgery
Continuous MONItoring of Blood LActate and Glucose Levels Using a New Central Veinous Microdialysis Catheter Device
Continuous lactate and glucose blood levels
- Trial name
- MONILAG (NCT02296593)
- Testing
- comparison of blood lactate and glucose levels
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Colectomy, Colectomy Left/Right/Total Under Laparotomy
Clinical Study on the Prevention and Treatment of Postoperative Gastrointestinal Dysfunction by Acupuncture Under ERAS Management Based on Artificial Intelligence Monitoring
Brief Summary: Acupuncture for Faster Recovery After Colorectal Surgery 1. What is this study about? Colorectal cancer is a common health condition that usually requires surgery.
- Conditions
- Colectomy, Colectomy Left/Right/Total Under Laparotomy, Cancer, Chinese Medicine
- Trial name
- NCT07335237
- Testing
- Accupuncture
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangsu Province Hospital of Traditional Chinese Medicine
Heart Valve Diseases, Mitral Valve Insufficiency
Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR
Surgical treatment is the only approach with potentially defined clinical success for organic mitral valve (MV) regurgitation. Recurrent or persistent complaints after initial successful MV repair is a clinical challenge in…
- Conditions
- Heart Valve Diseases, Mitral Valve Insufficiency, Heart; Dysfunction Postoperative, Cardiac Surgery, Heart; Disease, Mitral(Valve)
- Trial name
- SEP (NCT02371863)
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Other Functional Disturbances Following Cardiac Surgery
Study of Methemoglobin as a Biomarker of Tissue Hypoxia During Acute Hemodilution in Heart Surgery Patients
Acute and chronic anemia continue to be associated with increased mortality in a number of clinical settings, including cardiac and non-cardiac surgery.
- Trial name
- NCT01883713
- Testing
- Brain Oximetry
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Unity Health Toronto
Postoperative Delirium, Postoperative Cognitive Dysfunction
Risk Factor of POD and POCD After Cardiac Surgery
Postoperative delirium (POD) and postoperative cognitive decline (POCD) are common after surgeries in the elderly, especially after cardiothoracic surgery.
- Trial name
- NCT03635229
- Where
- Thailand
- Volunteers
- 360 people
- Sponsor
- Mahidol University
Left Ventricular Dysfunction, Quality of Recovery
Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgery
A randomized, controlled, double-blinded clinical trial evaluating the effect of the administration of a Maltodextrin solution on cardiac function in patients presenting for coronary artery bypass grafting surgery with a reduced…
- Conditions
- Left Ventricular Dysfunction, Quality of Recovery, Right Ventricular Dysfunction
- Trial name
- NCT05188222
- Testing
- Maltodextrin solution
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Jewish General Hospital
Insulin Resistance, Diabetes Mellitus Type 2
Insulin Sensitivity, Irisin and Adipokines as Outcome Parameters in Patients Undergoing Cardiac Surgery
BACKGROUND: Surgical injury and inflammation provoke a stereotypical stress response. Insulin resistance plays an intriguing role in these metabolic alterations and depends on the intensity of injury.
- Conditions
- Insulin Resistance, Diabetes Mellitus Type 2, Other Functional Disturbances Following Cardiac Surgery
- Trial name
- NCT02258698
- Testing
- Cardiac surgery
- Where
- Switzerland
- Volunteers
- 348 people
- Sponsor
- University Hospital, Basel, Switzerland
Other Functional Disturbances Following Cardiac Surgery, Memory Disorders
COGNITIVE - Cognitive Function After Sevoflurane or Propofol Anesthesia for Open-heart Operations
The aim of the study is to prove whether general anesthesia with inhaled sevoflurane reduces the frequency of neurological and cognitive impairment after open-heart operations with use of cardiopulmonary by-pass (CPB) in…
- Trial name
- NCT00541918
- Testing
- Diprivan (propofol, Astra Zeneca), Sevorane (sevoflurane, Abbott)
- Where
- 2 sites in Poland
- Sponsor
- Medical University of Gdansk
Cardiac Surgery Patients
Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction(POCD)
The aim of this study is to perform a whole-genome linkage analysis for identification of the susceptibility loci for POCD
- Trial name
- NCT02084030
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Postoperative; Dysfunction Following Cardiac Surgery
Intra-aortic Balloon Counterpulsation in Patients Undergoing Cardiac Surgery
The hypothesis of the study is to evaluate if the preoperative placement of IABP reduces clinical complications in high-risk patients undergoing cardiac surgery.
- Trial name
- IABCS (NCT02143544)
- Testing
- Intra-aortic balloon pump.
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- University of Sao Paulo
Postoperative; Dysfunction Following Cardiac Surgery
Multiple Daily Doses Of Aspirin To Overcome Aspirin Hyporesponsiveness Post Cardiac Bypass Surgery
Cardiac bypass surgery is an important treatment for patients with severely blocked arteries (tubes that delivery oxygen and nutrients to the heart).
- Trial name
- ASACABG (NCT01618006)
- Testing
- Aspirin
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Hamilton Health Sciences Corporation
Chronic Pain, Other Functional Disturbances Following Cardiac Surgery
Functional and Anatomical MRI of the Spinal Cord and Peri-spinal Tissues
The current study is an amendment to a previously approved blinded randomized controlled trial (NCT02697812) which examines the rate at which the sternal retraction maneuver is performed during cardiac surgery (standard over 30…
- Trial name
- NCT02925364
- Testing
- magnetic resonance imaging (MRI)
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Dr. Tarit Saha
Cerebral Desaturation, Surgery
Cerebral Oximetry to Reduce Organ Dysfunction After Non-cardiac Surgery
Number of elderly patients requiring general anesthesia for major surgical procedures is increasing dramatically. It is estimated that 20% of these patients will develop major complications after surgery.
- Trial name
- NCT03861026
- Testing
- Bilateral NIRS (Masimo, O3TM Regional Oximetry)
- Where
- 2 sites in Canada
- Volunteers
- 101 people
- Sponsor
- University Health Network, Toronto
Postoperative Cognitive Dysfunction
Feasibility and Acceptability of Home-based Computerised Cognitive Training After Cardiac Surgery
The aims of this study are to (1) evaluate the feasibility and acceptability of a home-based computerised cognitive training programme in the postoperative cardiac surgical population, and (2) estimate measures of precision about…
- Trial name
- FACCT (NCT05298540)
- Testing
- Home-based computerised cognitive training with BrainHQ
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Barts & The London NHS Trust
Postoperative; Dysfunction Following Cardiac Surgery
Stress, Anxiety and Type A Personality and Analgesics
Patients scheduled for elective cardiac surgery are preoperative evaluated using different personality type, stress and anxiety tests.
- Trial name
- SATA-1 (NCT02756598)
- Testing
- Sufentanil I, Sufentanil II, Propofol I
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Postoperative Complications, Heart Diseases
Detection of Right Ventricular Dysfunction by Portal Vein Doppler After Cardiac Surgery
Right ventricular (RV) failure after cardiac surgery is associated with morbidity and mortality, but is hard to diagnose with conventional echocardiographic means.
- Conditions
- Postoperative Complications, Heart Diseases, Heart Failure, Heart Valve Diseases
- Trial name
- DVDDP (NCT04890860)
- Testing
- cardiac surgery involving mitral or tricuspid valve repair procedure, with cardiopulmonary bypass
- Where
- France
- Volunteers
- 70 people
- Sponsor
- CMC Ambroise Paré