Clinical trials: Postoperative Neurocognitive Disorder
Pediatric ALL
Propofol to Reduce the Incidence of Postanesthetic Emergence Agitation in Pediatric Patients Under General Anesthesia
This study aimed to know the effectivity of 0.5 mg/kg propofol in the end of anesthesia to reduce the incidence of postanesthetic emergence agitation in pediatric patients under general inhalation anesthesia
- Trial name
- NCT03528954
- Testing
- Propofol
- Where
- Indonesia
- Volunteers
- 54 people
- Sponsor
- Universitas Indonesia
Delirium
Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Many individuals experience an acute change in thinking and reasoning skills after surgery. This is called post-operative delirium (PD). PD symptoms typically start 1-3 days after surgery.
- Trial name
- NCT02230605
- Testing
- Mini-Mental State Examination, Self-Administered Gerocognitive Examination, Geriatric Depression Scale
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Preoperative Anxiety, Postoperative Delirium
Effects of Preoperative Anxiety and Preemptive Analgesia on Postoperative Delirium in Septo/Rhinoplasty Surgery
Effects of Preoperative Anxiety and Preemptive Analgesia on Postoperative Delirium in Septo/Rhinoplasty Surgery
- Trial name
- NCT07010042
- Testing
- The Beck Anxiety Inventory (BAI) of adult patients
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Zonguldak Bulent Ecevit University
Emergence Agitation
Comparison of Effect of Dexmedetomidine and Midazolam on Emergence Agitation
Since the frequency of emergence agitation (EA) is relatively high in children while undergoing nasal surgery, and there is not much data available in Pakistan regarding EA in adults undergoing functional endoscopic sinus surgery…
- Trial name
- NCT07392983
- Testing
- Dexmedetomidine, Midazolam
- Where
- 2 sites in Pakistan
- Volunteers
- 146 people
- Sponsor
- Muhammad Aamir Latif
Intertrochanteric Fractures, Hip Fractures
Liposomal Bupivacaine Fascia Iliaca Block for Perioperative Sleep Quality in Elderly Patients With Intertrochanteric Fracture
Older adults with hip fracture often experience severe pain before and after surgery. This pain can cause anxiety and poor sleep, and may increase the risk of postoperative delirium (sudden confusion after surgery).
- Conditions
- Intertrochanteric Fractures, Hip Fractures, Sleep Disturbance, Postoperative Delirium
- Trial name
- NCT07892859
- Testing
- Liposomal Bupivicaine, Saline Solution (NaCl 0,9%)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Li Xiaoyuan
Postoperative Delirium
The Role of Remazolam in Reducing the Incidence of Postoperative Delirium in Elderly Patients
This study is a prospective, randomized, controlled trial.The selected patients were randomly divided into remazolam general anesthesia group and propofol + midazolam general anesthesia control group according to computer…
- Trial name
- NCT05466279
- Testing
- remazolam, Propofol, Midazolam
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Fang Jun
Postoperative Delirium
Effect of Es-ketamine on Postoperative Delirium Among Old Patients With Lobectomy
The purpose of this study is the efficiency of es-ketamine on postoperative delirium among old patients with elective lobectomy
- Trial name
- NCT04969523
- Testing
- lobectomy
- Volunteers
- 500 people
- Sponsor
- Zhongnan Hospital
One-Lung Ventilation, Thoracic Surgery
The Effect of Anesthesia on Cerebral Oxygenation
One-lung ventilation (OLV) may cause negative changes in the oxygenation of cerebral tissue which results in postoperative cognitive dysfunction.
- Conditions
- One-Lung Ventilation, Thoracic Surgery, Postoperative Cognitive Complications
- Trial name
- NCT04760262
- Testing
- Sevoflurane, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Preoperative Anxiety, Emergence Delirium in Pediatric Anesthesia
Personal Versus Hospital-Provided Dolls in Preschool Children
The goal of this study is to evaluate the effects of personal versus hospital-provided dolls on preoperative anxiety and postoperative delirium in preschool children aged 3-7 years undergoing elective adenoidectomy and/or…
- Trial name
- NCT07403773
- Testing
- Hospital-Provided Doll, Personal Doll, No Doll
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Delirium (POD), Abdominal Neoplasms
Perioperative Biomarkers and Postoperative Delirium in Older Adults Undergoing Abdominal Cancer Surgery
This prospective observational cohort study aims to investigate the relationship between perioperative endogenous melatonin levels and postoperative delirium in patients aged 65 years or older undergoing elective abdominal cancer…
- Trial name
- NCT07859488
- Testing
- Perioperative Biomarker Assessment, Confusion Assessment Method (CAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatma Cigdem Ozakin
Postoperative Cognitive Dysfunction
The Effect of Intraoperative Hypotension on Postoperative Cognitive Functions in Cesarean Section Operations
The aim of the study is to see whether the hypotension that develops during spinal anesthesia in cesarean section patients causes a decrease in the postoperative cognitive functions of the patient.
- Trial name
- NCT05843838
- Testing
- Hypotension during spinal anesthesia for cesarean section, Mini-mental test, Spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Cognitive Dysfunction, Burns
PRIME: Cognitive Outcome Following Major Burns
PRIME aims to demonstrate through neurocognitive assessment that BICU patients will have a degree of neurocognitive dysfunction following a major burn, that this neurocognitive dysfunction is due to an underlying…
- Conditions
- Cognitive Dysfunction, Burns, Inflammation, Brain, Quality of Life
- Trial name
- PRIME (NCT03242395)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Postoperative Delirium, PD
Cognitive Protection - Dexmedetomidine and Cognitive Reserve
This is a pilot study to evaluate the effect of dexmedetomidine in the prevention of delirium in non-cardiac surgical patients. The preliminary data regarding the effect of dexmedetomidine on delirium comes from a study underway…
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00455143
- Testing
- Precedex (Dexmedetomidine)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Cognitive Dysfunction, Repetitive Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation and Perioperative Neurocognitive Disorders
To investigate the impact of rTMS on the incidence of perioperative neurocognitive disorders in patients after after cardiac surgerysurgery. To explore the underlying mechanisms behind the efficacy.
- Trial name
- NCT05668559
- Testing
- repetitive transcranial magnetic stimulation
- Volunteers
- 280 people
- Sponsor
- Anshi Wu
Postoperative Delirium, Anesthesia
Effect of Prophylactic Application of 40Hz Transcranial Stimulation in AICU on Incidence of Postoperative Delirium in Elderly Patients Undergoing Elective Gastrointestinal Surgery
Postoperative delirium is an acute central nervous system dysfunction caused by surgical stress, which is manifested by postoperative acute, non-specific changes in consciousness level, attention, cognitive ability and…
- Conditions
- Postoperative Delirium, Anesthesia, Elderly
- Trial name
- NCT06542978
- Testing
- 40Hz stimulation
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Henan Provincial People's Hospital
Delirium
Effect of Preoperative Intervention With Folic Acid and Vitamin B12 on Postoperative Neurobehavioral Changes in Children
Comparison of preoperative folic acid and VitB12 intervention on postoperative delirium and long-term neurobehavioral changes in children under general anesthesia
- Trial name
- NCT04456985
- Testing
- Folic acid and vitamin B12, brown sugar aqueous
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Post Operative Delirium, Cognitive Impairment
Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression
This study will examine whether noninvasive, transcutaneous vagal nerve stimulation (tcVNS) can help restore consciousness in patients in the operating room and the Post Anesthesia Care Unit (PACU).
- Conditions
- Post Operative Delirium, Cognitive Impairment, Vagus Nerve Stimulation, Depression
- Trial name
- tVNS (NCT07610655)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Emergence Agitation, Anesthesia
Effect of Intraoperative and Awakening Electroencephalogram on Awakening Agitation After General Anesthesia in Children
The purpose of this study was to analyze the relationship between intraoperative and awakening electroencephalogram waveforms and awakening agitation after general anesthesia in children
- Conditions
- Emergence Agitation, Anesthesia, Children's Surgery
- Trial name
- NCT06079710
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Emergence Agitation
Propofol in Emergence Agitation
The purpose of the study is to see if a small dose of propofol given intravenously (through a needle into a vein) at the end of anesthesia can make it less likely that children will be agitated as the come out of the anesthetic.
- Trial name
- NCT00535613
- Testing
- Propofol
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Wisconsin, Madison
Postoperative Neurocognitive Disorders
Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients
Postoperative neurocognitive disorders (PND) are common postoperative complication of central nervous system, leading to increased risk of the working ability loss after surgery, longer hospital stay, increased medical costs and…
- Trial name
- NCT05613491
- Testing
- Intranasal insulin, Intranasal saline
- Where
- China
- Volunteers
- 438 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University