Clinical trials: Postoperative Residual Weakness
Postoperative Residual Neuromuscular Blockade
Electromyographic Monitoring and Postoperative Recovery
Residual neuromuscular blockade (weakness) is a common occurrence in the postanesthesia care unit when muscle relaxant drugs have been used in the operating room.
- Trial name
- NCT03891381
- Testing
- Tetragraph quantitative monitoring
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Postoperative Residual Curarization, Residual Neuromuscular Block
Comparison Between Cisatracurium and Rocuronium in Terms of Recovery of the Muscular Strength in the Postoperative Phase After Surgery and General Anaesthesia
The purpose of this study is to determine the incidence of post-operative residual curarization in our patients and to determine if Cisatracurium and Rocuronium behave differently from each other in terms of residual curarization.
- Trial name
- NCT01651572
- Testing
- Cisatracurium, Rocuronium
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera di Padova
Postoperative Residual Curarization, Neuromuscular Blockade
Comparison of Adductor Pollicis and Abductor Digiti Minimi Muscles (Thumb Vs. Fifth Digit) As Sites for Neuromuscular Monitoring with Electromyography
This study aims to evaluate the performance of the TetraGraph on two muscle groups: the adductor pollicis and the abductor digiti minimi. Theese muscles are located on the arms.
- Trial name
- NCT06691204
- Where
- 2 sites in Hungary
- Volunteers
- 46 people
- Sponsor
- Tamas Vegh, MD
Neuromuscular Blockade
Incidence of Incomplete Postoperative Neuromuscular Recovery From Anesthesia (P07535)(Completed)
This is a multicenter, observational study in adult participants undergoing different types of elective surgical procedures requiring general anesthesia.
- Trial name
- INSPIRE (NCT01181349)
- Testing
- Neuromuscular Blocking Agent (NMBA)
- Volunteers
- 350 people
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Blockade
Reducing the Incidence of PostOperative Residual Curarization
The NMB (Neuromuscular Blockade) is the most frequent complication in anesthesiology associated with an increase in adverse respiratory events in the postoperative period. Its appearance depends on multiple factors.
- Trial name
- PORCzero (NCT03128151)
- Testing
- Educational program for clinicians: implementation of a package of clinical prevention measures of NMB
- Where
- Spain
- Volunteers
- 2,314 people
- Sponsor
- Oscar Diaz-Cambronero
Polyneuropathies
Diagnostic Feasibility of 100 Hz Tetanic Stimulation
The goal of this observational study is to investigate the applicability of 100 Hz tetanic stimulation with an electromyography device in the exclusion of postoperative residual neuromuscular block.
- Trial name
- NCT06754995
- Where
- 2 sites in Hungary
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Debrecen
Residual Neuromuscular Blockade, Curarization, Postoperative Residual
Validation of the REPS Prediction Tool
Neuromuscular blocking agents' (NMBA) use during surgery is associated with postoperative respiratory complications and increased risk of readmission to the hospital following ambulatory surgery.
- Conditions
- Residual Neuromuscular Blockade, Curarization, Postoperative Residual, Postoperative Respiratory Complication
- Trial name
- NCT03585400
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 101,510 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
General Surgery
Sugammadex vs Placebo to Prevent Residual Neuromuscular Block
The study is designed to determine whether patients who receive sugammadex immediately after tracheal extubation will exhibit a decrease in the incidence of postoperative residual paralysis and an associated decrease in the…
- Trial name
- NCT02728726
- Testing
- Sugammadex
- Where
- 2 sites in United States
- Volunteers
- 260 people
- Sponsor
- Mayo Clinic
Residual Neuromuscular Blockade
Reversal of Neuromuscular Blockade in Thoracic Surgical Patients
The majority of patients undergoing surgery receive neuromuscular blocking agents (NMBAs) in the operating room. Reversal of neuromuscular blockade at the conclusion of a general anesthetic is accomplished with cholinesterase…
- Trial name
- NCT01837498
- Testing
- Neostigmine, Sugammadex
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Endeavor Health
Neuromuscular Blockade, Residual Neuromuscular Blockade
Neuromuscular Blockade Monitoring Using Kine-myography vs Electromyography.
This study aims to compare two monitoring methods of neuromuscular blockade - Kine-myography and Electromyography. The main questions to answer are: are electromyography and kine-myography interchangeable is electromyography…
- Trial name
- NCT05992090
- Where
- Czechia
- Volunteers
- 129 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Neuromuscular Block, Residual
Monitoring of Postoperative Residual Neuromuscular Blockade in Laparoscopic Surgery
Compare the reversal effect of neostigmine and sugammadex using quantitative neuromuscular monitoring
- Trial name
- NCT03292965
- Testing
- Neostigmine, Sugammadex
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Postoperative Residual Curarisation, Postoperative Hypoxemia
Postoperative Residual Curarisation at Arrival in the Post-anesthesia Care Unit
Several studies have documented that neuromuscular block often persists in the postanesthesia care unit (PACU). Residual paralysis is associated with postoperative complications such as hypoxia, weakness, and respiratory failure.
- Conditions
- Postoperative Residual Curarisation, Postoperative Hypoxemia, Postoperative Airway Obstruction
- Trial name
- NCT01362647
- Testing
- neuromuscular transmission monitoring, Pulse oximetry measurement
- Where
- Belgium
- Volunteers
- 625 people
- Sponsor
- Onze Lieve Vrouw Hospital
Residual Neuromuscular Blockade in Elderly Patients
The Effect of Age on the Incidence of Postoperative Residual Neuromuscular Blockade
Residual neuromuscular blockade is frequently observed in the early postoperative period when patients have received a general anesthetic with muscle relaxants.
- Trial name
- NCT01545193
- Testing
- Age and incidence of residual neuromuscular blockade
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Endeavor Health
Neuromuscular Blockade, Sugammadex
Residual Paralysis and Reversal With Routine Neostigmine Versus Half-dose Sugammadex and Routine Neostigmine
Sugammadex may prevent residual neuromuscular blockade by providing rapid reversal at the end of the operation. Our goal is to compare the half-dose use of sugammadex for reversing residual blockade after administration of…
- Conditions
- Neuromuscular Blockade, Sugammadex, Neostigmine, Complication of Anesthesia
- Trial name
- NCT05066035
- Testing
- Neostigmine, Sugammadex
- Volunteers
- 113 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Neuromuscular Blockade, Pulmonary Complication
Incidence of Residual Neuromuscular Blockade in Intra-abdominal Surgery: A Prospective, Observational Study
The aim of this prospective, observational study is to determine the incidence of post-operative residual neuromuscular blockade (PRNB) in patients undergoing intra-abdominal procedures compared to patients undergoing other…
- Trial name
- NCT02984839
- Testing
- Stimpod NMS450® Nerve Stimulator, by Xavant™ Technology
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- OhioHealth
Residual Neuromuscular Block
Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function
Residual neuromuscular blockade (NMB) after general anesthesia increases the risk of postoperative respiratory complications (atelectasis, pneumonia, re-intubation) and delays pulmonary function recovery.
- Trial name
- NCT07309393
- Testing
- Sugammadex, Neostigmine
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Chemotherapeutic Toxicity
Residual Neuromuscular Block of Rocuronium in Chemotherapy Patients Under Sevoflurane Anesthesia
Chemotherapy causes motor nerve dysfunction and degeneration that may alter the response to neuromuscular blocking drugs. To analyse the risk of residual neuromuscular block (RNMB) induced by rocuronium given in standard doses to…
- Trial name
- NCT04965532
- Testing
- sevoflurane anesthesia, Propofol Injection
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Muscle Weakness
The Impact of Quantitative Neuromuscular Monitoring in the PACU on Residual Blockade and Postoperative Recovery
Neuromuscular blocking drugs (NMBDs) provide anesthesiologists with powerful intraoperative tools, but their use carries the potential risk of serious postoperative complications.
- Trial name
- NCT01933841
- Testing
- TOF-Watch SX, Notify the provider
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Residual Curarization, Liver Transplantation
Sugammadex/Neostigmine and Liver Transplantation
Cirrhotic patients undergoing liver transplantation are at very high risk of post operative complication such as post-operative residual curarization.
- Trial name
- NCT02697929
- Testing
- sugammadex, Neostigmine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Neuromuscular Blockade
Reversal of Residual Neuromuscular Blockade at Train-of-four Ratio 0.3 With Sugammadex and Neostigmine
The aim of this study is to estimate the optimal dose of sugammadex and neostigmine reversal of a vecuronium-induced residual neuromuscular block at train-of-four ratio 0.3.
- Trial name
- NCT03656614
- Testing
- Sugammadex, Neostigmine, Saline 0.9%
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command