Clinical trials: Postoperative Respiratory Failure
Respiratory Failure, Respiratory Infection
Avoiding Neuromuscular Blockers to Reduce Complications
The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.
- Conditions
- Respiratory Failure, Respiratory Infection, Aspiration Pneumonia, Pneumonitis
- Trial name
- NCT03962725
- Testing
- Neuromuscular Blocking Agents, Anesthetic Adjuncts
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Beth Israel Deaconess Medical Center
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Cardiac Valve Disease, Coronary Artery Disease
Nasal Oxygen Therapy After Cardiac Surgery
NOTACS aims to determine if prophylactic use of high-flow nasal therapy (for a minimum of 16 hours after tracheal extubation, inclusive of up to one hour off randomised therapy for transfers around the hospital and/or physio…
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Respiratory Failure
- Trial name
- NOTACS (NCT05308719)
- Testing
- High Flow Nasal Therapy
- Where
- United Kingdom
- Volunteers
- 1,280 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Surgery, Cardiac
Incidence of Postoperative Persistent Diaphragmatic Dysfunctions in Cardiac Surgery
Postoperative respiratory complication is a common complication that occurs in 6% of patients after cardiac surgery and increases morbidity and mortality and hospital length of stay.
- Trial name
- INDYD (NCT04276844)
- Testing
- Ultrasonography using the two-dimensional (2D) mode, Respiratory Functional Explorations
- Where
- France
- Volunteers
- 157 people
- Sponsor
- CMC Ambroise Paré
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Coronary Artery Disease, Postoperative Pain
Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Rectus Sheath Block (RSB) in Cardiac Surgery
The purpose of this study is to determine if ultrasound-guided bilateral pectointercostal fascial plane blocks with bilateral rectus sheath blocks block decrease pain scores, decrease opioid consumption, improve respiratory…
- Conditions
- Coronary Artery Disease, Postoperative Pain, Respiratory Failure
- Trial name
- NCT04908449
- Testing
- Rectus sheath block with bupivacaine
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical College of Wisconsin
Diaphragmatic Paralysis, Brachial Plexus Block
Diaphragmatic Paralysis Comparison Between Local Anesthetic Volumen Doses After Interscalene Block
Arthroscopic shoulder surgery involves dynamic and severe postoperative pain. Interscalene brachial plexus block (IBPB) provides adequate analgesia but the spread of local anaesthetics administered causes a phrenic nerve block…
- Trial name
- REDOLEV-2019 (NCT04385966)
- Testing
- Interscalene brachial plexus block, Levobupivacaine Hydrochloride 2.5 MG/ML
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Postoperative Complications, Atelectasis
High-Flow Nasal Cannula After Major Abdominal Surgery to Prevent Postoperative Pulmonary Complications
Major abdominal surgery is associated with a substantial risk of early postoperative pulmonary complications, including atelectasis, hypoxemia, pneumonia, and increased need for respiratory support.
- Conditions
- Postoperative Complications, Atelectasis, Pneumonia, Respiratory Insufficiency
- Trial name
- NCT07528404
- Testing
- High flow nasal cannula (HFNC), Standard oxygen therapy
- Where
- South Korea
- Volunteers
- 580 people
- Sponsor
- Uijeongbu St. Mary Hospital
Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications
Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications
The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in…
- Conditions
- Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications, Postoperative Respiratory Failure, Postoperative Bronchospasm
- Trial name
- NCT07186933
- Testing
- PEEP titration for Minimum Driving Pressure, Lung Protective Ventilation
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University General Hospital of Patras
Surgical Procedures, Operative, Anaesthesia
POPULAR: POst-operative PULmonary Complications After Use of Muscle Relaxants in Europe
International multicenter observational study of a random-sample cohort of patients undergoing any in-hospital surgical procedure under general or regional anaesthesia during a continued 14-day period of recruitment.
- Trial name
- POPULAR (NCT01865513)
- Where
- 2 sites in Germany, Sweden
- Volunteers
- 22,000 people
- Sponsor
- European Society of Anaesthesiology
Postoperative Sore Throat, Nasal Obstruction
Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction
Postoperative sore throat (POST) affects 21-65% of patients after endotracheal intubation and is among the most common complaints after general anesthesia.
- Conditions
- Postoperative Sore Throat, Nasal Obstruction, Septoplasty
- Trial name
- POST-MUCOSAL R (NCT07870252)
- Testing
- Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube
- Where
- Saudi Arabia
- Volunteers
- 105 people
- Sponsor
- Mansoura University
Pulmonary Atelectasis, Respiratory Insufficiency
Respiratory Complications After Laparoscopic Surgery
The purpose of this study is to describe the magnitude of respiratory complications after laparoscopic hysterectomy and cholecystectomy.
- Conditions
- Pulmonary Atelectasis, Respiratory Insufficiency, Pneumonia
- Trial name
- NCT01476254
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Herlev Hospital
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
Pediatric Obstructive Sleep Apnea, Pediatric Obesity
Treating Children With Obstructive Sleep Apnea After Surgery Failure
The aim of this study is to evaluate the potential improvement of sleep quality in children who have residual obstructive sleep apnea, using either an orthodontic intervention or continuous positive airway pressure (CPAP), versus…
- Trial name
- NCT03821831
- Testing
- Continuous Positive Airway Pressure, Orthodontic intervention
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Respiratory Failure, Pneumothorax
Driving Pressure And EFL in Adult Cardiac Surgery
During general anesthesia, functional residual capacity (FRC) is reduced. If the FRC is lower than the minimum volume required to maintain the opening of the airways, there is a derecruitment of the lung parenchyma, leading to…
- Conditions
- Respiratory Failure, Pneumothorax, Atelectasis, Respiratory Infection
- Trial name
- NCT03064659
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Ospedale San Raffaele
Postoperative Respiratory Complication, Respiratory Failure
Assessment of Breathing Using an Under-bed Weighing Scale
The aim of this study is to assess the capability of a modified under bed weighing scale (contact-free unconstrained respiratory monitor, BSS) to predict postoperative pulmonary complications in high-risk surgical patients.
- Trial name
- NCT04736212
- Testing
- Bed sensor monitoring system
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity, Postoperative Respiratory Distress
NIV Prevents Post-operative Respiratory Failure After Bariatric Surgery
Postoperative non-invasive ventilation (NIV) has been proposed as an attractive strategy to reduce morbidity and improve postoperative outcomes in obese subjects undergoing general anesthesia.
- Trial name
- NCT04830475
- Testing
- Non invasive ventilation (NIV), Conventional Venturi Mask
- Where
- Italy
- Volunteers
- 107 people
- Sponsor
- University of Campania Luigi Vanvitelli
Edema, Bruising
Steroids for Rhinoplasty: Pain, Nausea, Edema and Ecchymosis
This study will be a prospective randomized study to evaluate the effect of medrol dosepaks (oral corticosteroids) on postoperative outcomes among patients undergoing rhinoplasty by Facial Plastic Surgeons at Vanderbilt.
- Conditions
- Edema, Bruising, Nasal Obstruction, Postoperative Pain
- Trial name
- NCT06483204
- Testing
- Medrol 4 MG Oral Tablet Includes Medrol Dosepak
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Anesthesia, General Anesthesia
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Postoperative Complications
- Trial name
- NCT02987985
- Testing
- Acetaminophen, gabapentin, Acetaminophen, Ketamine , Lidocaine , Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Saskatchewan
Respiratory Insufficiency, Pneumonia
Diaphragm Dysfunction and Ultrasound Perioperatively
This study aims at determining whether diaphragm ultrasound examining diaphragm thickening fraction, excursion and density before and after surgery can predict respiratory complications in the postoperative period.
- Conditions
- Respiratory Insufficiency, Pneumonia, Desaturation of Blood, Tachypnea
- Trial name
- DiaphPeriop (NCT05906030)
- Testing
- Diaphragm ultrasound
- Where
- 2 sites in Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital