Clinical trials: Pre Diabetic
Type 1 Diabetes, Prediabetic State
Trial of Early Initiation of CGM-Guided Insulin Therapy in Stage 2 T1D
This protocol is an intervention study to determine the best education and monitoring strategy for children ages 2-20 years with pre-symptomatic type 1 diabetes (T1D) because there currently exists no clinical guidelines for…
- Conditions
- Type 1 Diabetes, Prediabetic State, Dysglycemia, Autoimmune Diabetes
- Trial name
- TESS (NCT04335513)
- Testing
- Early CGM-guided education and initiation of insulin therapy., Usual care: glucometer surveillance and basic education.
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetic Retinopathy
OCTA in Epivascular Glia After Dex Implant
The aim of this prospective study was for the first time, to analyze specific morphologic features in diabetic eyes with macular oedema, such as changes of the foveal avascular zone and the presence of epivascular glia, and see…
- Trial name
- NCT05600179
- Testing
- Dexamethasone intravitreal implant
- Where
- Italy
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Federico II University
Diabetes Prevention
Diabetes Prevention Program Pilot Study
This pilot study is intended to demonstrate that we can actually deliver the Diabetes Prevention Program intervention well and to show that it is likely effective.
- Trial name
- DPP (NCT00729079)
- Testing
- DPP
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Pre Diabetes
Effects of Fos Biomedical Device on Diabetes Risk Factors and Sleep Quality in Adults at Risk for Type 2 Diabetes
Purpose Phototherapy has an array of potential benefits in human health. The effects of a non-transdermal Fos Biomedical product (which utilizes the concept of phototherapy) on diabetes risk factors and sleep quality in people at…
- Trial name
- NCT05628597
- Testing
- Fos Biomedical patch product
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Griffin Hospital
Cardiovascular Risk Factor, Prediabetes
Active You: Feasibility of a Unique Physical Activity Program to Prevent Diabetes and Heart Disease
Individuals who are overweight/obese are more vulnerable to type 2 diabetes (T2D). Current evidence suggests that PA, even without dietary prescription, can be efficacious in preventing T2D.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04621045
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Insulin Resistance, Insulin Sensitivity
Fructose: Substrate, Stimulus, or Both?
This objective of this study is to use sensitive methodology under controlled conditions to investigate the mechanisms by which fructose consumption contributes to excess fatty acid synthesis and elevations in blood glucose…
- Conditions
- Insulin Resistance, Insulin Sensitivity, Pre Diabetes
- Trial name
- NCT04168372
- Testing
- High fructose, fructose labeled meal, High fructose, pyruvate labeled meal, Low fructose, fructose labeled meal
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Touro University, California
Prediabetic State, Diabetes Mellitus, Type 2
Noninvasive Skin Spectroscopy for Diabetes Screening
The objective of this study is to assess the performance of a noninvasive device for the early screening of Diabetes Mellitus.
- Trial name
- NCT00358254
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- InLight Solutions
PreDiabetes
Effects of Bitter Melon on Cardiometabolic Health
The objectives of this study are to assess the effects of a bitter melon product at two doses, compared to control, on indicators of cardiometabolic health among men and women with prediabetes.
- Trial name
- NCT05540405
- Testing
- Low-dose bitter melon, High-dose bitter melon
- Where
- 3 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Prediabetes
Almond Effects on Glucose Intolerance Study
Diabetes is a major cause of morbidity and mortality worldwide. Prevention of diabetes is an important goal. The progression from impaired glucose tolerance to diabetes is thought to be promoted by the toxic effects of…
- Trial name
- AEGIS (NCT02260895)
- Testing
- Almond pre-test snack
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Memorial Hermann Health System
Oxidative Stress, Healthy Aging
Efficacy of Solarplast for Health and Oxidative Stress
Solarplast is a unique mixture of antioxidant enzymes and single antioxidant molecules that are capable of attack oxidants that cause damage to the cells in the human body and cause premature aging.
- Conditions
- Oxidative Stress, Healthy Aging, Skin Health
- Trial name
- NCT04144777
- Testing
- Solarplast
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes
Diabetes Mellitus, Type 2, Pre-diabetes
Tau PET Imaging in the Northern Manhattan Study of Metabolism and Mind.
This is a single center brain Positron Emission Tomography (PET) study of 18F-MK-6240. Eligible participants are persons from Northern Manhattan who self-identify as Hispanic, non-Hispanic Black, or Non-Hispanic White, who are 55…
- Trial name
- NOMEM-Tau (NCT03389100)
- Testing
- 18F-MK6240 injection
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Columbia University
Prediabetes
Trial of an Herb and Mineral Combination Product on Fasting Glucose in Adults at Risk for Developing Diabetes
This is a multi-center, randomized, double-blind, placebo-controlled study in approximately 104 subjects (52 per group) to evaluate the effectiveness of an herb and mineral combination product on fasting serum glucose levels in…
- Trial name
- NCT02146157
- Testing
- herb and mineral combination product
- Where
- 6 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- NewChapter, Inc.
Type 2 Diabetes, Prediabetes
Seum Bile Acid Profile in Type 2 Diabetes and Association Between Bile Cid Profile and Adipokine or Oxidative Stress
"The goal of this work is to critically test the hypothesis that there exists a different profile of bile acids (BAs) in patient with type 2 diabetes mellitus (T2DM) compared with normal controls.
- Conditions
- Type 2 Diabetes, Prediabetes, Non-alcoholic Fatty Liver Disease, Metabolic Syndrome
- Trial name
- NCT02650830
- Where
- South Korea
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Prediabetes, Impaired Glucose Tolerance
Step Up For Health Study: A Pedometer and Website Intervention in Those With Prediabetes
This study will examine whether a physical activity program, specifically increasing walking steps, offered over the internet is able to increase physical activity in adults with prediabetes.
- Trial name
- NCT05412264
- Testing
- Website intervention
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Alberta
PreDiabetes, Overweight and Obesity
Effect of a Probiotic on the Glycemic Profile and the Fecal Microbiota of Prediabetic Subjects (PREDIABETCARE)
According to the data from the Di@bet.es study, which is part of the National Diabetes Strategy, the prevalence of type 2 diabetes among Spanish population is 13.8%.
- Trial name
- PREDIABETCAR (NCT04863313)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Gestational Diabetes Mellitus, Pre-diabetes
A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus
Our goal is to test whether shared decision making for diabetes prevention can help women with a history of gestational diabetes mellitus (GDM) who are at high risk of developing type 2 diabetes (T2DM) increase weight loss and…
- Conditions
- Gestational Diabetes Mellitus, Pre-diabetes, Diabetes Mellitus, Type 2
- Trial name
- NCT04897945
- Testing
- Shared decision-making for diabetes prevention
- Where
- 2 sites in United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pre Diabetic
A Pilot Study to Determine the Effect of a Cobiotic Formulation on the Gastrointestinal Microbiome
This study aims to investigate the effect of a cobiotic formulation, prepared as a smoothie beverage, on the ratio of intestinal microbiota of the Bacteroidetes phylum to those of the Firmicutes phylum in the stool as well as the…
- Trial name
- NCT01724736
- Testing
- NM504:
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- NuMe Health
Pre-diabetes, Obesity
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further…
- Trial name
- NCT05051436
- Testing
- Mirabegron 50 MG, Tadalafil 10 MG
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Respiratory Disorder, Cardiovascular Diseases
Study of RE.DOCTOR Vitals® Software Accuracy
The purpose of this observational trial is to advance digital health monitoring through the analysis of Photoplethysmography (PPG) waveforms collected via RE.DOCTOR Vitals software.
- Conditions
- Respiratory Disorder, Cardiovascular Diseases, Diabetes, Pre-Diabetes
- Trial name
- RE-VITAL (NCT06237322)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- RE.DOCTOR LLC