Clinical trials: Postoperative Hypoxia
Myocardial Reperfusion Injury, Hypoxia
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases.
- Conditions
- Myocardial Reperfusion Injury, Hypoxia, Hyperoxia, Coronary Artery Disease
- Trial name
- NCT05354648
- Testing
- Hypoxic-hyperoxic preconditioning
- Volunteers
- 120 people
- Sponsor
- Alexander Averyanov
Hypoxic-Ischemic Encephalopathy, Post-Cardiorespiratory Arrest Coma
Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia
This study is designed to assess the effect of cerebral oxygen saturation as an early predictor of neurological outcomes in patients undergoing therapeutic hypothermia after cardiac arrest
- Conditions
- Hypoxic-Ischemic Encephalopathy, Post-Cardiorespiratory Arrest Coma, Cardiac Arrest
- Trial name
- NCT03024021
- Testing
- Near-infrared spectroscopy (NIRS) (INVOS®, Covidien)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Tepecik Training and Research Hospital
Hypoxemia
Reminder-enhanced Incentive Spirometry Evaluation
The purpose of this study is to test whether automatic reminders with a light and a soft sound help patients improve deep breathing exercises after surgery.
- Trial name
- RISE (NCT07728214)
- Testing
- Alarms ON
- Volunteers
- 88 people
- Sponsor
- University of Colorado, Denver
Postoperative Hypoxemia, Position Differences
Effect of Postural Changes on Postoperative Hypoxemia
The goal of this clinical trial is to learn which positioning strategy works better to prevent postoperative hypoxemia in surgical patients: semirecumbent positioning or lateral positioning.
- Trial name
- NCT07161817
- Testing
- Lateral positioning, Semirecumbent positioning
- Volunteers
- 1,200 people
- Sponsor
- Yuhu Ma
Pulmonary Complications, Hypoxemia During Surgery
Association of Different Tidal Volumes and Postoperative Pulmonary Complications
The incidence of lung cancer in China is increasing year by year. Currently, the treatment primarily based on video-assisted thoracoscopic surgery (VATS) is still considered the optimal approach for early-stage non-small cell…
- Conditions
- Pulmonary Complications, Hypoxemia During Surgery, Thoracic Surgery, Video Assisted, One Lung Ventillation (OLV)
- Trial name
- NCT07372378
- Volunteers
- 650 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Postoperative Hypoxia
HI-VISION Pilot Study
A prospective cohort pilot study of non-cardiac patients to determine the feasibility of recruiting 150 patients to undergo postoperative continuous hemodynamic monitoring for up to 3 days.
- Trial name
- HI-VISION (NCT02300441)
- Testing
- ECG, blood pressure and oximetry
- Where
- Canada
- Volunteers
- 133 people
- Sponsor
- McMaster University
Myocardial Ischemic-reperfusion Injury
Immunometabolic Pattern of Intermittent Hypoxia During ST-segment Elevation Myocardial Infarction
The aim of this study is to characterize the protective pattern of intermittent hypoxia, angina pectoris and remote ischemic conditioning, in reperfusion injury by determining and monitoring the plasma immunometabolic parameters…
- Trial name
- NCT05230966
- Testing
- Remote Ischemic Conditioning (RIC)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Ischemia-Reperfusion Injury, Myocardial Infarction
Infusion of a Single Dose of Erythropoietin to Prevent Injury in an Ischemia Reperfusion Forearm Model
Rationale: The investigators hypothesize that EPO protects against apoptosis after acute ischemia in man and that it is detectable using the annexin-A5 model.
- Trial name
- IPIIR (NCT00691613)
- Testing
- Epoetin alpha, NaCl
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Postoperative Complications, Abdominal Surgery
Postoperative Hypoxia and Body Position
The study aims at investigate whether the oxygen partial pressure is improved in the prone position postoperative after abdominal surgery. Included are 50 adults operated with abdominal surgery.
- Conditions
- Postoperative Complications, Abdominal Surgery, Hypoxia
- Trial name
- NCT05246605
- Testing
- change in body position
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Umeå University
Pulmonary Disease, Postoperative Respiratory Complications
Screening of Postoperative Pulmonary Complications by Electrical Impedance Tomography
The purpose of this study is to determine whether Electrical Impedance Tomography can be used as sensitive and specific predictor in the detection of postoperative pulmonary complications (e.g.
- Conditions
- Pulmonary Disease, Postoperative Respiratory Complications, Malignant Neoplasm of Stomach, Liver Diseases
- Trial name
- NCT02337673
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Johannes Gutenberg University Mainz
Aspiration, Respiratory, Hypoxia
Reverse Trendelenburg Positioning and Its Effect on Outcomes: a Retrospective Study of Consecutive Patients
The purpose of this study is to investigate whether intraoperative reverse Trendelenburg positioning decreases postoperative hypoxemia and perioperative pulmonary aspiration rates.
- Conditions
- Aspiration, Respiratory, Hypoxia, Perioperative Period, Supine Position
- Trial name
- NCT02984657
- Testing
- Surgical patients in 2012 with anesthesia and nursing staff less attuned to intraoperative RTP., Surgical patients in 2015 with enhanced anesthesia and nursing staff awareness and use of intraoperative RTP.
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- C. Michael Dunham
Hypoxia, Airway Obstruction, Postoperative
Endotracheal Tube Suctioning Versus No Suctioning During Emergence From General Anesthesia
The goal of this study is to determine whether omitting tracheal suctioning immediately prior to extubation is non-inferior to routine tracheal suctioning with respect to early postoperative oxygenation among adult surgical…
- Conditions
- Hypoxia, Airway Obstruction, Postoperative, Sore Throat, Cough, Postoperative
- Trial name
- NCT07287293
- Testing
- Routine Endotracheal Suctioning, Omission of Endotracheal Suctioning
- Where
- Thailand
- Volunteers
- 408 people
- Sponsor
- Mahidol University
Pulmonary Surgical Procedures, Recovery Period
Oxygen Peripheral Saturations and Lung Surgery
The purpose of this study is to compare the ability of two peripheral and non invasive devices to detect hypoxic events during one-lung ventilation and during the early postoperative period.
- Trial name
- NCT01255033
- Testing
- Monitoring of tissular oxygenation
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Hopital Foch
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Cerebral Hypoxia, Postoperative Cognitive Dysfunction
The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane
the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .
- Trial name
- NCT01757561
- Testing
- propofol, sevoflurane
- Where
- China
- Volunteers
- 144 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hypoxemia, Extubation
Postoperative Extubation in Hypoxemic Patients
The objective of this clinical trial is to assess whether early extubation of patients with hypoxemia during the spontaneous breathing trial (SBT) shortens the duration of ventilatory support.
- Conditions
- Hypoxemia, Extubation, Postoperative Respiratory Complication
- Trial name
- EPHYRE (NCT06688487)
- Testing
- early extubation of hypoxemic patients
- Where
- 12 sites in France
- Volunteers
- 152 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Hypoxemia
Transcutaneous Auricular Vagus Nerve Stimulation for Reducing Postoperative Hypoxemia
Hypoxemia is a common complication in the post-anesthesia care unit (PACU) and represents one of the most meaningful factors associated with poor patient prognosis. Obese patients have a relatively higher incidence of hypoxemia.
- Trial name
- NCT07827131
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulator
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Nantong University
Hypoxemia
Pulse Oximetry With Automated Verbal Prompts
This study will evaluate the effectiveness of an automated voice prompting system on post operative hypoxia within the Postoperative Anesthesia Care Unit (PACU).
- Trial name
- NCT02930863
- Testing
- pulse oximetry software, Brief post-PACU stay survey.
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Florida
Postoperative Respiratory Complications
Effect of Speaking Aloud After Abdominal Surgery.
Hypoxia and reduced vital capacity is commonly occurring after abdominal surgery. Positive expiratory pressure is one treatment suggested to improve lung function after surgery.
- Trial name
- NCT04276584
- Testing
- Positive expiratory pressure, Speaking loudly during about 3 minutes
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Umeå University
Pain, Postoperative, Obesity
TC02 Obese Women Using It Morphine vs PCA IV Hydromorphone for Post-Cesarean Analgesia
Cesarean deliveries are the most commonly performed surgery in the United States and account for 32.9% of all births.8,9 The ASA recommends the use of neuraxial opioids of post-cesarean analgesia partly because respiratory…
- Conditions
- Pain, Postoperative, Obesity, Respiratory Insufficiency
- Trial name
- NCT03282669
- Testing
- Intrathecal Morphine, Intravenous hydromorphone
- Sponsor
- Northwestern University