Clinical trials: Pre Diabetic
PreDiabetes, Aging
Safety and Efficacy of KH-1 for Stimulating Autophagy in Non-diabetic Adults With Elevated Blood Glucose Concentration
Aging significantly impacts overall health and is a risk factor for developing diabetes. An estimated 50% of U.S. adults aged ≥65 years were reported to have prediabetes (defined as having a fasting glucose concentration of…
- Trial name
- NCT06445569
- Testing
- KH-1
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kalin Health, LLC
Obesity, Diabetes Mellitus
Type 2 Diabetes Primary Prevention for At Risk Girls
Purpose: To evaluate two approaches to prevent obesity and type 2 diabetes in young girls. The Need: We are experiencing an epidemic of childhood obesity.
- Conditions
- Obesity, Diabetes Mellitus, Pre Diabetes
- Trial name
- NCT00063674
- Testing
- Nutrition Education, After-school dance class
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Prediabetes, Type 2 Diabetes
RISE Adult Medication Study
The RISE Adult Medication Study is a 4-arm, 3-center, clinical trial of adults with prediabetes and early type 2 diabetes to address the hypothesis that aggressive glucose lowering will lead to recovery of beta-cell function that…
- Trial name
- RISE Adult (NCT01779362)
- Testing
- Metformin, Liraglutide, Glargine
- Where
- 4 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- RISE Study Group
Diabetes Type 2, PreDiabetes
Cognitive Functions and BDNF in T2DM and Prediabetes Patients
Clinical and epidemiological studies suggest links between cognitive impairments and Type 2 diabetes (T2DM). The underlying mechanisms and causality in diabetes-related cognitive impairment are largely unknown.
- Conditions
- Diabetes Type 2, PreDiabetes, Cognitive Impairment
- Trial name
- NCT05654727
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Healthy Aging, Inflammaging
The Effects of Quercefit® and Ubiqsome™ in Mitigating Inflammation and Promoting Metabolic Health
The goal of this clinical trial is to learn if Quercefit® or Ubiqsome™ can improve markers of healthy aging, blood sugar control, and heart health in older adults. It will also learn about the safety of these supplements.
- Conditions
- Healthy Aging, Inflammaging, Metabolic Health, Quercetin
- Trial name
- NCT07760506
- Testing
- Quercetin (dietary supplement), Coenzyme Q10, Rice Flour
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Prediabetic State, Diabetes Mellitus, Type 2
Cardiorespiratory Fitness in Prediabetic,Type 2 Diabetic and Healthy Individuals
The aim of this study to investigate and compare cardiorespiratory fitness (CRF) parameters of prediabetic, type 2 diabetic and healthy individuals.
- Conditions
- Prediabetic State, Diabetes Mellitus, Type 2, Cardiorespiratory Fitness, Inflammation
- Trial name
- NCT03823664
- Testing
- Cardiorespiratory Fitness
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Prediabetic State
Effect of Mulberry Leaf Extract on Blood Glucose
The purpose of this study is to evaluate the effect of mulberry leaf extract on blood glucose in subjects with impaired fasting glucose.
- Trial name
- NCT01385865
- Testing
- Mulberry leaf extract
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University
Prediabetic State, Obesity
Presessions for the National Diabetes Prevention Program
The National Diabetes Prevention Program (NDPP) is a widely available, evidence-based intervention that promotes weight loss to prevent type 2 diabetes; however, participant attendance is problematic and leads to suboptimal…
- Conditions
- Prediabetic State, Obesity, Gestational Diabetes
- Trial name
- NCT04022499
- Testing
- Presessions, National Diabetes Prevention Program
- Where
- United States
- Volunteers
- 483 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Prediabetic State
A Pharmacist-Coordinated Implementation of the Diabetes Prevention Program
This proposed project will translate evidence-based strategies for diabetes prevention within the framework of an existing and highly utilized pharmacist-led diabetes care program.
- Trial name
- NCT02384109
- Testing
- Shared decision-making with pharmacists, Standard care from primary care providers
- Where
- 20 sites in United States
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diabete Mellitus, Pre-diabetes
Investigating the Syndrome Differentiation of Diabetic and Pre-diabetic Using Digitalized TCM Diagnostic Tools
The investigators aim to objectively identify the Traditional Chinese Medicine (TCM) syndrome differentiation of type II diabetic and prediabetic patients in Singapore through modern technologies thereby potentially increasing…
- Conditions
- Diabete Mellitus, Pre-diabetes, Healthy, Hypertension
- Trial name
- NCT05563090
- Testing
- Questionnaires+Tongue diagnosis+Pulse diagnosis
- Where
- Singapore
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Singapore Chung Hwa Medical Institution
Physical Inactivity, Cardiovascular Risk Factor
The Clinical Referral to Activity Study
The main aim of this effort is to test a physical activity intervention, for adult clinical care patients at risk of developing cardiovascular disease.
- Conditions
- Physical Inactivity, Cardiovascular Risk Factor, Obesity, Blood Pressure
- Trial name
- NCT04743856
- Testing
- ActiveGOALSv2, PAT
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Prediabetic State, Obesity
The PRE-D Trial: Effect of Dapagliflozin, Metformin and Physical Activity in Pre-diabetes
The overall objective is to compare the short-term (3 months) effectiveness of three glucose-lowering interventions (dapagliflozin, metformin and physical activity) on glucose variability, body composition, and cardiometabolic…
- Trial name
- NCT02695810
- Testing
- Dapagliflozin, Metformin, Exercise
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, Type 2, Glucose Intolerance
The Effects of Light on Glucose Metabolism
This study evaluates the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose and/or impaired glucose tolerance.
- Conditions
- Diabetes Mellitus, Type 2, Glucose Intolerance, Prediabetic State
- Trial name
- NCT03829982
- Testing
- Exposure to bright light during the day, Exposure to dim light during the day
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Pre-diabetes, Obese
Investigation of an Amino Acid Supplement on Glucose Levels in Obese Subjects
This study aims to determine whether the use of Branched-Chain Amino Acids (BCAA's) regulate insulin and glucagon secretion, and whether the supplement has any effect on body weight and body composition.
- Conditions
- Pre-diabetes, Obese, Glucose Intolerance
- Trial name
- NCT03715010
- Testing
- BCAA
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Aging
Metformin in Longevity Study (MILES).
Metformin, an FDA approved first-line drug for the treatment of type 2 diabetes, has known beneficial effects on glucose metabolism.
- Trial name
- MILES (NCT02432287)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults
The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes.
- Conditions
- Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetes / Type 2 Diabetes, Obesity & Overweight
- Trial name
- END-T2D (NCT07575438)
- Testing
- Fish Oil, Corn oil control
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- May Faraj, PDt, PhD
Prediabetes, Healthy (Controls)
Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?
Brief Summary The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with…
- Trial name
- NCT07546409
- Testing
- Ketone Monoester (KE)
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes Mellitus (T2DM), Hypertension (HTN)
Cohort Study of Metabolic Disease and Hypertension
The goal of this observational study is to learn how type 2 diabetes and high blood pressure develop over time in adults in Mexico.
- Trial name
- NCT07577063
- Testing
- Observational Study
- Where
- Mexico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Overweight, PreDiabetes
Hydroxytyrosol Dietary Supplement and Prevention of Age-Related Diseases
The primary objective of this study is to ascertain the effects of chronic consumption of a hydroxytyrosol-rich extract from olive in a population at high risk of developing age-related pathologies such as type 2 diabetes and…
- Trial name
- HT15 (NCT06295913)
- Testing
- Group 1, hydroxytyrosol-rich extract capsule
- Where
- Spain
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Pre Diabetes, Obesity
Beta Glucan and Acetate Production
Based on our hypothesis that orally administered resistant starch and beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we…
- Trial name
- NCT03714646
- Testing
- beta glucan and resistant starch, beta gluten
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center