Clinical trials: Postoperative Laminectomy Pain
Lumbar Spine Stenosis, Lumbar Spine Degeneration
OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research.
- Trial name
- NCT05452694
- Where
- 3 sites in United States
- Volunteers
- 235 people
- Sponsor
- OpalGenix, Inc
Post-Operative Pain, Lumbar Laminectomy
HTX-011 in Spinal Surgery
This is a Phase 2, multicenter study in subjects undergoing an open lumbar decompression surgery.
- Trial name
- NCT04911062
- Testing
- Bupivacaine HCI without epinephrine, HTX-011, Luer Lock Applicator
- Where
- 12 sites in United States
- Volunteers
- 32 people
- Sponsor
- Heron Therapeutics
Laminectomy
Esmolol Infusion During Laminectomy: Effect on Quality of Recovery
The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain…
- Trial name
- NCT01179113
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Cedars-Sinai Medical Center
Postoperative Pain, Postoperative Laminectomy Pain
Postoperative Analgesia in Laminectomy
Compare the analgesic effects of naproxen sodium codeine, paracetamol codeine and placebo on postoperative pain and tramadol (Contramal) consumption during the first 24 hour after a lumbar disk surgery.
- Trial name
- (PAL) (NCT02255955)
- Testing
- 550 mg naproxen sodium and 30mg codeine, 300 mg paracetamol and 30 mg codeine
- Volunteers
- 75 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Failed Back Surgery Syndrome
Clinical Evaluation of Direct Dorsal Column Stimulation
The study will examine the feasibility of Direct Dorsal Column Stimulation using existing Stimulation Leads (Ad-Tech). Secondary endpoints will include pain relief, somatosensory evoked potentials (SSEPs), stimulator settings…
- Trial name
- DDCS (NCT02020460)
- Testing
- Subdural trial lead, Epidural trial lead
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Persistent Spinal Pain Syndrome Type II, Failed Back Surgery Syndrome
Persistent Post-Lumbar Surgery Pain Syndrome (PSPS) Type II is a Common Condition Encountered in Pain Units, With Limited Available Therapeutic Options. Epidural Pulsed Radiofrequency (PRF) Administered Via Catheter Has Demonstrated Greater Efficacy Compared to the Transforaminal Approach. This Rand
This study is for people who continue to have low back pain after spinal surgery, a condition called persistent spinal pain syndrome type II. Current treatments, such as epidural injections, often provide only limited relief.
- Conditions
- Persistent Spinal Pain Syndrome Type II, Failed Back Surgery Syndrome, Chronic Low Back Pain, Post-Laminectomy Syndrome
- Trial name
- EPIPUL (NCT07156513)
- Testing
- Epidural Pulsed Radiofrequency, Betamethasone (Epidural Corticosteroid Injection)
- Where
- 4 sites in Spain
- Volunteers
- 131 people
- Sponsor
- Puerta de Hierro University Hospital
Opioid Use, Pain, Postoperative
Opioid Dispenser for Microdiscectomy/Laminectomy
The opioid crisis continues to plague the United States. While great strides have been made nationwide to decrease overprescribing, improvements are still needed to appropriately educate patients on the safe and responsible use…
- Conditions
- Opioid Use, Pain, Postoperative, Medical Device, Laminectomy
- Trial name
- NCT06358040
- Testing
- Opioid-Dispensing Device, App, Standard Opioid Pill Bottle
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hospital for Special Surgery, New York
Postoperative Pain
Erector Spinae Plane Block Impact on Quality of Recovery After Lumbar Spinal Decompression
Erector spinae plane block (ESPB) as a new trunk fascia block technique was proposed in 2016. ESPB has aroused the interest of many nerve block experts. The benefits of ESPB are not yet demonstrated.
- Trial name
- ESPB (NCT04943549)
- Testing
- Bupivacain
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Benha University
Failed Back Surgery Syndrome, Back Pain
Spinal Cord Stimulation for Predominant Low Back Pain
The purpose of this study is to compare the effectiveness of spinal cord stimulation (SCS) using the Medtronic Specify® 5-6-5 multicolumn surgical lead plus optimal medical management (OMM) versus OMM alone in patients suffering…
- Conditions
- Failed Back Surgery Syndrome, Back Pain, Pain in Leg, Unspecified
- Trial name
- PROMISE (NCT01697358)
- Testing
- Spinal Cord Stimulation (SCS), Optimal Medical Management (OMM)
- Where
- 28 sites in United States, Belgium and 7 more
- Volunteers
- 278 people
- Sponsor
- MedtronicNeuro
Failed Back Surgery Syndrome, Pain
Spinal Cord Stimulation With Precision® System Versus Reoperation for Failed Back Surgery Syndrome
The EVIDENCE trial is a randomized controlled trial comparing the therapeutic effectiveness and cost-effectiveness of the Precision® Spinal Cord Stimulation with that of reoperation as a treatment of pain in patients with Failed…
- Conditions
- Failed Back Surgery Syndrome, Pain, Back Pain
- Trial name
- Evidence (NCT01036529)
- Testing
- Precision Spinal Cord Stimulator, Back Surgery
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Laminectomy, Post-laminectomy Syndrome
Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase
Traditionally, pain relief through spinal cord stimulation has been associated with the appearance of paresthesia in the affected area.
- Conditions
- Laminectomy, Post-laminectomy Syndrome, Spinal Cord Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT03702010
- Testing
- spinal cord stimulation conventional, spinal cord stimulation experimental
- Where
- 2 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Patients Major Laminectomy Surgery
Evaluations of Optimizing Perioperative Fluid Management on Postoperative Pain Outcomes
Patient characteristics, duration of surgery, and infusion volumes will be compared between the groups. Oxygen transport and organ function will be compared Length of hospital stay, morbidity, postoperative pain intensity were…
- Trial name
- NCT02245581
- Testing
- SVV-guided fluid management, CVP-guided fluid management
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Failed Back Surgery Syndrome, Post-laminectomy Syndrome
Subcutaneous Nerve Stimulation for Failed Back Surgery Syndrome (FBSS) Patients
The purpose of this study is to assess the safety and efficacy of Subcutaneous Nerve Stimulation (SQS) (also known as Peripheral Nerve Stimulation [PNS]) in the reduction of chronic, intractable post-surgical back pain in adults.
- Trial name
- SubQStim (NCT01818297)
- Testing
- PrimeAdvanced® neurostimulator system
- Where
- 27 sites in United States
- Volunteers
- 137 people
- Sponsor
- MedtronicNeuro
Trigeminal Neuralgia, Microvascular Decompression Surgery
Post-Operative Trigeminal Pain After Microvascular Decompression for Trigeminal Neuralgia
The goal of this observational study is to learn about the long-term effects of microvascular decompression (MVD) in patients with trigeminal neuralgia (TN).
- Conditions
- Trigeminal Neuralgia, Microvascular Decompression Surgery, Post-operative Pain
- Trial name
- NCT07216547
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rutgers, The State University of New Jersey
Failed Back Surgery Syndrome, Postlaminectomy Syndrome
Low-Dose Radiation to Prevent Complications of Back Surgery
More than 10,000 people each year in the United States have "failed back surgery syndrome" caused by scars that form around the outer surface of the spinal cord.
- Conditions
- Failed Back Surgery Syndrome, Postlaminectomy Syndrome, Postdiscectomy Epidural Fibrosis
- Trial name
- NCT00018876
- Testing
- Lumbar nerve root decompression, Preoperative low-dose external beam radiation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Pittsburgh
Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain
Determining the Prognostic Value of Continuous Intrathecal Infusion
The purpose of this study will be to determine the efficacy and the prognostic value of a continuous intrathecal prognostic infusion test in an in-hospital setting for selecting patients who would have better long term outcomes…
- Conditions
- Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain, Vertebral Compression Fracture, Failed Back Surgery Syndrome
- Trial name
- NCT03523000
- Testing
- Continuous intrathecal prognostic infusion test, Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University Hospitals Cleveland Medical Center
Post-laminectomy Pain Syndrome
GRASSP: Gralise® for Spine Surgery Pain
Evaluate the analgesic benefit of Gralise® for post-laminectomy pain syndrome (PLPS)
- Trial name
- GRASSP (NCT01764464)
- Testing
- Gralise®
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Rochester
Postoperative Pain, Neurosurgery
Effects of Methylprednisolone Plus Ropivacaine Infiltration Before Wound Closure on Laminoplasty or Laminectomy
Laminoplasty and laminectomy are useful surgical procedures for the management of various conditions pertaining the spinal cord such as myelopathy, radiculopathy, neoplasm, stenosis, disc herniation, hematoma, abscess, traumatic…
- Trial name
- NCT04493463
- Testing
- Methylprednisolone 40 mg + Ropivacaine + Saline, Ropivacaine + Saline
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Beijing Tiantan Hospital
Herniated Disc, Intervertebral Disc Displacement
Efficacy of Gabapentin or Amitriptyline to Reduce Postoperative Pain After Lumbar Laminectomy and Diskectomy
The hypothesis of this study is that Gabapentin or Amitriptyline has no role in preemptive analgesia to reduce postoperative pain after lumbar diskectomies.
- Trial name
- NCT01014520
- Testing
- Gabapentin , Amitriptyline
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Tabriz University
Postoperative Pain
A Preemptive Epidural Ropivacaine for Postoperative Pain Relief in Degenerative Lumbar Spine Surgery
This prospective randomized study aims to evaluate the effectiveness of epidural injection of ropivacaine on the relief of pain in patients undergoing laminectomy.
- Trial name
- NCT01117610
- Testing
- Ropivacaine (epidural injection)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Chung-Ang University Hospital