Clinical trials: Posttraumatic Stress
Posttraumatic Stress Disorder
The Effectiveness of CFT for Reducing Self-criticism in Patients With Complex PTSD: a Single-case Experimental Study
PTSD is a mental disorder including psychological symptoms related to severe traumatic event(s). PTSD can negatively affect people's functioning in several life domains.
- Trial name
- NCT05791760
- Testing
- Compassion-focused therapy (CFT) for complex PTSD
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Twente
Posttraumatic Stress Disorder (PTSD)
Oxytocin and Affect Processing in Posttraumatic Stress Disorder
The investigators will use multiple methods (including Oxytocin intranasal inhalation, neuroimaging, behavioral measures, peripheral hormone measurements) to examine how individuals' behavior, cognition, and brain function is…
- Trial name
- NCT02546570
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
Stress Disorders, Post-Traumatic
Computational Assessment of GABA Receptor Modulation in PTSD
A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications.
- Trial name
- NCT06852469
- Testing
- Lorazepam 1 mg tablet
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorders, Cortisol Diurnal Variation
Cortisol Diurnal Variation and the Risk for Developing Post Traumatic Stress Disorder
The purpose of this study is to examine a possible link between the time of day of exposure to a traumatic event and the risk of developing post-traumatic stress disorder.
- Trial name
- NCT01914861
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Obstructive Sleep Apnea, PTSD
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke.
- Conditions
- Obstructive Sleep Apnea, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT02641496
- Testing
- CBT-OSA, Sleep Education
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD)
Veterans with Posttraumatic Stress Disorder (PTSD) will be randomly assigned to either Attention Bias Modification Treatment (ABMT) designed to reduce bias toward threat or a placebo control condition not designed to change…
- Trial name
- NCT01564667
- Testing
- Attention Bias Modification Training Protocol
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Creighton University
Posttraumatic Stress Disorder, Traumatic Brain Injury
Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder
Background: Some people who have a traumatic brain injury (TBI) recover completely. Others, however, develop post-traumatic stress disorder (PTSD), with anxiety and depression.
- Trial name
- NCT01547819
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Posttraumatic Stress Disorder, Pregnancy Related
Online Intervention to Promote Resilience to Traumatic Stress During Pregnancy
The investigators will design, construct, and pilot a prototype of a trauma-informed online intervention, which will be called "SunnysideFlex," that functionally integrates a web-based intervention targeting skills to decrease…
- Trial name
- NCT04992767
- Testing
- Sunnyside, SunnysideFlex
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Post-Traumatic Stress Disorder
Effect of Propranolol on Preventing Posttraumatic Stress Disorder
This study will assess the effectiveness of taking propranolol soon after a traumatizing incident in reducing the incidence and severity of posttraumatic stress disorder in acutely traumatized individuals.
- Trial name
- NCT00158262
- Testing
- Propranolol
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorders
Cognitive Training for Post Traumatic Stress Disorder: Effects on Cognitive, Emotional, and Brain Function
The purpose of this pilot study is to determine the effects of computer-based training in executive functioning compared to word games on cognitive and emotional aspects of combat-related PTSD.
- Trial name
- NCT01644851
- Testing
- Executive function training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Posttraumatic Stress Disorder With Attention Defic
Atomoxetine and Executive Function in PTSD
Attention deficits (AD) frequently co-occur with posttraumatic stress disorder (PTSD). The presence of AD is associated with greater PTSD clinical severity and poorer clinical outcomes.
- Trial name
- NCT06573970
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
GAMBIT Task With PTSD and Healthy Control Participants
This is a pilot study of a digital training task called GAMBIT. This study will be the first to examine potential relationships between GAMBIT task completion and brain circuit flexibility, behavior, and symptoms in participants…
- Trial name
- GAMBIT (NCT05313334)
- Testing
- GAMBIT Task
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Posttraumatic Stress Disorder
A Controlled Breathing Course for Social & Emotional Health for Vietnam Veterans With Chronic PTSD-RCT
The main aim of this project is to evaluate the use of a specific Yoga technique of controlled breathing in Vietnam War Veterans with chronic posttraumatic stress disorder.
- Trial name
- NCT00256477
- Testing
- Sudarshan KRIYA Breathing Technique
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
PTSD, Anxiety Disorders
Creating Resilient Workplaces Study
The proposed study aims to understand the impact of a 5-Class CBTm Course on variables contributing to workplace resilience among Public Safety Personnel (PSP).
- Conditions
- PTSD, Anxiety Disorders, Depression, Stress Disorders, Posttraumatic
- Trial name
- CReW (NCT04002050)
- Testing
- Cognitive Behavioural Therapy with Mindfulness Course
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Mental Health Disorder, Depression
Mobile Phone Based Intervention to Protect Mental Health in Healthcare Workers at Frontline Against COVID19
This study aims at evaluating the effectiveness of a mobile phone based intervention to prevent and manage mental health problems in healthcare workers at the frontline against COVID-19 in Spain.
- Conditions
- Mental Health Disorder, Depression, Posttraumatic Stress Disorder, Burnout
- Trial name
- PsyCovid_App (NCT04393818)
- Testing
- Intervention App
- Where
- Spain
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Well Being, Happiness
Laughie Prescription on the Well-being, Happiness, and Posttraumatic Stress Level of Nursing Students Affected by the Earthquake
This study aimed to evaluate the effect of the Laughie Prescription on Well-being, Happiness, and Postraumatic stress levels of nursing students affected by the earthquake in Türkiye.
- Conditions
- Well Being, Happiness, Post Traumatic Stress Disorders
- Trial name
- NCT07157176
- Testing
- Daily 3-Minute Laughter Practice (Laughie Prescription)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
PTSD
Prevention of Combat-related PTSD Using Attention Bias Modification (ABM): A Randomized Controlled Trial
Military deployment to combat zones involves exposure to trauma at a higher than average rate and therefore presents a unique opportunity to study predisposing factors to posttraumatic stress reactions and test strategies…
- Trial name
- NCT01723215
- Testing
- Active ABMT8, Active ABMT4
- Where
- Israel
- Volunteers
- 862 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
PTSD
Neurofeedback With Real-Time fMRI for Treatment of PTSD
PTSD is a debilitating and costly condition and currently available treatment options have risks and limitations that necessitate development of novel interventions.
- Trial name
- NCT03243149
- Testing
- fMRI - GE Medical System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Depressive; Episode, Major, Depression, Postpartum
Diagnostic Accuracy of the Stepped Screening Protocol and Its Screening Tools in the Perinatal Period.
It is known that 1 in 5 women experience psychological difficulties during their pregnancy or in the first year after giving birth.
- Conditions
- Depressive; Episode, Major, Depression, Postpartum, Anxiety Disorders, Obsessive-Compulsive Disorder
- Trial name
- DAS (NCT05961306)
- Testing
- SCID 5
- Where
- 2 sites in Belgium
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Posttraumatic Stress Disorder, Acute Post-Traumatic Stress Disorder
Prevention of Mental Health Problems in People Exposed to a Recent Highly Stressful Event.
This project evaluates the effectiveness of three intervention models for the prevention of mental health problems in people who have suffered a recent highly stressful event, through an experimental design, with a control group…
- Conditions
- Posttraumatic Stress Disorder, Acute Post-Traumatic Stress Disorder, Depressive Symptoms
- Trial name
- NCT04314115
- Testing
- Mindfulness, Systemic therapy, Cognitive behavioral therapy and positive psychology
- Where
- Chile
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas, Chile