Clinical trials: Postsurgical Pain
Breast Cancer, Postoperative Pain
Effectiveness of Ultrasound Guided Erector Spinae Plane Block Against Ultrasound Guided Serratus Anterior Block in Modified Radical Mastectomy
The aim of this study is to compare and evaluate the safety and analgesic efficacy of ultrasound guided ESP block and ultrasound guided serratus anterior plane block in patients undergoing modified radical mastectomy.
- Trial name
- NCT04606147
- Testing
- Serratus Anterior Plane Block, Erector spinae plane block
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Post-surgical Pain, Pain, Acute
Utility of CYP2D6 Genotyping to Improve the Efficacy and Safety of Tramadol
Randomized clinical trial to evaluate the utility of CYP2D6 genotyping to improve the efficacy and safety of tramadol in the treatment of acute postoperative pain.
- Conditions
- Post-surgical Pain, Pain, Acute, Postoperative Pain
- Trial name
- Tradol-PriME (NCT05657704)
- Testing
- The patients in experimental group will be genotyped before surgery and treatment will be prescribed according to the CYP2D6 phenotype
- Where
- 8 sites in Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Post Operative Pain
Optimal Effective Local Anesthetic Volume for Pain Relief Using Brachial Plexus Block
Prospective, patient-blinded study utilizing a novel Continuous Reassessment Method that concomitantly considers both block success and block side effects (lung dysfunction) for brachial plexus nerve blocks.
- Trial name
- NCT05868993
- Testing
- Dose of 0.5% Ropivacaine
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Analgesia
Peri-articular Nerve Group Block Versus Fascia Iliaca Block on Postoperative Pain After Hip Arthroscopy
The study aims to evaluate the efficacy of pericapsular nerve group block versus fascia iliaca block in reducing post operative pain within the first 24 hours following hip arthroscopy
- Trial name
- NCT04423419
- Testing
- PENG block, fascia iliaca block, IV analgesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spinal Anesthesia Suitability for Abdominoplasty
Abdominoplasty Under Spinal Anesthesia
100 patients undergoing abdominoplasty under spinal anesthesia. 100 patients undergoing abdominoplasty under general anesthesia
- Trial name
- NCT03810547
- Testing
- Propofol 10 Mg/mL Intravenous Emulsion
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Opioid Use, Pain, Postoperative
Timing of TAP Blocks in Bariatric Surgery
This clinical trial aims to determine the optimal timing for administering a Transversus Abdominis Plane (TAP) block in bariatric surgery, specifically investigating whether initiating TAP blocks at the beginning of surgery is…
- Trial name
- NCT06270147
- Testing
- Bupivacaine-epinephrine
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Acute, Post-operative Pain
Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ST-2427
This randomized, double-blind, placebo controlled, study will be conducted to evaluate the safety, tolerability, and pharmacokinetics of ST-2427.
- Trial name
- NCT04475198
- Testing
- ST-2427
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SiteOne Therapeutics, Inc.
Meniscus Tear, Meniscus Lesion
PROPER Trial of Pain and Inflammation After Knee Arthroscopy
The purpose of this study is to determine if ceftriaxone administered postoperatively via intravenous injection reduces postoperative visual analog scale (VAS) pain scores and narcotic consumption in patients undergoing knee…
- Conditions
- Meniscus Tear, Meniscus Lesion, Cartilage Injury
- Trial name
- PROPER (NCT05149287)
- Testing
- Ceftriaxone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Austin V Stone
Neuropathy;Peripheral
Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain
The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.
- Trial name
- NCT03037684
- Testing
- neurophysiology
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Post Operative Analgesia, Tonsillectomy
Weight-Adjusted Diclofenac Potassium Medicated Lollipop for Post-Adenotonsillectomy Pain in Children
Brief Summary This study aimed to develop and conduct a preliminary clinical evaluation of a novel weight-adjusted gelatin-based diclofenac potassium medicated lollipop for the management of postoperative pain following…
- Conditions
- Post Operative Analgesia, Tonsillectomy, Pediatric Anesthesia
- Trial name
- DICLOPOP (NCT07646093)
- Testing
- Diclofenac Potassium Medicated Lollipop
- Where
- Venezuela
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Caracas
Pain, Postoperative, Narcotic Use
Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery
The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption.
- Trial name
- NCT04791943
- Testing
- Melatonin 10 MG, Lactose pill
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Postoperative Pain
Influence of Apical Patency Concept Upon Postoperative Pain After Root Canal Treatment
The aim of this clinical study is to evaluate the influence of apical patency concept implementation upon postoperative pain following root canal treatment in a single visit approach in molars with pulpal disease.
- Trial name
- patency (NCT05170477)
- Testing
- apical patency, Non-apical surgery
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post-operative Pain Management
TAP Block , Intrathecal Morphine Or Their Combination For Post Operative Analgesia Following TAH
This randomized controlled clinical trial designed to evaluate the efficacy of transversus abdominis plane (TAP) block, intrathecal morphine, or their combination in postoperative pain relief, as assessed by time to first…
- Trial name
- NCT06882369
- Testing
- TAP Block, Intrathecal morphine injection, spinal anesthesia
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Minia University
Postoperative Pain, Postoperative Analgesia
Serratus Posterior Superior Intercostal Plane Block for Analgesia in Off-Pump Minimally Invasive CABG
Postoperative pain after cardiac surgery is commonly moderate to severe due to sternotomy, thoracotomy, internal mammary artery harvesting, and chest tube placement, and may contribute to adverse systemic and pulmonary outcomes…
- Trial name
- CABG (NCT07412522)
- Testing
- Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Bupivacaine, Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kartal Kosuyolu High Speciality Training and Research Hospital
Pain, Postoperative, Surgery
The Effect of Baduanjin on Patients Undergoing Knee Replacement Surgery
This randomized controlled trial aims to evaluate the effects of Baduanjin, a traditional Chinese mind-body exercise, on pain, comfort, and quality of recovery in patients undergoing total knee arthroplasty (TKA).
- Conditions
- Pain, Postoperative, Surgery, Knee Replacement, Nurse's Role
- Trial name
- NCT07109557
- Testing
- Baduanjin
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Niran Çoban
Acute Pain, Surgery
NSS-2 BRIDGE Device in Post-Operative Pain Management
The current opioid epidemic has led to a renewed interest in exploring non-pharmacological techniques to treat post-operative pain.
- Conditions
- Acute Pain, Surgery, Abdominal Cancer
- Trial name
- NCT03555266
- Testing
- NSS-2 Bridge
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Jacques E. Chelly
Postoperative Pain, Root Canal Infection
Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases
The purpose of this randomized clinical trial was to evaluate the incidence of postoperative pain after retreatment using different techniques. Patients whom need retreatment were included.
- Conditions
- Postoperative Pain, Root Canal Infection, Endodontic Disease
- Trial name
- NCT03042377
- Testing
- Single-Visit Retreatment, Multiple-Visit-"Calcium Hydroxide", Multiple-Visit-"Corticosteroid Paste"
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Dysphagia, Dysphonia
Prophylactic Racemic Epinephrine in Anterior Cervical Discectomy and Fusion
Our double-blinded, randomized control trial will assess the effect of nebulized racemic epinephrine inpatients undergoing anterior cervical discectomy and fusion (ACDF) procedures.
- Conditions
- Dysphagia, Dysphonia, Postoperative Pain
- Trial name
- NCT02724761
- Testing
- Racemic Epinephrine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Andrew Chung
Postoperative Pain
Intraoperative Magnesium Sulfate Administration During Orthotopic Liver Transplantation
The aim of study is to assess the effect of intraoperative use of magnesium sulfate in liver donating patients in reducing post-operative morphine requirements in early postoperative 24 hour in adult living liver donor.The…
- Trial name
- NCT03717467
- Testing
- isotonic saline, Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Postoperative Pain, Carpal Tunnel Release
Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries
The purpose of this study is to determine the efficacy of intra-operative administration of IV tylenol and/or IV toradol in minimizing post-operative pain for carpal tunnel patients and distal radius fracture patients.
- Conditions
- Postoperative Pain, Carpal Tunnel Release, Distal Radius Fracture
- Trial name
- NCT02313675
- Testing
- Acetaminophen, Ketorolac Tromethamine, Saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- John Fowler
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