Clinical trials: Postural Tachycardia Syndrome
Arrhythmias, Cardiac
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
- Trial name
- NCT00921986
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
POTS - Postural Orthostatic Tachycardia Syndrome
The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic…
- Trial name
- POTS (NCT05554107)
- Testing
- Training program
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University
Postural Tachycardia Syndrome
Autoimmune Basis for Postural Tachycardia Syndrome
The purpose of this study is to test the hypothesis that an antibody-mediated autoimmune reaction will cause symptoms of autonomic dysfunction in some patients with postural tachycardia syndrome (POTS).
- Trial name
- NCT05043051
- Testing
- Vagal stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Postural Orthostatic Tachycardia Syndrome (POTS)
Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)
This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS. The aim of the study is to see how safe, tolerable, and effective the study drug is.
- Trial name
- PINNACLE (NCT06593600)
- Testing
- REGN7544
- Where
- 16 sites in United States, Canada
- Volunteers
- 82 people
- Sponsor
- Regeneron Pharmaceuticals
Postural Orthostatic Tachycardia Syndrome
Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.
- Trial name
- NCT06292104
- Testing
- multimodal diagnostic testing
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections.
- Conditions
- Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), Long COVID, SARS CoV 2 Infection
- Trial name
- NCT05421208
- Testing
- Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls, Levels of inflammatory cytokine ( IL-6) in controls, Effect on inflammation after chronic PNS stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Postural Orthostatic Tachycardia Syndrome, COVID-19
Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized Controlled Study
Covid-19 has the potential to affect physical, cognitive and psychological functions in multiple ways. It has been clear that a significant proportion of patients with Covid-19 develop long-term symptoms.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, COVID-19, Post COVID-19 Condition, Post-Acute COVID-19 Syndrome
- Trial name
- NCT05877534
- Testing
- Individual tailored exercise
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Postural Tachycardia Syndrome
Vagal Stimulation in POTS
The purpose of this study is to investigate how the electrical stimulation of a nerve in the skin of the earlobe (transcutaneous vagal nerve stimulation), alone or in combination with two medications (galantamine and…
- Trial name
- NCT03124355
- Testing
- Pyridostigmine Pill, Galantamine Pill, Vagal stimulation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Vanderbilt University Medical Center
Long COVID-19, Acute COVID-19
Long COVID-19 Cutaneous Signatures: An ARPA Funded Research Project
This is a prospective, longitudinal study involving 300 participants for a single visit to compare Long COVID-19 neurocutaneous biosignatures with those of other disorders affecting the sensory and autonomic nervous system.
- Conditions
- Long COVID-19, Acute COVID-19, Postural Orthostatic Tachycardia Syndrome (POTS), Diabetic Neuropathy
- Trial name
- LCCS (NCT07005947)
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- CND Life Sciences
Postural Orthostatic Tachycardia Syndrome (POTS)
Beta-3 Enhanced Autonomic Therapy for POTS
The study will test the hypothesis that mirabegron is more effective than a placebo in alleviating postural orthostatic tachycardia (POTS) symptoms.
- Trial name
- BEAT-POTS (NCT07585513)
- Testing
- Mirabegron
- Volunteers
- 36 people
- Sponsor
- Cedars-Sinai Medical Center
Orthostatic Hypotension, Heart Rate
Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia Syndrome.
Postural orthostatic tachycardia POTS is characterized by excessive increase in heart rate when moving from lying to standing position, often accompanied by symptoms such as dizziness, fatigue, brain fog, lightheadedness, rapid…
- Conditions
- Orthostatic Hypotension, Heart Rate, Blood Pressure
- Trial name
- NCT07579026
- Testing
- diaphragmatic breathing exercise, educational retraining
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Postural Tachycardia Syndrome, Orthostatic Intolerance
Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem.
- Trial name
- NCT04271878
- Testing
- RespirAct™ system (Thornhill Research Inc., Toronto, Canada)
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome
Compression Garments in the Community With POTS
Compression Garments are a commonly prescribed treatment in Postural Orthostatic Tachycardia Syndrome (POTS). The effectiveness of a proof-of-concept compression garment has been demonstrated in an acute laboratory setting.
- Trial name
- COM-COM-POTS (NCT04881318)
- Testing
- Waist-High Compression Tights, Abdominal Compression Garments, Medications that modulate heart rate and blood pressure
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection
NC Testing in LC & POTS
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction.
- Trial name
- NCT05914649
- Testing
- IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome
CAlgary SAlt for POTS
Many patients with postural orthostatic tachycardia syndrome (POTS) have decreased plasma volume. Current POTS guidelines recommend ~10 g of salt and 2-3 L of fluid per day.
- Trial name
- CASA-POTS (NCT05924646)
- Testing
- Sodium Chloride Capsules, Microcystalline Cellulose Capsules
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Postural Tachycardia Syndrome
POTS Adrenergic Ab (CIHR Aims #1&2)
Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.
- Trial name
- NCT02673996
- Testing
- Phenylephrine, Isoproterenol
- Where
- Canada
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome
Low Dose Naltrexone Use in Patients With POTS
Many patients with Postural Orthostatic Tachycardia Syndrome (POTS) experience debilitating fatigue and this significantly impacts their daily lives.
- Trial name
- NCT05363514
- Testing
- Low Dose Naltrexone, Microcrystalline cellulose
- Volunteers
- 80 people
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome (POTS)
aVNT in POTS - Pilot
Autonomic nervous system imbalance causes postural tachycardia and related cardiac symptoms in Postural Orthostatic Tachycardia Syndrome (POTS). The impact of POTS is more far-reaching than postural tachycardia.
- Trial name
- NCT07026643
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome
Paediatric Syncope in the Emergency Department
The investigators will assess the efficacy of clinically recommended counterpressure maneuvers (CPM) in preventing syncope for paediatric patients.
- Conditions
- Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- DETECT-ED (NCT05555771)
- Testing
- Counterpressure Maneuvers, Usual Care
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Dr. Victoria Claydon
Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome
Postural Sway and Counterpressure Maneuvers for Pediatric Syncope
The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint.
- Conditions
- Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- NCT05633693
- Testing
- Counterpressure Maneuvers, Baseline Stand
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Simon Fraser University