Clinical trials: Postoperative Neurocognitive Disorder
Electroencephalogram, Postoperative Delirium (POD)
Electroencephalogram Characteristics of Surgical Anesthetized Patients and Postoperative Dilirium
Objective: To construct a perioperative EEG database for elderly patients under general anesthesia and to explore the relationship between their EEG spectrum characteristics and the occurrence and severity of postoperative…
- Trial name
- NCT06394778
- Testing
- Delirium test scale：3D-CAM
- Where
- China
- Volunteers
- 375 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Postoperative Delirium, PD
Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve
Elderly patients who undergo anesthesia and non-cardiac surgery are subject to deterioration of brain function including the development of postoperative delirium (PD) and postoperative cognitive dysfunction (POCD).
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00561678
- Testing
- Precedex (Dexmedetomidine)
- Where
- 10 sites in United States
- Volunteers
- 404 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anemia, Delirium
Elderly With Hip Fracture and Perioperative Hemoglobin and Perfusion Index Levels
The overall aim of the study is to investigate the time difference in the diagnosing of anemia among elderly with hip fracture, between measurements with standard blood samples and non-invasive SpHb-measuring.
- Trial name
- NCT02838706
- Testing
- Surgery for hip fracture
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Hvidovre University Hospital
Emergence Delirium, Perioperative Neurocognitive Disorder
Quantitative Neurofeedback Techniques for Treating Perioperative Cognitive Disorders in Elderly Patients
The goal of this clinical trial is to learn if quantitative measurement of brain and neurofeedback intervention techniques works to prevent perioperative neurocognitive deficits in elderly oncology patients who are to undergo…
- Trial name
- NCT06752148
- Testing
- neurofeedback intervention training game
- Volunteers
- 390 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Postoperative Cognitive Dysfunction
Implementation of a Cognitive Training Program to Reduce the Risk of Postoperative Cognitive Dysfunction
Background: The postoperative cognitive dysfunction (POCD) is a frequent complication, often underestimated and leads to a negative impact on the quality of life for patients and their families.
- Trial name
- NCT03620968
- Testing
- cognitive training
- Where
- Spain
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Centro Medico Teknon
Delirium, Postoperative Cognitive Deficit (POCD)
Neuroprotection With Dexmedetomidine in Patients Undergoing Elective Cardiac or Abdominal Surgery (Neuprodex)
The drug Dexmedetomidine will be investigated in 72 patients (men and women) undergoing elective cardiac or abdominal surgery. The study medication will be administered perioperatively by intravenous infusion continuously (at the…
- Trial name
- NCT02096068
- Testing
- Dexmedetomidine (Dexdor®), 0.9% Sodium Chloride
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Claudia Spies
Postoperative Delirium
Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients
The investigator aimed to evaluate the incidence of postoperative delirium after remimazolam-based total intravenous anesthesia (TIVA) compared to the propofol-based TIVA in patients undergoing neurosurgery.
- Trial name
- NCT06115031
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 696 people
- Sponsor
- Samsung Medical Center
Delirium, Thoracic Surgery
Cerebral Oxygen Desaturation and Post-Operative Delirium in Thoracic Surgical Patients
This study will assess the incidence and risk factors for post-operative delirium in patients undergoing thoracotomy. Specifically, the study will assess if there is any relationship between an intra-operative decrease in brain…
- Trial name
- NCT03165539
- Testing
- Cerebral oxygen saturation monitoring
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Remimazolam, Tonsillectomy
Remimazolam for Emergence Delirium Prevention in Children Undergoing Tonsillectomy
The aim of this study is to confirm the effectiveness of remimazolam in preventing delirium during emergence from anesthesia in children who will undergo elective procedures of tonsillectomy, adenotonsillectomy or adenoidectomy…
- Conditions
- Remimazolam, Tonsillectomy, Emergence Delirium
- Trial name
- NCT07704437
- Testing
- Remimazolam 20 MG Injection [Byfavo], NaCl (0,9%)
- Where
- Croatia
- Volunteers
- 110 people
- Sponsor
- University Hospital of Split
Emergence Delirium, Anesthesia, Preschool Age Children
Influence of Intraoperative Auditory Intervention on Emergence Delirium in Preschoolers: A Randomised Controlled Clinical Trial
Emergence delirium (ED), characterized by disorientation and altered cognitive behavior, is a common postoperative complication in pediatric surgery.
