Clinical trials: Postoperative Ileus.
Cancer Debulking, Enlarged Uterus
Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy
To determine if opioid consumption postoperatively among patients undergoing non-emergent laparotomy by the gynecologic oncology service who receive intrathecal morphine with intraoperative lidocaine (IML) infusion are lower than…
- Conditions
- Cancer Debulking, Enlarged Uterus, Fibroid Uterus, Adnexal Mass
- Trial name
- NCT05017246
- Testing
- Bupivacaine, Morphine, Lidocaine
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Washington University School of Medicine
Postoperative Ileus
Role of Chewing Gum in Reducing Post Operative Ileus After Reversal of Ileostomy
Postoperative ileus is generally referred to as the transient impairment of bowel motility after abdominal or other surgery and diagnosed by postoperative abdominal pain vomiting constipation and distension.
- Trial name
- NCT02155153
- Testing
- Sugar Free Chewing Gum
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Services Hospital, Lahore
Ileostomy; Complications, Bowel Obstruction
Implementing a Low Fiber Diet vs. Regular Diet in Postoperative Colorectal Patients With Ileostomies
The primary objective of this study is to prospectively evaluate rate of post-operative ileus or obstruction in patients with ileostomies receiving low fiber diet vs. regular diet starting post-operative day 1.
- Conditions
- Ileostomy; Complications, Bowel Obstruction, Postoperative Ileus
- Trial name
- NCT04675606
- Testing
- Regular diet, Low fiber diet
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Colorectal Cancer
Simo Decoction and Acupuncture on POI in Colorectal Cancer
Colorectal cancer resection is one of the most common types of abdominal surgery. Though most patients undergoing colorectal resection show recovery of bowel movements within a week, some have prolonged intestinal paralysis or…
- Trial name
- SMD/POI (NCT02813278)
- Testing
- simo decoction, gum chewing
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Postoperative Ileus
ANTERO-5: Gastric Motility in Postoperative Ileus
A monocenter, non-randomized interventional investigation in 3 panels of adult patients undergoing elective colorectal surgery who are at risk to develop postoperative ileus.
- Trial name
- ANTERO-5 (NCT04100265)
- Testing
- Panel 1 - High risk for postoperative ileus (VIPUN Gastric Monitoring System), Panel 2 - Postoperative ileus arm with investigational device (VIPUN Gastric Monitoring System)
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postoperative Ileus
Study of the Effect of Water Soluble Oral Contrast (Gastrografin) on Postoperative Ileus After Colorectal Surgery
The purpose of this trial is to determine whether the water-soluble contrast (gastrografin) is more effective in the treatment of postoperative ileus than the conventional one.
- Trial name
- NCT01440712
- Testing
- Gastrografin, physiological serum
- Where
- 3 sites in Spain
- Volunteers
- 58 people
- Sponsor
- Hospital Universitari de Bellvitge
Colorectal Cancer, Ileus Postoperative
Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery
There is pre-existing evidence that probiotics could be useful in the improvement of ileus rates. One metaanalysis of 30 studies demonstrated a reduction in the prevalence of post-operative ileus as determined by time to flatus…
- Conditions
- Colorectal Cancer, Ileus Postoperative, Flatus, Diet, Healthy
- Trial name
- PICCS-1 (NCT06456229)
- Testing
- Nestle Isocal, Nestle Boost Optimum
- Where
- Singapore
- Volunteers
- 162 people
- Sponsor
- National University Hospital, Singapore
Ileus, Gastro-Intestinal Disorder
A Study to Evaluate LB1148 for Return of Bowel Function in Subjects Undergoing Bowel Resection
The purpose of this study is to evaluate the safety and efficacy of LB1148 in subjects undergoing planned bowel resection.
- Trial name
- INTEGRITY (NCT05470387)
- Testing
- LB1148
- Where
- 23 sites in United States
- Volunteers
- 23 people
- Sponsor
- Palisade Bio
Abdominal Cancer
Effects of Rocking on Postoperative Ileus Duration Study
Primary Objective: 1. Compare the duration of postoperative ileus (POI) duration (time to first flatus), subjective reports of surgical and gas pain, postoperative pain medication (total milligrams per 24 hours) and postoperative…
- Trial name
- NCT00494806
- Testing
- Rocking Chair Intervention
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Ileus
Postoperative Ileus: Duration and Severity Assessment With the SmartPill®
Postoperative ileus (POI) is a frequent complication after abdominal surgery leading to nausea, vomiting and infectious complications.
- Trial name
- PIDuSA (NCT02329912)
- Testing
- SmartPill
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- University Hospital, Bonn
Ileus
Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus
Patients undergoing major abdominal surgery are at highest risk for developing postoperative ileus (POI), occurring in nearly all cases.
- Trial name
- NCT00388401
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Postoperative Ileus
The Effect of Rocking Chair Movement on the Start of Bowel Functions in Patients With Gastrointestinal System Surgery
The Effect of Rocking Chair Movement on the Start of Bowel Functions in Patients With Gastrointestinal System Surgery The research will be carried out as a randomized controlled experimental study in patients with open…
- Trial name
- NCT04466319
- Testing
- Rocking Chair
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Eskisehir Osmangazi University
Paralytic Ileus, Nausea
The Impact of Preoperative Bowel Exercise on Postoperative Bowel Functions in Gynecologic Malignancies
Gastrointestinal dysfunction is a common complication after abdominal gynecologic oncology surgery. There are numerous studies in the literature addressing the management of bowel function in the postoperative period.
- Conditions
- Paralytic Ileus, Nausea, Defecation Disorder
- Trial name
- IPBEPOBF (NCT06113718)
- Testing
- Abdominal Exercise (digital rectal stimulation, abdominal massage)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tepecik Training and Research Hospital
Ileus
Study to Evaluate LB1148 for Return of Gastrointestinal Function, Decrease Post-Operative Ileus
The purpose of this study is to establish preliminary evidence of the efficacy, safety, and tolerability of LB1148 for the treatment of return of gastrointestinal function and decrease Post-Operative Ileus in subjects undergoing…
- Trial name
- NCT05056935
- Testing
- LB1148
- Where
- 6 sites in China
- Volunteers
- 131 people
- Sponsor
- Newsoara Biopharma Co., Ltd.
Pain, Postoperative, Postoperative Ileus
Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery
Title: Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery: A Multicenter, Randomized, Controlled Trial The goal of this clinical trial is to evaluate the effectiveness and safety of tegileridine…
- Trial name
- NCT07412223
- Testing
- Tegileridine, Morphine
- Where
- 3 sites in China
- Volunteers
- 152 people
- Sponsor
- Xiangya Hospital of Central South University
Postoperative Ileus
Effects of Open and Laparoscopic Gastrointestinal Surgery on Gastrointestinal Function
A prospective study to compare the postoperative ileus in open and laparoscopic gastrointestinal surgery through the determination of the time the patient takes to pass flatus, pass stool, bowel movement, oral intake, the time of…
- Trial name
- NCT03887845
- Testing
- Surgery
- Where
- China
- Volunteers
- 401 people
- Sponsor
- West China Hospital
Ileus
A Study Evaluating Intravenous (IV) MOA-728 for the Treatment of Postoperative Ileus (POI) in Participants After Ventral Hernia Repair
This study will evaluate the safety and efficacy of two different dose regimens (12 milligrams [mg] and 24 mg) of IV MOA-728 versus placebo in shortening the time to return of bowel function in participants receiving opioid…
- Trial name
- NCT00528970
- Testing
- MOA-728
- Where
- 106 sites in United States, Australia and 9 more
- Volunteers
- 374 people
- Sponsor
- Bausch Health Americas, Inc.
Postoperative Ileus, Colorectal Surgery
Prucalopride in Postoperative Ileus
Postoperative ileus (POI) refers to the period of gut dysmotility that occurs after abdominal surgery. Patients with POI are unable to eat, suffer ongoing nausea and vomiting, are unable to open their bowels and have a prolonged…
- Conditions
- Postoperative Ileus, Colorectal Surgery, Postoperative Complications
- Trial name
- NCT02947269
- Testing
- Prucalopride
- Where
- New Zealand
- Volunteers
- 150 people
- Sponsor
- University of Auckland, New Zealand
Ileus
Does Chewing Gum After Elective Laparoscopic Colectomy Surgery Decrease Ileus?
The incidence of ileus after laparoscopic colectomy continues to pose complications for the patient, staff, and the healthcare system.
- Trial name
- NCT00632801
- Testing
- chewing gum
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- State University of New York - Upstate Medical University
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center