Clinical trials: Postoperative Pain Control, open to volunteers
Acute Postoperative Pain, Dental Pain
A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction
The primary objective of this trial is to assess the safety and tolerability of single, ascending doses of CYT-1010 in healthy male and female volunteers and in the treatment of acute postoperative pain after third molar…
- Trial name
- NCT07905105
- Testing
- CYT-1010
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cytogel Pharma, LLC
Pain Management, Mtapa Block
M-Tapa Block and Transversus Abdominal Plane Block for Postoperative Analgesia in Unilateral Open Inguinal Hernia Repair Surgery
Patients will be called to the operating room one hour before surgery and no premedication will be applied before coming to the operating room.
- Conditions
- Pain Management, Mtapa Block, TAP Block
- Trial name
- pain (NCT07311902)
- Testing
- TAP Block Group, M TAPA block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Erzurum Regional Training & Research Hospital
Cesarean Section, Postoperative Pain
Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section
The investigators aim to compare the analgesic efficacy of intravenous acetaminophen alone versus combination of acetaminophen/ibuprofen (Maxigesic®IV) in multimodal analgesia after cesarean section.
- Trial name
- NCT06479122
- Testing
- Acetaminophen, Acetaminophen/Ibuprofen
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pain, Postoperative, Liposomal Bupivacaine
Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain
The supraclavicular brachial plexus block (BPB) is a frequently used anaesthetic method for upper limb surgeries, including distal radial fracture surgery.
- Conditions
- Pain, Postoperative, Liposomal Bupivacaine, Dexamethasone, Supraclavicular Brachial Plexus Block
- Trial name
- NCT07665762
- Testing
- 10ml 0.5% plain bupivacaine with 10ml 1.33% liposomal bupivacaine, 19ml 0.5% plain bupivacaine with 1ml (4mg) dexamethasone
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Dexmedetomidine, Adjuvant
Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block Versus Bupivacaine Alone for Postoperative Pain Management in Patients Undergoing Craniotomy
This study aims to compare dexmedetomidine as an adjuvant to bupivacaine in scalp block versus bupivacaine alone for postoperative pain management in patients undergoing craniotomy.
- Conditions
- Dexmedetomidine, Adjuvant, Bupivacaine, Scalp Block
- Trial name
- NCT06993922
- Testing
- Scalp block, Scalp block + Dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Ventral Hernia, Ventral Incisional Hernia
The IMPACT Study: Personalized Physical Therapy for Better Recovery and a Stronger Core After Hernia Surgery
Ventral hernia repair is among the most common operations performed in the United States each year, yet the great majority of patients receive no structured rehabilitation for the persistent pain, weakness, and functional loss…
- Conditions
- Ventral Hernia, Ventral Incisional Hernia, Post Operative Pain
- Trial name
- IMPACT (NCT07145099)
- Testing
- PT Group, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Thomas Jefferson University
Postoperative Pain
Deep Subgluteal Block vs PENG Combined With LFCN Block for Analgesia After Hip Arthroplasty
This randomized, prospective study aims to compare the clinical efficacy of ultrasound-guided Deep Subgluteal Block (DSGB) versus Pericapsular Nerve Group (PENG) block combined with Lateral Femoral Cutaneous Nerve (LFCN) block…
- Trial name
- DSG-PENG (NCT07770932)
- Testing
- 0.25% Bupivacaine for Deep Subgluteal Block, 0.25% and 0.125% Bupivacaine for PENG+LFCN Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Chronic Post-surgical Pain, Acute Postoperative Pain
CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment
Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization.
- Conditions
- Chronic Post-surgical Pain, Acute Postoperative Pain, Cardiac Surgery
- Trial name
- CROPS (NCT07629453)
- Testing
- Standard Multimodal Opioid-Based Analgesia, Regional Anesthesia-Based Analgesia
- Volunteers
- 180 people
- Sponsor
- Kočan Ladislav
Arthroscopic Surgery
Effectiveness of Per-Operative Bupivicaine in Reducing Postoperative Pain at Port Site and Improving Mobility in Knee Arthoscopic Procedures
The investigator's aim is to evaluate the effectiveness of per-operative bupivacaine infiltration at arthroscopic port sites in reducing post-operative pain compared to placebo in patients undergoing knee arthroscopic procedures.
- Trial name
- NCT07090928
- Testing
- 5 ml of 0.5% bupivacaine infiltrated at each port site
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Teaching Hospital
Craniotomy Surgery
Sphenopalatine Ganglion Block Combined With Either Scalp Nerve Block or Local Wound Infiltration for Postoperative Analgesia in Adult Patients Undergoing Craniotomy: A Randomized Controlled Trial
The use of multimodal regional analgesia (scalp block, local scalp infiltration, and sphenopalatine ganglion block) for postoperative pain management after craniotomy
- Trial name
- NCT07886034
- Testing
- Group (c): control group patients will receive general anesthesia., Group (SS): Sphenopalatine Ganglion Block with either Scalp Nerve Block, Group (SL): patients will receive Sphenopalatine Ganglion Block with local wound infiltration
- Volunteers
- 54 people
- Sponsor
- Zagazig University
Hip Arthroplasty, Hip Fracture Surgeries
Sacral ESPB vs. PENG Block for Hip Hemiarthroplasty Analgesia
Sacral erector spinae plane block(S-ESPB) has been recently described. Case reports are showing that it is useful in various types of surgery.
- Conditions
- Hip Arthroplasty, Hip Fracture Surgeries, Femoral Neck Fractures, Postoperative Pain
- Trial name
- NCT07442721
- Testing
- Sacral erector spinae plane block, PENG block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Fayoum University Hospital
Acute Post Operative Pain, Third Molar Extraction Surgery
A Phase 1 Study of ARC-001 in Participants Undergoing Third Molar Extraction
The study will test the investigational product gel against placebo (which contains no active ingredient) to determine if it is safe after wisdom tooth extraction. The main questions the study will answer are: 1.
- Trial name
- NCT06864884
- Testing
- ARC-001
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arcato Laboratories, Inc.
Pain, Postoperative, Osteoarthritis, Knee / Osteoarthritis, Hip
iPACK Block vs. Periarticular Infiltration for TKA Pain Control
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA).
- Trial name
- NCT07267650
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Turgutlu State Hospital
Post-operative Pain
Dexmedetomidine Added to Bupivacaine for ESP Block in Children Undergoing Lower Abdominal Surgeries
This study aims to evaluate the effect of adding dexmedetomidine to bupivacaine in erector spinae plane (ESP) blocks on the duration of postoperative analgesia in pediatric patients undergoing lower abdominal surgery.
- Trial name
- NCT07023991
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Surgery, Laparoscopic
Low Versus Standard Pressure Pneumoperitoneum on Shoulder Tip Pain
This proposed study is a single-center, double blind, parallel group RCT comparing the use of low (10 mm Hg) versus standard pressure (15 mm Hg) pneumoperitoneum at the time of benign gynecologic laparoscopic surgery.
- Conditions
- Surgery, Laparoscopic, Laparoscopy, Penumoperitoneum
- Trial name
- NCT06504277
- Testing
- Low Pressure Penumoperitoneum, Standard Pressure Group (No intervention- active comparator)
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Pain After Surgery, Pain and Anxiety
The Effect of Virtual Reality Headsets on Pain, Anxiety, Patient Satisfaction, and Physiological Parameters in Patients Undergoing Open-Heart Surgery
This randomized controlled trial aims to investigate the effects of virtual reality headset use on pain, anxiety, patient satisfaction, and physiological parameters in patients undergoing open-heart surgery.
- Conditions
- Pain After Surgery, Pain and Anxiety, Anxiety After Surgery, Anxiety
- Trial name
- NCT07843511
- Testing
- Virtual Reality Glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Dokuz Eylul University
Pain Management, Overweight , Obesity
Safety and Analgesic Efficacy of the Biased μ-Opioid Receptor Agonist Tegileridine for Post-Operative Analgesia in Patients Undergoing Bariatric Surgery
This single-center, stratified randomized double-blind trial tests tegileridine, a new pain drug, for pain relief after weight-loss surgery. Researchers will compare tegileridine with standard opioid pain medicine.
- Conditions
- Pain Management, Overweight , Obesity, Respiration; Sleep Disorder
- Trial name
- NCT07844512
- Testing
- Tegileridine (tegileridine fumarate injection, IV), Sufentanil
- Where
- China
- Volunteers
- 148 people
- Sponsor
- The First Hospital of Jilin University
Hip Replacement Surgery, Hip Replacement, Total
OPPOSED (anteriOr hiP arthroPlasty regiOnal aneSthEsia stuDy) Study
Main indications for total hip arthroplasty (THA) are degenerative osteoarthritis of the coxofemoral joint, osteonecrosis of the hip, congenital disorders such as dysplasia and inflammatory arthritis.
- Conditions
- Hip Replacement Surgery, Hip Replacement, Total, Hip Pain, Hip Arthroplasty
- Trial name
- NCT07017192
- Testing
- SIFI Block, ESP block
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Acute Postoperative Pain, Thoracic Surgical Procedures
Transcutaneous Electrical Nerve Stimulation for Acute Postoperative Pain After Video-Assisted Thoracoscopic Surgery
This randomized, double-blind, sham-controlled study aims to evaluate the effects of transcutaneous electrical nerve stimulation (TENS) on acute postoperative pain, sleep quality, and quality of life in patients undergoing…
- Trial name
- NCT07732764
- Testing
- Active TENS
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Fooyin University
Post Operative Swelling
Geko™ Device in Prevention of Pain and Swelling Following Knee Arthroscopy
report on post-operative effectiveness of the Geko™ device in prevention of pain and swelling after arthroscopic anterior cruciate ligament reconstruction and repairs
- Trial name
- NCT07896499
- Testing
- Geko, control
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
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