Clinical trials: Postpartum Bleeding, open to volunteers
Post Partum Hemorrhage
Prophylactic Regimen of Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative for Primary Prevention of Postpartum Hemorrhage in Intrapartum Cesarean Section Versus Intravenous Carbetocin Alone
While Carbetocin is effective in reducing PPH, the combination of oxytocin, Tranexamic acid, and Ergot derivatives may offer additional benefits in high-risk populations.
- Trial name
- NCT07318467
- Testing
- Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative, Intravenous Carbetocin alone
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postpartum Hemorrhage
Oxytocin Maintenance Infusion in Labouring Women Undergoing Cesarean Delivery: an Up-down Sequential Allocation Study
This study is designed to determine the minimal effective oxytocin maintenance infusion required in labouring women undergoing cesarean delivery to achieve the best effect.
- Trial name
- NCT05290129
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section
Cesarean section (CS) is one of the most frequently performed operative interventions worldwide [1]. Cesarean section rates increase each year throughout the world.
- Trial name
- NCT06765473
- Testing
- Misoprostol
- Volunteers
- 400 people
- Sponsor
- Assiut University
Delayed and Secondary Postpartum Hemorrhage
Immediate vs Delayed Postpartum Implanon-NXT
This prospective observational cohort study aims to compare immediate postpartum insertion (within 72 hours after delivery) versus delayed insertion (4-6 weeks postpartum) of the etonogestrel subdermal implant (Implanon-NXT®️)…
- Trial name
- NCT07626502
- Testing
- Etonogestrel subdermal implant (Implanon-NXT®)
- Volunteers
- 90 people
- Sponsor
- Assiut University
Postpartum Hemorrhage, Uterine Atony
Oxytocin Bolus Versus Infusion in High-Risk Patients Undergoing Elective Cesarean Section (INBOX-HR)
The goal of this randomized, double-blind clinical trial is to learn if Oxytocin is most effective at achieving adequate uterine tone (important for preventing postpartum hemorrhage) when administered as a bolus or an infusion in…
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Uterine Atony With Hemorrhage, Elective Cesarean Section
- Trial name
- INBOX-HR (NCT07688512)
- Testing
- Oxytocin Bolus or Oxytocin Infusion
- Volunteers
- 180 people
- Sponsor
- Stony Brook University
Postpartum Hemorrhage, Twin Pregnancy
Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage
The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies.
- Trial name
- CUTT-PPH (NCT07401524)
- Testing
- Carbetocin, Oxytocin
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Postpartum Hemorrhage
TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA
Several randomized, controlled trials, mostly involving women undergoing cesarean delivery, have shown that the prophylactic intravenous administration of 1 g of tranexamic acid after childbirth reduced blood loss.
- Trial name
- TRAAPrevia (NCT04304625)
- Testing
- Tranexamic Acid / Sodium chloride
- Where
- France
- Volunteers
- 1,380 people
- Sponsor
- University Hospital, Bordeaux
Post Partum Hemorrhage
Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery
The goal of this study is to compare 2 medications that are commonly used to prevent excess uterine bleeding (postpartum hemorrhage, or PPH) following cesarean delivery (CD), oxytocin and carbetocin.
- Trial name
- NCT06333340
- Testing
- Oxytocin, Carbetocin
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Post Partum Hemorrhage
Prevention of Postpartum Hemorrhage With Tranexamic Acid
In part 1 of the study, the investigators conducted a prospective, open-label, dose finding pharmacokinetic (PK) study in 43 pregnant 3rd trimester women scheduled for non-emergent cesarean section.
- Trial name
- Optimum OB-TXA (NCT05370820)
- Testing
- Tranexamic acid, No intervention
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Postpartum Hemorrhage, Maternal Death
Novel Vacuum-Induced Hemorrhage Control for Postpartum Hemorrhage
This will be the first, definitive, randomized control trial (N=424) to test the hypothesis that the Jada® System is effective, safe and cost-effective in treating PPH, compared to standard care.
- Trial name
- NOVIC (NCT05382403)
- Testing
- Jada® System, Standard care
- Where
- 2 sites in Ghana
- Volunteers
- 424 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Cesarean Delivery, Postpartum Hemorrhage (PPH)
Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo.
- Conditions
- Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
- Trial name
- NCT07362992
- Testing
- Tranexamic Acid (Topical)
- Where
- 4 sites in Israel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Postpartum Hemorrhage
The Effect of Placental Cord Drainage on the Third Stage of Labor and the Amount of Postpartum Bleeding
The aim of the study was to evaluate the effect of controlled placental cord drainage by opening the clamp at the maternal end after the umbilical cord is cut during birth on the duration of the third stage of labor (departure of…
- Trial name
- NCT07279545
- Testing
- Placental cord drainage
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Postpartum Hemorrhage, Coagulation Disorder
SWIFT - SWIss Factor XIII Trial in PPH
The goal of this trial is to determine if postpartum blood loss can be reduced by replenishing coagulation factor XIII (FXIII) at an early stage of postpartum hemorrhage (PPH).
- Conditions
- Postpartum Hemorrhage, Coagulation Disorder, Coagulation Factor Deficiency, Hemorrhage
- Trial name
- SWIFT (NCT06481995)
- Testing
- Fibrogammin
- Where
- 9 sites in Switzerland
- Volunteers
- 988 people
- Sponsor
- Christian Haslinger
Post Partum Hemorrhage, Cesarean Section Complications
Oxytocin Pharmacokinetics and Pharmacodynamics
Oxytocin is the first-line drug to promote contraction of the uterus and prevent atony immediately after delivery. Nonetheless, unpredictable uterine atony refractory to oxytocin affects roughly 250,000 parturients annually in…
- Conditions
- Post Partum Hemorrhage, Cesarean Section Complications, Blood Loss
- Trial name
- NCT05488457
- Testing
- deuterated oxytocin (d5OT)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Hemorrhage Management Training, Gamification in Health Education
Web-Based Gamification in Postpartum Hemorrhage Management Education Among Midwifery Students
This study was designed to compare the effects of web-based gamification and online classical teaching methods on knowledge level, motivation toward instructional materials, clinical self-efficacy, and satisfaction in midwifery…
- Trial name
- NCT07688122
- Testing
- Web-Based Gamification Education, Online Classical Education
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Mersin University
Postpartum Hemorrhage
Efficacy of Balloon Tamponade in Post-partum Hemorrhage Within 24 Hours After Delivery
Postpartum hemorrhage (PPH) is a major cause of maternal death, especially in developing countries like Pakistan where it accounts for up to 34% of maternal deaths.
- Trial name
- BT-PPH (NCT07845240)
- Testing
- Intrauterine Balloon Tamponade - Condom Catheter
- Where
- Pakistan
- Volunteers
- 121 people
- Sponsor
- Aziz Fatimah Medical & Dental College, Faisalabad
Game-based Education
Effect of Postpartum Hemorrhage Management Education Given With Kahoot Method on Knowledge, Self-Confidence in Intervention and Motivation Levels of Midwifery Students
This study was planned to investigate the effect of postpartum hemorrhage management training given with the Kahoot method on the knowledge, self-confidence in intervention and motivation levels of midwifery students.
- Trial name
- NCT06897371
- Testing
- Games-based education
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Midwifery Student
The Effect of Gamification-Based Instructional Design Developed
Turkish) Abstract: Purpose: Considering the importance of postpartum hemorrhage management in reducing preventable maternal deaths and the key role midwives play in providing this care, it is important to increase the knowledge…
- Trial name
- PPH-GamEd (NCT07207590)
- Testing
- web-based gamification application, control group: traditional classroom learning techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Pregnancy Related, Post Partum Hemorrhage
Postpartum Ultrasound Evaluation to Assess Risk of Hemorrhage
Up to 5% of patients in the United States have a postpartum hemorrhage. "Postpartum hemorrhage" means excessive bleeding after delivery. The majority of these bleeds occur immediately with delivery.
- Trial name
- NCT06898034
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 1,725 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Thrombocytopenia, Postpartum Haemorrhage (PPH)
Prediction of Platelet Function Using Viscoelastic Test (ROTEM® Sigma) in Obstetric Anesthesia.
This prospective observational, non-interventional, single-center study aims to evaluate whether the viscoelastic parameter PLTEM, derived from ROTEM® sigma testing (EXTEM-A5 minus FIBTEM-A5), can accurately estimate platelet…
- Trial name
- NCT07616349
- Testing
- No Intervention: Observational Cohort
- Where
- Spain
- Volunteers
- 85 people
- Sponsor
- Nicolas Brogly