Clinical trials: Postoperative Cognitive Dysfunction
Cognitive Decline
Early Postoperative Cognitive Impairment in Elderly Patients Following Ocular Surgery
This project will investigate changes in cognitive function in the early postoperative phase (<24 hours) after minor surgery in patients of older age (≥65 years).
- Trial name
- NCT03775343
- Testing
- Neurocognitive Test Battery, Blood sampling
- Where
- Austria
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Postoperative Cognitive Dysfunction
Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery
To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。
- Trial name
- NCT03703973
- Testing
- Neuropsychology test
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Postoperative Cognitive Decline, Inflammation, and Plasma Levels of Beta-amyloids
Postoperative cognitive dysfunction (POCD) can be a serious complication. The development of therapeutic strategies for the prevention and treatment of this condition requires the identification of subgroup of patients with the…
- Trial name
- NCT00850928
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Quality of Life, Surgery
Determination of the Effect of Puzzle Use in Elderly Patients
The aim of this study is to determine the effects of the use of a simple, reliable and cost-effective puzzle on post-operative cognitive function changes, postoperative recovery, and quality of life using questionnaires and…
- Conditions
- Quality of Life, Surgery, Postoperative Confusion, Cognitive Dysfunction
- Trial name
- NCT05796830
- Testing
- Puzzle application
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Postoperative Cognitive Impairment, Optic Nerve Sheath Edema
Effect of Different Ventilation Modes on POCD in Elderly Patients with Abdominal Wall Hernia
The purpose of this clinical trial is to understand the effect of different ventilation patterns during surgery on postoperative cognitive impairment in elderly patients with abdominal wall hernias.
- Trial name
- NCT06764745
- Testing
- PC Ventilation Modes, VC Ventilation Modes, PRVC Ventilation Modes
- Where
- China
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Inner Mongolia University of Science and Technology
Postoperative Cognitive Dysfunction
Effects of Thoracic Paravertebral Block Combined With S-ketamine on Postoperative Pain and Cognitive Function After Thoracoscopic Surgery
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block combined with intraoperative infusion of s-ketamine on postoperative acute pain and cognitive function in patients with thoracoscopic surgery
- Trial name
- NCT05341375
- Testing
- Thoracic paravertebral block, Esketamine, Measurement of cognitive function
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Cognitive Impairment, Frail Elderly Syndrome
Preoperative Cognitive Screening in Older Spinal Surgical Patients
The objectives of this study are to determine whether identifying patients with baseline cognitive deficits or frailty predict postoperative delirium.
- Trial name
- NCT02922634
- Testing
- Mini Cog
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Postoperative Cognitive Dysfunction, Acute Postoperative Pain
Effect of TPVB on Postoperative Pain and Cognitive Function After VATS in Elderly Patients
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block on postoperative acute and chronic pain and cognitive function in elderly patients with thoracoscopic partial lung resection.
- Conditions
- Postoperative Cognitive Dysfunction, Acute Postoperative Pain, Chronic Postsurgical Pain
- Trial name
- NCT05364216
- Testing
- Measurement of cognitive function, Thoracic paravertebral block, The assessment of cognitive function
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Prostate Cancer, Carcinoma of the Rectum
Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
Postoperative cognitive dysfunction (POCD) and postoperative delirium occurs mainly in aged patients. POCD and POD may increase the mortality and morbidity.
- Conditions
- Prostate Cancer, Carcinoma of the Rectum, Colon Cancer, Renal Carcinoma
- Trial name
- MAPOCD (NCT02928692)
- Testing
- Minocycline
- Where
- 5 sites in China
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Heart Rate Variability
Predicting Postoperative Delirium With Heart Rate Variability Obtained by Analgesia Nociception Index
The aim of this pilot study is to establish a correlation between perioperative heart rate variability (HRV) as an expression of the shift in the balance of the autonomic nervous system and the occurrence of postoperative…
- Conditions
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Heart Rate Variability, Biomarkers
- Trial name
- DANI (NCT06709482)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Delirium, Cognitive Dysfunction
Can a New EEG Based Tool Predict Post-operative Delirium and Cognitive Dysfunction?
As the population ages and medical progress is made, many elderly patients that previously would not have been candidates for surgery are now undergoing operations.
- Trial name
- NCT03293550
- Where
- Israel
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Delirium and Post-operative Cognitive Dysfunction (POCD)
Cognitive Outcome After Two-stage Liver-Operation
Cognitive outcome (delirium and post-operative cognitive deficiency) in patients undergoing two-time liver resection.
- Trial name
- 2-StaLi (NCT01809782)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Delirium, Cognitive Impairment
Preoperative BAMCOG and Cortisol and Postoperative DeltaScan in AVR Patients (Aortic Valve Replacement)
There is lack of attention to preoperative cognitive function and delirium in elderly who underwent surgery. The investigators are investigating different tools that can help to screen for cognitive dysfunction and delirium in…
- Conditions
- Delirium, Cognitive Impairment, Cognitive Dysfunction, Cognitive Dysfunction, Postoperative
- Trial name
- NCT05209555
- Testing
- MoCA, BAMCOG, DeltaScan
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Postoperative Cognitive Dysfunction
POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.
To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.
- Trial name
- NCT03084393
- Where
- China
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Dementia, Mild Cognitive Impairment
Evaluation of the Effect of Cataract Surgery on Cognitive Function in Very Elderly Patients
The study intends to measure the evolution over time of the cognitive capacity of patients undergoing cataract surgery in relation to the opaque lens removal surgery (cataract) in a population considered to be at risk of…
- Conditions
- Dementia, Mild Cognitive Impairment, Cataract Senile, Cataract
- Trial name
- NCT04047485
- Testing
- Visual Acuity, CAM (Confusion Assesment Method), CATQUEST 9-SF
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up
The aim of this study is to quantify the incidence of postoperative cognitive dysfunction in the elderly patient (>60y) after total hip or knee replacement surgery.
- Trial name
- NCT01103752
- Testing
- no intervention, descriptive study
- Where
- Denmark
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Lene Krenk
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes
To study on the Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes.To explore whether the olfactory dysfunction could be used as a predictor of POCD and to provide reference for…
- Trial name
- NCT02992600
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Han Yuan
Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Cognitive Changes After Major Joint Replacement
Patients assume that cognitive performance rapidly returns to baseline after anesthesia and surgery. Several studies have shown that one week after major non-cardiac surgery about 27% of patients have postoperative cognitive…
- Conditions
- Postoperative Cognitive Dysfunction, Mild Cognitive Impairment, Delirium, Cognitive Deficit
- Trial name
- Cognigram (NCT02964221)
- Testing
- Cognitive Testing
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr. Stephen Choi
Postoperative Delirium, Postoperative Cognitive Dysfunction
Greek Validation of ACE III Test in Perioperative Patients
Postoperative neurocognitive disorders, including postoperative delirium (POD) and postoperaive cognitive dysfunction (POCD), are common complications of perioperative neurocognition in elderly patients undergoing surgery.
- Trial name
- NCT04312516
- Where
- Greece
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki