Clinical trials: Pre Diabetic
Pre Diabetes, Obesity
Beta Glucan and Acetate Production
Based on our hypothesis that orally administered resistant starch and beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we…
- Trial name
- NCT03714646
- Testing
- beta glucan and resistant starch, beta gluten
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
PreDiabetes, Aging
Effects of Progressive Intensity Exercise Training on Glycemic Control in Older Adults
The purpose of this study is to compare the effects of moderate versus vigorous intensity exercise training on glycemic control in older adults.
- Trial name
- GLYDE (NCT03154073)
- Testing
- Moderate Intensity Exercise Training (MOD), Vigorous Intensity Exercise Training (VIG)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Physical Activity
Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
The investigators propose that post-exercise milk protein feeding will enhance the mitochondrial protein synthesis (biogenesis) response to an exercise-training program.
- Trial name
- NCT02552355
- Testing
- Metformin, Carbohydrate Beverage, Protein Beverage
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Impaired Glucose Tolerance, Pre-diabetes
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
The purpose of the study is to determine the role of beta-cell function and insulin resistance in the development of impaired glucose tolerance (IGT) and type 2 diabetes in children and adolescents who have an increased risk of…
- Conditions
- Impaired Glucose Tolerance, Pre-diabetes, Childhood Obesity, Insulin Resistance
- Trial name
- NCT00536250
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Yale University
PreDiabetes, Body Weight
Effect of Empagliflozin Versus Placebo on Brain Insulin Sensitivity in Patients With Prediabetes
Recently, various sodium glucose cotransporter 2 (SGLT2) inhibitors have been approved for the treatment of type 2 diabetes mellitus. Empagliflozin is a preparation of this class of substances.
- Trial name
- NCT03227484
- Testing
- Empagliflozin 25mg
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Diabetes Mellitus, Type 2, Obesity
The Glycemic Effect of Added Sugar on Bake Beans
To investigate the effect of added sugar to bake beans on glycemic and insulinemic response.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, PreDiabetes
- Trial name
- GIF (NCT03868683)
- Testing
- Glucose Reference 1, Glucose Reference 2, Glucose reference 3
- Where
- Singapore
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Prediabetes, Depressive Symptoms Mild to Moderate in Severity
Mindfulness-based Personalized Health Planning for Reducing Risk of Heart Disease and Diabetes
The purpose of this study is to compare the effectiveness of educational and lifestyle intervention programs aimed at reducing fasting blood sugar and emotional distress in adults with prediabetes.
- Trial name
- AWARENESS (NCT01430221)
- Testing
- Mindfulness-based Personalized Health Planning, Structured & Guided Education
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity
Identification of Muscle-specific Biomarkers of Fatty Acid Beta-oxidation
Elevated fat levels within skeletal muscle cells (intramyocellular lipids) are highly correlated with muscle and whole-body insulin resistance, and more prevalent in obesity.
- Trial name
- FL-68 (NCT01494025)
- Testing
- Diet and Exercise
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Diabetes, PreDiabetes
Study of Diabetes' Risk Factors and Accelerated Aging According to Socio-economic Status in a Population From the North of France
Populations in precarious situations or with low socio-economic status have an increased risk of diabetes and accelerated aging.
- Trial name
- PREVENDIAB (NCT05717491)
- Testing
- Biological analysis, Physical examination and Questionnaires, Physical examination and Questionnaires
- Where
- France
- Volunteers
- 2,014 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Pre-diabetes, Obese
Investigation of an Amino Acid Supplement on Glucose Levels in Obese Subjects
This study aims to determine whether the use of Branched-Chain Amino Acids (BCAA's) regulate insulin and glucagon secretion, and whether the supplement has any effect on body weight and body composition.
- Conditions
- Pre-diabetes, Obese, Glucose Intolerance
- Trial name
- NCT03715010
- Testing
- BCAA
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Prediabetes, Insulin Resistance
Pilot Study on Metabolic Effects of Fish Peptides and Vitamin D
The overall goal of this study is to investigate the effects and the mechanisms of action of a fish peptide and vitamin D on glucose metabolism, insulin secretion, and cardiometabolic risk profile in overweight men.
- Trial name
- BONITO (NCT02668159)
- Testing
- Fish peptide supplement, Vitamin D supplement, Fish peptide + Vitamin D3 supplements
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Laval University
Pediatric Obesity, Prediabetic State
Health Outcomes of Teens Participating in Summer Employment Immersion Programs
This study is a collaboration between investigators and two community partners: a youth employment program and an urban farm. The community partners hire 300+ adolescents for summer jobs at various organizations.
- Trial name
- NCT02886208
- Testing
- Measurement
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy, Obesity & Overweight
Growth Hormone Resistance of Beta-cells
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with impaired fasting glucose or impaired…
- Conditions
- Healthy, Obesity & Overweight, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (Prediabetes)
- Trial name
- GHRB-C (NCT07581860)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Diabetes Mellitus, Type 2, Family Health
Family-based Prevention of Diabetes Through Eating Habits and Physical Activity
Introduction: Type 2 diabetes represents a growing health risk for the society. An easy-access and low-cost intervention for the whole family will be developed to help families with (at risk of) type 2 diabetes maintain…
- Conditions
- Diabetes Mellitus, Type 2, Family Health, Health Behavior, Healthy Lifestyle
- Trial name
- GO_EASY (NCT05694351)
- Testing
- Healthy meals and physical activity in families with type 2 diabetes
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Slagelse Hospital
Prediabetes
Efficacy of Diacylglycerol Oil on Metabolic Risk Factors in Prediabetes
This study will implement a four-week dietary intervention among middle-aged and older adults with pre-diabetes. Participants assigned to the intervention arm will replace their usual cooking oil with diacylglycerol (DAG) oil…
- Trial name
- NCT07289880
- Testing
- Diacylglycerol oil, Colza Oil
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangdong Pharmaceutical University
Diabetes Mellitus, Type 2, PreDiabetes
18F-FDOPA PET/CT Imaging in Patients Undergoing Metabolic Surgery
The aim of the study is to compare the endocrine function of pancreas between pre and post metabolic surgery in patients with type 2 diabetes or prediabetes.
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Obesity
- Trial name
- NCT03821961
- Testing
- Metabolic Surgery
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Pre-Diabetes, Diabetes
A1c FIT TEST: An Epidemiological Study Correlating Hemoglobin A1c With Results of the Air Force Physical FITness TEST.
The purpose of this study is to evaluate the prevalence of pre-diabetes and diabetes among those Air Force personnel who have not passed the Air Force physical fitness test (AFPT) and to evaluate the usefulness of the AFPT as a…
- Conditions
- Pre-Diabetes, Diabetes, Cardiovascular Risks
- Trial name
- NCT01301339
- Where
- United States
- Volunteers
- 535 people, healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
Chronic Periodontitis, Type 2 Diabetes Mellitus
Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy
1. Are adipokines involved in pathogenesis of periodontal disease in diabetic patients? 2. Does their level change after periodontal therapy?
- Trial name
- NCT02174146
- Testing
- non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Overweight, Obesity
Effects of a Wholegrain Diet on Body Composition and Energy Balance
The purpose of this study is to compare a diet containing whole grains versus an energy matched diet using refined grains on body composition and metabolism.
- Conditions
- Overweight, Obesity, Pre-diabetic
- Trial name
- NCT01411540
- Testing
- Whole grains
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Type 2 Diabetes, Overweight and Obesity
Acute Timed Exercise and 24h Metabolism
The primary objective of this randomized controlled cross-over study is to investigate if an acute, glycogen lowering exercise bout performed either in the morning or late afternoon differentially affects the respiratory exchange…
- Trial name
- TIM (NCT05073068)
- Testing
- Timing of exercise, Control
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Maastricht University