Clinical trials: Postoperative Delirium (POD)
Cardiac Surgery, Intraoperative Hemodynamic Instability
Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery
Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear.
- Conditions
- Cardiac Surgery, Intraoperative Hemodynamic Instability, Postoperative Complication, Acute Kidney Injury
- Trial name
- NCT07324694
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Postoperative Delirium (POD)
Intranasal Insulin for Postoperative Delirium in Older Patients With T2DM
Postoperative delirium (POD) is highly prevalent in older patients with type 2 diabetes mellitus (T2DM). Cerebral insulin resistance is considered a key pathophysiological mechanism underlying this association.
- Trial name
- NCT07720479
- Testing
- Insulin, human
- Volunteers
- 210 people
- Sponsor
- Weidong Mi
Postoperative Delirium (POD), Postoperative
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotions in Patients Undergoing Cardiac Surgery
A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on the incidence of postoperative delirium and negative…
- Conditions
- Postoperative Delirium (POD), Postoperative, Anxiety, Depression
- Trial name
- NCT07476742
- Testing
- Active taVNS
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Delirium, Postoperative Cognitive Dysfunction
Risk Factor of POD and POCD After Cardiac Surgery
Postoperative delirium (POD) and postoperative cognitive decline (POCD) are common after surgeries in the elderly, especially after cardiothoracic surgery.
- Trial name
- NCT03635229
- Where
- Thailand
- Volunteers
- 360 people
- Sponsor
- Mahidol University
Postoperative Delirium (POD), Intraoperative Hypotension
Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac Surgery
In older patients having surgery, postoperative delirium (an acute disturbance in awareness, attention, or cognition) is common and associated with short-term and long-term morbidity and mortality.
- Trial name
- ASPIRE-85 (NCT07713121)
- Testing
- MAP at 85 mmHg or higher (intervention group), MAP at 65 mmHg or higher (control group)
- Where
- Germany
- Volunteers
- 3,432 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ephedrine, Norepinephrine
Postoperative Delirium After Intraoperative Ephedrine Versus Norepinephrine
This retrospective study aims to investigate the effects of norepinephrine compared to ephedrine, administered on the day of surgery, on the incidence of postoperative delirium.
- Conditions
- Ephedrine, Norepinephrine, Postoperative Delirium (POD)
- Trial name
- NCT06844201
- Testing
- Ephedrine, Norepinephrine
- Volunteers
- 10,000 people
- Sponsor
- Riverside University Health System Medical Center
Postoperative Delirium (POD), Postoperative Sleep Disturbance
Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery
Postoperative delirium (POD) is a common surgical complication.It is associated with a range of negative outcomes such as delayed postoperative recovery,prolonged hospitalization,additional medical expenditures and higher…
- Trial name
- EPISODE (NCT06900205)
- Testing
- Esketamine, 0.9 % saline
- Where
- China
- Sponsor
- RenJi Hospital
Postoperative Delirium (POD), Heart Rate Variability (HRV)
Heart Rate Variability Changes and Postoperative Delirium After Major Abdominal Surgery
This prospective observational cohort study aims to investigate whether early postoperative changes in heart rate variability (HRV) relative to baseline are associated with the development of postoperative delirium (POD) in older…
- Trial name
- HRVPOD (NCT07783464)
- Testing
- Perioperative Heart Rate Variability Changes
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Postoperative Delirium (POD), Prostate Cancer
Preoperative Breathing Exercise Training and Postoperative Delirium After Robotic Radical Prostatectomy
Postoperative delirium is an acute and fluctuating disturbance in attention, awareness, and thinking that may occur after major surgery.
- Trial name
- NCT07766603
- Testing
- Preoperative Deep Breathing Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- ALİ DEMİRTAŞ
Postoperative Delirium, Elderly
The Association Between SIRI and POD in Older Patients
Postoperative delirium (POD) remains one of most common complication in elderly patients receiving surgery, which is characterized by acute and fluctuating change in the level of cognition and consciousness.
- Conditions
- Postoperative Delirium, Elderly, Surgery
- Trial name
- NCT05797194
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Changhai Hospital
Postoperative Delirium
An Observational Study on the Relationship Between Tear Metabolomics and POD
To explore the correlation between tear metabolomics and POD. The purpose of this study was to compare the results of tear metabolomics between POD and non-POD elderly patients undergoing abdominal surgery, to clarify the…
- Trial name
- NCT05548153
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Delirium, Cognitive Dysfunction
Post-operative Delirium (POD) in Patients Undergoing Hip Fracture Surgery
The primary endpoint of the study is the appearance of Post Operative Delirium within the first 3 months. The secondary endpoints are the development of POCD, dementia of any type of new onset at 12 months, mortality at 30 days…
- Trial name
- NCT05105906
- Testing
- cognitive tests performed
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Delirium
Incidence, Long- Term Outcome and Factor Related to Non- Cardiac Postoperative Delirium in Elderly Patients
The purpose of this study is to determine the incidence, long term outcome and factor related to postoperative delirium in elderly patients after non-cardiac surgery.
- Trial name
- POD-I (NCT02131181)
- Where
- Thailand
- Volunteers
- 400 people
- Sponsor
- Chiang Mai University
Postoperative Delirium (POD)
Ketofol Versus Ketodex for POD Prophylaxis in Elderly Cancer Surgery
Postoperative delirium (POD) is a common and serious neurocognitive complication after surgery, particularly in elderly patients undergoing major cancer surgeries.
- Trial name
- NCT07627906
- Testing
- Group ketofol, Group ketodex, Group Control
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Cairo University
Electroencephalogram, Postoperative Delirium (POD)
Electroencephalogram Characteristics of Surgical Anesthetized Patients and Postoperative Dilirium
Objective: To construct a perioperative EEG database for elderly patients under general anesthesia and to explore the relationship between their EEG spectrum characteristics and the occurrence and severity of postoperative…
- Trial name
- NCT06394778
- Testing
- Delirium test scale：3D-CAM
- Where
- China
- Volunteers
- 375 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Postoperative Delirium, Cardiac Surgery
Effect of RIPC on the Prevention of POD in Patients Undergoing Cardiac Surgery
Postoperative delirium (POD) is one of the most frequent neurological complications in elderly patients and is closely associated with longer ICU stay and hospitalization, deterioration of long-term neurocognitive function, and…
- Trial name
- NCT05434455
- Testing
- RIPC induced with 3 cycles of 5 minutes of ischaemia and 5 minutes of reperfusion
- Volunteers
- 216 people
- Sponsor
- Shanghai Zhongshan Hospital
Hip Arthroplasty, Postoperative Pain
Comparison of Pericapsular Nerve Group+ Lateral Femoral Cutaneous Nerve Block Versus Lumbar Erector Spinae Plane Block in Hip Arthroplasty Surgery
Hip replacement surgery (partial or total hip arthroplasty) is commonly performed in elderly patients and is associated with significant postoperative pain.
- Conditions
- Hip Arthroplasty, Postoperative Pain, Hip Fractures, Postoperative Delirium (POD)
- Trial name
- NCT07445009
- Testing
- PENG + LFCN Block, PENG + Lumbar ESP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Postoperative Delirium (POD), Prostate Cancer
A Phase II Clinical Two-Stage Study of Transcranial Magnetic Stimulation in Preventing Postoperative Delirium in Elderly Patients After Urological Surgery
Cases were included based on the inclusion and exclusion criteria, and induction, maintenance, and recovery were conducted in accordance with the standard protocol for general anesthesia.
- Conditions
- Postoperative Delirium (POD), Prostate Cancer, Kidney Tumor
- Trial name
- NCT07480044
- Testing
- Transcranial Magnetic Stimulation Device
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Zhejiang University
Sevoflurane, Propofol
Sevoflurane, Propofol and Desflurane on POD/POCD
The investigators will perform clinical studies to test the hypothesis that participants who have total hip/knee replacement under sevoflurane, propofol or desflurane anesthesia will have different effects on the incidence and…
- Conditions
- Sevoflurane, Propofol, Desflurane
- Trial name
- NCT03326960
- Testing
- Sevoflurane, Propofol, Desflurane
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Post Operative Delirium
The Effect of Preoperative Duloxetine on the Occurance of Postoperative Delirium in Patients Undergoing Cancer Surgery.
This is prospective double-blinded placebo-randomized controlled trial that aims to compare the effect of preoperative administration of oral duloxetine 60 mg on decreasing the incidence of postoperative delirium in cancer…
- Trial name
- NCT05949229
- Testing
- Duloxetine 60 MG
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Amira Hassan Ahmed Ali