Clinical trials: Pre Diabetic
Cardiovascular Diseases, Metabolic Syndrome
Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials.
- Conditions
- Cardiovascular Diseases, Metabolic Syndrome, Obesity, Prediabetes
- Trial name
- NCT07106879
- Testing
- Blood Work
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Clindove Research LLC
PreDiabetes
Prediabetes and Metabolic Parameters Among Young Adults at Assiut University Hospital
Prediabetes is a major public health problem that increases the risk of developing type 2 diabetes mellitus and cardiovascular complications.
- Trial name
- NCT07259954
- Testing
- No intervention
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Overweight, Obesity
Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study)
Type 2 diabetes and prediabetes, which are mainly caused by a lack of physical activity and excess weight, put people at an increased risk of cardiovascular disease.
- Conditions
- Overweight, Obesity, Type 2 Diabetes, Prediabetes
- Trial name
- SHAPE3 (NCT00928005)
- Testing
- Weight loss diet, Weight loss diet plus exercise
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Assessing the Impact of a Plant-Based Diet for Diabetes Prevention
The primary purpose of this study is to determine the sex-specific metabolic and molecular response, among adults with prediabetes, when moving from a Western Diet to plant-based diet.
- Trial name
- NCT06571279
- Testing
- Plant-based diet
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Jean L. Fry
Weight Loss, PreDiabetes
Diabetes Prevention Program to Treat Overweight and Obesity
The purpose of this study is to demonstrate the efficacy of the diabetes prevention program for the treatment of overweight and obesity within the community pharmacy setting.
- Trial name
- DPP-TOO (NCT05640869)
- Testing
- Modified Diabetes Prevention Program Curriculum
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Auburn University
Pre Diabetes
Impact of Whey and Leucine on Glycaemia in Adults Without Diabetes
Higher than average blood sugar (glucose) levels are linked to an increased risk of developing type 2 diabetes. As such, there is interest in identifying dietary factors that could lower blood glucose to help reduce the number of…
- Trial name
- Whey2Glo (NCT03785951)
- Testing
- Whey Protein Isolate, Wheat Protein, Wheat Protein with Leucine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Type 2 Diabetes, Muscle Atrophy
The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults
The goal of this study is to determine the impact of pre-diabetes and type 2 diabetes on muscle atrophy during a period of bed rest and recovery of muscle mass, strength, and physical function following bed rest.
- Conditions
- Type 2 Diabetes, Muscle Atrophy, Aging, Sedentary Behavior
- Trial name
- REST (NCT03761446)
- Testing
- Bed rest
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Diabetes, Prediabetes
Meta-analyses of Pasta as Part of Low Glycemic Index Diets and Adiposity
Pasta is an important example of a food which can lower the glycemic index (GI) of the diet, a property that has been exploited extensively in studies of low GI dietary patterns.
- Conditions
- Diabetes, Prediabetes, Overweight, Obesity
- Trial name
- NCT02961088
- Testing
- Pasta as part of a low GI/GL diet
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Prediabetes, Prehypertension
Health Coaching to Effect Lifestyle Behaviour Change
A health coaching intervention in those with pre-disease (pre-hypertension or pre-diabetes) but without pre-existing cardiovascular disease will effectively help participants change their lifestyle behaviour and prevent or delay…
- Trial name
- HC (NCT01458496)
- Testing
- Health Coaching
- Where
- 2 sites in Canada
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Marshal Godwin
Patients With Type 2 Diabetes (FSG: More Than 7.1 and Not Higher Than 15.8 mmol/L)
Short-term Effect of Pomegranate Juice on Blood Sugar and Its Controlling Hormones in Pre-diabetic and Type II Diabetic Patients.
Fresh pomegranate juice at 1.5 mL/kg of body weight was administered by recruited healthy individuals and patients with type 2 diabetes of fasting serum glucose between 7.1 and 15.8 mmol/L after approximately 12 hours fasting.
- Trial name
- NCT03902288
- Testing
- Fresh pomegranate juice
- Where
- Jordan
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Diabete Mellitus, Pre-diabetes
Investigating the Syndrome Differentiation of Diabetic and Pre-diabetic Using Digitalized TCM Diagnostic Tools
The investigators aim to objectively identify the Traditional Chinese Medicine (TCM) syndrome differentiation of type II diabetic and prediabetic patients in Singapore through modern technologies thereby potentially increasing…
- Conditions
- Diabete Mellitus, Pre-diabetes, Healthy, Hypertension
- Trial name
- NCT05563090
- Testing
- Questionnaires+Tongue diagnosis+Pulse diagnosis
- Where
- Singapore
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Singapore Chung Hwa Medical Institution
PreDiabetes
Screening for Risk Factors of Prediabetes Among Adult Patients at Sohag University Hospital
Prediabetes is an intermediate state of hyperglycemia with glycemic parameters above normal but below the diabetes threshold.. during the average 3 years of follow-up Prediabetes is diagnosed based on laboratory tests: fasting…
- Trial name
- NCT05864183
- Testing
- HbA1c, lipid profile, CBC
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical Study
This observational study aims to understand the metabolic characteristics and long-term changes in adults with prediabetes and to identify risk and protective factors associated with progression to diabetes or return to normal…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DM-PIONEER (NCT07854002)
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Prediabetic State, Diabetes type2
Effect of Totum-63 on Glucose and Lipid Homeostasis in Subjects With Dysglycemia (REVERSE-IT)
This clinical study aims to assess the efficacy of TOTUM-63, a mix of 5 plant extracts, consumed at the daily regimen of three times per day on glucose and lipid homeostasis in dysglycemic subjects.
- Conditions
- Prediabetic State, Diabetes type2, Dysglycemia
- Trial name
- REVERSE-IT (NCT04423302)
- Testing
- TOTUM-63 3 intakes per day, TOTUM-63 2 intakes per day
- Where
- 52 sites in Bulgaria, France and 5 more
- Volunteers
- 636 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Cardiovascular Risk Factor, Prediabetes
Active You: A Novel Exercise Program for African Americans
Barriers to physical activity (PA) among African Americans (AAs) have been extensively studied, yet there is a paucity of innovative PA interventions designed to address them.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04280783
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
PreDiabetes, Obesity
Dinner Time for Obesity and Prediabetes
Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity.
- Conditions
- PreDiabetes, Obesity, Healthy
- Trial name
- DTOP (NCT05745441)
- Testing
- Early Dinner, Late Dinner, Early Dinner tracer
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Metabolic Syndrome, Postmenopausal Symptoms
Circadian Rhythms in Postmenopausal Women
This is a randomized, parallel two-arm clinical trial design to study the efficacy of time-restricted feeding on metabolic risk in postmenopausal women, who may be particularly vulnerable to disruption of circadian eating rhythms…
- Trial name
- NCT04893226
- Testing
- Time-Restricted Feeding (TRF)
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Julie Pendergast
Prediabetes / Type 2 Diabetes, Obesity and Overweight
An Integrative Study of the Role of Microbiome, Metabolome, Transcriptome and Chronobiology in the Context of Type 2 Diabetes.
The goal of this descriptive clinical study is to investigate daily oscillations in glycaemic control between healthy adults and adults with excess weight and who have early-stage prediabetes or T2D and are not taking medications…
- Conditions
- Prediabetes / Type 2 Diabetes, Obesity and Overweight, Insulin Resistance
- Trial name
- KRONODIABET (NCT06783218)
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Pre Diabetes, Diabetes
Metabolic Response Evaluation of Low-sugar Snack Bars
To determine the post-prandial metabolic response and biomarker response, following the consumption of newly developed low glycaemic index (GI) snack bars.
- Conditions
- Pre Diabetes, Diabetes, Obesity
- Trial name
- NCT04653220
- Testing
- Control 1, Control 2, Standard Crokao
- Where
- Singapore
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Diabetes Mellitus, Type 2, Pre-diabetes
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans
The rationale for the proposed research is that elucidating changes in localized diacylglycerol (DAG) and sphingolipid species that predict insulin sensitivity will reveal specific localized lipids to target in therapeutics for…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Obesity
- Trial name
- NCT03077360
- Testing
- Lifestyle
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver