Clinical trials: Pre Eclampsia
Preeclampsia
Standard 24-hour Urine Protein vs Shorter Period for Diagnosis of Pre-eclampsia
Background and project rationale: Preeclampsia is a common complication of pregnancy, affecting 6-8% of all pregnancies and constitutes a leading cause of maternal morbidity and mortality.
- Trial name
- PET and urine (NCT01881542)
- Where
- Israel
- Volunteers
- 307 people
- Sponsor
- HaEmek Medical Center, Israel
Preeclampsia Postpartum
Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT05937841
- Testing
- Compound 21
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Preeclampsia
Study to Determine if Serum BNP Levels Are Elevated in Pregnant Women With Pre-Eclampsia
Preeclampsia is a common disease state occurring in the third trimester of pregnancy, with an incidence of approximately 5-10% in the US.
- Trial name
- NCT00533871
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Ohio State University
Preeclampsia
Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure
The postpartum period represents a stage of the pregnancy-puerperal still rarely addressed scientifically. There are no reports in the literature and concrete enough to elucidate important issues, especially in the field of…
- Trial name
- CLONCAP (NCT01761916)
- Testing
- CLONIDINE, CAPTOPRIL
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Pre-eclampsia, Hypertension, Pregnancy-Induced
Assessment of Physical Exercise Using Stationary Bicycle for Pregnant Women With Risk for Preeclampsia Development
Introduction: Hypertensive disorders during pregnancy are an important issue in global public health. It is current the leading cause of maternal mortality in Brazil.
- Conditions
- Pre-eclampsia, Hypertension, Pregnancy-Induced, Pregnancy, High-Risk
- Trial name
- NCT01395342
- Testing
- Exercise using stationary bicycle
- Where
- Brazil
- Volunteers
- 116 people
- Sponsor
- University of Campinas, Brazil
Pulmonary Artery Doppler
Pulmonary Artery Doppler in Preeclamptic Mothers
Evaluation of Pulmonary artery Doppler parameters in fetuses of mothers with severe preeclampsia
- Trial name
- NCT06755073
- Testing
- Pulmonary artery Doppler ultrasound
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Cardiovascular Diseases, Heart Diseases
Hypertensive and Normal Pregnancy--Calcium Metabolism and Renin-Angiotensin - SCOR in Hypertension
To study calcium metabolism and the renin-angiotensin system in hypertensive and normal pregnancy.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Eclampsia
- Trial name
- NCT00005456
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pregnancy Related
Longitudinal Study of Gene Expression in the Human Placenta During First-trimester and Full-term Pregnancy at the Single Cell Level
The single nucleus RNA-seq approach allows the placental transcriptome to be analyzed from nuclei, thus preserving the integrity of placental syncytium.
- Trial name
- VilliRNAseq (NCT06427408)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia
Clinical Trial of a COX-2 Inhibitor for the Treatment of Women With Preeclampsia
Preeclampsia is a hypertensive disorder of pregnancy and a leading cause of fetal and maternal morbidity and mortality. Recent findings indicate preeclampsia is an inflammatory disorder associated with increased expression of…
- Trial name
- NCT00442676
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Preeclampsia Possible
Impact of the sFlt-1/PlGF Ratio on Medical Decision-making and on Maternal and Neonatal Outcomes in Women Suspected of Preeclampsia
Previous studies demonstrated that Placental Growth Factor (PIGF) and Vascular Endothelial Growth Factor (VEGF) produced by trophoblast cells decreases during Preeclampsia, whereas soluble fms-like tyrosine kinase-1 (sFlt-1), an…
- Trial name
- NCT06314555
- Testing
- Blood sample, Vascular-renal sample
- Where
- France
- Volunteers
- 314 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hypertension, Postpartum Preeclampsia
Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
- Trial name
- NEPHRON (NCT07363343)
- Testing
- Nifedipine and Enalapril, Nifedipine and Labetalol
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic
Pre-Eclampsia
Placental Growth Factor as a Predictor of Adverse Pregnancy Outcomes in Preeclamptic Women
Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality worldwide, and it affects 3% to 8% of all pregnancies.
- Trial name
- NCT04374604
- Testing
- Placental growth factor
- Where
- Nigeria
- Volunteers
- 140 people
- Sponsor
- Johnbosco Ifunanya Nwafor
Pre-Eclampsia
Evaluation of HALP Score in Preeclampsia
Preeclampsia is a serious condition that can occur during pregnancy and can pose problems for both the mother and the baby. It occurs in approximately 2-8% of all pregnancies globally and is caused by issues with blood vessels…
- Trial name
- NCT05816044
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Preeclampsia, Hypertension
Hypertension and Urine Protease Activity in Preeclampsia
Preeclampsia (PE) is a common disorder of pregnancy that complicates 4-7% of all pregnancies. It is a serious condition with acute proteinuria and hypertension and varying degrees of edema after 20 weeks of gestation.
- Conditions
- Preeclampsia, Hypertension, Proteinuria, Pregnancy
- Trial name
- HUPP (NCT01828138)
- Testing
- Sodium
- Where
- Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Preeclampsia
the Implications of Pathogenesis of Pre-Eclampsia
Preeclampsia is a severe complication of human pregnancy. It occurs in 4-5% of all pregnancies and remains a leading cause of maternal and neonatal mortality and morbidity.
- Trial name
- NCT00154934
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Preeclampsia and Eclampsia
Springfusor for Administration of Magnesium Sulphate in Preeclampsia and Eclampsia
Magnesium Sulphate is the drug of choice for prevention and treatment of seizures in preeclampsia and eclampsia. It is administered parenterally by intravenous (IV) and or intramuscular (IM) routes.
- Trial name
- NCT03549767
- Testing
- Springfusor, Standard of care
- Where
- Uganda
- Volunteers
- 241 people
- Sponsor
- Makerere University
Preeclampsia, Severe Preeclampsia
Pre-Eclampsia And Growth Restriction: a Longitudinal Study
Preeclampsia may have several causes leading to different characteristics of the pathology. Differentiation between the "type of preeclampsia" would help to treat patients more accurately.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PEARL (NCT02379832)
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Preeclampsia
Social Risks-Focused Lifestyle Intervention to Reduce Preeclampsia (SAIL)
Preeclampsia is a disease of pregnancy and first few weeks after birth. It is diagnosed as new onset of high blood pressure and injury to organs such as kidneys, liver, and brain.
- Trial name
- SAIL (NCT04958057)
- Testing
- SAIL
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Preeclampsia Severe
Effect of Magnesium Sulphate on the Intracranial Pressure of Preeclamptic Patients
It had been shown that high percentage of severe preeclampsia patients got a high cerebral perfusion pressure (CPP) due to abnormal autoregulation of cerebral blood vessels with associated endothelial dysfunction and disrupted…
- Trial name
- NCT03210350
- Testing
- Optic nerve sheath diameter
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Corniche Hospital
Pre-Eclampsia, Pregnancy Complications
ASA Patterns for Prevention of Preeclampsia in SLE Pregnancies
Preeclampsia is a serious maternal condition affecting up to 5% of pregnancies from the general population and up to 30% of lupus pregnancies.
- Conditions
- Pre-Eclampsia, Pregnancy Complications, Systemic Lupus
- Trial name
- NCT03749044
- Testing
- Patient Educational Tool
- Where
- Canada
- Volunteers
- 73 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre