Clinical trials: Postoperative Ileus.
Postoperative Ileus
Study of Dexamethasone-Allantoin-Metronidazole (DAM) Solution in the Treatment of Post-Operative Ileus (POI)
This study is being conducted to determine whether Dexamethasone-Allantoin-Metronidazole (DAM) Solution can accelerate recovery of gastrointestinal function following abdominal operation when compared with a placebo.
- Trial name
- NCT01863407
- Testing
- DAM, Normal Saline
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Beijing Bozhiyin T&S Co., Ltd.
Ileus
Safety and Efficacy of Ipamorelin for Management of Post-Operative Ileus
The purpose of this study is to determine if ipamorelin is safe and effective in the management of post-operative ileus.
- Trial name
- NCT00672074
- Testing
- Ipamorelin
- Where
- 19 sites in United States
- Volunteers
- 117 people
- Sponsor
- Helsinn Therapeutics (U.S.), Inc
Postoperative Complications, Constipation
Study Evaluating the Safety of MOA-728 Administered Orally to Healthy Subjects
This is the first multiple-dose experience in humans with MOA-728 in an oral formulation. This study will provide an assessment of the safety, tolerability, and pharmacokinetics (PK) of MOA-728 following administration of…
- Trial name
- NCT00311350
- Testing
- MOA-728
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Lumbar Spine Surgery Postoperative Ileus
Ileus After Lumbar Spine Surgery
Postoperative ileus (POI) after lumbar spine surgery is not uncommon. However, the incidence, severity and risk factors of ileus after spine surgery remain uncertain because there is not yet a prospective investigation using a…
- Trial name
- NCT04057599
- Where
- Taiwan
- Volunteers
- 156 people
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer
Intra-op Lidocaine and Ketamine Effect on Postoperative Bowel Function
Bowel function after bowel surgery is delayed (postoperative ileus)by both opiates and the surgery itself. We hypothesized that decreasing opiate use by other analgesics will speed the return of bowel function after surgery.
- Trial name
- NCT00229567
- Testing
- Lidocaine infusion plus ketamine injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Cesarean Section Complications
Outcomes of Early Versus Delayed Oral Feeding After Cesarean Section in Korle-bu Teaching Hospital
study compares the outcomes of feeding mothers early (4 hours ) after cesarean section compared to delayed feeding (on post operation day 1) in terms of gastrointestinal function and maternal satisfaction with the feeding…
- Trial name
- NCT03070795
- Testing
- early feeding, delayed feeding
- Where
- Ghana
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Ghana Medical School
Living Donor Liver Transplantation
Effect of Ascites Replacement Strategy on Time to 1st Flatus After LDLT
The aim of this study is to evaluate difference in the rate of recovery of intestinal motility according to different ascites replacement strategy after living donor liver transplantation.
- Trial name
- NCT04184401
- Testing
- Ascites replacement with albumin and hartmann's solution, Ascites replacement with hartmann's solution
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Postoperative Ileus
Subcutaneous Methylnaltrexone Versus Placebo for Postoperative Ileus Prevention
This randomized controlled trial will prospectively evaluate the clinical benefit for subcutaneous methylnaltrexone (MNTX) in counteracting the obstipatory (causing constipation) effects of spinal surgery without increasing…
- Trial name
- NCT03852524
- Testing
- Methylnaltrexone
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Ohio State University
Bowel Ileus, Flatus
Chewing Gum on Postoperative Ileus in Children
Traditional postoperative care has been challenged recently to improve and speedup recovery (including the return of bowel function) such that patients can be discharged to home more quickly.
- Trial name
- GUM_1 (NCT03666377)
- Testing
- Gum chewing
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Postoperative Ileus
Goal Directed Fluid Therapy and Postoperative Ileus
Despite Goal Directed Fluid Therapy (GDFT) has shown a reduction of hospitalization and overall complications in patients undergoing abdominal surgery, there is a need to address the effect of implementing GDFT on the incidence…
- Trial name
- NCT01818375
- Testing
- Goal Directed Fluid Therapy (GDFT)-Esophageal doppler guided, Standard fluid therapy
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- Gabriele Baldini, MD, MSc, Assistant Professor
Postoperative Ileus
The Effect of Acupoint Application on Postoperative Ileus
This study aims to verify the therapeutical effect and mechanism of acupoint application on postoperative ileus.
- Trial name
- NCT04008667
- Testing
- Acupoint application, Fake acupoint application
- Where
- China
- Volunteers
- 540 people
- Sponsor
- li xiong
Ileus
Interventions to Decrease the Impact of Post-OPerative Ileus After Liver Transplant or Resection Surgery
This is a randomized controlled trial to assess ways to address post-operative ileus (POI) in adult patients on the liver transplant service undergoing either liver transplant or resection surgery.
- Trial name
- NCT01156129
- Testing
- stool softener, Arm B: Acupressure bracelet, sugar free gum
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Nebraska
Pancreas Neoplasm
Effects of Chewing Gum Against Postoperative Ileus
The purpose of this study is to determine whether the use of chewing gum effects postoperative ileus after pancreaticoduodenectomy
- Trial name
- NCT04768660
- Testing
- gum
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Assiut University
Post Operative Ileus
Chewing Gum Use to Reduce Post-operative Ileus in Pediatric Patients
Post- operative ileus refers to the time after surgery before coordinated electromotor bowel function resumes. It's treatment and prevention may signify an elevated hospitalization cost and the exposure to the patient to adverse…
- Trial name
- NCT01583452
- Testing
- Chewing Gum
- Where
- Mexico
- Volunteers
- 41 people
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey
Colorectal Surgery
Study of Postoperative Ileus in Digestive Surgery
Post-operative ileus is a temporary stoppage of bowel function following surgery. Indeed it can occur in 20% of cases during post-operative follow-up of bowel surgery.
- Trial name
- IPCID (NCT06018961)
- Testing
- Post-operative ileus surgery
- Where
- 2 sites in France
- Volunteers
- 161 people
- Sponsor
- University Hospital, Toulouse
Fracture of Hip, Ileus
Peripheral Perfusion Index in Acute Surgical Patients
Introduction Perioperative haemodynamic instability is associated with postoperative morbidity and mortality. Macrocirculatory parameters, such as the conventionally obtained mean arterial blood pressure and cardiac output, may…
- Conditions
- Fracture of Hip, Ileus, Perforated Viscus, Anastomotic Leak
- Trial name
- NCT03757442
- Where
- Denmark
- Volunteers
- 1,338 people
- Sponsor
- Hvidovre University Hospital
Postoperative Ileus
Does Coffee Intake Reduce Postoperative Ileus After Elective Colorectal Surgery
The aim of the study is to investigate if postoperative coffee intake decreases the time until first bowel movement in elective colorectal surgery with primary anastomosis.
- Trial name
- COFFEE (NCT02469441)
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- Kantonsspital Baden
Postoperative Ileus
The Effect of Gum Chewing on Postoperative Ileus After Gynecologic Surgery
The investigators are randomizing patients to receive chewing gum (Extra Sugar Free, Spearment) every 4 hours during waking hours for 15 minutes versus standard postoperative care.
- Trial name
- GumGyn (NCT01579175)
- Testing
- Chewing gum
- Where
- 2 sites in United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postoperative Ileus
Intravenous (IV) Methylnaltrexone (MNTX) in the Prevention of Post-Operative Ileus
A double-blind, randomized, parallel-group study designed to evaluate the safety and activity of IV MNTX in the treatment of Post-Operative Ileus (POI) in patients who underwent segmental colectomies via laparotomy.
- Trial name
- NCT01367548
- Testing
- IV Methylnaltrexone (MNTX)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Bausch Health Americas, Inc.