Clinical trials: Postoperative Cardiovascular Complication
Hematoma, Subdural, Chronic
Irrigation of Chronic Subdural Hematomas - is More Better?
There are numerous reported ways to treat chronic subdural hematomas (CSDH) and practice is still differing considerably between departments.
- Trial name
- NCT01930617
- Testing
- Burr hole surgery with various drainage techniques
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 1,258 people
- Sponsor
- St. Olavs Hospital
Liver Transplantation, Ischaemia Reperfusion Injury
Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation
Hepatic reperfusion during liver transplantation remains a critical phase associated with significant hemodynamic and systemic disturbances, despite advances in surgical and anesthetic management.
- Conditions
- Liver Transplantation, Ischaemia Reperfusion Injury, Perioperative Complications
- Trial name
- NCT07631689
- Testing
- Reperfusion Blood Discard, Standard Liver Transplantation
- Volunteers
- 132 people
- Sponsor
- University of Sao Paulo General Hospital
CHD, Heart Defects, Congenital
The Effects of Different Prone Positioning Angles on Cardiopulmonary Function in Children After Congenital Heart Disease Surgery: A Randomized Controlled Trial
The goal of this randomized controlled trial is to learn if different head-elevated prone positioning angles can optimize cardiopulmonary function and enteral nutrition tolerance in infants and children after congenital heart…
- Conditions
- CHD, Heart Defects, Congenital, Hypoxia, Respiratory Insufficiency
- Trial name
- PACE-CHD (NCT07323979)
- Testing
- 10° Head-Elevated Prone Positioning, 30° Head-Elevated Prone Positioning, 45° Head-Elevated Prone Positioning
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Guangdong Provincial People's Hospital
Primary Graft Dysfunction
Pneumoproteins Expression in the Organ Donor
Primary graft dysfunction, a form of reperfusion pulmonary edema that occurs early after lung transplantation, shares key clinical and pathological features with acute lung injury and its more severe form, the acute respiratory…
- Trial name
- NCT02032069
- Testing
- no intervention
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital of Mont-Godinne
Delayed Graft Function, Kidney Transplantation
The Impact of Intraoperative Diuretic Use on Delayed Graft Function Following Deceased Donor Renal Transplantation
Delayed graft function, defined as the need for dialysis within seven days of kidney transplantation, is a common complication affecting deceased-donor kidney transplant recipients.
- Trial name
- NCT07726134
- Testing
- Furosemide, Mannitol
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Myocardial Reperfusion Injury
Ciclosporin to Reduce Reperfusion Injury in Primary PCI
Routine primary percutaneous coronary intervention (PPCI) for a heart attack involves opening a blocked artery with a balloon then inserting a metal scaffold (stent) to hold the artery open.
- Trial name
- CAPRI (NCT02390674)
- Testing
- Ciclosporin, Saline
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Ischemia-reperfusion Injury
Effects of Dexmedetomidine on the Liver Injury After Hepatectomy
To investigate whether dexmedetomidine reduce liver injury after hepatectomy. During hepatectomy, surgeons always took inflow occlusion to reduce blood loss with Pringle maneuver.
- Trial name
- NCT02833688
- Testing
- dexmedetomidine, 0.9% sodium chloride
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Chinese PLA General Hospital
Reperfusion Injury
Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Reperfusion Injury
"Remote Ischaemic PreConditioning" (RIPC) is performed prior to partial nephrectomy. Postoperative calprotectin dynamics and Blood Oxygen-Level-Dependent (BOLD) MRI are used to to demonstrate the potential renoprotective effect…
- Trial name
- NCT03068689
- Testing
- RIPC
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Vascular Diseases, Peripheral Vascular Disease
Topical Gentamicin and Vancomycin for Vascular Surgical Site Infection Prophylaxis
Many patients who undergo vascular surgery to improve the blood flow to their legs are at risk of developing an infection in the surgical site and are then at risk of serious complications such as hospital readmission, failure of…
- Conditions
- Vascular Diseases, Peripheral Vascular Disease, Surgical Site Infection, Bypass Complication
- Trial name
- NCT04238923
- Testing
- Topical vancomycin paste (1g vancomycin powder + 4mL sterile saline) and Collatamp G gentamicin-eluting sponge (Azralez Pharmaceuticals; 2.0mg gentamicin sulphate/cm2 to cover wound)
- Volunteers
- 356 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hypertension
Postoperative Pain and Angiotensin II Receptor Antagonists
An angiotensin II type 2 receptor (AT2R) antagonist has been assessed for its efficacy in neuropathic pain with promising results.
- Trial name
- PP&ARA (NCT02513979)
- Testing
- Angiotensin type II receptor antagonists
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens
Ischemia Reperfusion Injury, Delayed Graft Function
Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transplantation
The objectives of this study are to test the preliminary safety and efficacy of a two-day peri-operative course of treprostinil in reducing ischemia-reperfusion injury in adult patients receiving a deceased donor kidney…
- Trial name
- NCT04005469
- Testing
- Treprostinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rhode Island Hospital
Diabetic Foot Ulcers, Venous Stasis Ulcer
Cellular and Tissue Based Therapy Registry
The goal of the Cellular and Tissue Based Therapy Registry (CTPR) for Wounds is to provide real world patient data from electronic health records submitted to meet Stage 2 Meaningful Use in order to understand the value of these…
- Conditions
- Diabetic Foot Ulcers, Venous Stasis Ulcer, Pressure Ulcer, Chronic Non Healing Wound
- Trial name
- CTPR (NCT02322554)
- Testing
- Cellular and tissue based products
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- U.S. Wound Registry
Reperfusion Injury, Oxidative Stress
Comparison of Oxidative Stress Changes in Different Ventilation Strategies During Gynecologic Laparoscopic Surgery
Ischemia-reperfusion injury resulted from pneumoperitoneum during laparoscopic surgery have been reported in some literatures. There are no studies investigating the time course of changes in oxidative stress markers in…
- Trial name
- NCT02512640
- Testing
- Volume-controlled ventilation, Pressure-controlled ventilation
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Endoleak, Aortic Aneurysm, Abdominal
CQDSA in Evaluation of Prognosis After EVAR
Re-hospitalization or re-intervention is sometimes necessary to treat type I and type III endoleaks after EVAR for its persistent increasing of pressure in aneurysm lumen.
- Trial name
- NCT02016131
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Shanghai Zhongshan Hospital
Liver Transplant; Complications, Vasoplegia
Angiotensin II in Liver Transplantation
The purpose of this study is to determine the efficacy and safety of Angiotensin II as a second-line vasopressor (drug that raises the blood pressure) during liver transplantation.
- Trial name
- AngLT-1 (NCT04901169)
- Testing
- Angiotensin II, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Delayed Graft Function, Kidney Transplant; Complications
Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys
The aim of the study is to evaluate the feasibility of this bubble and surface oxygenation and to determine the optimal timing of surface oxygenation (continuous versus intermittent) as alternative for membrane-oxygenated…
- Conditions
- Delayed Graft Function, Kidney Transplant; Complications, Ischemia Reperfusion Injury, Mitochondrial
- Trial name
- HMPO2 (NCT05430620)
- Testing
- Oxygen
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Vasoplegia
Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
Vasopressors are medications that are given intravenously to increase the blood pressure of patients with illnesses that cause dangerous blood pressure drops.
- Trial name
- NCT05058612
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers (VLUs)
Study of Miro3D Wound Matrix for Healing Wounds and Ulcers in Outpatient Care
This clinical study is being conducted to evaluate how well the Miro3D Wound Matrix helps heal difficult wounds and ulcerations in an outpatient care setting.
- Conditions
- Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers (VLUs), Pressure Ulcers, Surgical Wound Dehiscence (SWD)
- Trial name
- NCT06939673
- Testing
- Acellular Porcine-Derived Wound Matrix
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Reprise Biomedical, Inc.
Sudden Cardiac Death, Ventricular Fibrillation
Prognostic Value of Ventricular Fibrillation Spectral Analysis in Sudden Cardiac Death
Ventricular fibrillation (VF)-related sudden cardiac death (SCD) is a leading cause of mortality. Patients may survive with neurological damage despite state-of-the-art treatment.
- Conditions
- Sudden Cardiac Death, Ventricular Fibrillation, Reperfusion Injury
- Trial name
- AWAKE (NCT03248557)
- Testing
- Spectral analysis of ventricular fibrillation tracings
- Where
- 5 sites in Spain
- Volunteers
- 168 people
- Sponsor
- Hospital San Carlos, Madrid
Reperfusion Injury
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
The purpose of this study is to establish the effectiveness of the combined drug approach (anti-thrombin III, infliximab, apotransferrin, human recombinant erythropoietin beta, C1-inhibitor, glutathione, alfa-tocopherol…
- Trial name
- CAPITL (NCT02251041)
- Testing
- Antithrombin-III, Infliximab, Apotransferrin
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven