Clinical trials: Postoperative Residual Weakness
Neuromuscular Blockade
Comparison of Mechanomyographic 100 Versus 200 Hz 5 Second Tetanic Fade Ratios During Neuromuscular Block Recovery
Two recent pilot studies suggested the potential interest of 100 and 200 Hz tetanic stimulations to detect with mechanomyography (MMG) very low levels of residual neuromuscular blockade (NMB).
- Trial name
- NCT05474638
- Testing
- Isometric Thumb Force (isometric mechanomyography) compared to TOF-Watch SX (acceleromyography)
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire UCLouvain Namur
Obesity, Neostigmine
Observational Study in Bariatric Surgery
Obesity in the world represents a growing share of the general population. At hospital, the management of these patients could be problematic especially when calculating the drug dosage.
- Conditions
- Obesity, Neostigmine, Residual Neuromuscular Blockade
- Trial name
- NEOCURE (NCT04244266)
- Testing
- NO INTERVENTION, it is an observational study
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
Comparison of Sugammadex and Sugammadex-neostigmine Combination in the Antagonism of Moderate Neuromuscular Block
In this prospective randomized controlled study the investigators compare the sugammadex-neostigmine combination and single dose sugammadex in terms of side effects and cost for the antagonism of moderate neuromuscular block…
- Trial name
- NCT05228223
- Testing
- Neuromuscular monitoring, reverse of NMB with sugammadex, reverse of NMB with Sugammadex and neostigmin low dose
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Neuromuscular Block, Residual
Evaluation of Residual Neuromuscular Blockade and of Late Recurarization in the Post Anesthesia Care Unit in Patients Undergoing Videolaparoscopic Cholecystectomy
Neuromuscular blockade is essential to provide optimal conditions for tracheal intubation and also to facilitate the performance of surgeries involving mainly the abdominal cavity.
- Trial name
- NCT03831815
- Testing
- Cisatracurium
- Where
- Brazil
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Incidence of Postoperative Residual Curarization
Combined Use of Low-dose Sugammadex Plus Neostigmine Administered for Reversal of Rocuronium
Reversal of rocuronium-induced neuromuscular block by the combination of low-doses of neostigmine plus sugammadex decreases the cost of anesthetic medications, while maintaining efficacy of reversal in obese patients.
- Trial name
- NCT03328312
- Testing
- Sugammadex, neostigmine+atropine, neostigmine+atropine+sugammadex
- Volunteers
- 90 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Frailty, Neuromuscular Blockade
Incidence of Residual Neuromuscular Blockade in Fraility in OncoGynae Surgery
Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital…
- Conditions
- Frailty, Neuromuscular Blockade, General Anesthetic Drug Adverse Reaction, Gynecologic Cancer
- Trial name
- FIGO (NCT06216002)
- Testing
- Train of four nerve stimulator
- Where
- Thailand
- Volunteers
- 356 people
- Sponsor
- Mahidol University
Residual Neuromuscular Blockade
Effect of Calcium Chloride on Recovery From Neuromuscular Blockade
The purpose of this study is to evaluate the effect of calcium chloride against residual neuromuscular blockade at the end of general anesthesia
- Trial name
- NCT02213848
- Testing
- Calcium, control
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Respiratory-Gated Imaging Techniques
Functional Respiratory Imaging After Neostigmine or Sugammadex
The use of neuromuscular blocking agents (NMBAs) is still associated with postoperative pulmonary complications. The investigators rely on acceleromyography (AMG) of a peripheral nerve/muscle to assess the patients' breathing…
- Trial name
- FRINeoS (NCT02284412)
- Testing
- Neostigmine, Sugammadex, Water for injection
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Onze Lieve Vrouw Hospital
Residual Neuromuscular Blockade
Visual and Electromyography Assessments in Response to Train-of-Four Stimulation of the Ulnar Nerve
Researchers are comparing the accuracy of measuring muscle relaxation during and after surgery with a device that provides numeric value versus visual observation to count of muscle twitches or absence of them by a medical…
- Trial name
- NCT04352127
- Testing
- TetraGraph
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Mayo Clinic
Postoperative Pulmonary Complications
Postoperative Pulmonary Complications in Major Abdominal Surgery
Incidence of Postoperative Pulmonary Complications (PPCs) varies from 2% to 19%, according to the population under examination and the criteria used to define pulmonary complications. There is no univocal definition of PPCs.
- Trial name
- NCT01701908
- Where
- 40 sites in Italy
- Volunteers
- 1,542 people
- Sponsor
- University of Udine
Postoperative Residual Curarization, Neuromuscular Block
Reversal With Low Doses of Sugammadex in Patients Undergoing Non-cardiac Surgery
Neuromuscular blocking agents (NMBA) are among the most commonly used drugs during general anesthesia and may induce complete muscle paralysis.They are used clinically to facilitate endotracheal intubation and to optimize…
- Trial name
- NCT03460509
- Testing
- Sugammadex
- Volunteers
- 144 people
- Sponsor
- The Hospital of Vestfold
Neuromuscular Blockade
Improving Neuromuscular Monitoring and Reducing Residual Neuromuscular Blockade Via E-learning
To assess the impact of an e-learning course in neuromuscular monitoring on the frequency of application of objective neuromuscular monitoring for assessment of depth of neuromuscular blockade in general anaesthesia and…
- Trial name
- INVERT (NCT02925143)
- Testing
- E-learning course in neuromuscular monitoring
- Where
- Denmark
- Volunteers
- 6,525 people
- Sponsor
- Herlev Hospital
Residual Neuromuscular Blockade, Residual Paralysis, Post-Anesthesia
Incidence of Postoperative Residual Neuromuscular Blockade in Portugal
This is an epidemiological multicenter, observational, prospective study, designed to determine the incidence of postoperative residual neuromuscular blockade - defined by a TOF (train-of-four) ratio < 0.9 - at PACU arrival.
- Conditions
- Residual Neuromuscular Blockade, Residual Paralysis, Post-Anesthesia, Observational Study, Complication of Anesthesia
- Trial name
- NCT03417804
- Where
- 10 sites in Portugal
- Volunteers
- 366 people
- Sponsor
- Centro Hospitalar do Porto
Neuromuscular Blockade
Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor
A quantitative neuromuscular monitoring device is desirable to titrate the depth of neuromuscular block (NMB) during a procedure, and to prevent residual effects after removal of the endotracheal tube.
- Trial name
- NCT05632107
- Testing
- TOF-Watch®；DELSYS® Wireless surface EMG
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Huazhong University of Science and Technology
Residual Neuromuscular Block
Neostigmine Reversal And Neuromuscular Recovery
Patients undergoing surgery often receive paralytic agents (or neuromuscular blocking agents (NMBAs)) to facilitate the procedure. At the end of surgery, the effects NMBAs are reversed with a drug called neostigmine.
- Trial name
- NCT02433808
- Testing
- Neostigmine Group, No Neostigmine group
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Perioperative/Postoperative Complications, PORC (Postoperative Residual Curarization)
A Study of Residual Curarization Incidence in China
The purpose of this study is to determine the incidence of residual curarization in PACU and relevant risk factors.
- Trial name
- NCT01690338
- Testing
- Vecuronium Bromide, Rocuronium, Cisatracurium
- Where
- 22 sites in China
- Volunteers
- 6,090 people
- Sponsor
- Peking University First Hospital
Residual Neuromuscular Blockade
Residual Neuromuscular Blockade in Pediatric Anesthesia
Residual neuromuscular blockade (RNB) is frequent and it is associated with postoperative morbidity and mortality. The incidence of the RNB in pediatric anesthesia is currently not known.
- Trial name
- REPEB (NCT02939911)
- Testing
- Residual neuromuscular blockade measurement
- Where
- Czechia
- Volunteers
- 291 people
- Sponsor
- Brno University Hospital
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis
The use of intravenous muscle relaxants during anaesthesia can significantly facilitate endotracheal intubation and reduce the chance of possible airway complications during intubation.
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
- Trial name
- NCT07080528
- Testing
- Sevofluorane, Propofol
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Tamas Vegh, MD
Residual Neuromuscular Blockade
Incidence and Severity of Residual Neuromuscular Blockade
This prospective study will take place at Harborview Medical Center (HMC) and the University of Washington Medical Center (UWMC), and will enroll adult patients undergoing abdominal surgery.
- Trial name
- NCT02660398
- Testing
- Standardized NMBD Management
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
TOF
Residual Neuromuscular Blockade and PACU Admission
Residual neuromuscular blockade (RNMB) remains an underrecognized postoperative safety concern associated with pulmonary complications, prolonged post-anesthesia care unit stay, and reduced patient satisfaction.
- Trial name
- NCT07758868
- Where
- Turkey (Türkiye)
- Volunteers
- 179 people
- Sponsor
- Ankara Etlik City Hospital