- Conditions
- Emergence Delirium, Anesthesia, Preschool Age Children, Emergence Agitation
- Trial name
- NCT07630922
- Testing
- Classical Music Group, Mother's Heartbeat Recording Group, Mother's Lullaby Recording Group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Henan Provincial People's Hospital
Agitation, Emergence
Single Bolus Dose of Ketodex Versus Ketofol For Prevention Of Emergence Agitation In Adults Undergoing Nasal Surgeries
emergence agitation is seen in around 68% after nasal surgeries. Agitated patients needs more staff and nurses to control their abnormal movement which leads to self extubation , removal of catheters and bruises in the…
- Trial name
- NCT04018157
- Testing
- "Ketamine" and "dexmedetomidine" and "propofol" and "0.9%saline"
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Emergence Agitation
Comparison Between Propofol and Fentanyl for Prevention of Emergence Agitation in Children After Sevoflurane Anesthesia
The occurrence of emergence agitation (EA) in pediatric patients who have received sevoflurane anesthesia is a common postoperative problem.
- Trial name
- NCT01506622
- Testing
- Administration of propofol, Administration of fentanyl, Administration of saline
- Where
- South Korea
- Volunteers
- 222 people
- Sponsor
- Yonsei University
Post-Operative Confusion, Long Term Adverse Effects
Depth of Anaesthesia and Long-term Survival: The Balanced Anaesthesia Follow-up Study
Anaesthetic depth and complications after major surgery: an international, randomised controlled trial - The BALANCED trial. In this large, international, randomised controlled trial that enrolled patients aged 60 years and over…
- Conditions
- Post-Operative Confusion, Long Term Adverse Effects, Surgery--Complications, Cognitive Dysfunction, Postoperative
- Trial name
- BALANCEDLT (NCT04965324)
- Testing
- Anaesthesia Depth
- Where
- New Zealand
- Volunteers
- 6,644 people
- Sponsor
- Auckland City Hospital
Postoperative Delirium
EEG-TMS Intervening Against Postoperative Delirium
Postoperative delirium is common in elderly surgical patients and is associated with complications and prolonged hospitalisation.
- Trial name
- RECOVER (NCT07100197)
- Testing
- continuous Theta-burst stimulation
- Where
- China
- Volunteers
- 98 people
- Sponsor
- RenJi Hospital
Emergence Delirium
Ketofol Versus Dexmedetomidine for Prevention of Emergence Delirium in Pediatric Patients Undergoing Squint Surgeries
The aim of the study is to compare the effectiveness of ketofol for the prevention of emergence delirium in pediatric patients undergoing squint surgery, in comparison to dexmedetomidine.
- Trial name
- NCT06545890
- Testing
- Ketamine, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Delirium, Hip Fracture
Evaluating the Addition of Regional Analgesia to Reduce Postoperative Delirium in Patients Having Hip Fracture Surgery.
Post operative delirium is common after hip fracture surgery and is associated with increased length of hospital stay, delayed recovery and increased mortality.
- Trial name
- RASAPOD (NCT02689388)
- Testing
- Femoral Nerve Block
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Auckland City Hospital
Postoperative Pain, Adults
Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in adults in perioperative settings.
- Conditions
- Postoperative Pain, Adults, Anesthesia
- Trial name
- NCT04837170
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Volunteers
- 12,000 people
- Sponsor
- Chinese PLA General Hospital
Anesthesia, Postoperative Pain
Opioid-free Anesthesia and Acute Postoperative Pain
Control of intraoperative and postoperative pain with the use of opioids constitutes normal practice. Opioid free anesthesia (OFA) is a relatively recent anesthesiology practice according to which opioids are not administered…
- Conditions
- Anesthesia, Postoperative Pain, Cognitive Impairment, Variable
- Trial name
- NCT04976842
- Testing
- OFA, OBA
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Attikon Hospital
Postoperative Delirium, Aging Disorder
Non-pharmacological Prevention of Postoperative Delirium by Occupational Therapy Teams
In the world, 230 million surgeries are performed every year and US data indicates that more than a third of patients who undergo surgery are older than 65 years, in which between 10 and 70% develop postoperative delirium (POD).
- Trial name
- PREPODOT (NCT03704090)
- Testing
- Occupational therapy intervention, Standard non-pharmacological prevention intervention
- Where
- Chile
- Volunteers
- 160 people
- Sponsor
- University of Chile
Postoperative Cognitive Dysfunction
Cognitive Dysfunction Following Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is the most common complication after cardiac surgery. This prospective study was conducted to investigate the mechanisms of development of POCD following cardiac surgery taking into…
- Trial name
- CDCS (NCT02767713)
- Testing
- Dexamethasone
- Volunteers
- 171 people
- Sponsor
- Clinical Hospital Center, Split