Clinical trials: Postoperative Cardiovascular Complication
Myocardial Infarction, Reperfusion Injury
Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction
There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on…
- Trial name
- R²ACE (NCT01414452)
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universiteit Antwerpen
Postoperative Pain, Hemorrhoids Third Degree
Efficacy of Ice Packing Application in Post-Hemorrhoidectomy Recovery
According to the previous study, surgical intervention exhibited significant differences in daily life before and after a hemorrhoidectomy.
- Conditions
- Postoperative Pain, Hemorrhoids Third Degree, Hemorrhoids Fourth Degree, Hemorrhoids
- Trial name
- ICE-HEMO (NCT07186348)
- Testing
- Ice packing, Standard Care (in control arm)
- Where
- Taiwan
- Volunteers
- 429 people
- Sponsor
- Chang Gung Memorial Hospital
Hypotension
Intraopertive Hypotension and Postoperative Cardiovascular Complications Among Chinese Elderly Patients Undergoing Oncardiac Surgery : a Retrospective Cohort Study
To explore the relationship of intraoperative hypotension and perioperative cardiovascular complications in elderly noncardiac surgical patients
- Trial name
- NCT06017206
- Volunteers
- 35,262 people
- Sponsor
- Hao Li
Ischemia-reperfusion Injury.
The Safety of Vardenafil in Patients Undergoing Cardiac Surgery
The purpose of this study is to evaluate the safety of vardenafil in cardiac surgery patients.
- Trial name
- NCT01260285
- Testing
- Vardenafil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- McGuire Research Institute
Liver Diseases, Reperfusion Injury
Effect Inhaled Nitric Oxide in Adult Liver Transplant
Liver transplantation remains the only cure for patients with end-stage liver disease. Despite continuous advances in medical care, ischemia-reperfusion injury (IRI) (tissue damage that occurs when blood supply is restored to an…
- Conditions
- Liver Diseases, Reperfusion Injury, Vasoplegia
- Trial name
- NCT07125443
- Testing
- Prospective iNO Administration ("After" Group), No Intervention Retrospective "Before" Group
- Volunteers
- 260 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Reperfusion Injury, Oxidative Stress
Comparison of Oxidative Stress Changes in Different Ventilation Strategies During Gynecologic Laparoscopic Surgery
Ischemia-reperfusion injury resulted from pneumoperitoneum during laparoscopic surgery have been reported in some literatures. There are no studies investigating the time course of changes in oxidative stress markers in…
- Trial name
- NCT02512640
- Testing
- Volume-controlled ventilation, Pressure-controlled ventilation
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Glycemic Control, Surgical Site Infections
A Quality Initiative to Improve Glycemic Control in Diabetic and Non-Diabetic Insulin Study
The aim of this study is to examine the effect of moderate glucose (blood sugar) control in diabetic and non-diabetic patients undergoing leg bypass surgery (LEB) or open abdominal aortic aneurysm (AAA) repair.
- Conditions
- Glycemic Control, Surgical Site Infections, Cardiac Complications, Length of Stay
- Trial name
- NCT01916733
- Testing
- standard insulin protocol post-op (continuous IV insulin)
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Vermont Medical Center
Non Shockable Out of Hospital Cardiac Arrest
Cyclosporine A in Cardiac Arrest
The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and…
- Trial name
- CYRUS (NCT01595958)
- Testing
- Cyclosporine A, cardio-pulmonary resuscitation
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Hospices Civils de Lyon
Ischemia Reperfusion Injury, Myocardial Injury
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
A Randomized, Double-blind, placebo-controlled Trial to Evaluate the Efficacy of Oral Nam for the Prevention of Acute Kidney Injury in Patients Undergoing On-Pump Cardiac Surgery
- Conditions
- Ischemia Reperfusion Injury, Myocardial Injury, Acute Kidney Injury
- Trial name
- NACAM (NCT04750616)
- Testing
- Niacinamide
- Where
- United States
- Volunteers
- 331 people
- Sponsor
- Kaiser Permanente
Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction
RaGuS Trial by Postoperative Patients
Vasoplegic syndrome is characterized clinically by reduced systemic vascular resistance and normal or increased cardiac output. It is principally observed in cardiovascular and orthopedic interventions and is characterized by a…
- Conditions
- Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction, Orthostatic Hypotension
- Trial name
- RaGuS (NCT04440085)
- Testing
- Midodrine Hydrochloride
- Volunteers
- 50 people
- Sponsor
- Bürgerspital Solothurn
Hematoma, Subdural, Chronic
Irrigation of Chronic Subdural Hematomas - is More Better?
There are numerous reported ways to treat chronic subdural hematomas (CSDH) and practice is still differing considerably between departments.
- Trial name
- NCT01930617
- Testing
- Burr hole surgery with various drainage techniques
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 1,258 people
- Sponsor
- St. Olavs Hospital
Hyperbilirubinemia, Hepatic Impairment
The Investigation of the Causes of Hepatic Dysfunction in the Postoperative Period During Open-heart Surgeries
In a prospective observational study during the six-month duration, coronary artery bypass graft surgery (CABG) and valve repair surgery (mitral, mitral, and aortic valve and/or tricuspid valve) patients were investigated for…
- Conditions
- Hyperbilirubinemia, Hepatic Impairment, Surgery, Cardiac Disease
- Trial name
- NCT04271098
- Testing
- Open-Heart Surgery for nine months duration, Relation between possible risk factors and hyperbilirubinemia, Follow-up period
- Volunteers
- 340 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Postoperative Pain
Efficacy of Parasternal Blocks in Cardiovascular Surgery Patients Undergoing Median Sternotomy
Acute and chronic pain after cardiac surgery is a common problem that negatively affects quality of life. Postoperative pain after cardiac surgery is most intense in the first two days and decreases in the following period.
- Trial name
- NCT06387095
- Testing
- 1. no block, 2. superficial parasternal block, 3. deep parasternal block
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital
Acute Myocardial Infarction
Efficacy Study of Glucagonlike Peptide-1 to Treat Reperfusion Injury
The investigators planned to research the cardioprotective effects of intravenous liraglutide on reperfusion injury.
- Trial name
- NCT02001363
- Testing
- liraglutide (Novo Nordisk, Bagsværd, Denmark)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chen Wei Ren, MD
Ischemia Reperfusion Injury
Does Caffeine Reduce Rosuvastatin-Induced Protection Against Ischemia-Reperfusion Injury?
Does caffeine reduce rosuvastatin induced protection against ischemia reperfusion injury?
- Trial name
- NCT00457652
- Testing
- Rosuvastatin
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cardiotoxicity
Effect of Remote Ischaemic Conditioning in Oncology Patients
Cancer survival has improved steadily due to earlier detection and treatment. Despite the established efficacy of anthracycline chemotherapy, its damaging effects on the heart (cardiotoxicity) limits treatment and confers acute…
- Trial name
- ERIC-ONC (NCT02471885)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Arterial Disease
Dynamic Arterial Elastance: an Indirect Marker of the Critical Capillary Pressure at the Microcirculatory Level
The measurement of dynamic arterial elastance (Eadyn) was proposed as a marker of vascular tone. It is calculated by the ratio of the respiratory variation of the pulse pressure and the respiratory variation of stroke volume.
- Trial name
- POEME (NCT03478709)
- Testing
- volume expansion, norepinephrine
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Postoperative Complications, Heart Failure
Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery
Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess…
- Trial name
- LIFESAVE (NCT06777355)
- Testing
- Transthoracic and Transesophageal echography within 24 hours post cardiac surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CMC Ambroise Paré
Vomiting, Postoperative, Postoperative Complications
The Effect of Intravenous Granisetron and Ondansetron in Patients Undergoing Cesarean Section
This study compared the effects of prophylactic intravenous (IV) infusion of ondansetron and granisetron before the spinal anesthesia on hemodynamic parameters in patients undergoing elective cesarean section.
- Conditions
- Vomiting, Postoperative, Postoperative Complications, Hypotension
- Trial name
- NCT04613726
- Testing
- ondansetron, Granisetron, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ataturk University