Clinical trials: Postpartum Bleeding
Postpartum Haemorrhage
World Maternal Antifibrinolytic Trial
The WOMAN trial is a large pragmatic randomised double-blind, placebo controlled trial to quantify the effects of the early administration of tranexamic acid on death, hysterectomy and other relevant outcomes.
- Trial name
- WOMAN (NCT00872469)
- Testing
- Tranexamic acid
- Where
- Nigeria
- Volunteers
- 20,060 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Postpartum Hemorrhage
Double Simultaneous Uterotonic Agents Versus Single Agent Regimen to Prevent Early Postpartum Hemorrhage
To determine the effectiveness of using two medications simultaneously versus one medication, as is standard of care, in preventing early postpartum hemorrhage.
- Trial name
- NCT05245227
- Testing
- Sublingual Misoprostol, IV Oxytocin
- Where
- United States
- Volunteers
- 1,358 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Puerperal Sepsis, Postpartum Hemorrhage
Assessing Childbirth-related Complications at the Community Level in Kenya
Kenya is one of the countries in sub-Saharan Africa that still experience high maternal mortality. For instance, in 2008/09 maternal mortality ratio was estimated to be 488/100,000 live births.
- Conditions
- Puerperal Sepsis, Postpartum Hemorrhage, Preeclampsia and Eclampsia, Retained Placenta, Without Hemorrhage
- Trial name
- NCT01665456
- Where
- Kenya
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- Wilson Liambila
Postpartum Hemorrhage (Primary)
Carbetocin Versus Oxytocin for the Prevention of Postpartum Hemorrhage in Emergency Caesarean Delivery
Postpartum haemorrhage keeps to be the leading cause of maternal mortality in middle and low-income countries, including Iraq. Much advancement had been made in the field of treatment for postpartum haemorrhage but no much…
- Trial name
- NCT03755531
- Testing
- Carbetocin, Oxytocin
- Where
- Iraq
- Volunteers
- 300 people
- Sponsor
- Al-Kindy College of Medicine
Teaching Innovation, Midwifery Students Education
Flipped Learning in PPH Education: Impact on Midwifery Students' Knowledge, Skills, Self-Efficacy, and Satisfaction
Maternal death refers to a woman's death due to direct or indirect causes during pregnancy, childbirth, or within 42 days postpartum.
- Conditions
- Teaching Innovation, Midwifery Students Education, Postpartum Hemorrhage, Flipped Classroom Model in Teaching
- Trial name
- NCT06861296
- Testing
- Intervention Group
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Primary Postpartum Hemorrhage, Administration of Sulprostone
Vacuum Device for Hemostasis in Obstetrics and Gynecology
Postpartum hemorrhage (PPH), is the leading cause of maternal mortality and is responsible for approximately 25% of maternal mortality deaths.It is defined as blood loss in excess of 500 ml following vaginal childbirth.
- Conditions
- Primary Postpartum Hemorrhage, Administration of Sulprostone, Vaginal Childbirth
- Trial name
- HEMOGYN2 (NCT02816203)
- Testing
- Hemostatic Intra-Uterine suction cup
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Postpartum Hemorrhage, Uterine Atony
Does Intramyometrial Oxytocin Improve Outcome in Elective Cesarean Delivery?
Oxytocin use has become routine practice in elective cesarean delivery to promote uterine contraction and reduce blood loss. However, there is a lack of consensus regarding the best dose of oxytocin and the most effective route…
- Trial name
- NCT01252342
- Testing
- Oxytocin, Saline
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Uterine Atony, Postpartum Hemorrhage
Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT
This is a double-blind 3-arm randomized clinical trial to determine whether higher dose oxytocin regimens (compared to the standard regimen) reduce the frequency of uterine atony and postpartum hemorrhage after vaginal delivery.
- Trial name
- NCT00790062
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 1,798 people
- Sponsor
- University of Alabama at Birmingham
Postpartum Hemorrhage
Buccal Misoprostol Versus IV Oxytocin in Prevention of Postpartum Hemorrhage
Cesarean delivery is defined as fetal birth through incisions in the abdominal wall and the uterine wall (hysterotomy). This definition does not include removal of the fetus from the abdominal cavity in the case of uterine…
- Trial name
- NCT03676621
- Testing
- Misoprostol, Oxytocin
- Where
- Egypt
- Volunteers
- 154 people
- Sponsor
- Assiut University
Post Partum Hemorrhage
Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage
Post partum Hemorrhage (PPH) is one of three main causes of death in pregnant women. Oxytocin is widely used for prevention of PPH. Some studies suggested misoprostol as an alternative treatment when Oxytocin isn't available.
- Trial name
- NCT01863706
- Testing
- Misoprostol, Oxytocin
- Where
- Iran
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hormozgan University of Medical Sciences
Postpartum Hemorrhage, Twin
Carbetocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With Twin Pregnancy.
Poor uterine tone after the birth of a baby can cause excess bleeding (called postpartum hemorrhage or PPH). This is a major cause of maternal death worldwide.
- Trial name
- NCT04182360
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage, Immediate
Minimum Effective Duration of Intrauterine Balloon Tamponade for the Management of Postpartum Hemorrhage
Intrauterine balloon tamponade (IUBT) is recommended worldwide as the second-line therapy to treat postpartum hemorrhage. While much literature demonstrates the effectiveness of this therapy, little is known about how long the…
- Trial name
- NCT04467996
- Testing
- Intrauterine balloon tamponade
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Denver Health and Hospital Authority
Postpartum Hemorrhage
Prevention of Postpartum Haemorrhage With Sublingual Misoprostol or Oxytocin
Sublingual misoprostol produces rapid peak concentration and is more effective than oral misoprostol for prevention of excessive postpartum bleeding.
- Trial name
- NCT01373359
- Testing
- Misoprostol, Oxytocin
- Where
- India
- Volunteers
- 652 people
- Sponsor
- Jawaharlal Nehru Medical College
Anemia
Safety of FCM vs. Standard of Care in Treating Iron Deficiency Anemia in Heavy Uterine Bleeding and Post Partum Patients
The Objective of this study is to study the safety of FCM in patients with anemia caused by Heavy Uterine Bleeding and the Post Partum state.
- Trial name
- NCT00548860
- Testing
- Ferric Carboxymaltose, Standard Medical Care (SMC)
- Where
- United States
- Volunteers
- 2,018 people
- Sponsor
- American Regent, Inc.
Postpartum Hemorrhage
The Use of the Bakri Postpartum Balloon in the Management of Postpartum Hemorrhage Refractory to Conservative Measures
The broad objective of the study is to determine if the Bakri Postpartum Balloon is effective in preventing morbidity and mortality from postpartum hemorrhage (PPH) as part of a standardized management algorithm.
- Trial name
- NCT01844089
- Where
- 2 sites in Kenya
- Volunteers
- 57 people
- Sponsor
- Duke University