Clinical trials: Postprandial Inflammation
Metabolic Syndrome, Obesity
Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1
Phase 1 of this study involves determining how consumption of dairy fat fractions rich in milk fat globule membrane influences postprandial inflammation in participants with metabolic syndrome or obesity during a high dietary fat…
- Trial name
- NCT01811329
- Testing
- Dairy fat, Dairy fat + MFGM, Palm fat
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Healthy
Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of mixed of herbs and spices on gene expression of pathways associated with glucose homeostasis, oxidative stress, inflammation and its interrelation with circulating miRNA, in the…
- Trial name
- NCT02931643
- Testing
- High fat challenge breakfast, High fat challenge breakfast with mixed-spices
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Type 2 Diabetes Mellitus
The Effect of Exenatide Compared to Lantus Insulin on Vascular Function in Type 2 Diabetes
The main goals of the study are to evaluate the effect of Exenatide on endothelial-dependent vasodilation, as measured by flow mediated dilation (FMD), to evaluate the effect on endothelial-independent vasodilation, as measured…
- Trial name
- NCT00353834
- Testing
- Exenatide, Glargine Insulin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus, Adult-Onset, Platelet Dysfunction
Oleocanthal Rich Olive Oil Acute Effects on Hyperglycemia and Platelet Activation in T2DM
This is a pilot acute dietary intervention study with a randomized cross-over design aiming to investigate whether acute supplementation of extra virgin olive oil (EVOO) rich in oleocanthal could attenuate postprandial…
- Conditions
- Diabetes Mellitus, Adult-Onset, Platelet Dysfunction, Postprandial Hyperglycemia, Lipidemia
- Trial name
- NCT04419948
- Testing
- White bread, Butter, Refined olive oil
- Where
- Greece
- Volunteers
- 15 people
- Sponsor
- Harokopio University
Alzheimer's Disease
Attenuation of Postprandial Inflammatory Processes in Alzheimer's Disease Patients by Consumption of Pomace Oil
This research project is based on previous studies suggesting that certain components of olive pomace oil can reduce inflammation in the brain associated with neurodegenerative diseases like Alzheimer\'s.
- Trial name
- CORDIAL (NCT06245616)
- Testing
- Consumption of olive pomace olive oil by alzheimer's patients, Consumption of high-oleic sunflower oil by alzheimer's patients
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council
Inflammation
Metabolic and Immune System Responses to a Mixed Meal
Overweight and obesity are major problems and their complications such as cardiovascular disease and type 2 diabetes mellitus pose great burdens on healthcare systems.
- Trial name
- NCT02416843
- Testing
- Consumption of a mixed meal
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Inflammation, Metabolic Disorder
Impact of Aronia Berry Consumption on Inflammation, Metabolites, and the Gut Microbiome
The goal of this project is to elucidate interactions between the gut microbiome, anti-inflammatory/anti-oxidant food metabolomic signatures, and human inflammation phenotypes.
- Conditions
- Inflammation, Metabolic Disorder, Hypertriglyceridemia
- Trial name
- NCT05255718
- Testing
- Aronia juice
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Montana State University
Oxidative Stress, Endothelial Function
Effect of Tahini in Oxidative Stress and Endothelial Function in Diabetes
Cardiovascular disease (CVD), a cluster of disorders that affect heart and blood vessels, is the leading cause of morbidity and mortality around the world and is responsible for 17.9 million deaths annually worldwide.
- Conditions
- Oxidative Stress, Endothelial Function, Blood Pressure, Arterial Stiffness
- Trial name
- NCT05396079
- Testing
- tahini and bread, margarine, cheese and bread
- Where
- Greece
- Volunteers
- 12 people
- Sponsor
- Harokopio University
Overweight, Obese
Acute Effects of Coffee Beverage on Postprandial Inflammation and Oxidative Stress - A Pilot Study
The primary objective is to test if acute supplementation with Coffee would improve antioxidant status, following consumption of a pro-oxidative high carbohydrate, high fat meal in over weight/ obese humans.
- Conditions
- Overweight, Obese, Healthy
- Trial name
- COF1 (NCT02174640)
- Testing
- Coffee, Water
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Type II Diabetes Mellitus
Effects of a Spiced Meat Patty on Inflammation in Men With Type 2 Diabetes
Polyphenols belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile…
- Trial name
- NCT01076829
- Testing
- Spice polyphenols
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Atherosclerosis Cardiovascular Disease, Obesity
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.
This study aims to investigate how moderate wine consumption influences circulating extracellular vesicles (EVs) in healthy adults.
- Conditions
- Atherosclerosis Cardiovascular Disease, Obesity, Metabolic Syndrome, Metabolic Disorders
- Trial name
- (WINEVOME) (NCT07361887)
- Testing
- White Wine, Red Wine, Water
- Where
- Spain
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Seville
Endotoxemia
The Role of Dietary Fat on Postprandial Endotoxemia in Healthy Adults
The purpose of this study was to determine the effect of different dietary fats (saturated or unsaturated) on postprandial endotoxemia and systemic low grade acute inflammation.
- Trial name
- NCT02521779
- Testing
- Low-fat Treatment Meal, Saturated-fat Treatment Meal, N-3 fat Treatment Meal
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Postprandial Hypoglycemia, End-stage Renal Disease (ESRD)
Anakinra for the Treatment of Postprandial Hypoglycemia in a Patient With Total Gastrectomy and End-Stage Renal Disease
Post-meal low blood sugar (postprandial hypoglycemia) is a common problem after certain stomach surgeries like gastric bypass or stomach removal.
- Conditions
- Postprandial Hypoglycemia, End-stage Renal Disease (ESRD), Gastrectomy, Glucose Metabolism Disorders
- Trial name
- AnPHy-ReD (NCT07580079)
- Testing
- Anakinra (interleukin-1 receptor antagonist)
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Marc Donath
Markers of Inflammation, Hyperglycemia, Postprandial
Effect of Hibiscus Sabdariffa Beverage
There are numerous plant foods that are a source of bioactive compounds, which can induce an anti-inflammatory effect on various pathways of inflammatory processes in the body as it may be useful in decreasing markers of…
- Conditions
- Markers of Inflammation, Hyperglycemia, Postprandial, Hyperinsulinism
- Trial name
- Hibiscus (NCT05774613)
- Testing
- Effect of a Hibiscus sabdariffa beverage
- Where
- Mexico
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Instituto Tecnológico y de Estudios Superiores de Occidente
Cigarette Smoking, Coronary Heart Disease
Exercise and Coronary Heart Disease Risk Markers in Male Smokers and Non-Smokers
The present study will investigate the effect of acute exercise on fasting and postprandial risk markers for coronary heart disease (CHD) in healthy male cigarette smokers and non-smokers.
- Conditions
- Cigarette Smoking, Coronary Heart Disease, Cardiovascular Risk Factor, Insulin Resistance
- Trial name
- NCT03735186
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Diabetes, Obesity
Eradication of Gut Microbiota
The aim of the study is to assess the effect of eradication of gut microbiota on 1) glucose metabolism including postprandial plasma responses of the incretin hormones GIP and GLP-1, insulin, C-peptide and glucagon, 2)…
- Conditions
- Diabetes, Obesity, Osteoporosis, Inflammation
- Trial name
- ERA (NCT01633762)
- Testing
- meropenem, gentamicin, vancomycin (together)
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Arthritis, Rheumatoid, Inflammatory Response
Postprandial Inflammation in Rheumatoid Arthritis
Patients with RA will be studied to see whether meals of different content will affect inflammation and metabolic variables in the postprandial state.
- Conditions
- Arthritis, Rheumatoid, Inflammatory Response, Dietary Exposure, Diet, Healthy
- Trial name
- PIRA (NCT04247009)
- Testing
- Meal based on red meat, fish products or vegan products, Meal based on red meat
- Where
- Sweden
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Endothelial Dysfunction
Different Oils For Frying and Endothelial Function
The purpose of this study is to compare the effects of the consumption of different oils (olive oil, sunflower oil, sunflower plus dimethyl-polysiloxane, sunflower plus phenols) previously submitted to heating in postprandial…
- Trial name
- NCT00837317
- Testing
- Olive Oil, SF, SF+DMP, SF+phenols
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Inflammatory Response, Inflammation
Fat Quality and Postprandial Inflammation
This aim of this randomized controlled postprandial study is to compare the effects of four different far sources (butter, coconut, corn oil and flax seed oil) on postprandial inflammation and metabolic response.
- Trial name
- PI:fat (NCT05674708)
- Testing
- Fat intake
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Lipid Metabolism, Postprandial Inflammation
Modulating Immune Responses After Consistent Lipid Exposure
Background of the study: Enhanced immune responses can lead to chronic hyperinflammation, which contributes to the development of non-communicable diseases such as type 2 diabetes and cardiovascular disease.
- Trial name
- MIRACLE (NCT07502898)
- Testing
- Dairy-derived breakfast shake consumption, Plant-derived breakfast shake consumption
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Wageningen University