Clinical trials: Postpartum Pregnancy-Induced Hypertension
Hypertension in Pregnancy
STAMPP-HTN in a High-risk Rural Population of Women
The purpose of this study is to determine if monitored blood pressure paired with education reduces maternal mortality and morbidity during the post-partum period in a high-risk rural population of women.
- Trial name
- NCT04570124
- Testing
- Home Blood Pressure Telemonitoring
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Mississippi Medical Center
Hypertension in Pregnancy, Hypertension, Pregnancy-Induced
Innovation in Postpartum Care for Women With Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy (HDP) affect up to 10% of mother-infant dyads and account for 7.4% of cases of maternal mortality in the United States.
- Conditions
- Hypertension in Pregnancy, Hypertension, Pregnancy-Induced, Postpartum Preeclampsia, Blood Pressure Disorders
- Trial name
- NCT03613714
- Testing
- At-home Blood Pressure Monitoring
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Preeclampsia
Hypertonic Saline Use in Preeclampsia
To compare hypertonic saline to Lactated Ringer's solution and assess whether one speeds up the process of getting rid of extra body water faster in women with preeclampsia.
- Trial name
- NCT00181077
- Testing
- 2% buffered hypertonic saline administration
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Preeclampsia Postpartum
Aspirin for Postpartum Patients With Preeclampsia
The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth.
- Trial name
- ASAPP (NCT05924971)
- Testing
- Aspirin 81Mg Ec Tab
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- MemorialCare Health System
Hypertension, Preeclampsia
A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia
This is an open-label, randomized feasibility trial in which patients admitted to Oregon Health \& Science University (OHSU) after a pregnancy complicated by preeclampsia who are considering a progestin-only pill contraception…
- Trial name
- NCT07293728
- Testing
- Norethindrone 0.35 MG, Drospirenone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Pre-eclampsia
Disease Modification in Toxaemia of Pregnancy
Short description of the primary purpose of the protocol intended for the lay public. Include brief statement of study hypothesis Pre-eclampsia (toxemia of pregnancy) is the most cause of death among pregnant women in North…
- Trial name
- NCT00175695
- Testing
- Recombinant human activated protein C or drotrecogin alpha
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Hypertension, Pregnancy-Induced
Postpartum Hypertension: Remote Patient Monitoring
The purpose of this study is to see if Honeywell Genesis Android Touch Bluetooth System (mobile health) can improve patient satisfaction and quality of care provided to women experiencing complications due to high blood pressure…
- Trial name
- NCT03111095
- Testing
- Mobile Health
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- University of Wisconsin, Madison
Patient Satisfaction
Patient Satisfaction With Abbreviated Postpartum Magnesium Sulfate for Severe Preeclampsia
Preeclampsia is a common and potentially devastating disease that affects only pregnant or postpartum patients. It is a leading cause of maternal mortality not only worldwide, but in the United States as well.
- Trial name
- NCT05789381
- Testing
- Magnesium sulfate
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Preeclampsia, Gestational Hypertension
Postpartum NSAIDS and Maternal Hypertension
Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the postpartum period.
- Conditions
- Preeclampsia, Gestational Hypertension, Superimposed Preeclampsia, Chronic Hypertension in Obstetric Context
- Trial name
- NCT03824119
- Testing
- Ibuprofen 600 mg, Standard Postpartum Care without NSAIDs
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Hypertension in Pregnancy, Postpartum Preeclampsia
Rhode Island - Statewide Postpartum Hypertension Remote Surveillance
This is a hybrid type 1 non-inferiority implementation effectiveness trial among postpartum patients with hypertension (N=1536) that will test the hypothesis that RI-SPHERES (a technologically enabled collaborative care model) is…
- Conditions
- Hypertension in Pregnancy, Postpartum Preeclampsia, Postpartum Complication
- Trial name
- RI-SPHERES (NCT06842875)
- Testing
- RI-SPHERES, Standard self-measured blood pressure program
- Where
- 5 sites in United States
- Volunteers
- 1,536 people
- Sponsor
- Women and Infants Hospital of Rhode Island
PPH - Postpartum Hemorrhage, Eclampsia
Comparing Simulated Patients and Manikin Based Simulation in Obstetrics
The aim of this randomized study is to compare a live, trained simulated patient with a high-fidelity manikin in obstetric emergency team training using two standardized scenarios.
- Trial name
- NCT07857551
- Testing
- Trained, standardized patient, MamaAnne Patient Simulator
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Gestational Diabetes Mellitus, Hypertension in Pregnancy
Supporting Transitions to Primary Care Among Under-resourced, Postpartum Women (STEP-UP)
STEP-UP will promote linkage to primary care and ongoing chronic disease evaluation for postpartum women with prior gestational diabetes mellitus (GDM) and/or hypertensive disorders of pregnancy (HDP).
- Conditions
- Gestational Diabetes Mellitus, Hypertension in Pregnancy, Dysglycemia
- Trial name
- NCT05852054
- Testing
- OB Provider Clinical Decision Support (CDS), Patient Education (OB Visit), Text messaging
- Where
- 2 sites in United States
- Volunteers
- 2,306 people
- Sponsor
- Northwestern University
Preeclampsia, Hypertensive Disorder of Pregnancy
Cardiovascular Protection After Preeclampsia With Enalapril
The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.
- Conditions
- Preeclampsia, Hypertensive Disorder of Pregnancy, Hypertension, Gestational Hypertension
- Trial name
- CAPP-E (NCT07222852)
- Testing
- Enalapril, Standard treatment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Hypertension, Hypertension in Pregnancy
Bridging the Gap From Postpartum to Primary Care
Chronic health conditions affect most older adults. Preventative medicine and risk management strategies, especially when applied earlier in life, are essential to altering the trajectory of a disease and ultimately improving…
- Conditions
- Hypertension, Hypertension in Pregnancy, Diabetes Mellitus, Gestational Diabetes
- Trial name
- NCT05543265
- Testing
- Default appointment scheduling, Targeted messaging, Nudge Reminders
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Massachusetts General Hospital
Severe Preeclampsia
Furosemide vs Placebo in Severe Preeclampsia Postpartum
This randomized, double-blind, placebo-controlled trial evaluates whether oral furosemide 40 mg, initiated 12 hours postpartum, reduces hospital length of stay compared to placebo (folic acid 5 mg) in postpartum women with severe…
- Trial name
- FUROPE (NCT07648251)
- Testing
- Furosemide, Folic Acid 5 MG
- Where
- Honduras
- Volunteers
- 186 people
- Sponsor
- Universidad Nacional Autonoma de Honduras
Preeclampsia
ToRsemide for pOstpartum HYpertension
Currently there is no intervention to prevent persistent postpartum hypertension in preeclamptic women. Physiologically, the use of a pharmacokinetically predictable loop-diuretic is a reasonable intervention to increase…
- Trial name
- TROPHY (NCT02813551)
- Testing
- Torsemide
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Hypertensive Disorder of Pregnancy, Pre-Eclampsia
Optimal Blood Pressure Treatment Thresholds Postpartum
The objective of this research project is to conduct a single-site pilot trial within our institution's clinical remote blood pressures (BP) management program to assess the feasibility and effect of tight blood pressure control…
- Conditions
- Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia
- Trial name
- NCT06069102
- Testing
- Usual care, Tight blood pressure control
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Alisse Hauspurg
Preeclampsia, Preeclampsia Severe
Preeclampsia Educational Program Study (PrEPS)
Preeclampsia complicates approximately 8% of all pregnancies. A critical factor of outpatient monitoring is patient education; specifically, education regarding nature of the disease, ongoing short- and long-term risks, and…
- Conditions
- Preeclampsia, Preeclampsia Severe, Preeclampsia Mild, Preeclampsia Postpartum
- Trial name
- PrEPS (NCT06373367)
- Testing
- Illustration based application, Text based application
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- MemorialCare Health System
Hypertension in Pregnancy, Hypertension in Postpartum
Is Procardia XL 60 mg Q Daily Equivalent to 30 mg XL Given Twice Daily?
Antihypertensive therapy has been used in pregnant patients antepartum to improve blood pressure (BP) elevation in cases of chronic hypertension, and postpartum for persistent hypertension after delivery in cases of gestational…
- Trial name
- NCT03595982
- Testing
- Procardia XL 30Mg, Procardia XL 60Mg
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Critical Illness, Difficult; Intubation, Postpartum, During Puerperium
Ultrasound Airway Assessment of Critically Ill Preeclamptic; Comparison Between Two Technique
Unexpected difficult airway exposes the patient to serious morbidity and even mortality. The changes in pregnancy and preeclampsia increase the risk of difficult intubation.
- Conditions
- Critical Illness, Difficult; Intubation, Postpartum, During Puerperium, Pre-Eclampsia
- Trial name
- NCT06651879
- Testing
- techniques of ultrasound examination of the airway
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University