Clinical trials: Postoperative Air Leak
Non-Small Cell Lung Cancer, Postoperative Air Leak
Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC
This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard…
- Conditions
- Non-Small Cell Lung Cancer, Postoperative Air Leak, NSCLC
- Trial name
- E-SEAL (NCT07479277)
- Testing
- Progel Platinum, Mechanical Stapling
- Where
- 6 sites in Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Postoperative Air Leak, Lung Resection
Comparison Between the Non-powered AEON™ Endostapler and Echelon FLEX™ Powered Plus Stapler With Regards to the Closure of Lung Tissue After Lung Resection in the Presence of Severe Lung Emphysema
Prolonged air leak is reported in up to 60 to 75% of patients after lung operation in the presence of severe lung emphysema. The effect of the non-powered AEONTM Endostapler as compared to the Echelon FlexTM Powered plus stapler…
- Trial name
- Stapler (NCT05628415)
- Testing
- Non-powered AeonTM Endostapler (according to manufacturer medical device classification IIb), Echelon FLEX™ Powered plus Stapler (according to manufacturer medical device classification IIb)
- Where
- Switzerland
- Volunteers
- 19 people
- Sponsor
- University Hospital, Basel, Switzerland
Prolonged Air Leak, Post-operative Pain
Phrenic Nerve Infiltration: Pulmonary Expansion and Pain Control
Between January 2021-2023, 65 consecutive patients at risk for PAL (defined in accordance to "2019 Society of Thoracic Surgery score-criteria of PAL") underwent lung resection (lobectomy or sublobar resection) for malignancy.
- Trial name
- NCT06356038
- Testing
- intra-operative phrenic nerve infiltration
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Azienda Ospedaliera "Sant'Andrea"
Prolonged Air Leak, Postoperative Air Leak
Neoveil® Versus TachoSil® for the Treatment of Pulmonary Air Leaks Following Lung Operation
Postoperative prolonged air leak (PAL), referring to the passage of air from the lung parenchyma into the pleural space, is one of the most frequent postoperative complications after lung resection.
- Trial name
- NCT04065880
- Testing
- TachoSil®, Neoveil®
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Air Leak
Prolonged Air Leakage After Major Lung Resection
The goal of this prospective randomized controlled trial is to investigate the clinical effects of autologous blood pleurodesis in the treatment of pulmonary air leaks on the first postoperative day following VATS pulmonary…
- Trial name
- PRAL (NCT05638113)
- Testing
- Pleural injection of autologous blood
- Where
- Denmark
- Volunteers
- 182 people
- Sponsor
- Odense University Hospital
Postoperative Air Leak
Pleurodesis Using Hypertonic Glucose to Treat Post-operative Air Leaks
The investigators will define the most appropriate safe dose of D50 to heal air leaks in patients that have undergone lung resection surgery
- Trial name
- PLUG-I (NCT03905408)
- Testing
- 50 mL of 50% Glucose, 100 mL of 50% Glucose, 150 mL of 50% Glucose
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postoperative Air Leaks in Risk Patients
Clinical Trial Phase I/II Prospective, Open Nonrandomized for Treatmen of Postoperative Air Leak After Lung Resection in High Risk Patients Through the Administration of Mesenchymal Autologous Cells
The purpose of this study is to analyze the safety and feasibility of the implantation of autologous mesenchymal stem cells (MSCs) expanded "in vitro" and administered directly in the lung line of suture as a treatment for…
- Trial name
- CSM/FAP/2012 (NCT02045745)
- Testing
- Implantation of autologous mesenchymal stem cells (CSM) expanded "in vitro" and administered directly into the lung suture line
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Red de Terapia Celular
Postoperative Air Leak
The Efficacy of OK-432 Pleurodesis on Postoperative Air Leak
The purpose of this study is (1) The success rate of OK-432 pleurodesis after thoracic surgery that air leak over 48 hours (2)The side effects and treatments of OK-432 pleurodesis.
- Trial name
- NCT02502643
- Testing
- OK-432 pleurodesis, normal saline pleurodesis
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital