Clinical trials: Postoperative Hyperalgesia
Pain, Head and Neck Disorder
Effect of Remifentanil on the Recovery Profile After Prolonged Head and Neck Surgery
Opioid tolerance in the perioperative period is inevitable especially with ultra-short acting agents such as remifentanil. Existing evidence had shown that opioid induced hyperalgesia due to neuroplastic changes in the central as…
- Trial name
- NCT02416752
- Testing
- Remifentanil, choice of intra-operative opioids were left to the discretion of anesthesiologist
- Where
- Singapore
- Volunteers
- 222 people
- Sponsor
- Singapore General Hospital
Hypertensive Disease, Pain, Postoperative
Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
The purpose of this randomized clinical trial is to evaluate the effect of acute arterial hypertension maintained during surgery on morphine's requirements in patients undergoing laparoscopic cholecystectomy
- Trial name
- NCT01897155
- Testing
- SBP 20-30% over baseline, SBP 20-30% under baseline
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Hyperalgesia, Secondary
Transversus Abdominis Plane (TAP) Block for Cesarean Section
The purpose of this study is to determine whether a transversus abdominis plane (TAP) block with Clonidine added to the injectate (Clo-TAP) performed approximately 2hrs after the cesarean section (CS) will decrease the amount of…
- Trial name
- CLOTAP (NCT01015807)
- Testing
- Bupivacaine, Clonidine
- Where
- 2 sites in United States, Brazil
- Volunteers
- 90 people
- Sponsor
- University of Washington
Postoperative Hyperalgesia
Epidural Clonidine for Postoperative Hyperalgesia
We propose performing a study in which we compare the effects of bupivacaine and fentanyl with a different drug combination - bupivacaine and clonidine. The principal research questions of the study are: 1.
- Trial name
- NCT00417443
- Testing
- Clonidine
- Where
- United Kingdom
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Persistent Pain, Postoperative Hyperalgesia
Prevention of Persistent Postsurgical Pain After Thoracotomy
Postthoracotomy acute pain is followed by persistent postsurgical pain in 20-30% of the patients, defined as pain that lasts more than 3-6 months after surgery.
- Trial name
- NCT01243801
- Testing
- Ketamine
- Where
- 2 sites in Spain
- Volunteers
- 104 people
- Sponsor
- Hospital Clinic of Barcelona
Pain, Postoperative
Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia
In this multicenter, randomised, placebo-controlled, double-blind trial, hyperalgesia area around the scarce following colorectal laparoscopic surgery (piece removal) will be assessed in 3 groups of patients : group 1: continuous…
- Trial name
- CATCH (NCT01077752)
- Testing
- continuous ropivacaine preperitoneal infusion, intravenous lidocaine infusion, parenteral analgesia combining acetaminophen and morphine
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyperalgesia, Pain
Local Anesthetic Infusion and Sternotomy
Cardiac surgery often induces acute postoperative pain and moreover chronic dysesthesia frequently occur long-term after sternotomy.
- Trial name
- CARDIODOLAL (NCT00802048)
- Testing
- Local anesthetic (Ropivacaine), Saline
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
Thoracotomy, Hyperalgesia
Central Sensitisation and Postoperative Pain
One out of 10 patients undergoing surgery develops persistent post-surgical pain (PPSP). Unfortunately, available therapies for treating this pain have limited success.
- Conditions
- Thoracotomy, Hyperalgesia, Hyperalgesia, Secondary, Central Sensitisation
- Trial name
- NCT04220697
- Testing
- electroencephalography (EEG), questionnaires, high frequency electrical stimulation of the forearm skin (HFS)
- Where
- 2 sites in Belgium
- Volunteers
- 70 people
- Sponsor
- Université Catholique de Louvain
Hyperalgesia
Local Anesthetic Infiltration to Prevent Postoperative Pain After Lumbar Surgery
Posterior lumbar arthrodesis causes severe postoperative pain, hampering patients's postoperative reconvalescence especially functional rehabilitation.
- Trial name
- ICALP (NCT00825422)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Postoperative Pain
Sufentanil for Anesthesia Induction in Continuous Remifentanil Anesthesia
The appropriate management of postoperative pain is recognized as an important clinical challenge with implications beyond humanitarian issues.
- Trial name
- SAIRA (NCT01777100)
- Testing
- Sufentanil
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Postoperative Pain Management, Pain Threshold, Shoulder Pain, Laparoscopies
Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies
This prospective, double blind, placebo-controlled, parallel group study will be conducted in the first affiliated hospital of Sun yat-sen university in Guangzhou, China.
- Trial name
- NCT01843010
- Testing
- Parecoxib
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hyperalgesia
Opioid-induced Hyperalgesia After Remifentanil Infusion
Remifentanil is a rapid-acting opioid which has been widely used in pain treatment during surgery for the last 15 years 1. Remifentanil is rapidly eliminated (minutes) from the body after end of infusion, and this makes it easily…
- Trial name
- NCT01702389
- Testing
- Remifentanil
- Where
- Norway
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Pain
The Effect of Ultra-low-dose Naloxone on Remifentanil-induced Postoperative Hyperalgesia - A Randomized Controlled Study
High-dose remifentanil infused intraoperative ironically results in postoperative hyperalgesia. Ultra-low dose nalxone is demonstrated to prevent these opioid-induced hyperalgesia in animal model.
- Trial name
- NCT02856087
- Testing
- High dose Remifentanil, Naloxone, Low dose remifentanil
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Seoul National University Hospital
Postoperative Hyperalgesia
Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery
Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of pain or increased sensitivity to non-painful stimuli at the site of surgery or at a surrounding area that was not directly injured.
- Trial name
- NCT05016128
- Testing
- S-ketamine, saline
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Pain
Factors Predicting Postoperative Cesarean Section Pain
In spite of identical analgesic protocols, parturients suffer different levels of pain postoperative lay. In this study we hope to identify factors which influence the perception of pain including preoperative anxiety, sleep…
- Trial name
- NCT02033304
- Where
- 2 sites in Israel
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Postoperative Pain
Effect of S-ketamine in Cesarean Section Combined Anesthesia
To compare the anti-hyperalgesia effect between S-ketamine with placebo for Maternal receiving elective Cesarean Section under Combined spinal and epidural analgesia.
- Trial name
- NCT05414006
- Testing
- S-ketamine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Pain, Postoperative, Breast Cancer
Postoperative Analgesia Impact of Narcotic Free Anesthesia
The first hypothesis of the study is that substituting fentanyl by esmolol and metoprolol during general anesthesia for patients undergoing mastectomy will result in less pain and less narcotic consumption in the recovery room.
- Conditions
- Pain, Postoperative, Breast Cancer, Postoperative Nausea and Vomiting
- Trial name
- PAINFree (NCT01544959)
- Testing
- fentanyl, beta-blocker (esmolol, metropolol)
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Université de Sherbrooke
Hyperalgesia
Drip-infusion of Remifentanil for RIH
The development of remifentanil-induced hyperalgesia (RIH) is an unpleasant experience for surgical patients. An alternative management, gradual withdrawal of remifentanil was effective in prevention of RIH.
- Trial name
- NCT04387097
- Testing
- remifentanil
- Where
- Taiwan
- Volunteers
- 559 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Symptomatic Apical Periodontitis, Postoperative Pain
Photobiomodulation After Nonsurgical Root Canal Treatment
This randomized, double-blind controlled clinical trial will evaluate whether adjunctive photobiomodulation improves recovery after nonsurgical root canal treatment in adults with teeth diagnosed with symptomatic apical…
- Conditions
- Symptomatic Apical Periodontitis, Postoperative Pain, Mechanical Allodynia
- Trial name
- NCT07886723
- Testing
- Adjunctive Photobiomodulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Post Operative Pain, Hyperalgesia
Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery.
- Trial name
- NCT01594047
- Testing
- ketamine infusion, Methadone PCA
- Where
- Italy
- Volunteers
- 113 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano