Clinical trials: Postoperative Wound Infection-deep
Femur Fracture, Periprosthetic Fracture of Hip
Dose-Response Association Between Cerclage Wire Number and Infection Risk
The purpose of this dual-center retrospective study is to investigate the relationship between the number of metallic cerclage wires used in femoral fracture surgery and the risk of developing deep infections.
- Conditions
- Femur Fracture, Periprosthetic Fracture of Hip, Periprosthetic Fracture of the Femur, Surgical Site Infection (SSI)
- Trial name
- C-INFECT (NCT07434258)
- Testing
- 1 Metallic Cerclage Wiring, 2 metalic cerclage wire, 3 metalic cerclage wire
- Volunteers
- 148 people
- Sponsor
- Istanbul University
Spinal Fusion, Spinal Stenosis
Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery
Deep surgical site infection (DSSI) is one of the most challenging complications for spinal surgeons and can lead to a poor clinical outcome.
- Conditions
- Spinal Fusion, Spinal Stenosis, Spondylolisthesis
- Trial name
- NCT03883022
- Testing
- with U-VANCO (vancomycin hydrochloride), without U-VANCO (vancomycin hydrochloride)
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Postoperative Wound Infection Superficial Incisional, Postoperative Wound Infection Deep Incisional Surgical Site
Safety and Efficacy of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery.
This study is aimed to assess the anti-infective efficacy of D-PLEX over a period of 3 months post operation as well as the safety over a period of 6 months, by preventing sternal infection post cardiac surgery in patients above…
- Trial name
- NCT02731573
- Testing
- D-PLEX, Open heart surgery
- Where
- 5 sites in Israel
- Volunteers
- 81 people
- Sponsor
- PolyPid Ltd.
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if photodynamic therapy has an effect on bacterial skin colonization and decrease number of…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- PHOMIC (NCT04067843)
- Testing
- Photodynamic treatment
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Antibiotic Reaction, Wound Infection Superficial
Antibiotic Prophylaxis in Metabolic Bariatric Surgery
SUMMARY Rationale: Prophylactic antibiotics in laparoscopic surgeries, including Metabolic Bariatric Surgery (MBS), are routinely provided to reduce postoperative infections, especially at wound incision sites.
- Conditions
- Antibiotic Reaction, Wound Infection Superficial, Wound Infection Deep, Bariatric Surgery Candidate
- Trial name
- NCT06510452
- Testing
- 2000 mg of Cefazolin, 500 mg of Metronidazole IV, NACL 0.9% 100 ml
- Where
- 2 sites in Egypt, Netherlands
- Volunteers
- 3,352 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Cardiac Surgery, Bone Wax, NU-KNIT, Median Sternotomy, Deep Sternal Wound Infection, Surgical Site Infection
Surgicel NU-KNIT Vs Bone Wax on Median Sternotomy
Bone wax is traditionally used as part of surgical procedures to prevent bleeding from exposed spongy bone. It is an effective hemostatic device which creates a physical barrier.
- Trial name
- NBCS (NCT06869772)
- Testing
- Closure of sternotomy
- Where
- Qatar
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Heart Attack, Cardiac Arrest
Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys
Based on limited published epidemiological data, up to an alarming 1 in 50 surgical inpatients die within 30 postoperative days.
- Conditions
- Heart Attack, Cardiac Arrest, Congestive Heart Failure, Atrial Fibrillation
- Trial name
- SATISFY-SOS (NCT02032030)
- Where
- United States
- Volunteers
- 73,952 people
- Sponsor
- Washington University School of Medicine
Bacterial Transmission, S.Aureus Transmission
Impact of Germicidal Light
Visible light at 405nm has been shown to be germicidal. The hypothesis is that use of this light (Indigo-Clean Lights) in operating rooms will reduce S.
- Conditions
- Bacterial Transmission, S.Aureus Transmission, Operating Room Exposure to S. Aureus, 90-day Postoperative Surgical Site Infections, Superficial and Deep
- Trial name
- NCT03886337
- Testing
- Germicidal lighting
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Iowa
Cava-pulmonary Anastomosis
Surgical Site Infection Study
The purpose of this study is to investigate the pharmacokinetics of cefazolin using both plasma and microdialysate sampling methods in children with single ventricle physiology undergoing their second palliation procedure.
- Trial name
- SSI (NCT01449669)
- Volunteers
- 14 people
- Sponsor
- Children's Hospital of Philadelphia
Postoperative Wound Infection Superficial Incisional, Postoperative Wound Infection Deep Incisional Surgical Site
Is the NPWTi Better Than the Conventional NPWT
The goal of this clinical trial is to compare the effectiveness of NPWTi and NPWT in superficial and deep surgical site infections using an improvised system with continuous lavage with saline and chlorhexidine.
- Trial name
- NCT06014788
- Testing
- NPWTi, Conventional NPWT
- Where
- Bulgaria
- Volunteers
- 100 people
- Sponsor
- Military Medical Academy, Bulgaria
Vancomycin, Implantable Neural Stimulator
Intrawound Vancomycin Prophylaxis for Neural Stimulator
The implantable pulse generator (IPG) is a device that generates electrical current to stimulate the spine, heart, or brain for various chronic conditions.
- Conditions
- Vancomycin, Implantable Neural Stimulator, Deep Brain Stimulation, Surgical Site Infection
- Trial name
- IV-DIRT (NCT03221023)
- Testing
- Vancomycin Hydrochloride, Saline Solution
- Where
- Canada
- Volunteers
- 900 people
- Sponsor
- University of British Columbia
Surgical Wound Infections
Prevention of Neurosurgical Wound Infections
The goal of this study is to determine whether injecting the antibiotic vancomycin directly into surgical wounds can decrease the rate of infection following implantation of neurosurgical devices.
- Trial name
- POWI (NCT00915967)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- Oregon Health and Science University
Postoperative Complications, Postoperative Wound Infection
Influence of Deep Versus Moderate Neuromuscular Blockade During General Anesthesia on 30-day Readmission Rates
Deep neuromuscular block (NMB) has shown to produce superior surgical conditions during various abdominal and non abdominal surgeries.
- Conditions
- Postoperative Complications, Postoperative Wound Infection, Pneumonia
- Trial name
- NCT03174223
- Testing
- deep neuromuscular block
- Where
- Netherlands
- Volunteers
- 460 people
- Sponsor
- Leiden University Medical Center
Complicated Appendicitis, Acute Appendicitis
Antibiotic Instillation in Appendicitis
Appendicitis (inflammation of the wall of the appendix, causing pain and tenderness in the abdomen) has a range of severity that goes from simple to complicated.
- Trial name
- NCT05470517
- Testing
- Ceftriaxone, Intra-peritoneal Fluid Aspiration
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Johns Hopkins All Children's Hospital
Deep Surgical Site Infection, Spine Surgery
Risk Factors Associated With Infection After Spine Surgery
Surgical site infection (SSI), particularly deep SSI, is one of the most serious complications after spinal surgery. evaluating the risk of SSI and, correspondingly, prescription of prophylactic measures are extremely important…
- Trial name
- NCT05740865
- Testing
- open posterior instrumented thoracolumbar surgery
- Where
- China
- Volunteers
- 3,419 people
- Sponsor
- Xuanwu Hospital, Beijing
Postoperative Wound Infection-deep, Post Operative Wound Infection
A Phase I/II Double-Blind, Randomized, Controlled Study to Evaluate the Safety and Efficacy of RUT058-60
This is a double-blind, randomized, parallel-group, controlled, multi-center study to evaluate the safety and efficacy of RUT058-60 (Group A) as an intra-cavity lavage compared to sterile saline (Group B) in adult subjects…
- Trial name
- NCT02280395
- Testing
- RUT058-60, Sterile saline for irrigation
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Pulmatrix Inc.
Wound Infections
Cubicin(R) for Complicated Post-surgical Wound Infections
The purpose of the study is to describe the clinical efficacy of CUBICIN therapy in patients with superficial and deep post-surgical Gram-positive wound infections
- Trial name
- PSW (NCT00651131)
- Testing
- daptomycin
- Volunteers
- 69 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Prosthesis and Implants, Surgical Site Infection
Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-III)
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if PDT has an effect on bacterial skin colonization in order to improve skin antisepsis…
- Conditions
- Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection, Postoperative Wound Infection Deep Incisional Surgical Site
- Trial name
- NCT05676801
- Testing
- Photodynamic Therapy
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Surgical Site Infection (SSI), Mediastinitis
Use of Platelet-Rich Plasma to Reduce Sternal Wound Complications After CABG With Median Sternotomy
The goal of this clinical trial is to learn whether applying autologous platelet-rich plasma (PRP) to the sternal wound during heart surgery improves wound healing and reduces complications after surgery.
- Conditions
- Surgical Site Infection (SSI), Mediastinitis, Delayed Wound Healing
- Trial name
- NCT07352020
- Testing
- Autologous Platelet-Rich Plasma (PRP) Application, Standard Sternal Wound Closure
- Where
- Pakistan
- Volunteers
- 98 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Surgical Site Infection
AI Algorithm for Surveillance of Deep Surgical Site Infections After Elective Colorectal Surgery.
Epidemiological surveillance is one of the eight core components of the World Health Organization Infection Prevention and Control Programmes. These include surveillance programmes for surgical site infection (SSI).
- Trial name
- Infect-IA-2 (NCT07130656)
- Testing
- Diagnosis of SSI
- Where
- Spain
- Volunteers
- 1,200 people
- Sponsor
- Hospital de Granollers