Clinical trials: Postoperative Hemorrhage
Blood Loss
Tranexamic Acid for Unilateral Total Knee Arthroplasty
Total knee arthroplasty is often associated with excessive postoperative bleeding due to increased fibrinolysis. Hence, the objective of the proposed of this multicentre study is to determine the peri-operative bleeding comparing…
- Trial name
- TRANEXTOP (NCT01594671)
- Testing
- Tranexamic Acid, haemostasia
- Where
- 2 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Blood Loss, Postoperative, Blood Loss, Surgical
EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS IN REAMED INTRAMEDULLARY NAILING OF DIAPHYSEAL FEMORAL AND TIBIAL FRACTURES: A PROSPECTIVE COMPARATIVE STUDY
Perioperative blood loss is one of the most frequently encountered and significant complications of spine surgery. Intraoperative and post-operative bleeding cause various complications and negatively affect patient outcomes.
- Conditions
- Blood Loss, Postoperative, Blood Loss, Surgical, Femoral Fracture, Tibial Fracture
- Trial name
- NCT07625709
- Testing
- Intervention with Tranexamic Acid, Control group (Normal Saline)
- Where
- Nepal
- Volunteers
- 54 people
- Sponsor
- Kathmandu University School of Medical Sciences
Dexmedetomidine, Bleeding
Dexmedetomidine Improves the Surgical Field and Postoperative Recovery of Nasal Endoscopic Surgery
Studies showed dexmedetomidine (DEX) could improve surgical field, but the effect for functional nasal endoscopic surgery (FESS) was unclear.
- Conditions
- Dexmedetomidine, Bleeding, Surgical Field
- Trial name
- NCT04276545
- Testing
- IV administration of DEX to investigate the effects for functional nasal endoscopic surgery, IV administration of Midazolam to investigate the effects for functional nasal endoscopic surgery
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Surgical Site Infection, Bleeding
Mild Hypothermia Influence on Patient Outcome in Major Abdominal Surgery
This study investigate associations between mild hypothermia (patients' core temperature ≤ 36.0 degrees Celsius) and intra-operative blood loss and surgical site infections (SSI) in patients undergoing major abdominal surgery.
- Trial name
- NCT03112317
- Testing
- Prevention of hypothermia
- Where
- 2 sites in Norway
- Volunteers
- 3,059 people
- Sponsor
- Haukeland University Hospital
Surgical Site Infection, Length of Stay
Prevena to Prevent Surgical Site Infection After Emergency Abdominal Laparotomy
Post-operative wound complications in abdominal surgery have a major impact on patient outcomes and the real impact of Closed incision negative pressure therapy (CINVt) is not clear in the literature moreover concerning its…
- Conditions
- Surgical Site Infection, Length of Stay, Seroma, Hematoma
- Trial name
- CiPNT/SSI (NCT04496180)
- Testing
- Closed incision negative pressure therapy versus standard dressing after emergency abdominal laparotomies
- Volunteers
- 334 people
- Sponsor
- University Hospital, Geneva
Hypothermia
Study to Determine the Effects of Pre-warming on OR Patient Temperatures and Surgical Outcomes
The application of active warming to patients whether awake or under general anesthesia has been proven safe in numerous studies and it is common practice to use warmers.
- Trial name
- NCT02177903
- Testing
- Bair Paws Patient Adjustable Warming System
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Solventum US LLC
Hysterotomy Closure
Study to Compare Suture Material in Closure of Uterine Incision in Cesarian Section
Prospective single blinded trial comparing standard synthetic suture material to a synthetic barbed suture in closure of uterine incision, during Cesarean section procedures.
- Trial name
- Stratafix (NCT02517710)
- Testing
- Stratafix synthetic barbed suture
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Evangelical Community Hospital, Lewisburg, PA
Surgical Blood Loss, Total Knee Arthroplasty
Topical Tranexamic Acid for Total Knee Arthroplasty
Total knee arthroplasty (TKA), the definitive treatment of osteoarthritis, is often associated with excessive postoperative bleeding due to increased fibrinolysis.
- Trial name
- NCT00985920
- Testing
- tranexamic acid
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- University Health Network, Toronto
Epistaxis, Nasal Obstruction
The Effect of Packing in Post Operative Management of FESS
Chronic sinusitis is a very common problem. The functional endoscopic sinus surgery is a prevalent option to treat this disease.During usage of different techniques of surgery, the need for packing after surgery is debatable…
- Conditions
- Epistaxis, Nasal Obstruction, Pain
- Trial name
- NCT00793117
- Testing
- packing
- Where
- Iran
- Volunteers
- 66 people
- Sponsor
- Tehran University of Medical Sciences
Wound Healing, Pain, Postoperative
Evaluation of the Effects of Platelet Rich Fibrin on the Palatal Mucosal Healing
Subepithelial connective tissue graft (SCTG) has greater predictability for root coverage and causes minimal discomfort to patient.
- Conditions
- Wound Healing, Pain, Postoperative, Bleeding Wound
- Trial name
- NCT03734328
- Testing
- connective tissue graft, connective tissue graft&PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Diabetic Retinopathy, Postoperative Recurrent Vitreous Hemorrhage
A Prospective Study of Ranibizumab in the Treatment of Postoperative Recurrent Vitreous Haemorrhage of Diabetic Retinopathy
Diabetic retinopathy (DR) is one of the main complications in diabetes, the proliferative diabetic retinopathy (PDR) is the most important one of the reasons leading to decreased vision, PDR is the stage of clinical intervention.
- Conditions
- Diabetic Retinopathy, Postoperative Recurrent Vitreous Hemorrhage, Pars Plana Vitrectomy, Ranibizumab
- Trial name
- NCT05248334
- Testing
- Ranibizumab Injection, PPV
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Eye Hospital
Postpartum Hemorrhage, Pain
Do Elastic Abdominal Binders Reduce Post Operative Pain and Blood Loss?
This is a pilot study investigating the use of abdominal binders after cesarean sections. The researchers are testing whether elastic abdominal binders improve postoperative pain control and reduce postoperative blood loss.
- Trial name
- NCT01786330
- Testing
- Procare abdominal binder, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zachary Kuhlmann, DO
ENT Disease, Tonsil Disease
Bizact Tonsillectomy: Postoperative Pain, Bleeding and Cost-effectiveness (Randomized Study)
Randomized trial assessing Bizact-instrument in tonsillectomy and it's impact on postoperative recovery (pain, hemorrhage)
- Conditions
- ENT Disease, Tonsil Disease, Surgery
- Trial name
- NCT07842419
- Testing
- Tonsillectomy
- Where
- Finland
- Volunteers
- 224 people
- Sponsor
- Helsinki University Central Hospital
Bariatric Surgery Candidate, Obesity, Morbid
Suture Reinforcement to Reduce the Leak Rate After Sleeve Gastrectomy
Staple line reinforcement (SLR) has been suggested as a mean of reducing the risk of sleeve leakage or bleeding. The aim of this study is to analyze if the suture reinforcement can be used to reduce the leakage rate after sleeve…
- Conditions
- Bariatric Surgery Candidate, Obesity, Morbid, Leak, Anastomotic, Bleeding
- Trial name
- NCT05987787
- Testing
- laparoscopic sleeve gastrectomy without suture reinforcement, laparoscopic sleeve gastrectomy with suture reinforcement
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- University of Foggia
Perioperative Bleeding, Coagulopathy During Cardiac Surgery
Flow-Based Platelet Function Assessment Using Total Thrombus-Formation Analysis System (T-TAS) and Early Bleeding After Cardiac Surgery With Cardiopulmonary Bypass (CPB)
The goal of this observational study is to learn how flow-based platelet function measured with the Total Thrombus-formation Analysis System (T-TAS) relates to early postoperative bleeding in adults undergoing cardiac surgery…
- Conditions
- Perioperative Bleeding, Coagulopathy During Cardiac Surgery, Platelet Dysfunction, Cardiac Surgery
- Trial name
- TTAS-CPB (NCT07619261)
- Testing
- Total Thrombus-formation Analysis System (T-TAS)
- Volunteers
- 30 people
- Sponsor
- Hospital de la Santa creu i Sant Pau - Barcelona
Atrial Fibrillation New Onset, Hemorrhage
Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation
The aim of this study is to evaluate the prophylactic effects of Ranolazine on new onset atrial fibrillation in post-operative coronary artery bypass graft and valve surgery patient population at Staten Island University hospital.
- Conditions
- Atrial Fibrillation New Onset, Hemorrhage, Prolonged QTc Interval, Ventricular Tachycardia
- Trial name
- NCT01590979
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Surgical Blood Loss, Transfusion-dependent Anemia
Tranexamic Acid for Reduction of Transfusion in Abdominal Surgery
The goal of this clinical trial is to learn if the administration of tranexamic acid can reduce the necessity of blood transfusions in adult patients undergoing major abdominal surgery. .
- Conditions
- Surgical Blood Loss, Transfusion-dependent Anemia, Abdomen Disease
- Trial name
- TATRA (NCT06414031)
- Testing
- Tranexamic Acid
- Where
- 2 sites in Germany
- Volunteers
- 892 people
- Sponsor
- Ulrich Ronellenfitsch, MD
Hemorrhage Postoperative, Total Blood Loss
Noninferiority Oral Tranexamic Acid vs Intravenous Administration in Total Hip Arthroplasty
To find noninferiority relationship between oral and intravenous administration of tranexamic acid on peroperative and postoperative blood loss and serum concentration during primary total hip arthroplasty.
- Conditions
- Hemorrhage Postoperative, Total Blood Loss, Arthroplasty Complications
- Trial name
- NCT04691362
- Testing
- Tranexamic Acid Oral Product, Tranexamic acid injection
- Where
- Belgium
- Volunteers
- 230 people
- Sponsor
- University of Liege
Urologic Neoplasms, Benign Prostatic Hyperplasia
Spinal Versus General Anesthesia in Open Simple Prostatectomy
Open simple prostatectomy is still performed for selected patients with benign prostatic hyperplasia, particularly in cases with large prostate volume.
- Conditions
- Urologic Neoplasms, Benign Prostatic Hyperplasia, Anesthesia
- Trial name
- NCT07643415
- Testing
- Spinal anesthesia, General anesthesia
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Hitit University
Hemorrhage, Surgical, Tonsillar Bleeding
TEAPOT Study Multisite
After a child has their tonsils removed, sometimes they might bleed which can be a problem. There is a special mist medicine called nebulized tranexamic acid (TXA) that might help stop the bleeding without having to touch the…
- Trial name
- TEAPOT (NCT07565753)
- Testing
- Tranexamic Acid Injectable Product, Normal Saline
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio