Clinical trials: Postsurgical Pain
Asymptomatic Apical Periodontitis
Comparison of the Effects of Bio Ceramic and Epoxy Resin-based Sealers on Postoperative Pain After Root Canal Treatment
This study aims to compare the effect of bio ceramic sealer and resin-based sealer on the intensity and occurrence of post operative pain in single rooted teeth with asymptomatic apical periodontitis.
- Trial name
- NCT06543004
- Testing
- AH plus sealer, Bioceramic sealer
- Where
- Qatar
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Primary Health Care Corporation, Qatar
Postoperative Pain
Total Knee Replacement TIVA With Robotic Arm Assisted
Total knee replacement (TKR) is a commonly performed surgical procedure, and is associated with moderate to severe acute postoperative pain.
- Trial name
- NCT04002271
- Testing
- Propofol, Sevoflurane, Spinal anaesthesia
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pain, Postoperative
Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .
Analgesia in liver surgery is a challenge, postoperative coagulopathy risk raises fears an epidural haematoma formation following the epidural analgesia, "gold standard" in major abdominal surgery.
- Trial name
- CATHEPAT (NCT03238430)
- Testing
- intrathecal morphine, Morphine PCA, Ropivacaine infiltration
- Where
- France
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Postoperative Pain
Effect of Resin, Calcium Silicate and Silicone Based Root Canal Sealers on Postoperative Pain
After endodontic procedures, depending on the individual and many variables, postoperative pain can be occur within hours and continue for days following the treatment.
- Trial name
- NCT05033093
- Testing
- Root Canal Sealants
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Postoperative Pain, Cesarean Section
Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section
The purpose of this study is to compare the effectiveness of local wound infiltration of EXPAREL® (liposomal bupivacaine) with bupivacaine HCl compared to active control with bupivacaine HCl alone following elective primary or…
- Trial name
- NCT04232306
- Testing
- Liposomal bupivacaine, Bupivacaine HCl
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post Operative Pain, Cesarean Section
The Effect of Intravenous Infusion of Tramadol-ondansetron on Recovery After Caesarean Section.
It will be a prospective observational cohort study. The investigators will compare post-cesarean section recovery in patients receiving intravenous infusion of tramadol-ondansetron versus epidural catheter with infusion of local…
- Conditions
- Post Operative Pain, Cesarean Section, Tramadol, Postoperative Recovery
- Trial name
- TRON (NCT05879536)
- Testing
- Tramadol-ondansetron continuous infusion, Ropivacaine via epidural catheter
- Where
- Spain
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe
Postoperative Pain, Postoperative Complications
Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction
The purpose of this clinical study is to compare the effects of mouthwashes containing Chlorhexidine and tea tree oil on edema, pain, and trismus after the extraction of impacted third molars.
- Conditions
- Postoperative Pain, Postoperative Complications, Trismus, Periodontal Health
- Trial name
- NCT07180498
- Testing
- Chlorhexidine Gluconate 0.12% Mouthwash, Tea Tree Oil mouthwash
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Harran University
Pain, Postoperative
Assessment of Pain in Surgical Patient by PMD 200
The trial will estimate post-operative pain management in elective surgical patients using the PMD-200 device. The device measures physiological parameters by placing a non-invasive sensor on a fingertip and displays an objective…
- Trial name
- NCT03252301
- Testing
- PMD 200
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Meir Hospital, Kfar Saba, Israel
Morphine
Epidural Low Dose Morphine in Postoperative Pain After Posterior Lumbar Spinal Surgery
The effect of epidural low-dose morphine-soaked microfibrillar collagen sponge in postoperative pain control after posterior lumbar spinal surgery: a randomized, double-blind, placebo-controlled study
- Trial name
- NCT02067338
- Testing
- 1 mg morphine soak in epidural oxidized cellulose, normal saline
- Where
- Thailand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Postoperative Pain
Analgesic Efficacy of an Opioid-free Postoperative Pain Management Strategy Versus a Conventional Opioid-based Strategy Following Video-assisted Thoracoscopic Lobectomy
Investigators have designed a randomized controlled trial. Utilizing an open-label, randomized, controlled study methodology, this trial aims to explore a opioid-free, safe, and effective analgesic approach for thoracic surgery.
- Trial name
- NCT06570538
- Testing
- Ropivacaine, Sufentanil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Opioid-Related Disorders, Pain, Acute
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of a new and a marketed tablet formulation under fasted and fed conditions in healthy adults.
- Conditions
- Opioid-Related Disorders, Pain, Acute, Pain, Postoperative
- Trial name
- NCT03137017
- Testing
- Norco 5Mg-325Mg Tablet, GRT7014 - Abuse Deterrent Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Post-operative Pain
Intrathecal Opioid Study
This is an interventional drug trail to evaluate the effect of different intrathecal opioids on post-operative pain experiences in women who have undergone caesarean section surgery.
- Trial name
- NCT02577809
- Testing
- Morphine100, Morphine50, Fentanyl
- Where
- South Africa
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Chronic Post Operative Pain
Prevalence and Risk Factors for Postsurgical Pain After the Open Reduction and Internal Fixation of Lower Limbs.
The objective of this study is to specify the demographic and medical factors that most likely constitute a risk of developing CPSP in the patients with lower limb.
- Trial name
- NCT06136663
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Regional Anesthesia Morbidity, Postoperative Pain
Local Anesthesia Spread After an Erector Spinae Plane Block.
This a single-center prospective spread-evaluation study where the primary objective is to assess the spread of local anesthesia in an ESPB using magnetic resonance imaging (MRI).
- Trial name
- NCT05012332
- Testing
- Erector Spinae Plane Block
- Where
- Norway
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Post Operative Analgesia, Tonsillectomy
Weight-Adjusted Diclofenac Potassium Medicated Lollipop for Post-Adenotonsillectomy Pain in Children
Brief Summary This study aimed to develop and conduct a preliminary clinical evaluation of a novel weight-adjusted gelatin-based diclofenac potassium medicated lollipop for the management of postoperative pain following…
- Conditions
- Post Operative Analgesia, Tonsillectomy, Pediatric Anesthesia
- Trial name
- DICLOPOP (NCT07646093)
- Testing
- Diclofenac Potassium Medicated Lollipop
- Where
- Venezuela
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Caracas
Postoperative Pain
Perioperative Lidocaine and Ketamine in Abdominal Surgery
The investigators propose to test the hypothesis that perioperative infusions of lidocaine and/or ketamine reduce opioid consumption and pain scores in adults recovering from elective inpatient abdominal surgery.
- Trial name
- NCT04084548
- Testing
- Lidocaine and ketamine, Lidocaine, Ketamine
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Pain, Postoperative, Adverse Reaction to Epidural Anesthesia
Pediatric Caudal Anesthesia Block. And Pain Control
Caudal epidural block CEB is the most commonly performed neuraxial block to provide effective pain relief and analgesia in patients undergoing infra-umbilical pediatric surgery.
- Conditions
- Pain, Postoperative, Adverse Reaction to Epidural Anesthesia, Anesthesia, Caudal
- Trial name
- CEB (NCT05581940)
- Testing
- Group A Caudal Epidural Anesthesia with bupivacaine 0.25% and group B with opioid intervenors
- Where
- Bahrain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Salmaniya Medical Complex
Persistent Post Operative Opioid Use, Post-surgical Pain
Personalized Post-Operative Pain Management
The main questions this study aims to answer are: Does perioperative PGx personalized opiate therapy reduce persistent post-operative opioid use dependency, improve pain management and reduce opiate related adverse events in…
- Trial name
- NCT06669650
- Testing
- PGx guided personalized post-operative pain management, Oxycodone, Hydromorphone
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Impacted Mandibular Third Molar, Wound Healing
Adjacent Molar Outcomes After Third Molar Surgery With PRF or Collagen Sponge
This study aims to compare platelet-rich fibrin (PRF) and an absorbable collagen sponge in extraction sockets following impacted mandibular third molar removal in terms of postoperative clinical healing and periodontal and…
- Conditions
- Impacted Mandibular Third Molar, Wound Healing, Postoperative Pain
- Trial name
- PRFvsCOLL-3M (NCT07530068)
- Testing
- Platelet-rich fibrin (PRF), Absorbable Collagen Sponge
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Gazi University
Analgesia
Comparing QLB Type I Block to Intraperitoneal Instillation Added to Wound Infiltration for Postoperative Cesarian Pain
This study aimed to compare the efficacy of local anaesthetic infiltration into all layers of the anterior abdominal wall with peritoneal instillation and QLB type I for pain reduction in women undergoing elective cesarean…
- Trial name
- NCT06129032
- Testing
- Wound infiltration (LWI) + Intraperitoneal local anaesthetic (IPLA) instillation, Group QUADRATUS LUMBORUM BLOCK (QLB)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ataturk University
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