Clinical trials: Postoperative Knee Function
Acute Pain
Comparison Between Percutaneous Femoral Nerve Neuromodulation Associated With Femoral Nerve Block and Standard Clinical Practice in Patients Undergoing Knee Arthroplasty.
The goal of this clinical trial is to compare the maximum isometric contraction force differential of the quadriceps in the postoperative period after the use of a peripheral nerve neuromodulation program in patients undergoing…
- Trial name
- NEPFAR (NCT05971095)
- Testing
- Percutaneous neuromodulation using the EPTE® Bipolar System device
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Hospital General Universitario de Valencia
Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction
Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair
The anterior cruciate ligament (ACL) is the primary structure responsible for controlling anterior-posterior translation and rotational stability of the knee joint.
- Conditions
- Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction, Isokinetic Test
- Trial name
- NCT07318272
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Gazi University
Postoperative Analgesia, Anesthesia; Functional
Comparison of Two Regional Technics In Knee Artroplasty
Purpose: This prospective, randomised, controlled, single-blind, multicentre study was designed to investigate the effects of peripheral nerve block methods (applied using unilateral spinal anaesthesia [USA] on elderly patients…
- Trial name
- CTRTIKA (NCT03021421)
- Testing
- intratechal (subarachnoidal )injection, lombar plexus and sciatic nerve injection
- Volunteers
- 60 people
- Sponsor
- Ordu University
Sleep Quality Post-TKA, Postoperative Knee Function
Doxepin Alone or Combined With Ramelteon Versus Placebo for Improving Sleep Quality After Primary Total Knee Arthroplasty
Many patients experience poor sleep during recovery after total knee arthroplasty (TKA). Disturbed sleep can last weeks to months and may worsen pain, slow healing, and reduce overall quality of life.
- Conditions
- Sleep Quality Post-TKA, Postoperative Knee Function, Quality of Life After Primary TKA
- Trial name
- NCT07598734
- Testing
- Doxepin 6 mg, Ramelteon 8 mg
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of Washington
Knee Arthritis, Anesthesia, Local
The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers
The aim of this study is to evaluate the Popliteal Plexus Block (PPB) effect on motor nerve branches of the sciatic and femoral nerve, when using different volumes of local anesthetics for PPB.
- Conditions
- Knee Arthritis, Anesthesia, Local, Post Surgical Pain
- Trial name
- NCT05464862
- Testing
- Popliteal Plexus Block with 10 ml, Popliteal Plexus Block with 20 ml, Popliteal Plexus Block with 30 ml
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charlotte Runge
Pain, Postoperative, Pain, Chronic
Pain and Impact of Chronic Pain on Function After Total Knee Replacements
After Institutional Review Board approval, adult patients scheduled for total knee arthroplasty (TKA) will be enrolled into the study after obtaining informed consent over a 24 month period.
- Conditions
- Pain, Postoperative, Pain, Chronic, Osteogenic Sarcoma, Knee Arthropathy
- Trial name
- NCT03032679
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 139 people
- Sponsor
- Tata Memorial Centre
Postoperative Pain
Effect of Volume of Local Anesthetic for Adductor Canal Block on Quadriceps Muscle Function: A Dose Finding Study
Adductor canal block is commonly offered to provide pain relief following knee surgery with the hope that they cause less leg weakness than traditionally performed femoral nerve block.
- Trial name
- NCT02541552
- Testing
- Ropivacaine 0.5%
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Pain
fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study
Painful osteoarthritis (OA) is the 4th largest cause of disability in the UK. Preoperative temporal summation, a measure of central pain facilitation, has been shown to predict postoperative pain after total knee replacement…
- Conditions
- Osteoarthritis, Pain, Postoperative Pain, Surgery
- Trial name
- NCT03126279
- Testing
- Total Knee Replacement Surgery
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Total Knee Arthroplasty
Medrol Dosepak for Outpatient Total Knee Arthroplasty
The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA).
- Trial name
- NCT05097976
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Postoperative Pain
Effects of Nerve Block on Knee Function After Knee Replacement
Early physical therapy after knee surgery is very painful on top of pain from surgery. Pain following surgery can limit recovery. One way to treat pain is by giving intravenous (IV) pain medication with morphine.
- Trial name
- NCT00358241
- Testing
- Nerve block
- Where
- United States
- Sponsor
- Johns Hopkins University
Knee Osteoarthritis
Effects of Bandaging and Kinesiotaping® in Patients With Total Knee Arthroplasty
The study aimed to compare the effectiveness of elastic bandaging, Kinesio taping, and short stretch bandaging techniques on postoperative pain, edema, and functional level in the early stage after total knee arthroplasty.
- Trial name
- NCT05847725
- Testing
- Elastic bandaging, Short stretch bandaging, Kinesio taping
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Pain
Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty
Multi-center, randomized, blinded, sham-controlled study to determin the safety and efficacy of the NOVABLOC system on post-operative pain in patients undergoing TKA procedures.
- Trial name
- NOVABLOC-TKA (NCT07191067)
- Testing
- Percutaneous radiofrequency electrical nerve stimulation, Non-therapeutic stimulation
- Where
- 5 sites in United States
- Volunteers
- 123 people
- Sponsor
- Synaptrix, Inc.
Pain Postoperative, Total Knee Anthroplasty
Comparative Analgesic Effect After Total Knee Arthroplasty Between Intraosseous and Peri-articular Injection
The goal of this RCT is to compare analgesic effect after total knee arthroplasty between intraosseous multimodal analgesic agent injection versus periarticular injection.
- Conditions
- Pain Postoperative, Total Knee Anthroplasty, Functional Outcomes
- Trial name
- NCT06800846
- Testing
- Intraosseous Morphine, Periarticular Injection
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Thammasat University Hospital
Osteoarthritis, Knee
Preoperative Strength Training in Patients With Total Knee Arthroplasty
The purpose of this study is to investigate if preoperative strength training will result in faster recovery and higher level of function six weeks after total knee arthroplasty (TKA).
- Trial name
- NCT01647243
- Testing
- Preoperative strength training
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Aarhus
Arthropathy, Obesity
Postoperative BMI Changes and Functional Outcomes in Knee and Hip Arthroplasty
PURPOSE Obesity poses challenges to preoperative mobility and functional recovery for arthroplasty patients, yet postoperative weight loss remains elusive.
- Trial name
- NCT06440863
- Testing
- Total Knee Arthroplasty, Total Hip arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 459 people
- Sponsor
- Istanbul University - Cerrahpasa
Degenerative Joint Disease, Osteoarthritis
Comparison of Clinical Outcomes and Performance of Total Knee Replacement Patients Before and After Surgery
This study is to determine the relevancy of clinical scales for outcome measures as compared to flexion angle and other gait measures.
- Conditions
- Degenerative Joint Disease, Osteoarthritis, Knee Injury, Trauma, Connective Tissue Disorder
- Trial name
- TKR (NCT01379118)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Tourniquets, Knee Arthroplasty, Total
Tourniquet Pressure in Primary Total Knee Arthroplasty
This proposed novel randomized control trial (RCT) seeks to address this gap in TKA protocol by gaining a better understanding of the relationship between tourniquet pressure and time, and intraoperative performance and…
- Conditions
- Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
- Trial name
- NCT02830087
- Testing
- Tourniquet Cuff Pressure
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Postoperative Pain
Pain Control With Total Knee Replacement
The purpose of this project is to study the effects of gabapentin on pain control in the perioperative and post-operative period of total knee arthroplasty.
- Trial name
- L12-078 (NCT01680549)
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Total Knee Replacement
Postural Correctors & Activity Trackers in Total Knee Replacement Rehab
To assess the impact of postural corrector on post-operative knee function and activity To evaluate the role of activity tracker in monitoring and enhancing post-operative rehabilitation To assess the effects of postural…
- Trial name
- NCT06877845
- Testing
- Activity Tracker & Postural Corrector, Conventional Therapy
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Total Knee Arthroplasty
Femoral Triangle and Adductor Canal Blocks Versus Femoral Nerve Block for Total Knee Arthroplasty
This prospective, double-blinded, randomized controlled study evaluates effects of femoral triangle and adductor canal blocks in comparison with femoral nerve block for primary total knee arthroplasty.
- Trial name
- NCT03645954
- Testing
- Femoral Nerve Block, Femoral Triangle & Adductor Canal Blocks
- Where
- Lithuania
- Volunteers
- 80 people
- Sponsor
- Lithuanian University of Health Sciences