Clinical trials: Postoperative Patients
Postoperative Pain, Postoperative Nausea and Vomiting
Low Doses of Ketamine and Postoperative Quality of Recovery
There are evidences that intraoperative administration of low doses of ketamine may contribute to control the postoperative pain by acting on the N-methyl-D-aspartate (NMDA) channel, reducing the effects related to the tolerance…
- Trial name
- NCT02571153
- Testing
- Ketamine 0.4 mg/kg, Normal saline, Ketamine 0.2 mg/kg
- Where
- Brazil
- Volunteers
- 135 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
COVID-19, Myocardial Reperfusion Injury
Myocardial Injury and Major Adverse Outcomes in Patients With COVID-19
The study will analyze the incidence, clinical outcomes and predictors of myocardial injury in a large patient population with COVID-19 treated in Mount Sinai Hospital (MSH) system.
- Conditions
- COVID-19, Myocardial Reperfusion Injury, Cardiovascular Diseases
- Trial name
- NCT04397939
- Where
- United States
- Volunteers
- 4,695 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Osteoarthritis, Knee
Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
This study will evaluate the use of a local injection around the knee (periarticular) during total knee replacement (TKR) surgery to see if it reduces postoperative pain levels.
- Trial name
- NCT02570503
- Testing
- Ropivacaine, Ketorolac, Clonidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Acute Moderate-to-severe Pain
A Multicenter, Open-Label Trial to Evaluate the Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg in Patients With Post-Operative Pain
This is a multicenter, open-label study in patients 40 years and older who are undergoing a surgical procedure. Patients may receive one dose of ST 30 mcg as needed for pain management, but no more frequently than every 60…
- Trial name
- NCT02662556
- Testing
- sufentanil sublingual tablet 30 mcg
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Talphera, Inc
Loco-regional Esophageal Cancer
Phase II Trial for Patients With Loco-Regional Esophageal Carcinoma
The purpose of this study is to determine whether bevacizumab can improve the outcome of treatment for patients with esophageal cancer whose disease is confined to the esophagus or the closely surrounding lymph nodes.
- Trial name
- NCT00570531
- Testing
- Bevacizumab, Paclitaxel, Cisplatin
- Volunteers
- 6 people
- Sponsor
- University of Michigan Rogel Cancer Center
Sinusitis, Nasal Polyps
Comparison of Nasal Steroids After FESS in CRSwNP
The purpose of this study is to compare intranasal fluticasone spray with budesonide nasal saline rinses in both the upright and head forward positions in patients who have had functional endoscopic sinus surgery (FESS) for…
- Trial name
- NCT02194062
- Testing
- fluticasone nasal spray, Budesonide head upright, Budesonide head forward
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Yale University
Hip Arthroplasty
Effect of Spinal Ketorolac on Mechanical Hypersensitivity After a Total Hip Replacement
Chronic pain in patients following total hip replacement seems to be a significant problem. Previous research has shown that more effective pain management in the early postoperative period may decrease the incidence of the…
- Trial name
- NCT00621530
- Testing
- ketorolac tromethamine opthalmic solution
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Wake Forest University
Pain, Postoperative, Opioid Use
Cannabidiol for Bilateral Total Knee Arthroplasty
In light of the opioid epidemic and evidence suggesting that cannabis may be opioid-sparing, we are in a unique position to conduct a novel, high-impact study that would set the stage for future RCTs examining the effects of a…
- Conditions
- Pain, Postoperative, Opioid Use, Knee Osteoarthritis
- Trial name
- NCT04749628
- Testing
- cannabidiol, Ora-sweet SF
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Hospital for Special Surgery, New York
Venous Thromboembolism, Deep Venous Thrombosis
Minimization of Bleeding Related Adverse Drug Events in Plastic & Reconstructive Surgery
Plastic and reconstructive surgeons consistently create large, raw surfaces as part of their operative procedures. Thus, plastic \& reconstructive surgery patients are among those at highest risk for anticoagulant-associated…
- Conditions
- Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolus, Reconstructive Surgery
- Trial name
- NCT03212365
- Testing
- Fixed dose, Variable dose
- Where
- 2 sites in United States
- Volunteers
- 295 people
- Sponsor
- University of Utah
Pain, Postoperative, Lung Diseases
Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection
This is a single center, single surgeon, prospective, randomized trial examining the addition of Cryo Nerve Block during robot assisted thoracoscopic anatomic lung resection surgery
- Trial name
- NCT05144828
- Testing
- Intercostal Nerve Cryoablation, Patient-controlled analgesia (PCA)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical College of Wisconsin
Coronary Artery Disease, Postoperative Cognitive Dysfunction
Cerebral Oximetry and Neurocognitive Functions in Cardiosurgical Patients
It is previously reported that the cerebral oxygen desaturation during cardiac surgery is associated with an increased incidence of cognitive impairment.
- Conditions
- Coronary Artery Disease, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT00917124
- Testing
- INVOS
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University of Zagreb
Dumping Syndrome
Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome
multi-center, phase II study evaluating efficacy, safety and pharmacokinetics of pasireotide in patients with dumping syndrome
- Trial name
- NCT01637272
- Testing
- SOM230
- Where
- 17 sites in United States, Belgium and 3 more
- Volunteers
- 43 people
- Sponsor
- Novartis Pharmaceuticals
Surgery, Shoulder Impingement
Pupillary Pain Index to Evaluate Interscalene Block and Postoperative Pain in Patients Underwent Shoulder Surgery
When an individual encounters nociceptive pain stimuli, the pupil dilates in a unique manner known as Pupil reflex dilation (PRD).The degree of pupillary reflex dilatation can be further quantified into an objective parameter…
- Trial name
- NCT05590767
- Testing
- Patients scheduled to undergo shoulder rotators repair surgery
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Adenoid Hypertrophy
A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients
This proposed study will assess analgesic efficacy of a multi-modal, non-opioid analgesic regimen for providing surgical analgesia in pediatric patients undergoing adenoidectomy and to assess recovery characteristics in the…
- Trial name
- NCT03714919
- Testing
- Dextromethorphan, Acetaminophen, Dexmedetomidine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Arlyne Thung
Post-operative Pain, Gynecological Surgery
Acupuncture for Post-Operative Pain Control for Patients Undergoing Gynecological Surgery
This study investigates the role of acupuncture in controlling post-operative pain in patients who have undergone gynecological surgery.
- Conditions
- Post-operative Pain, Gynecological Surgery, Acupuncture
- Trial name
- NCT02855567
- Testing
- Acupuncture needles
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cerebrospinal Fluid Leaks
TASALL - TachoSil® Against Liquor Leak
The primary objective is to demonstrate superiority of TachoSil® compared to current practice as an adjunct in sealing the dura mater. The efficacy of the dura mater sealing must be evaluated post-operatively.
- Trial name
- NCT01355627
- Testing
- TachoSil®, Current Practice
- Where
- 39 sites in Austria, Belgium and 9 more
- Volunteers
- 726 people
- Sponsor
- Takeda
Post Operative Analgesia, Bariatric Surgery
Oral Acetaminophen for Post-Op Pain Management in Bariatric Surgery Patients
Adult patients with morbid obesity who have had Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (LSG) surgery have impaired drug metabolism.
- Conditions
- Post Operative Analgesia, Bariatric Surgery, Bariatric Surgery (Gastric Bypass), Bariatric Surgery Patients
- Trial name
- NCT06658574
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Rutgers, The State University of New Jersey
Cerebral Oxygen Desaturation, Post-operative Delirium
Cerebral Oxygenation in Total Hip Arthroplasty Patients
We plan to investigate the relationship between hypotensive epidural anesthesia for hip arthroplasty and cerebral oxygen saturation.
- Trial name
- THANIRS (NCT02325154)
- Testing
- Cerebral Oximeter
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Breast Cancer, Perioperative/Postoperative Complications
Fibrin Sealant in Preventing Fluid Build Up During Surgery in Patients Undergoing Breast Reconstruction
The purpose of this study is to investigate the efficacy of an alternative surgical technique and the use of fibrin sealant in preventing post-operative seroma formation.
- Trial name
- NCT01649505
- Testing
- fibrin sealant (Beriplast P, TISSEEL VH), breast reconstruction
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- OHSU Knight Cancer Institute
Mammoplasty, Postoperative Pain
Study of EXPAREL in Patients Undergoing Breast Augmentation
This is a Phase 4, prospective, open-label, non-randomized, sequential study with two treatment groups differing only in the technique used for EXPAREL administration (instillation or infiltration).
- Trial name
- NCT01582490
- Testing
- Instillation - EXPAREL, Infiltration - EXPAREL
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Pacira Pharmaceuticals, Inc