Clinical trials: Postoperative Cardiovascular Complication
Vasoplegia, Hypotension
Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery
This is a pilot study to determine the hemodynamic effects when hydroxocobalamin vs methylene blue is administered during cardiopulmonary bypass in patients at risk of vasoplegia by measuring mean arterial pressure (MAP)…
- Conditions
- Vasoplegia, Hypotension, Coronary Artery Disease, Cardiac Valve Disease
- Trial name
- NCT03446599
- Testing
- Hydroxocobalamin, Methylene Blue, Normal saline
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Out of Hospital Cardiac Arrest, Inflammatory Response
Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response.
The on-going randomized clinical trial TTM2 (Target Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, NCT02908308) investigates if there is a difference in mortality, neurological function or quality…
- Conditions
- Out of Hospital Cardiac Arrest, Inflammatory Response, Ischemia Reperfusion Injury, Hypothermia
- Trial name
- IH3 (NCT03743584)
- Testing
- Targeted temperature management, Standard care, early treatment of fever
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Abdominal Aortic Aneurysms
Prevention of Endoleaks Using Autologous Platelet Gel on Unruptured Abdominal Aortic Aneurysms
The main risk of aortic aneurysms is rupture that leads to a high risk of death. A preventive surgical treatment is thus needed.
- Trial name
- NCT00372138
- Testing
- PRP + autologous thrombin
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Rennes University Hospital
Cardiac Anaesthesia
Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity.
- Trial name
- NCT06581289
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Vasoplegic Shock, Cardiopulmonary Bypass
Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V)
The goal of this study is to conduct a prospective trial implementing a modified version of the Emory Protocol for administering ANG II to patients with post cardiac bypass vasoplegia.
- Conditions
- Vasoplegic Shock, Cardiopulmonary Bypass, Vasoplegia
- Trial name
- ANGII_V (NCT07671365)
- Testing
- Angiotensin II (Giapreza®)
- Volunteers
- 329 people
- Sponsor
- Methodist Healthcare System of San Antonio
Ovarian Cancer
Tranexamic Acid in Surgery of Advanced Ovarian Cancer
The purpose of the study is to determine if a standardized single dose tranexamic acid given intravenously immediately preoperatively reduces the perioperative bleeding volume and reduces the need of blood transfusion in women…
- Trial name
- NCT00740116
- Testing
- Tranexamic acid, 0.9% NaCl solution
- Where
- 3 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Preben Kjolhede, MD, professor
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Acute Myocardial Infarction, Myocardial Reperfusion Injury
Optimized Cardioprotection Therapy in Obese Subjects With AMI
The purpose of this study is to investigate the efficacy and mechanism of Adipokines Cardiac Protection in Obese Patients With acute myocardial infarction (AMI) Who Have Undergone Percutaneous Coronary Intervention (PCI).
- Conditions
- Acute Myocardial Infarction, Myocardial Reperfusion Injury, Obesity, Adiposis; Heart
- Trial name
- NCT04570514
- Testing
- PCI
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Vasoplegia Syndrome
Dynamic Arterial Elastance Measured by Uncalibrated Pulse Contour Analysis Predicts Arterial Pressure Response to a Decrease in Norepinephrine
Dynamic arterial elastance (Eadyn) has been proposed as an indicator of arterial tone that can predict norepinephrine-dependent arterial pressure.
- Trial name
- VESA (NCT03455738)
- Testing
- vasoplegic syndrome
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hemorrhoids, Postoperative Pain
Pudendal Nerve Block for Hemorrhoidectomy
Patients undergoing Milligan-Morgan hemorrhoidectomy will be randomized to receive or not the pudendal nerve block after the spinal anesthesia.
- Trial name
- NCT04251884
- Testing
- Local anesthetic (ropivacaine)
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- Francesco Mongelli
Hemorrhoids, Open Hemorrhoidectomy
Hemorrhoids: Options of Traditional Hemorrhoidectomy
The goal of this prospective clinical trial is to compare the outcomes of several technical options of open hemorrhoidectomy in patients with symptomatic hemorrhoids.
- Trial name
- NCT06132152
- Testing
- Open hemorrhoidectomy with 'cold' scalpel, Open hemorrhoidectomy with electrosurgical scalpel
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- Center of Endourology "Endocenter"
Adrenaline; Aortic Dissection; Drug Dose; Nervous System; Ischemia Reperfusion Injury
Effects of Different Doses of Epinephrine on Biomarkers of Nervous System Ischemia-reperfusion Injury in Patients With Stanford Type A Dissection
Aortic dissection is the most common aortic disease leading to death. Among them, patients with Stanford type A dissection (TAAD) are prone to dissection rupture in the early stage, and their condition deteriorates rapidly.
- Trial name
- NCT05151536
- Volunteers
- 132 people
- Sponsor
- Yunlong Fan
Surgery, Survival, Prosthesis
15 Years Outcomes Following Bioprosthetic vs Mechanical Aortic Valve Replacement Between 50-65 Years
Currently there is an increase in the use of bioprosthesis worldwide (> 70% according to national data of the Spanish Society of Thoracic and Cardiovascular Surgery).
- Conditions
- Surgery, Survival, Prosthesis, Valve Heart Disease
- Trial name
- ANDALVALVE (NCT03239509)
- Testing
- bioprosthesis implantation between 2000-2015, mechanical prosthesis implantation between 2000-2015
- Where
- 7 sites in Spain
- Volunteers
- 1,200 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Post-Cardiac Arrest Syndrome
Clinical Cohort Construction Program of Peking University Third Hospital
Cardiac arrest is one of the leading life-threatening emergencies, with approximately 540,000 cases occurring annually in China.
- Trial name
- NCT07762144
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking University Third Hospital
Myocardial Reperfusion Injury
Investigation Into the Role of GTN & RIPC in Cardiac Surgery
The purpose of this study is to determine whether Glyceryl Trinitrate (GTN) reduces injury to the heart during heart-lung bypass surgery in combination with the newer technique of remote ischaemic preconditioning (RIPC).
- Trial name
- ERIC-GTN (NCT01864252)
- Testing
- Remote ischaemic preconditioning, IV Normal saline, IV Glyceryl trinitrate 2-5ml/h
- Where
- United Kingdom
- Volunteers
- 192 people
- Sponsor
- University College, London
Myocardial Infarction, Reperfusion Injury, Myocardial
Trans-coronary Cooling and Dilution for Cardioprotection During Revascularisation for ST-elevation Myocardial Infarction
A heart attack (myocardial infarction) occurs when an artery supplying blood to the heart is suddenly blocked resulting in damage to the heart muscle.
- Trial name
- STEMI-Cool (NCT06128993)
- Testing
- Transcoronary cooling and dilution, Standard of care
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Aortic Dissection, Acute Kidney Injury
Prediction of Postoperative Acute Kidney Injury in Patients With Acute Type A Aortic Dissection Using Cystatin C
The research aimed to predict postoperative acute kidney injury in patients with acute type A aortic dissection preliminarily by exploring the correlation of preoperative cystatin C level and incidence of postoperative acute…
- Trial name
- NCT05039814
- Testing
- postoperative acute kidney injury, none postoperative acute kidney injury
- Where
- China
- Volunteers
- 249 people
- Sponsor
- Qilu Hospital of Shandong University
Postoperative Delirium, Stroke
Cyclopofol Versus Propofol for Postoperative Delirium in Elderly Patients Having Orthopedic Surgery
Postoperative delirium (POD) is common in elderly patients recovering from surgery and anesthesia. POD has adverse effects on early and long-term prognosis.
- Trial name
- NCT06046638
- Testing
- Cyclopofol, Propofol
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Lung Transplantation
Point-of-care Management of Coagulopathy in Lung Transplantation
Pulmonary transplantation is a very demanding surgical procedure, often accompanied by coagulopathy and severe perioperative bleeding.
- Trial name
- NCT03598907
- Testing
- Fresh frozen plasma
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital, Motol
Vital Sign Monitoring, Post Operative Complications
Continuous Vital Sign Monitoring Versus Routine Spot-checks in Patients After Non-cardiac Surgery
The "COME ON, NOW!" trial is a randomized, single-center trial in patients recovering from non-cardiac surgery on normal wards investigating whether continuous vital sign monitoring - compared to routine spot-checks by nurses …
- Conditions
- Vital Sign Monitoring, Post Operative Complications, Non-cardiac Surgery, RCT
- Trial name
- COME ON NOW (NCT07385092)
- Testing
- Unblinded continuous vital sign monitoring, Blinded continuous vital sign monitoring
- Where
- Germany
- Volunteers
- 264 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf