Clinical trials: Postpartum Uterine Bleeding
Hemorrhage, Postpartum, Hemorrhage
A Pilot Study to Assess the Feasibility and Tolerability of the AccuFlow Perfusion Sensor for Intrapartum Hemorrhage
Obstetric hemorrhage is one of the leading causes of maternal death worldwide. One of the challenges in management of hemorrhage is that young, healthy women compensate for blood loss via peripheral vasoconstriction, so they…
- Conditions
- Hemorrhage, Postpartum, Hemorrhage, Vasoconstriction
- Trial name
- NCT04370639
- Testing
- AccuFlow sensor, Survey
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Megan Lord
Postpartum Hemorrhage
Uterine Massage After Vaginal Delivery
The participants will be randomized into an oxytocin plus uterine massage group and an oxytocin-only group in the third stage of the labor.
- Trial name
- NCT03858569
- Testing
- active management of third stage of labor
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Postpartum Haemorrhage
Carbetocin Versus Oxytocin in Caesarean Section for the Control of Postpartum Haemorrhage
Post-partum haemorrhage is one of the life threatening emergencies. It accounts for nearly one-quarter of all maternal death worldwide. Atonic uterus contributes about 80% among the causes.
- Trial name
- NCT02396303
- Testing
- Carbetocin
- Where
- Bangladesh
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Postpartum Hemorrhage
Active Management of the Third Stage of Labour: Uterine Tonus Assessment by Midwife vs. Patient Self-administration
To determine whether there is a difference in effectiveness of routine uterine tonus assessment (every 15 minutes, for 2 hours) when performed by a midwife or self-administered by a patient on the incidence of postpartum…
- Trial name
- UTAMP (NCT02223806)
- Testing
- Uterine Tonus Assessment by Midwife, Patient self-assessment of uterine tonus
- Where
- Ghana
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Umbilical Cord
Timing of Umbilical Cord Clamping: One to Three Minutes vs. After Cessation of Cord Pulsation
The timing of umbilical cord clamping has been widely discussed in the scientific community. As part of the worldwide strategies to reduce childhood iron deficiency anemia, the incorporation of late clamping (at least one minute…
- Trial name
- CORD (NCT03844490)
- Testing
- CESSATION OF CORD PULSE, CONTROL
- Where
- Brazil
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Postpartum Hemorrhage
Accuracy of Blood Loss Estimation After Vaginal Delivery
Post-partum hemorrhage (PPH) is defined as blood loss greater than 500 mL after vaginal delivery. Delayed diagnosis of PPH is a major cause of maternal morbidity and mortality.
- Trial name
- NCT00462839
- Testing
- blood loss estimation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Postpartum Hemorrhage, Postpartum Preeclampsia
Postpartum Video Education
This is a prospective, single-center, randomized control study to determine if video education at the time of postpartum discharge improves patient knowledge on the warning signs for the top three causes of severe maternal…
- Conditions
- Postpartum Hemorrhage, Postpartum Preeclampsia, Postpartum Sepsis, Postpartum Depression
- Trial name
- NCT05159726
- Testing
- Video Education
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale University
Post Partum Hemorrhage
Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage
Post partum Hemorrhage (PPH) is one of three main causes of death in pregnant women. Oxytocin is widely used for prevention of PPH. Some studies suggested misoprostol as an alternative treatment when Oxytocin isn't available.
- Trial name
- NCT01863706
- Testing
- Misoprostol, Oxytocin
- Where
- Iran
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hormozgan University of Medical Sciences
Postpartum Hemorrhage
Buccal Misoprostol During Cesarean Section for Preventing Postpartum Hemorrhage
Objective: to demonstrate that buccal misoprostol administration during cesarean delivery in women with risk factors for uterine atony decreases the need for additional uterotonic medications, uterine atony and postpartum…
- Trial name
- NCT01733329
- Testing
- Misoprostol, Folic Acid
- Where
- Mexico
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Postpartum Hemorrhage
Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization: an In-vitro Analysis of Oxytocin Receptor Expression and Signaling
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity worldwide, and is caused most commonly by poor uterine muscle contraction after delivery of the baby and placenta.
- Trial name
- NCT02762669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Bleeding
Postpartum Uterotonic Administration
The investigators are planning to determine the effect of the timing of oxytocin administration on the amount of blood loss, necessity for additional medical or surgical interventions.
- Trial name
- NCT02495272
- Testing
- Oxytocin
- Where
- Turkey (Türkiye)
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Postpartum Hemorrhage, Postsurgical Bleeding
Abdominal Ultrasound Assessment in the Post-cesarean Patient
This study is designed to see if abdominal ultrasound after planned cesarean delivery can identify women with ongoing intra-abdominal bleeding.
- Conditions
- Postpartum Hemorrhage, Postsurgical Bleeding, Abdominal Ultrasound, FAST Scan
- Trial name
- NCT02159105
- Testing
- FAST scan and non-invasive hemoglobin measurement
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Postpartum Hemorrhage
Pharmacokinetics of Oxytocin at Cesarean Delivery
The primary objective is to obtain data to inform the design of a population pharmacokinetic study of oxytocin after administration at CD as per standard institutional practice.
- Trial name
- Peacocks (NCT03898882)
- Testing
- oxytocin, Shore durometer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Postpartum Hemorrhage, Vaginal Delivery
Prophylactic Tranexamic Acid Use After Vaginal Delivery
In this study, our aim was to evaluate the effectiveness of prophylactic tranexamic acid use after vaginal delivery in pregnant women aged 18-45 years and 34-42 weeks according to the risk of postpartum hemorrhage.
- Conditions
- Postpartum Hemorrhage, Vaginal Delivery, Prophylactic Tranexamic Acid Use
- Trial name
- NCT05429580
- Testing
- Tranexamic acid, 5% Dextrose
- Where
- Turkey (Türkiye)
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Postpartum Hemorrhage, Uterine Atony
Comparison of Effect of Two Different Doses of Intravenous Oxytocin on Patients Undergoing Elective Cesarean Section
Uterine atony and postpartum hemorrhage are important causes of maternal morbidity and mortality following cesarean section. Oxytocin is routinely administered to stimulate uterine contractions and prevent postpartum uterine…
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Elective Cesarean Section
- Trial name
- OXY-CS (NCT07922083)
- Testing
- Oxytocin 5 IU (Low Dose), Oxytocin 10 IU (High Dose)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shalamar Hospital
Postpartum Hemorrhage
Video Debriefing at the Delivery Ward
Postpartum hemorrhage continues to be the leading cause of maternal morbidity and mortality worldwide. Successful management of postpartum hemorrhage requires not only administration of the right medicine, but also a rapid and…
- Trial name
- NCT04646486
- Testing
- Video debriefing
- Where
- 2 sites in Denmark
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Simulation Training
Are Serious Games Scenarios Specifically Designed for Learning Non Technical Skills More Effective Than Baseline Scenarios in Soft Skills Training
The aim of the study is to assess if a training on post-partum hemorrhage management with serious game scenarios specifically designed to teach non technical skills improve non technical skills scoring in a high-fidelity…
- Trial name
- NCT03592953
- Testing
- Serious game simulation training sessions
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ilumens
Postpartum Hemorrhage (PPH), Postpartum Hemorrhage Third Stage of Labour Retained Placenta
Intra-Umbilical Vein Oxytocin Injection as an Adjunct to Active Management of the Third Stage of Labour
This randomized controlled clinical trial evaluates the effect of umbilical vein injection of oxytocin given in addition to routine active management of the third stage of labour.
- Trial name
- NCT07436286
- Testing
- Oxytocin
- Where
- Nigeria
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Dangana Zakari Adeka
Postpartum Hemorrhage, Venous Thromboembolism
Haemorrhages and Thromboembolic Venous Disease of the Postpartum
The aim of this study is to evaluate the frequencey and the determinants of postpartum major complications (hemorrhage and thrombosis) up to 3 months after delivery in the maternity hospitals of Finistère (Bretagne - France)
- Trial name
- HEMOTHEPP (NCT02443610)
- Where
- 6 sites in France
- Volunteers
- 20,241 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Postpartum Hemorrhage
Misoprostol for Preventing Postpartum Hemorrhage
This hospital-based, multicenter, randomized, placebo-controlled trial will assess the effects of misoprostol as part of active management of the third stage of labor on postpartum blood loss, complications, and side effects.
- Trial name
- NCT00124540
- Testing
- misoprostol
- Where
- 5 sites in Nigeria, South Africa and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects