Clinical trials: Postpartum Bleeding
Postpartum Hemorrhage, Cesarean Section Complications
Tranexamic Acid in Patients for Caesarian Delivery.
This is a prospective, double-blinded, randomized placebo-controlled trial. The study will be approved by the DUHS institutional review board (IRB) and the trial will be registered at clinical trial registry.
- Conditions
- Postpartum Hemorrhage, Cesarean Section Complications, Obstetric Anesthesia Problems
- Trial name
- TXA; CD (NCT05759156)
- Testing
- Tranexamic acid injection
- Where
- Pakistan
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Postpartum Hemorrhage, Postsurgical Bleeding
Abdominal Ultrasound Assessment in the Post-cesarean Patient
This study is designed to see if abdominal ultrasound after planned cesarean delivery can identify women with ongoing intra-abdominal bleeding.
- Conditions
- Postpartum Hemorrhage, Postsurgical Bleeding, Abdominal Ultrasound, FAST Scan
- Trial name
- NCT02159105
- Testing
- FAST scan and non-invasive hemoglobin measurement
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Postpartum Hemorrhage
Amr's Maneuver and Postpartum Hemorrhage
The impacts of using Amr's manoeuvre (cervical traction) on atonic postpartum hemorrhage is a randomized controlled, multi-centre study that aims to compare the incidence of post partum hemorrhage (PPH> 500 ml blood loss) within…
- Trial name
- NCT02660567
- Testing
- Amr maneuver
- Where
- Egypt
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- ClinAmygate
Obstetric and Perinatal Complications, Postpartum Hemorrhage
A Skills and Drills Intervention for Emergency Obstetrics and Neonatal Care at First Referral Units of North Karnataka
To evaluate the effectiveness of a First Referral Unit (FRU) Emergency Obstetric and Newborn Care (EmONC) skills and drills intervention, to estimate the appropriateness and effectiveness of referrals in intervention arm compared…
- Conditions
- Obstetric and Perinatal Complications, Postpartum Hemorrhage, Preeclampsia/Eclampsia, Obstructed/Prolonged Labor
- Trial name
- NCT01865656
- Testing
- Skills training, Emergency obstetric drills, Revised Case Sheets
- Volunteers
- 15,018 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Postpartum Hemorrhage, Vaginal Delivery
Prophylactic Tranexamic Acid Use After Vaginal Delivery
In this study, our aim was to evaluate the effectiveness of prophylactic tranexamic acid use after vaginal delivery in pregnant women aged 18-45 years and 34-42 weeks according to the risk of postpartum hemorrhage.
- Conditions
- Postpartum Hemorrhage, Vaginal Delivery, Prophylactic Tranexamic Acid Use
- Trial name
- NCT05429580
- Testing
- Tranexamic acid, 5% Dextrose
- Where
- Turkey (Türkiye)
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Primary Postpartum Haemorrhage
Comparative Study on the Effects of Sublingual Misoprostol in Addition to Standard AMTSL in Low Risk Parturients in LASUTH, Ikeja.
Postpartum haemorrhage is the leading cause of maternal haemorrhage globally. With active management of labour 3 to 16.5% of parturients still experience postpartum haemorrhage.
- Trial name
- NCT02424201
- Testing
- Misoprostol, vitamin c
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Lagos State University
Postpartum Hemorrhage
Oxytocin Maintenance Infusion in Labouring Women Undergoing Cesarean Delivery: an Up-down Sequential Allocation Study
This study is designed to determine the minimal effective oxytocin maintenance infusion required in labouring women undergoing cesarean delivery to achieve the best effect.
- Trial name
- NCT05290129
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Post Partum Hemorrhage
Prevention of Postpartum Hemorrhage With Tranexamic Acid
In part 1 of the study, the investigators conducted a prospective, open-label, dose finding pharmacokinetic (PK) study in 43 pregnant 3rd trimester women scheduled for non-emergent cesarean section.
- Trial name
- Optimum OB-TXA (NCT05370820)
- Testing
- Tranexamic acid, No intervention
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Postpartum Hemorrhage
The Effect of Game-Based Learning and Telesimulation on Nursing Students' Management of Postpartum Hemorrhage
This study was conducted to evaluate the effects of Kahoot and telesimulation methods on the knowledge, skills, motivation and clinical performance of nursing students in the management of postpartum hemorrhage and to examine the…
- Trial name
- NCT05323903
- Testing
- Telesimulation, Kahoot Game
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Postpartum Hemorrhage
The Relaxant Effect of Nitroglycerin on Oxytocin Desensitized Human Myometrium
Oxytocin causes myometrial contraction via the oxytocin receptor (OTR). Desensitization of the OTR after exposure to oxytocin has been demonstrated in previous studies.
- Trial name
- NCT03408054
- Testing
- Oxytocin, Nitroglycerin
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Misoprostol Allergy
Pre Versus Post-operative Misoprostol in Reducing Blood Loss After Cesarean Section
Cesarean section is the most common performed major surgical interventions among women all over the world.Cesarean section has many serious complications, including primary postpartum hemorrhage (PPH).
- Trial name
- NCT05928871
- Testing
- Misoprostol 200mcg Tab, Misoprostol Pill
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hemorrhage, Postpartum, Hemorrhage
A Pilot Study to Assess the Feasibility and Tolerability of the AccuFlow Perfusion Sensor for Intrapartum Hemorrhage
Obstetric hemorrhage is one of the leading causes of maternal death worldwide. One of the challenges in management of hemorrhage is that young, healthy women compensate for blood loss via peripheral vasoconstriction, so they…
- Conditions
- Hemorrhage, Postpartum, Hemorrhage, Vasoconstriction
- Trial name
- NCT04370639
- Testing
- AccuFlow sensor, Survey
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Megan Lord
Skin to Skin Contact
The Effect of Skin to Skin Contact on Postpartum Hemorrhage, Pain And Breastfeeding
The aim of this study was to determine the effect of postpartum hemorrhage, pain and onset of early breastfeeding so that the skin applied at the third stage of birth is in contact with the skin.
- Trial name
- NCT04425096
- Testing
- Skin to skin contact
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Postpartum Hemorrhage
Carbetocin at Cesarean Delivery for Labor Arrest
In 2009, the Society of Obstetricians and Gynecologists Canada, which produces national clinical guidelines on important women's health issues, recommended that a bolus of carbetocin 100 mcg into your vein should be used at…
- Trial name
- NCT01725243
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Analgesia, Obstetrical, Postpartum Hemorrhage
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
In this randomized, double-blind control trial to evaluate the effect of ketorolac given at the time of cord clamp has on estimated blood loss and postcesarean pain control.
- Conditions
- Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT02509312
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Postpartum Hemorrhage, Twin
Carbetocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With Twin Pregnancy.
Poor uterine tone after the birth of a baby can cause excess bleeding (called postpartum hemorrhage or PPH). This is a major cause of maternal death worldwide.
- Trial name
- NCT04182360
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Bloodloss in Pregnancy
Evaluation of Peripartum Blood Loss and Postpartum Anaemia in Macrosomia & Gemini
Anaemia in pregnant women occurs at a haemoglobin (Hb) concentration <11 g/dL and treatment is essential to prevent increased maternal morbidity, fetal morbidity and mortality.
- Trial name
- NCT06201910
- Testing
- Observation of Blood loss
- Where
- 2 sites in Germany
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Goethe University
Bilateral Iliac Artery Ligation, Postpartum Hemorrhage
Influence of BIIAL Following PPH on Dorsal Clitoral Artery Blood Flow and FSFI
Dorsal clitoral artery Doppler examinations in women with bilateral internal iliac artery ligation due to postpartum hemorrhage (study group) and age-matched healthy puerperal women were performed regularly in the postoperative…
- Trial name
- NCT02409602
- Testing
- Doppler ultrasonographic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
PPH
Postpartum Hemorrhage Reduction With Oral Tranexamic Acid: a Clinical Trial
This is a multicentre randomized placebo-controlled double-blinded phase IV study among 1000 women in Sweden and South Africa on the effect of oral tranexamic acid on PPH after vaginal delivery.
- Trial name
- PROTECT (NCT06025916)
- Testing
- Tranexamic acid
- Where
- Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Healthy Participants
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Tranexamic acid is a well-established treatment for post-partum hemorrhage. This study aims to examine the effect of tranexamic acid administration rates on blood pressure changes over 1 minute compared to 10 minutes in healthy…
- Trial name
- RateTXA (NCT06356948)
- Testing
- Tranexamic Acid (TXA)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia