Clinical trials: Postoperative Complication
Pain, Postoperative
The Use of Cannabidiol (CBD) in Pain Reduction and Opioid Use After Shoulder Arthroscopy
This study is designed to evaluate the effects of administering CBD to control post-operative pain in patients undergoing shoulder arthroscopy.
- Trial name
- NCT04672252
- Testing
- CBD Oral Disintegrating Tablet (ODT)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Surgical Wound Infection, Postoperative Wound Infection
Study Evaluating Severe Surgical Site Infections (SSIs) Following Contaminated Or Dirty-infected Abdominal Surgery
This is an observational study to evaluate the relative importance of the known risk factors for severe surgical site infections (SSIs) on the development of the more severe SSI cases, and to describe the demographic, clinical…
- Trial name
- EURIDICE (NCT00906074)
- Testing
- Elective or emergency abdominal surgery
- Volunteers
- 180 people
- Sponsor
- Pfizer
Outpatient Surgery, Pain, Postoperative
Patient Narcotic Requirements After Outpatient Otolaryngology Procedures
Patient's pain level and narcotic requirements will be evaluated after routine outpatient Otolaryngology procedures. This will be done by having study participants record their pain level and medication usage from home.
- Trial name
- NCT03404518
- Testing
- Norco, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Postoperative Pain
Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration
This randomized, controlled, observer-blinded study clinical trial was designed to evaluate ultrasound-guided fascia iliaca compartment block with ropivacaine and periarticular infiltration with ropivacaine for postoperative pain…
- Trial name
- NCT02658240
- Testing
- Ropivacaine, Epinephrine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Chemotherapy-Induced Nausea and Vomiting, Postoperative Nausea and Vomiting
A Study to Investigate the Safety and Tolerability of MK-0517 in Healthy Subjects (MK-0517-012)
This 5-part study will evaluate the safety, tolerability, and pharmacokinetics of two formulations of MK-0517 (with and without polysorbate 80) and aprepitant in healthy adults.
- Trial name
- NCT00990821
- Testing
- 90 mg MK-0517 (PS80), 100 mg MK-0517 (PS80), 100 MK-0517 (PS80) + 2 mg midazolam
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Post Operative Pain, Hyperalgesia
Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery.
- Trial name
- NCT01594047
- Testing
- ketamine infusion, Methadone PCA
- Where
- Italy
- Volunteers
- 113 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Postoperative Pain, Postoperative Vomiting and Nausea
Efficacy Side-effect Score (ESS): Development and Evaluation of a New Tool for Patients After Surgery
We hypothesized that better control of postoperative pain treatment and its side effects by monitoring ESS might influence the degree of mobility and morbidity in surgical patients and consequently reduce LOS.
- Conditions
- Postoperative Pain, Postoperative Vomiting and Nausea, Postoperative Complications, Mental Status Changes Postoperative
- Trial name
- ESScore (NCT02143128)
- Testing
- Efficacy Safety Score, Verbal Numeric Rating Scale
- Where
- 2 sites in Kazakhstan, Russia
- Volunteers
- 1,152 people, healthy volunteers welcome
- Sponsor
- Vestre VikenHF Kongsberg Sykehus
Hip Fracture, Myocardial Ischemia
Pilot Study of Atorvastatin for Orthopedic Surgery Patients
Up to 35% of hip fracture patients have been shown to experience heart injury after surgery, and as many as 10% have a heart attack or die in the three months after surgery.
- Conditions
- Hip Fracture, Myocardial Ischemia, Inflammation
- Trial name
- POST-OP Pilot (NCT02197065)
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Hospital for Special Surgery, New York
Postoperative Pain, Postoperative Nausea and Vomiting
Low Doses of Ketamine and Postoperative Quality of Recovery
There are evidences that intraoperative administration of low doses of ketamine may contribute to control the postoperative pain by acting on the N-methyl-D-aspartate (NMDA) channel, reducing the effects related to the tolerance…
- Trial name
- NCT02571153
- Testing
- Ketamine 0.4 mg/kg, Normal saline, Ketamine 0.2 mg/kg
- Where
- Brazil
- Volunteers
- 135 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Pain, Postoperative
Opioid & Steroid Use Following Tonsillectomy in Pediatric Patients
The purpose of this study is to determine if a post-operative course of oral dexamethasone affects opioid usage in pediatric patients undergoing tonsillectomy.
- Trial name
- NCT04541147
- Testing
- Dexamethasone, Analgesics
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Postoperative Pain, Opioid Use
Improving Post-Operative Pain and Recovery in Gynecologic Surgery
This is a clinical investigation to determine the efficacy of rectal versus intravenous acetaminophen in patients undergoing a minimally invasive hysterectomy.
- Conditions
- Postoperative Pain, Opioid Use, Acetaminophen
- Trial name
- NCT04175509
- Testing
- Rectal acetaminophen, Intravenous acetaminophen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aultman Health Foundation
Pain
Phase 3 Study of Local Administration of SKY0402 for Postoperative Analgesia in Subject Undergoing Breast Augmentation
The purpose of this study is to provide a more effective postoperative method of pain control for patients undergoing cosmetic sub-muscular breast augmentation.
- Trial name
- NCT00813111
- Testing
- SKY0402, Bupivacaine HCl
- Where
- 15 sites in United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Postoperative Pain
Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty
The primary objectives of Part 1 are to (1) evaluate three dose levels of liposome bupivacaine versus placebo with respect to the magnitude and duration of the analgesic effect achieved following single dose injection femoral…
- Trial name
- NCT01683071
- Testing
- EXPAREL 67 mg, EXPAREL 133 mg, EXPAREL 266 mg
- Where
- 30 sites in United States
- Volunteers
- 297 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Hernia, Obesity
Evaluation of Surgisis Gold Graft for Incision Reinforcement After Open Bariatric Surgery
The primary objective is to compare the effectiveness of the Surgisis Gold Graft to suture closure alone in preventing an incisional hernia after open bariatric surgery.
- Trial name
- NCT00274625
- Testing
- Surgisis Gold Graft, Control
- Where
- 2 sites in United States
- Volunteers
- 402 people
- Sponsor
- Cook Group Incorporated
Bleeding, Surgical Blood Loss
DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
The aim is to conduct a double-dummy multi-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TxA) versus the usual intravenous TxA in patients undergoing on-pump cardiac surgery.
- Conditions
- Bleeding, Surgical Blood Loss, Seizures
- Trial name
- DEPOSITION (NCT03954314)
- Testing
- Tranexamic Acid
- Where
- 16 sites in Canada, China and 4 more
- Volunteers
- 3,242 people
- Sponsor
- Population Health Research Institute
Surgical Site Infection, Vancomycin
Pharmacokinetics of Preoperative Vancomycin
A study of plasma and tissue vancomycin pharmacokinetics in pediatric surgical patients.
- Trial name
- NCT03453684
- Testing
- Administration of Vancomycin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Interstitial Cystitis
Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis
The purpose of this study is to assess the effects of dexmedetomidine while patients undergo treatment for Interstitial Cystitis (IC).
- Trial name
- NCT01195116
- Testing
- Dexmedetomidine, Normal Saline
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Rochester
Pain, Postoperative, Pelvic Organ Prolapse
Ice T Postoperative Multimodal Pain Regimen in FPMRS Surgery
The purpose of this randomized controlled trial is to determine whether, "ICE-T," a novel multimodal postoperative pain regimen composed of around the clock ice packs, toradol, and tylenol, has improved pain control intake…
- Trial name
- ICET (NCT03052816)
- Testing
- Ice T, Motrin/Percocet/Dilaudid for breakthrough
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Endodontic Disease, Post Operative Pain
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
- Conditions
- Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- Trial name
- NCT05338671
- Testing
- Local anesthetic
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
Total Knee Replacement, Total Knee Arthroplasty
Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty (TKA) Using the SPRINT System
The purpose of this study is to determine if electrical stimulation (small levels of electricity) can safely and effectively reduce pain following total knee replacement (or total knee arthroplasty (TKA)).
- Conditions
- Total Knee Replacement, Total Knee Arthroplasty, Pain, Postoperative Pain
- Trial name
- NCT02468934
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- SPR Therapeutics, Inc.