Clinical trials: Potassium Depletion
Heterozygous Carriers of Gitelman Syndrome
Clinical Significance of Heterozygosity for Mutations of the SLC12A3 Gene Coding for the Thiazide Sensitive Na-Cl Cotransporter
Gitelman syndrome is a salt wasting tubulopathy caused by mutations in the SLC12A3 gene coding for the thiazide sensitive sodium chloride cotransporter.
- Trial name
- HEPHYGI (NCT02035046)
- Testing
- Samplings of blood, Sampling of urine, Measure of the blood pressure
- Where
- 5 sites in France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Decompensated Heart Failure
Dopamine in Acute Decompensated Heart Failure II
The aim of this study is to compare the effects of 1) high-dose furosemide, 2) low-dose furosemide, and 3) low-dose furosemide combined with low-dose dopamine on diuresis, clinical status, renal function, electrolyte balance…
- Trial name
- DAD-HF II (NCT01060293)
- Testing
- High-dose furosemide, Low-dose furosemide, Low-dose furosemide combined with low-dose dopamine
- Where
- 6 sites in United States, Greece
- Volunteers
- 161 people
- Sponsor
- Larissa University Hospital
Aldosterone-Producing Adenoma
CXCR4 Targeted PET Imaging in APA Preoperative Localization Diagnosis
The goal of this clinical trial is to evaluate the effectiveness of CXCR4 targeted PET imaging in preoperative localization diagnosis of primary aldosteronism (PA).
- Trial name
- NCT05839483
- Testing
- CXCR4
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongnan Hospital
Bartter Syndrome
Acetazolamide (AZ) for Management of Alkalosis in Bartter Syndrome
In this prospective controlled cross over clinical trial, the investigators aim to evaluate the efficacy and safety of acetazolamide for the management of metabolic alkalosis in children with Bartter syndrome.
- Trial name
- AZ (NCT03847571)
- Testing
- Acetazolamide
- Where
- 4 sites in Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Vitamin K Deficiency, End Stage Renal Disease
The Effect of Vitamin K2 Supplementation on Arterial Stifness and Cardiovascular Events in PEritonial DIAlysis
VIKIPEDIA is a multi-centre, placebo-controlled, randomized, open-label intervention clinical trial on Peritoneal Dialysis (PD) patients.
- Conditions
- Vitamin K Deficiency, End Stage Renal Disease, Peritoneal Dialysis, Arterial Stiffness
- Trial name
- VIKIPEDIA (NCT04900610)
- Testing
- MenaQ7 ®, Nattopharma, ASA, Hovik, Norway
- Volunteers
- 120 people
- Sponsor
- Aristotle University Of Thessaloniki
Heart Failure
Hypokalemia in Hospitalized Patients for Heart Failure in the Therapeutic Cardiac Failure Unit
Hypokalemia is very common in heart failure patients. Deleterious effects have been report on the cardiovascular system. Most of the clinical data concerning this ionic trouble are based on post-hoc study and some findings seemed…
- Trial name
- HYPIC (NCT03405051)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Proton Pump Inhibitor Adverse Reaction, Hypomagnesemia
Hypomagnesemia Associated With Proton-Pump Inhibitor Use
Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of…
- Conditions
- Proton Pump Inhibitor Adverse Reaction, Hypomagnesemia, Arrhythmias, Cardiac, Seizures
- Trial name
- PPI_HypoMg (NCT04426994)
- Testing
- proton pump inhibitor use
- Where
- Singapore
- Volunteers
- 211,672 people
- Sponsor
- Changi General Hospital
Refeeding Syndrome
The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer
The study is based on a master thesis which showed that 72% of patients with head and neck cancer admitted to a Danish hospital (Rigshospitalet, Copenhagen) developed refeeding syndrome after admission.
- Trial name
- NCT01845922
- Testing
- Low sodium diet
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment
Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension
Primary aldosteronism (PA) is characterized by hypertension, frequent hypokalaemia, and an inappropriately high aldosterone-to-renin ratio (ARR).
- Conditions
- Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment, Adrenalectomy
- Trial name
- ADERADHTA2 (NCT07470580)
- Testing
- RFA -radiofrequency ablation, Adrenalectomy
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Toulouse
Hyperkalemia, Hypokalemia
Description of the Clinical Outcomes of Hospitalized Patients With Heart Failure With Different Serum Potassium Levels
China National Heart Failure Registration Study (CN-HF) is a nationwide, hospital-based, multicentre, prospective registry study sponsored by Ministry of Science and Technology of the People's Republic of China.
- Conditions
- Hyperkalemia, Hypokalemia, Heart Failure
- Trial name
- SPLENDID (NCT05184998)
- Where
- China
- Volunteers
- 6,950 people
- Sponsor
- AstraZeneca
Renal Insufficiency, Chronic, Potassium Depletion
Potassium Supplementation in CKD
The current high-sodium, low-potassium diet contributes to the high prevalence of high blood pressure (hypertension). Indeed, the anti-hypertensive effects of potassium supplementation are well-established.
- Conditions
- Renal Insufficiency, Chronic, Potassium Depletion, Hypertension, Hyperkalemia
- Trial name
- K+ in CKD (NCT03253172)
- Testing
- Potassium Chloride, Potassium Citrate
- Where
- 4 sites in Netherlands
- Volunteers
- 532 people
- Sponsor
- Erasmus Medical Center