Clinical trials: Postoperative Cardiovascular Complication
Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis
Fibrin Clot Properties and Blood Loss Following Coronary Artery By-pass Grafting
Up to 15% of operations in cardio-pulmonary by-pass are complicated by excessive postoperative blood loss, which negatively affects the outcomes.
- Conditions
- Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis, Coronary Artery Bypass, Blood Loss, Postoperative
- Trial name
- NCT03622671
- Testing
- Skeletonized LIMA, Pedicled LIMA
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- Jagiellonian University
Septic Shock, Vasopressor Resistance
Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock
Septic shock is one of the most frequent reasons for admission to intensive care units and remains associated with a high mortality rate of approximatively 40% at 28 days.
- Trial name
- ADRESS (NCT07569536)
- Testing
- Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care
- Where
- 18 sites in France
- Volunteers
- 360 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Stroke, Acute
Reperfusion With Cooling in Cerebral Acute Ischemia
The purpose of this study is to determine whether reducing a patients body temperature (mild hypothermia of 33 degrees Centigrade) will significantly reduce the risk of brain injury (notably reperfusion injury and hemorrhagic…
- Trial name
- ReCCLAIM (NCT01585597)
- Testing
- Zoll- Coolgaurd 3000
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Hypoxemia, Postoperative Complications
Sigh Ventilation on Postoperative Hypoxemia in Cardiac Surgery
Postoperative pulmonary complications (PPCs) remain a frequent event after pump-on cardiac surgery and are mostly characterized by postoperative hypoxemia.These complications are significant contributors to prolonged intensive…
- Conditions
- Hypoxemia, Postoperative Complications, Cardiac Disease, Acute Lung Injury
- Trial name
- NCT06248320
- Testing
- Sigh ventilation
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Zhongda Hospital
Hernia, Ventral, Hernia Incisional
Renal- and Pulmonary Function in Relation to Abdominal Hypertension After Abdominal Reconstruction
An incisional hernia is technically challenging to operate and is the most frequent long-term complication after open surgery, resulting in impaired quality of life and reduced physical ability.
- Conditions
- Hernia, Ventral, Hernia Incisional, Acute Kidney Injury, Restrictive Lung Disease
- Trial name
- REPARE (NCT04143776)
- Testing
- Abdominal reconstruction
- Where
- Denmark
- Sponsor
- Bispebjerg Hospital
Acute Coronary Syndrome, Myocardial Infarction
Efficacy of Preoperative Electrocardiography
A preoperative electrocardiogram (ECG) is nearly routinely performed by anesthesiologists in elderly non-cardiac surgery patients as part of pre-anesthesia evaluation.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Cardiac Arrest
- Trial name
- NCT00928460
- Testing
- Removal of preoperative electrocardiogram
- Where
- Netherlands
- Sponsor
- UMC Utrecht
Hemorrhoids, Pain, Postoperative
HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial
HYPOTHESIS 1. HAL- RAR causes a lower immediate postoperative pain compared with excision hemorrhoidectomy. 2. HAL - RAR achieves similar immediate and long term results compared to the excision hemorrhoidectomy in the control of…
- Trial name
- NCT02216305
- Testing
- Hemorrhoidectomy, HAL-RAR
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Plató
C.Surgical Procedure; Cardiac
PWV for Cardiovascular Complication After Cardiac Surgery
Arterial stiffness has been suggested as an independent risk factor for the development of coronary artery disease and stroke. Pulse wave velocity (PWV) is an noninvasive established index to quantify arterial stiffness.
- Trial name
- NCT02014012
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Vasoplegic Syndrome
Weaning of Norepinephrine Guided by the Dynamic Arterial Compliance in Cardiac Surgery Post Operative.
After cardiac surgery, vasoplegic syndrome is a hemodynamic state characterized by profound hypotension associated with a decrease in systemic vascular resistance.
- Trial name
- SNEAD (NCT02479529)
- Testing
- Norepinephrine
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Reperfusion Injury
Role of Volatile Anesthetics for Hepatic Protection
This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of…
- Trial name
- NCT00516711
- Testing
- Sevoflurane
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Coagulation, Blood, Compression Devices, Intermittent Pneumatic
Alterations of Blood Clotting With the Use of Sequential Compression Devices on the Lower Limbs
This study aims to assess possible alteration in coagulation (blood clotting) following treatment with sequential compression devices (SCD) plus low-molecular weight heparin (LMWH) as opposed to LMWH alone.
- Conditions
- Coagulation, Blood, Compression Devices, Intermittent Pneumatic, Postoperative Complications, Thrombelastography
- Trial name
- TEGLeg (NCT00726570)
- Testing
- Sequential compression device therapy, Dalteparin, TEG
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Parma
Gynecologic Neoplasms, Venous Thromboembolism
Thromboprophylaxis After Surgery for Gynecologic Malignancy in China
Venous thromboembolism (VTE) is an important cause of post-operative morbidity and mortality in women undergoing surgery for gynecologic malignancies.
- Conditions
- Gynecologic Neoplasms, Venous Thromboembolism, Low Molecular Weight Heparin, Argatroban
- Trial name
- NCT02935530
- Testing
- s-LMWH, LMWH, Argatroban
- Where
- China
- Volunteers
- 315 people
- Sponsor
- Huazhong University of Science and Technology
Orthostatic Intolerance, Orthostatic Hypotension
Postoperative Orthostatic Intolerance and Hypotension in Unilateral TKA
Incidence of Postoperative Orthostatic Intolerance and Postoperative Orthostatic Hypotension in Patients Undergoing Unilateral Total Knee Arthroplasty
- Conditions
- Orthostatic Intolerance, Orthostatic Hypotension, Postoperative Complications
- Trial name
- NCT03743116
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Hvidovre University Hospital
Epilepsy, Cardiac Disease
Epileptic Potentials During Cardiac Surgery and Association With Postoperative Neurological Outcome
Primarily, the investigators want to test the hypothesis that it is possible to detect epileptiform EEG during cardiac surgery under general anesthesia.
- Conditions
- Epilepsy, Cardiac Disease, Peroperative Complications, Anesthesia; Adverse Effect
- Trial name
- EPOCAS (NCT02976584)
- Where
- Switzerland
- Volunteers
- 1,067 people
- Sponsor
- Heiko Kaiser
Shock, Surgical, Shock
Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients
The current standard of catecholamine vasopressor management of perioperative hypotension in kidney transplant patients carries significant risks and falls short in many ways.
- Conditions
- Shock, Surgical, Shock, Hypotension and Shock, Kidney Transplant; Complications
- Trial name
- NCT04529005
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
Obesity, Sleep Apnea
Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery
The purpose of this study is to determine if Dexmedetomidine given at the end of surgery will reduce postoperative morphine consumption and improve postoperative quality of recovery as compared to morphine in patients undergoing…
- Conditions
- Obesity, Sleep Apnea, Diabetes, Hypertension
- Trial name
- NCT02213159
- Testing
- Dexmedetomidine, Morphine
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- American University of Beirut Medical Center
Coronary Artery Bypass Surgery, Postoperative Complications
Glutamate for Metabolic Intervention in Coronary Surgery II
The aim of GLUTAMICS II is to evaluate whether intravenous glutamate infusion surgery reduces the risk of postoperative heart failure as measured by plasma NT-proBNP in patients undergoing moderate to high-risk coronary artery…
- Conditions
- Coronary Artery Bypass Surgery, Postoperative Complications, Heart Failure
- Trial name
- GLUTAMICSII (NCT02592824)
- Testing
- glutamate infusion, saline infusion
- Where
- 4 sites in Sweden
- Volunteers
- 321 people
- Sponsor
- University Hospital, Linkoeping
Coronary Artery Disease, Coronary Artery Bypass
Nitric Oxide-mediated Cardioprotection During Cardiac Surgery With Cardiopulmonary Bypass
This prospective randomized study elucidates the effects of exogenous nitric oxide delivered to the extracorporeal circulation circuit for cardioprotection against ischemia-reperfusion injury during coronary artery bypass graft…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Cardiopulmonary Bypass, Nitric Oxide
- Trial name
- NOinCPB (NCT03500783)
- Testing
- Nitric Oxide, Standard CPB
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Cardiology, Critical Care Medicine, Emergency Medical Service
TIMECARD(TaIwan Network of Post-arrest ManagEment for CARDiac Arrest)IIRegistry
This study aims to collect the post-cardiac arrest patients with ICU admission.
- Trial name
- TIMECARDII (NCT06218329)
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Clinical Trial Center