Clinical trials: Pre Diabetes
Diabetes (DM), Pre Diabetes
FastForward: A Prospective Analysis of Long-term Fasting and Subsequent Food Reintroduction in Humans
This study explores what happens in the body and wellbeing during and after a period of long-term fasting. At the Buchinger Wilhelmi Clinic, participants follow a medically supervised fasting program lasting five or more days…
- Conditions
- Diabetes (DM), Pre Diabetes, Overweight (BMI > 25)
- Trial name
- FastForward (NCT07155993)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Buchinger Wilhelmi Development & Holding GmbH
Prediabetes
The Association Between Body Constitution and Meridian Energy in Prediabetes
Traditional Chinese medicine (TCM) theories assert that body constitution and meridian energy are the foundations for disease prevention. However, few studies have incorporated TCM concepts into risk factors.
- Trial name
- NCT05475587
- Testing
- Routine care
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Diabetes Mellitus, Type 2, Insulin Resistance
Exercise to Restore 24h Rhythms in Metabolism
This study will investigate the effect of exercise training on 24h rhythms in substrate metabolism in overweight subjects with impaired glucose tolerance. Subjects will perform exercise training for 12 weeks.
- Trial name
- RESTORE (NCT04565418)
- Testing
- High-intensity interval training
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Intervention
To Evaluate the Impact of Consumption of Bioactive Compounds Extracted From Hemp Hull and Black Pepper on Fasting Blood Glucose Levels in People With Pre-diabetes: A Randomized Placebo-Controlled Parallel Arm Trial
This is randomized controlled parallel arm study on free living Asian Indians. Eligible subjects will undergo one-week run-in period and subjects will be asked to maintain their usual diet and exercise regime.
- Trial name
- NCT06454773
- Testing
- NCT/NFT
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Medication Adherence
Imagine to Remember: Improving Medication Adherence in Pre- and Type 2 Diabetes
Determine if an intervention consisting of future-thinking improves different facets of memory/executive function and/or decision-making.
- Trial name
- NCT04157673
- Testing
- Episodic Future Thinking
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Diabetes Mellitus, Type 2, Diabetes
Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
This study is to investigate how adipocyte (fat cell) function and fat distribution differ between individuals with normal-weight type 2 diabetes (NWD), those with overweight type 2 diabetes (OWD), and normal-weight controls…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes, Type 2 Diabetes, Pre Diabetes
- Trial name
- NCT06657209
- Testing
- Insulin resistance testing, OGTT, Fat biopsy
- Where
- 2 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type 1 Diabetes
Beta Cell Function in (Pre) Type 1 Diabetes
This study will establish criteria indicating short-term loss of beta cell mass and therefore accelerated progression towards type 1 diabetes.
- Trial name
- NCT00800085
- Testing
- glucose 20%
- Where
- 4 sites in Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Cystic Fibrosis
The Impact of Insulin Therapy on Protein Turnover in Pre-Diabetic Cystic Fibrosis Patients
Insulin replacement therapy may be effective in breaking the cycle of protein catabolism, undernutrition and overall clinical deterioration in pre-diabetic, insulin insufficient CF youth because of its potent anabolic effect.
- Trial name
- NCT02496780
- Testing
- novolog insulin, levemir insulin
- Where
- 2 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy, Prediabetic State
Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile in Prediabetic and Healthy Subjects
To investigate the effect of two different dosages collagen hydrolysate (CH) on postprandial blood glucose and insulin profile in prediabetic and normo-glycaemic subjects.This will be investigated in a cross-over randomized…
- Trial name
- NCT05887791
- Testing
- Collagen hydrolysate
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Atherosclerosis
Vitamin D Supplementation on Surrogate Markers of Atherosclerosis
For this study, our sample population is individuals with prediabetes, who are at an increased risk for atherosclerosis. In this proposed randomized placebo-controlled prospective trial, we would be enrolling 120 subjects with…
- Trial name
- NCT05478291
- Testing
- Vitamin D supplementation
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Pre Diabetes
Personalized Nutrition for Pre-Diabetes
The Personalized Nutrition Project for Prediabetes (PNP3) study will investigate whether personalized diet intervention will improve postprandial blood glucose levels and other metabolic health factors in individuals with…
- Trial name
- NCT03222791
- Testing
- Algorithm-based diet, Mediterranean-style low-fat diet
- Where
- Israel
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Weizmann Institute of Science
Overweight and Obesity, PreDiabetes
Effect of Time-restricted Eating on Behaviour and Metabolism in Overweight Individuals at High Risk of Type 2 Diabetes
The aim of the present study is to investigate effects of 12 weeks time-restricted eating on behaviour and metabolism in individuals with overweight or obesity at high risk of type 2 diabetes.
- Trial name
- RESET (NCT03854656)
- Testing
- Time-restricted eating
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kristine Færch
Pregnancy in Diabetics
Blood Pressure, Antihypertensive Treatment and Preeclampsia in Pregnant Wom-en With Pre-existing Diabetes
Aim: First, to investigate the prevalence of a) confirmed hypertension, b) white coat hypertension and c) normal blood pressure in pregnant women with pre-existing diabetes.
- Trial name
- NCT02890836
- Testing
- Antihypertensiva, mainly Metyldopa
- Where
- Denmark
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Overweight, Obesity
Effect of Dietary Habits on Metabolic Health
The goal of this application is to understand the connection between people's eating habits and the risk for developing diabetes, obesity, and cardiovascular disease.
- Conditions
- Overweight, Obesity, Prediabetes, Meals
- Trial name
- NCT02298790
- Testing
- Meal schedule
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetes, Prediabetic State
The Effect of Vitamin K Supplementation on Glucose Metabolism
The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response.
- Trial name
- NCT00960973
- Testing
- Menatetrenone
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Prediabetic State, Life Style
PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes
Nearly half of adults in the United States have or are at risk of developing type 2 diabetes. The overall goal of this community-engaged research is to examine the efficacy of an innovative couple-based lifestyle intervention to…
- Conditions
- Prediabetic State, Life Style, Intervention Study, Social Support
- Trial name
- PT2T (NCT06690788)
- Testing
- Individual intervention condition (PreventT2), Couple-based intervention condition (PreventT2 Together; couple-based adaptation of 2021 PreventT2; approved by the CDC in November 2022 as an Alternate Curriculum for use in the NDPP)
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- University of Utah
Spinal Cord Injuries (SCI), Prediabetes / Type 2 Diabetes
Neuromodulation for Metabolic Dysfunction
This study evaluates the use of noninvasive transcutaneous spinal cord stimulation (tSCS) to improve glucose regulation and metabolic function in individuals with and without spinal cord injury (SCI) across a spectrum of…
- Trial name
- NCT07597161
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rahul Sachdeva
Pre-diabetes, Obesity
Project Plant Protein: the P3 Study in Humans
The objective of this study is to compare the effects of adding three plant-based proteins (rice, oats and pea proteins) to a breakfast beverage on the glycemic response, appetite and subsequent food intake of healthy adults.
- Trial name
- NCT02933424
- Testing
- Protein Powder
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
PreDiabetes
Efficacy of Physical Exercise on Glucose Control in People With Prediabetes (GLYCEX) - Phase II
Aim: To assess the efficacy of different frequencies of physical exercise on glycaemic control in adults with prediabetes. Methods: parallel, randomised, controlled, clinical trial will be carried out, with a total of 90…
- Trial name
- GLYCEX (NCT05658770)
- Testing
- 5 days/ week, 3 days/ week, 2 days/ week
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Type 2 Diabetes, Gestational Diabetes, Pre-diabetes
Toronto Gestational Glucose Tolerance Cohort
In this prospective observational cohort study, women representing the full spectrum of gestational glucose tolerance status are undergoing longitudinal cardiometabolic characterization at regular intervals in the years after the…
- Trial name
- NCT02583061
- Testing
- There is no intervention. An exposure of interest is glucose tolerance status in pregnancy
- Where
- Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada