Clinical trials: Postoperative Pancreatic Fistula
Pancreas Head Cancer, Pancreas Adenocarcinoma
Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA)
The PANENCA trial aims to reduce postoperative complications in patients undergoing pancreatoduodenectomy (also known as a Whipple procedure), a complex surgical operation performed to remove tumors located in or near the head of…
- Conditions
- Pancreas Head Cancer, Pancreas Adenocarcinoma, IPMN, Pancreatic, Cholangio Carcinoma
- Trial name
- PANENCA (NCT07262957)
- Testing
- HOP bundle
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreatic Fistula
Study of Pancreatic Enzymes in the Drains as Early Biomarkers of Post-operative Pancreatic Fistula and Its Clinical Repercussions
Surgery is the principal treatment for benign and malignant pancreatic tumours. This surgery can be accompanied by complications among which the main one is pancreatic fistula, which leads to the flow of pancreatic juices into…
- Trial name
- LIPA-DRAIN (NCT02784990)
- Testing
- Lipase, amylase and CRP (C-reactive protein) dosages
- Where
- 10 sites in France
- Volunteers
- 770 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Saleh's Technique for Pancreaticojejunostomy (Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate)
This study investigates the safety and efficacy of injecting N-butyl-2-cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the pancreaticojejunostomy (PJ)…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07132541)
- Testing
- Pancreatic parenchymal injection of N-butyl-2-cyanoacrylate(Histoacryl®)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Minia University
Pancreatic Fistula
Comparison of Effectiveness of TissuePatchTM in Preventing Postoperative Pancreatic Fistula
Postoperative pancreatic fistula is one of the most serious complications after gastric cancer surgery and can lead to surgery-related death.
- Trial name
- NCT05404256
- Testing
- Radical gastrectomy +D2 lymphadenectomy+TissuePatchTM to seal pancreatic tissue surface, Radical gastrectomy +D2 lymphadenectomy
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Different Pancreaticojejunostomy After Pancreaticoduodenectomy
The aim of this study was to reduce the incidence of postoperative pancreatic fistula after pancreaticoduodenectomy by using different pancreaticojejunostomy methods according to the position of the pancreatic duct.
- Trial name
- NCT05475275
- Testing
- pancreaticojejunostomy
- Where
- China
- Volunteers
- 924 people
- Sponsor
- Junjie Xiong
Pancreatic Fistula
One-layer Versus Two-layer Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy
The aim of this study is to investigate a new pancreaticojejunal (PJ) anastomosis procedure named "One-layer duct-to-mucosa pancreaticojejunostomy" in pancreatoduodenectomy, which could provide a feasible option to pancreatic…
- Trial name
- NCT02511951
- Testing
- pancreaticojejunostomy
- Where
- China
- Volunteers
- 114 people
- Sponsor
- The Second Hospital of Anhui Medical University
Pancreatic Fistula, Pancreatic Neoplasms
Greater Omentum Binding to the Pancreatic Stump to Prevent Pancreatic Fistula Following Distal Pancreatectomy
Background and aim: Distal pancreatectomy (DP) is often performed for primary benign or malignant lesions occurred in the body or tail of the pancreas.
- Trial name
- NCT03752086
- Testing
- greater omentum binding, Pancreatic stump exposed without omentum binding
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tongji Hospital
Pancreaticoduodenectomy, Distal Pancreatectomy
The Novel Modified Cattell-Warren Duct-To-Mucosa Pancreaticojejunostomy Technique Significantly Reduces POPF.
Pancreatic surgeries, such as pancreaticoduodenectomy and distal pancreatectomy, are associated with high morbidity and mortality. The most common cause of this morbidity is postoperative pancreatic fistula(POPF).
- Conditions
- Pancreaticoduodenectomy, Distal Pancreatectomy, Postoperative Pancreatic Fistula
- Trial name
- POPF (NCT07038161)
- Testing
- Modified Cattell-Warren duct-to-mucosa pancreaticojejunostomy, Institutional Prehabilitation Protocol
- Where
- Nepal
- Volunteers
- 27 people
- Sponsor
- Nepal Medical College and Teaching Hospital
Pancreatic Cancer, Periampullary Cancer
Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas
This is a single-center, randomized controlled trial comparing the efficacy of pancreaticojejunostomy with modified N-butyl-2-cyanoacrylate(Glubran® 2) versus standard pancreaticojejunostomy without cyanoacrylate in preventing…
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Duodenal Cancer, Cholangiocarcinoma
- Trial name
- NBCA-MS (NCT07155525)
- Testing
- Pancreaticojejunostomy with Modified N-Butyl-2-Cyanoacrylate (Glubran® 2), Standard(duct-to-mucosa) Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Minia University
Pancreatic Fistula
Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy
Patients who are diagnosed with periampullary cancer will be performed pancreaticoduodenectomy with 3 types of pancreatic-jejunal anastomosis reconstructions.
- Trial name
- NCT05017207
- Testing
- Pancreaticoduodenectomy
- Where
- Vietnam
- Volunteers
- 183 people
- Sponsor
- Vo Truong Quoc
Pancreatectomy
Tomoelastography in Predicting Postoperative Pancreatic Fistula
Postoperative pancreatic fistula (POPF) is a prevalent and severe complication of pancreaticoenteric anastomosis; however, its accurate preoperative prediction is challenging.
- Trial name
- POPF (NCT07014800)
- Where
- China
- Volunteers
- 157 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum
Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula
Curative management of locally resectable invasive adenocarcinomas located in the cephalic region of the pancreas (pancreas, duodenum and ampulla of Vater) requires a pancreaticoduodenectomy followed by adjuvant chemotherapy.
- Conditions
- Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum, Ampullary Adenocarcinoma
- Trial name
- TPIAT-01 (NCT05116072)
- Testing
- total pancreatectomy, intraportal islet autotransplantation
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Lille
Pancreatic Cancer, Sepsis
Colonization of Bile Ducts and Postoperative Infectious Complications of Pancreaticoduodenectomies
The aim of the present prospective study was, first, to verify the correlation between biliary colonization and postoperative infectious complications, and secondarily to asses morbidity and mortality for patients who underwent…
- Conditions
- Pancreatic Cancer, Sepsis, Bile Duct Cancer, Duodenal Cancer
- Trial name
- NCT03525067
- Testing
- Bile sampling for bacterial examination
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Healing Time of Post Operative Pancreatic Fistulas
Does Post Operative Pancreatic Fistula, After Left Sided Resections, Heal Faster After the Introduction of a Pancreatic Stent?
Dividing pancreas when performing left-sided resections opens the risk for leakage from the divided end of the pancreas. Pancreatic juices could have a severe effect on surrounding abdominal tissues with abscess formation…
- Trial name
- NCT02220010
- Testing
- Pancreatic stent
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Pancreatic Cancer
A Study in Postoperative Pancreatic Fistula
The International Study Group of Pancreatic Surgery (ISGPS) issued the definition and classification system of postoperative pancreatic fistula (POPF), and received widespread recognition.
- Trial name
- NCT03129607
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreatic Fistula
Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula
For periampullary and pancreatic head disorders, pancreaticoduodenectomy (PD) is the standard treatment. However, PD is technically demanding and has high morbidity and mortality rates.
- Trial name
- NCT05687825
- Testing
- pancreaticoduodenectomy procedure
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- South Valley University
Postoperative Pancreatic Fistula, Distal Pancreatectomy
Prophylactic Abdominal Drainage vs no Drainage After Distal Pancreatectomy
Postoperative pancreatic fistula (POPF) is a major source of morbidity and mortality after pancreatic resection, especially after distal pancreatectomy (PD).
- Conditions
- Postoperative Pancreatic Fistula, Distal Pancreatectomy, Drainage
- Trial name
- PANDREAS (NCT06141044)
- Testing
- Avoid surgical drainage
- Volunteers
- 104 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Pancreas; Fistula, Pancreas Cancer
Assessing Pancreatic Fistula Rates After Distal Pancreatectomy Using AEON Endostapler
This prospective, observational study evaluates the rate of postoperative pancreatic fistula (POPF) following distal pancreatectomy (DP) using the AEON™ Endostapler.
- Conditions
- Pancreas; Fistula, Pancreas Cancer, Pancreatic Disease, Surgery-Complications
- Trial name
- AEON-DP (NCT06764134)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Hospital Heidelberg
Post Operative Pancreatic Fistula
Predictors of Severity of Postoperative Pancreatic Fistula After Pancreatoduodenectomy
Pancreaticoduodenectomy is one of the commonly performed procedure for periampullary carcinoma/distal cholangio carcinoma/head of pancreas carcinoma.
- Trial name
- NCT05291923
- Testing
- no intervention
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Pancreatitis, Pancreatic Fluid Collection
Management and Outcomes of Local Complications of Acute Pancreatitis and Postoperative Pancreatic Fistula
This multicenter prospective observational registry will evaluate the clinical characteristics and treatment outcomes of adults with local complications of acute pancreatitis or postoperative pancreatic fistula.
- Conditions
- Acute Pancreatitis, Pancreatic Fluid Collection, Postoperative Pancreatic Fistula
- Trial name
- WONDERFUL (NCT07862088)
- Testing
- Routine Clinical Management of Local Complications
- Where
- 12 sites in Japan
- Volunteers
- 5,000 people
- Sponsor
- Tokyo University