Clinical trials: Pre - Delivery Pregnant Women
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Low Birthweight, Pre-Term
Low-birthweight Infant Feeding Exploration
Globally, 15% of all babies, amounting to 20 million infants each year, are born low birthweight (LBW), defined less than 2500 grams (5.5 lbs).
- Trial name
- LIFE (NCT04002908)
- Where
- 3 sites in India, Malawi and 1 more
- Volunteers
- 3,188 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Pregnancy Related, Diet Modification
Effects of Diet on Pregnancy Outcome and Child Obesity
The purpose of the study is to compare 3 different diets in pregnancy, equal in calories, and fats, different in refined grains compared to whole grains as a source of carbohydrates, and in calories from carbohydrate, compared to…
- Conditions
- Pregnancy Related, Diet Modification, Obesity, Hypertension
- Trial name
- NCT03232762
- Testing
- Refined Grains, Whole Grains
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Postpartum Hemorrhage
Prophylactic Oxytocin Before Versus After Placental Delivery to Reduce Blood Loss in Vaginal Delivery
Randomized controlled study to assess the efficacy and safety of the timing of administration of prophylactic oxytocin via intramuscular route (before compared to after placental delivery) on blood loss in vaginal delivery.
- Trial name
- NCT03006380
- Testing
- oxytocin
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Habitual Abortion
Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion
1 % of all pregnancies end in habitual/recurrent abortion. In about half of women with habitual abortions (HAB) hereditary or acquired (antiphospholipid antibodies) thrombophilia are observed.
- Trial name
- HABENOX (NCT00959621)
- Testing
- Aspirin, Klexane, Klexane and ASA
- Where
- Finland
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Hypertension, Premature Birth
Trial of Exercise to Prevent HypeRtension in Young Adults
TEPHRA investigates the effect of exercise on blood pressure and other cardiovascular factors in young adults with different birth histories.
- Trial name
- TEPHRA (NCT02723552)
- Testing
- Aerobic Exercise
- Where
- United Kingdom
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Venous Thromboembolism, Postpartum Period
Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The pilot PARTUM trial is a randomized, multicenter, placebo-controlled trial. Women who are at modest risk of VTE (as defined by the inclusion criteria) will be identified during pregnancy, labor and delivery and up to 48 hours…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin
- Trial name
- PARTUM (NCT04153760)
- Testing
- Aspirin 81 mg
- Where
- 7 sites in Canada, France and 2 more
- Volunteers
- 257 people
- Sponsor
- University of Calgary
Premature Birth
Human Milk Fortifier - Growth Evaluation
It it is hypothesized that the growth of preterm infants receiving a new human milk fortifier will be equal or superior to the growth of preterm infants receiving a currently marketed human milk fortifier with a lower protein…
- Trial name
- NCT01771588
- Testing
- Human milk fortifier
- Where
- 11 sites in Belgium, France and 3 more
- Volunteers
- 186 people
- Sponsor
- Société des Produits Nestlé (SPN)
Premature Delivery
New Biomarkers Associated With the Risk of Premature Delivery.
Despite the progress made in the organization of care and neonatal care, prematurity remains the main cause of morbidity and perinatal mortality.
- Trial name
- PROTEOMAP (NCT04067908)
- Testing
- 2 tubes of 5ml during the blood collection and 2 swabs during vaginal sampling
- Volunteers
- 111 people
- Sponsor
- University Hospital, Bordeaux
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Infertile Females or Females With Ovarian Insufficiency, Pre - Delivery Pregnant Women
The Effect of a Mindfulness-Based Stress Reduction Program on Pregnancy Adaptation, Stress, and Fetal Anxiety Levels in Women Who Conceived After Infertility Treatment
Infertility treatment is a long and challenging process. Women who become pregnant after this process may experience stress, anxiety and intense concerns about the baby's health alongside their happiness.
- Trial name
- MBSR-PAFS (NCT07307196)
- Testing
- MBSR
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Prenatal Disorder, Premature Birth
Develop a Multi-disciplinary Approach for a Personalized Prenatal Diagnostics and Care for Twin Pregnancies
Different screening modalities evaluation to develop algorithms to predict pregnancy complications in twin pregnancies, and evaluation of serologic response to BNT162b2 Pfeizer/BioNTech vaccination.
- Conditions
- Prenatal Disorder, Premature Birth, Twin Pregnancy With Antenatal Problem, Twin; Pregnancy, Affecting Fetus or Newborn
- Trial name
- PRETWINSCREN (NCT04595214)
- Testing
- TTTS cases are treated by intra-uterine laser for separation.
- Where
- 7 sites in Belgium, Canada and 4 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Pregnancy Complications
Diamine Oxidase and Adverse Pregnancy Outcomes
In normal pregnancies, blood histamine concentration remains within normal values; however, the serum histaminolytic activity is increased.
- Trial name
- NCT06281366
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Premature Infant
Effects Of Not Measuring Gastric Residual Content On Feeding Tolerance In Premature Infants iNFANTS
Omitting evaluation of gastric residual contents prior to feeding very premature infants will increase the feeding intake at 2 weeks, and total caloric intake and growth by 3 weeks, as well as decrease the time required for…
- Trial name
- NCT01965769
- Testing
- No gastric residual evaluation
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Florida
Low Birth Weight, Preterm Birth
Animal Source Food Supplement and Pregnancy in Vietnam
The purpose of this study is to determine if a nutrient-rich supplement of animal-source foods ingested 5d/wk from pre-conception to term improves maternal nutrient status, decreases infections, and improves birth weight and…
- Trial name
- VACVINA (NCT01235767)
- Testing
- Food
- Where
- Vietnam
- Volunteers
- 291 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Myocardial Dysfunction, Newborn Morbidity
Myocardial Deformation Before and After Birth
Knowledge on the changes in myocardial function in the last weeks before birth and during the first year of life is limited. Through fetal and post-natal echocardiography we intend to describe these changes using myocardial…
- Conditions
- Myocardial Dysfunction, Newborn Morbidity, Maternal Obesity
- Trial name
- NCT04060381
- Testing
- Blood transfusion, Ibuprofen, or epinephrine, norepinephrine or dopamine
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Haukeland University Hospital
Blood Pressure, Hypertension
Community-based Implementation of Adapted STAC
This study is being done to adapt the Staying Healthy After Childbirth (STAC) intervention for implementation among Black Women and Birthing Persons (WBP).
- Conditions
- Blood Pressure, Hypertension, Pregnancy Related, Health Equity
- Trial name
- NCT06689930
- Testing
- PDSA Cycles
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Polycystic Ovary Syndrome, Preterm Birth
Metabolic and Endocrine Status in Women With Prior Preterm Birth
The prevalence of preterm birth is rising in most western countries. The causes of preterm birth is not fully understood and seem to be multifactorial.
- Conditions
- Polycystic Ovary Syndrome, Preterm Birth, Diabetes Mellitus
- Trial name
- NCT01355536
- Where
- Norway
- Volunteers
- 262 people
- Sponsor
- Namsos Hospital
Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia), Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe)
Impedance Cardiographic (ICG) Assessment of Pregnant Women With Severe Hypertension to Assess Impact of Standard Therapy
The utilization of external cardiohemodynamic patient assessment, applying non-invasive stick-on contact patches to the mother's neck on either side and chest wall on either side, enables the practitioner to have information…
- Conditions
- Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia), Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe), Pregnancy; Hypertension, Gestational Hypertension, With Albuminuria (Severe Pre-eclampsia)
- Trial name
- ICASH (NCT01248169)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Mississippi Medical Center
Endometriosis Related Infertility
Surgery Before Embryo Transfer in ERROR (Endometrioma Related Reduction in Ovarian Reserve)
This prospective study evaluates the pregnancy results after laparoscopic endometriosis operation in infertile patients with ERROR (endometrioma related reduction in ovarian reserve)
- Trial name
- NCT04233983
- Testing
- Laparoscopic Endometriosis Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Uludag University