Clinical trials: Postoperative Pulmonary Complication
Atelectasis, Postoperative Pulmonary
Evaluation of the Effects of Different Ventilation Modes Used During Anesthesia Awakening on the Frequency of Postoperative Atelectasis
In our study, we aimed to detect atelectasis developing in patients undergoing surgery under general anesthesia using transthoracic lung ultrasonography and to investigate the effect of ventilation methods used during recovery…
- Trial name
- NCT06358027
- Testing
- lung ultrasound
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Assessment
Evaluation of Protective Pulmonary Ventilation by Pulmonary Ultrasound
Peri - operative ultrasonography was used to evaluate the effects of protective lung ventilation on the postoperative lungs of obese patients.The purpose of this study was to apply ultrasound lung ventilation area score to the…
- Trial name
- NCT04991727
- Testing
- recruitment maneuvers
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Bladder Tumors, Spinal Anesthesia
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
This randomized controlled trial evaluated the effects of intraoperative intravenous magnesium sulfate versus dexmedetomidine on postoperative pain, analgesic consumption, hemodynamic stability, and respiratory function in…
- Conditions
- Bladder Tumors, Spinal Anesthesia, Postoperative Pain, Magnesium Sulfate
- Trial name
- TURBT (NCT07445451)
- Testing
- magnesium sulfate, Dexmedetomidine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Lung Injury
Effects of Different Ventilation Patterns on Lung Injury
In 1967, the term "respirator lung" was coined to describe the diffuse alveolar infiltrates and hyaline membranes that were found on postmortem examination of patients who had undergone mechanical ventilation.This mechanical…
- Trial name
- NCT03960853
- Testing
- pressure-controlled ventilation-volume guaranteed, volume controlled ventilation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Postoperative Pain
NSAIDs With Morphine-PCA Compared to Epidural Analgesia in Thoracotomy Pain
The investigators investigated whether a strictly controlled pain management with patients participating in a clinical study can attenuate persistence of post-thoracotomy pain.
- Trial name
- NCT01541137
- Testing
- Diclofenac, parecoxib/ valdecoxib, patient controlled epidural analgesia
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Esophageal Cancer
Effect of Neutrophil Elastase Inhibitor on Lung Injury After Esophagectomy
A neutrophil elastase inhibitor may have effect on suppression of the lung injury after thoransthoracic esophagectomy. The investigators hypothesized that postoperative complication, particularly respiratory complication may be…
- Trial name
- NEIE (NCT01170845)
- Testing
- sivelestat sodium hydrate
- Where
- Japan
- Volunteers
- 31 people
- Sponsor
- Yokohama City University Medical Center
Anesthesia, Postoperative Complications
Evaluation of V/Q Mismatch as Predictor of Pulmonary Postoperative Complications in Patients Undergoing Major Surgery
Pulmonary postoperative complications (PPC) are among the main causes of surgical complications affecting both postoperative morbidity and mortality.
- Conditions
- Anesthesia, Postoperative Complications, Mechanical Ventilation Complication
- Trial name
- VQppc (NCT05454917)
- Testing
- Measure of ventilation/perfusion (V/Q) mismatch using Beacon ALPE (Automatic Lung Paramether Estimator)
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Università degli Studi di Ferrara
Pulmonary Resection Surgery, One Lung Ventillation (OLV)
BMI-Adjusted PEEP During One-Lung Ventilation in Thoracic Surgery
One-lung ventilation (OLV) is required during many thoracic surgical procedures and is associated with reduced functional residual capacity, atelectasis, ventilation-perfusion mismatch, hypoxemia, and potentially…
- Conditions
- Pulmonary Resection Surgery, One Lung Ventillation (OLV), General Anesthetic
- Trial name
- SIMPLE-PEEP (NCT07851740)
- Testing
- Fixed PEEP, BMI-adjusted PEEP
- Where
- 4 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Jesús Manuel Nieves Alonso
Head and Neck Cancer
Comparison of AIRVO High Flow Oxygen Therapy With Standard Care for Prevention of PPCs After Major H&N Surgery
Patients undergoing major head and neck surgery often develop breathing difficulties as a result of build up of sputum and difficulty taking deep breaths.
- Trial name
- NCT03828578
- Testing
- High flow oxygen therapy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Cardiff and Vale University Health Board
Postoperative Pulmonary Complications (PPCs)
Perioperative Prophylactic Positive Pressure Ventilation Reduces Postoperative Pulmonary Complications.
The incidence of postoperative pulmonary complications (PPCs) ranges from 5% to 33%. PPCs significantly prolong hospital stay, increase the economic burden, and are associated with postoperative mortality at 30 days and 1 year.
- Trial name
- NCT07461285
- Testing
- Conventional Ventilation, Perioperative positive pressure ventilation
- Volunteers
- 206 people
- Sponsor
- Jun Zhang
Ultrasonography, Postoperative Complications
Use of Point-of-care Lung Ultrasound Before and After Surgery Trying to Predict Post-operative Pulmonary Complications
Patients undergoing surgery inside their abdomen, with no serious heart or lung diseases, will have a lung ultrasound exam before and after surgery.
- Conditions
- Ultrasonography, Postoperative Complications, Anesthesia, Surgery-Complications
- Trial name
- NCT05502926
- Testing
- lung ultrasound score
- Where
- Israel
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Moshe Rucham MD
Emergency Abdominal Surgery, Mechanical Ventilation
Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery
The aim of this study is to compare the effects of a strategy aimed at increasing alveolar recruitment (high PEEP levels adjusted according to driving pressure and recruitment maneuvers) with that of a strategy aimed at…
- Conditions
- Emergency Abdominal Surgery, Mechanical Ventilation, General Anesthesia, Postoperative Morbidity
- Trial name
- IMPROVE-2 (NCT03987789)
- Testing
- Driving-pressure-guided group, Low PEEP
- Where
- 28 sites in France
- Volunteers
- 707 people
- Sponsor
- University Hospital, Clermont-Ferrand
Airway Management, Tracheal Extubation
Interest of Tracheal Extubation in Positive Pressure on Postoperative Oxygenation in Adult Digestive Surgery
Evaluation of a postoperative tracheal extubation protocol under positive pressure in accordance with international recommendations.
- Conditions
- Airway Management, Tracheal Extubation, Postoperative Respiratory Complications, Postoperative Hypoxemia
- Trial name
- ExPress (NCT04381949)
- Testing
- positive pressure extubation
- Where
- France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Rouen
Postoperative Pulmonary Complications (PPCs), Atelectasis
Evaluation of the Effectiveness of Lung-Protective Ventilation in Patients Undergoing Laparoscopic Gastrectomy
The goal of this clinical trial is to learn if lung-protective ventilation can improve perioperative oxygenation and reduce postoperative pulmonary complications in patients undergoing elective laparoscopic gastrectomy.
- Trial name
- NCT07823816
- Testing
- Conventional Ventilation, Lung-Protective Ventilation
- Where
- Vietnam
- Volunteers
- 102 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Mechanical Ventilation Complication, Surgery
a Bayesian Analysis of Three Randomised Clinical Trials of Intraoperative Ventilation
The investigators designed a protocol for a Bayesian unplanned posthoc analysis using the pooled dataset from three large randomized clinical trials.
- Conditions
- Mechanical Ventilation Complication, Surgery, Pulmonary Complication, Postoperative Complications
- Trial name
- NCT05886387
- Testing
- High PEEP + Recruitment maneuvers, Standard PEEP. Low positive end-expriatory pressure
- Where
- 4 sites in Brazil, Italy and 2 more
- Volunteers
- 3,836 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Pain, Postoperative, Pain, Chronic
Pain and Impact of Chronic Pain on Function After Total Knee Replacements
After Institutional Review Board approval, adult patients scheduled for total knee arthroplasty (TKA) will be enrolled into the study after obtaining informed consent over a 24 month period.
- Conditions
- Pain, Postoperative, Pain, Chronic, Osteogenic Sarcoma, Knee Arthropathy
- Trial name
- NCT03032679
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 139 people
- Sponsor
- Tata Memorial Centre
Surgical Procedures, Operative, Anaesthesia
POPULAR: POst-operative PULmonary Complications After Use of Muscle Relaxants in Europe
International multicenter observational study of a random-sample cohort of patients undergoing any in-hospital surgical procedure under general or regional anaesthesia during a continued 14-day period of recruitment.
- Trial name
- POPULAR (NCT01865513)
- Where
- 2 sites in Germany, Sweden
- Volunteers
- 22,000 people
- Sponsor
- European Society of Anaesthesiology
Postoperative Complications, Thoracic Surgery
Influence of Postoperative Bronchoscopy on Pulmonary Complications After Anatomical Lung Resections.
Respiratory complications are the largest group of complications following anatomical lung resections. Most of these complications result from a disrupted evacuation of respiratory secretions.
- Trial name
- NCT03307018
- Testing
- Postoperative systematic bronchial aspiration.
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii
Atelectasis, Postoperative Pulmonary Complications
Effect of Inspired Oxygen Concentration on Postoperative Atelectasis After VATS Lobectomy
This study aims to investigate whether using 50% FiO₂ during one-lung ventilation, compared with 100% FiO₂, reduces postoperative atelectasis in the non-dependent (healthy) lung of patients undergoing VATS pulmonary lobectomy…
- Trial name
- NCT07721558
- Testing
- Low inspired oxygen concentration (FiO₂=50%) during one-lung ventilation, High inspired oxygen concentration (FiO₂=100%) during one-lung ventilaion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Chronic Postoperative Pain
Data Collection for Prediction of Postoperative Chronic Pain for a Software
Postoperative Persistent Pain (PPP) is reported with a high incidence in adults 11.5-47%. This high incidence effects quality of life of patients causes social-economical problems and arises medico-legal issues.
- Trial name
- NCT02190682
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 733 people
- Sponsor
- Istanbul University